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| Product | Description | |
|---|---|---|
| RNase A, Bovine pancreas | RNase A, Bovine pancreas (Ribonuclease A) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, bovine pancreas catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ribonuclease A; EC 4.6.1.18; RNase A. CAS No. 9001-99-4. Pack Sizes: 25 mg; 50 mg. Product ID: HY-129046. |  |
| Citric acid trisodium salt hydrate,dnase,rnase and protease free,for molecular biology,99.8% | Heterocyclic Organic Compound. Alternative Names: CITRIC ACID TRISODIUM SALT HYDRATE, DNASE, RNASE AND PROTEASE FREE, FOR MOLECULAR BIOLOGY, 99.8%;CITRIC ACID TRISODIUM SALT HYDRATE, 99.8%, DNASE, RNASE AND PROTEASE FREE, FOR MOLEC;Citric acid, trisodium salt hydrate, DNAse, RNAse and Protease free, for. CAS No. 114456-61-0. Molecular formula: C6H5Na3O7.xH2O. Mole weight: 258.08. Catalog: ACM114456610. |  |
| Immobilized RNase A on G3m | RNase A is an endonuclease that cleaves RNA but not DNA. RNase A specifically cuts pyrimidine ribonucleotides at the 3'-adjacent phosphodiester bond Py/pN, with the intermediary formation of nucleoside-2',3'-cyclophosphate. G3m: 25 ug (2. 5 Kunitz units) RNase A per CR-column immobilized on dextranThis G3m-column digests at least 200 ug RNA per application. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5 (also active with 1% SDS)Nr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5The columns are provided in storage buffer. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ...lease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3. 1. 27. 5. Storage: 4 °C. Source: Bovine pancreas. Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4; Immobilized RNase A. Cat No: NATE-1773. |  |
| Native Bovine Deoxyribonuclease I RNase-free solution | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Applications: Used in molecular biology applications for removing dna during rna purifica...zyme Commission Number: EC 3.1.21.1. CAS No. 9003-98-9. DNASE1. Mole weight: mol wt 29.1 kDa. Storage: -20°C. Form: buffered aqueous glycerol solution. Source: Bovine pancreas. Species: Bovine. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: NATE-0199. | |
| Reaction Buffer for Ribonuclease H (RNase H) (10X) | Reaction Buffer for Ribonuclease H (RNase H) (10X). Group: Molecular Biology. Alternative Names: E. coli; cRNAse H. Grades: Molecular Biology Grade. CAS No. 9050-76-4. Pack Sizes: 1ml. US Biological Life Sciences. |  Worldwide |
| Recombinant DNase I (RNase-free) | Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9003-98-9. Pack Sizes: 200 U; 500 U; 1 KU. Product ID: HY-108882A. | |
| RNase H | RNase H. Ribonuclease h (rnase h) specifically degrades the rna strand in rna-dna hybrids. it does not hydrolyze the phosphodiester bonds within single-stranded and double-stranded dna and rna. this product is purified from e. coli expressing the recombinant rnha gene on a plasmid with 17 kda molecular weight and it can be inactivated by heating at 65°c for 20 minutes. Group: DNA Modifying Enzymes. Purity: 100U; 5*100KU. Storage: Store at -20°C. Cat No: ME-4003. | |
| tRNase Z | No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii. Group: Enzymes. Synonyms: 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Enzyme Commission Number: EC 3.1.26.11. CAS No. 98148-84-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3587; tRNase Z; EC 3.1.26.11; 98148-84-6; 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Cat No: EXWM-3587. | |
| 2'-5' oligoadenylate synthase | The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity. Group: Enzymes. Synonyms: OAS. Enzyme Commission Number: EC 2.7.7.84. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3297; 2'-5' oligoadenylate synthase; EC 2.7.7.84; OAS. Cat No: EXWM-3297. | |
| 2'-Deoxy-6-thio Guanosine | Guanosine derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA. Group: Biochemicals. Alternative Names: 2-Amino-9-(2-deoxy- β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione; 2-Amino-9-(2-deoxy- β-D-erythro-pentofuranosyl)-6-mercaptopurine; 2'-Deoxythioguanosine; 2'-Desoxy-6-thioguanosine; NSC 71261; TGdR; Thioguanine Deoxyriboside; β-Thioguanine Deoxyriboside. Grades: Highly Purified. CAS No. 789-61-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Hydroxyisoquinoline-1,3(2H,4H)-dione | 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. It was investigated its interaction with Mg2+ and Mn2+ using different spectroscopic techniques and report that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent. Group: Biochemicals. Alternative Names: 2-Hydroxy-1,3(2H,4H)-isoquinolinedione. Grades: Highly Purified. CAS No. 6890-08-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4μ8C | 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. Synonyms: IRE1 Inhibitor III; 8-Formyl-4-methylumbelliferone; 8-Formyl-7-hydroxy-4-methylcoumarin; 4-Methyl-7-hydroxy-8-formylcoumarin; 7-Hydroxy-8-formyl-4-methylcoumarin; 8-Formyl-7-hydroxy-4-methyl-2H-1-benzopyran-2-one. Grades: >98%. CAS No. 14003-96-4. Molecular formula: C11H8O4. Mole weight: 204.18. |  |
| Agarose | Agarose. High purity agarose which is free of dnase, rnase, and protease. staining with ethidium bromide or gel stain provides low background, strong electrophoretic separation performance, and clear bands. agarose is suitable for electrophoresis of various dna and rna. Group: Markers & Ladders. Storage: Store at room temperature for two years. Cat No: MK-2002. | |
| AMG 18 hydrochloride | AMG-18 hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. AMG-18 is a potent and selective IRE1α inhibitor with IC50 of 13 nM for recombinant and IC50 of 99 nM for cellular IRE1&alpha. Synonyms: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride; Kira8 hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C31H29ClN6O3S·HCl. Mole weight: 637.58. | |
| Bacillus subtilis ribonuclease | This enzyme catalyses the following chemical reaction: endonucleolytic cleavage to 2',3'-cyclic nucleotides. Group: Enzymes. Synonyms: Proteus mirabilis RNase; ribonucleate nucleotido-2'-transferase (cyclizing). Enzyme Commission Number: EC 3.1.27.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3600; Bacillus subtilis ribonuclease; EC 3.1.27.2; Proteus mirabilis RNase; ribonucleate nucleotido-2'-transferase (cyclizing). Cat No: EXWM-3600. | |
| B I09 | B I09 is a cell permeable IRE-1 RNase inhibitor (IC50 = 1.23 μM) that blocks IRE-1/XBP1 pathway. B I09 exhibits an inhibitory effect on growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model. Uses: Potential treatment of cll. Synonyms: B-I09; B I09; BI09; 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one. Grades: ≥98% by HPLC. CAS No. 1607803-67-7. Molecular formula: C16H17NO5. Mole weight: 303.31. | |
| Diethyl pyrocarbonate | Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1609-47-8. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-D0846. | |
| Diethylpyrocarbonate (DEPC) | DEPC is a strong nuclease inhibitor, utilizing a mechanism which modifies His and Tyr residues in proteins. Used as a RNase and DNase inhibitor for Molecular Biology solutions. DEPC is a chemical use to inactivate RNase enzymes and is sensitive to moisture and pH. It decomposes at 155°C, to ethanol and carbon dioxide in aqueous solution. DEPC is also sensitive to ammonia, which causes decomposition to urethane, a possible carcinogen. Group: Biochemicals. Alternative Names: Diethyloxydiformate; Ethyloxyformic acid anhydride; Diethyl dicarbonate; DEP; DEPC; EC 216-542-8. Grades: Molecular Biology Grade. CAS No. 1609-47-8. Pack Sizes: 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
| Diethyl Pyrocarbonate (DEPC) 99+% (GC) | DEPC is a strong nuclease inhibitor, utilizing a mechanism which modifies His and Tyr residues in proteins. Used as a RNase and DNase inhibitor for Molecular Biology solutions. DEPC is a chemical use to inactivate RNase enzymes and is sensitive to moisture and pH. It decomposes at 155°C, to ethanol and carbon dioxide in aqueous solution. DEPC is also sensitive to ammonia, which causes decomposition to urethane, a possible carcinogen. Group: Biochemicals. Alternative Names: Diethyloxydiformate; Ethyloxyformic acid anhydride; Diethyl dicarbonate; DEP; DEPC; EC 216-542-8. Grades: Molecular Biology Grade. CAS No. 1609-47-8. Pack Sizes: 5g, 25g, 100g, 250g. Molecular Formula: C6H10O5, Molecular Weight: 162.14. US Biological Life Sciences. | Worldwide |
| Ethynylcytidine | Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule. Synonyms: ECyd; TAS-106; TAS 106; TAS106; 3'-C-Ethynylcytidine; AIDS241582; AIDS 241582; AIDS-241582; SB-596168; SB596168; SB 596168; 3'-Ethynylcytidine. CAS No. 180300-43-0. Molecular formula: C11H13N3O5. Mole weight: 267.241. | |
| exoribonuclease II | Preference for single-stranded RNA. The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5 ribonuclease P. Group: Enzymes. Synonyms: ribonuclease II; ribonuclease Q; BN ribonuclease; Escherichia coli exo-RNase II; RNase II; exoribonuclease (misleading); 5'-exoribonuclease (misleading). Enzyme Commission Number: EC 3.1.13.1. CAS No. 37288-24-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3536; exoribonuclease II; EC 3.1.13.1; 37288-24-7; ribonuclease II; ribonuclease Q; BN ribonuclease; Escherichia coli exo-RNase II; RNase II; exoribonuclease (misleading); 5'-exoribonuclease (misleading). Cat No: EXWM-3536. | |
| Formamide | Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to ÂflowÂ. Group: Biochemicals. Alternative Names: Amide C1; Formic amide; Carbamaldehyde; Formimidic Acid; Methanamide; NSC 748. Grades: Highly Purified. CAS No. 75-12-7. Pack Sizes: 500g. Molecular Formula: CH3NO, Molecular Weight: 45.04. US Biological Life Sciences. | Worldwide |
| Formamide-13C | Isotope labelled Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to ÂflowÂ. Group: Biochemicals. Grades: Highly Purified. CAS No. 51284-91-4. Pack Sizes: 50mg, 100mg. Molecular Formula: 13CH3NO. US Biological Life Sciences. | Worldwide |
| Framycetin | Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K i of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a K i of 13.5 μM. Framycetin, a 5"-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Neomycin B; Fradiomycin B. CAS No. 119-04-0. Pack Sizes: 25 mg (16.27 mM * 2.5 mL in 0.9% NaCl); 50 mg (16.27 mM * 5 mL in 0.9% NaCl); 100 mg (16.27 mM * 10 mL in 0.9% NaCl). Product ID: HY-17624. | |
| Framycetin sulfate | Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K i of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a K i of 13.5 μM. Framycetin sulfate, a 5"-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Neomycin B sulfate; Fradiomycin B sulfate. CAS No. 4146-30-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-17624A. | |
| Guanidine Hydrochloride | Guanidine Hydrochloride is used as a common protein denaturant in the purification and extraction of mRNA, nucleic acids and proteins from cellular material. It acts as a strong RNase inhibitor, protecting cellular transcripts from degradation during tissue extraction. Group: Biochemicals. Alternative Names: Aminomethanamidine hydrochloride, Aminoformamidine hydrochloride, Carbamidine hydrochloride, Guanidine chloride, Guanidinium chloride, Guanidinium hydrochloride, Iminourea. Grades: Molecular Biology Grade. CAS No. 50-01-1. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg, 10Kg. Molecular Formula: CH5N3 HCl, Molecular Weight: 95.53. US Biological Life Sciences. | Worldwide |
| Guanidine Hydrochloride 6M Solution | Guanidine Hydrochloride 6M Solution is a convenient preparation of our ultrapure molecular biology grade guanidine hydrochloride. It is used as a common protein denaturant in the purification and extraction of mRNA, nucleic acids and proteins from cellular material, acting as a strong RNase inhibitor, protecting cellular transcripts from degradation during tissue extraction.No contaminating RNase, DNase or Proteases detectedPrepared with ultrapure molecular biology grade water0.2um Sterile-filtered. Group: Biochemicals. Alternative Names: Aminomethanamidine hydrochloride, Aminoformamidine hydrochloride, Carbamidine hydrochloride, Guanidine chloride, Guanidinium chloride, Guanidinium hydrochloride, Iminourea. Grades: Molecular Biology Grade. CAS No. 50-01-1. Pack Sizes: 100ml, 500ml, 1L, 2L, 2x2L. Molecular Formula: CH5N3 HCl H2O, Molecular Weight: 95.53. US Biological Life Sciences. | Worldwide |
| Guanidine Hydrochloride 7M Solution | Guanidine Hydrochloride 7M Solution is a convenient preparation of our ultrapure molecular biology grade guanidine hydrochloride. It is used as a common protein denaturant in the purification and extraction of mRNA, nucleic acids and proteins from cellular material, acting as a strong RNase inhibitor, protecting cellular transcripts from degradation during tissue extraction. Group: Biochemicals. Alternative Names: Aminomethanamidine hydrochloride, Aminoformamidine hydrochloride, Carbamidine hydrochloride, Guanidine chloride, Guanidinium chloride, Guanidinium hydrochloride, Iminourea. Grades: Molecular Biology Grade. CAS No. 50-01-1. Pack Sizes: 100ml, 500ml, 1L, 2L, 2x2L. Molecular Formula: CH5N3 HCl, Molecular Weight: 95.53. US Biological Life Sciences. | Worldwide |
| Guanidine Hydrochloride 8M Solution | Guanidine Hydrochloride 8M Solution is a convenient preparation of our ultrapure molecular biology grade guanidine hydrochloride. It is used as a common protein denaturant in the purification and extraction of mRNA, nucleic acids and proteins from cellular material, acting as a strong RNase inhibitor, protecting cellular transcripts from degradation during tissue extraction. Group: Biochemicals. Alternative Names: Aminomethanamidine hydrochloride, Aminoformamidine hydrochloride, Carbamidine hydrochloride, Guanidine chloride, Guanidinium chloride, Guanidinium hydrochloride, Iminourea. Grades: Molecular Biology Grade. CAS No. 50-01-1. Pack Sizes: 100ml, 500ml, 1L, 2L, 2x2L. Molecular Formula: CH5N3 HCl H2O, Molecular Weight: 95.53. US Biological Life Sciences. | Worldwide |
| Guanidine Thiocyanate | Guanidinium thiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used in the extraction of DNA and RNA.Note: this compound may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation, [CH6N3]+.Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 Spanish flu, so that it can be studied safely. This application is presumably based on its denaturation activity.Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them. These enzymes would otherwise damage the extract.A commonly used method is guanidinium thiocyanate-phenol-chloroform extraction. It is not strictly necessary to use phenol or chloroform if extracting RNA for Northern blotting or DNA for Southern blot analysis because the gel electrophoresis followed by transfer to a membrane will separate the RNA/DNA from the proteins. Additionally, since these methods use probes to bind to their conjugates, peptides that get through the process dont generally matter unless a peptide is an RNase or DNase, and then only if the enzyme manages to renature, which should not occur if p | |
| Guanidine Thiocyanate (GuSCN) | Stronger chaotropic agent than Guanidine Hydrochloride. Used in total RNA preparation as guanidinium solution. Guanidine Thiocyanate is used as a common protein denaturant in the purification and extraction of mRNA, nucleic acids and proteins from cellular material, acting as a strong RNase inhibitor, protecting cellular transcripts from degradation during tissue extraction. Group: Biochemicals. Alternative Names: Guanidine isothiocyanate; Aminomethanamidine thiocyanate, Guanidinium thiocyanate. Grades: Molecular Biology Grade. CAS No. 593-84-0. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg, 5Kg. Molecular Formula: CH5N3 HSCN, Molecular Weight: 118.16. US Biological Life Sciences. | Worldwide |
| IPTG Dioxane Free, Sterile Solution, 1M | Sterile solution of dioxane-free IPTG manufactured according to Maniatas, et al. Suitable for use in molecular cloning and M13 bacteriophage plating. Prepared with sterile, RNase and DNase-free molecular biology grade water and ultrapure RNase and DNase-free IPTG.IPTG is a carbohydrate used to induce b-galactosidase in the selection of recombinant plasmids. Used to select for lac Y mutants and to induce the lac operon in E.coli. IPTG will induce the cellular content of lactose permease. Water:Distilled, deionized waterFiltration: Sterile filtered (0.2um)IPTG Component: ≥99%Dioxane: ≤ 0.001%RNase, DNase, Proteases: None Detected. Group: Biochemicals. Alternative Names: IPTG; Isopropyl-ß-D-thiogalactopyranoside; Isopropyl-ß-D-thiogalactoside. Grades: Molecular Biology Grade. CAS No. 367-93-1. Pack Sizes: 10ml, 5x10ml, 100ml. Molecular Formula: C9H18O5S, Molecular Weight: 238.31. US Biological Life Sciences. | Worldwide |
| IRE1 Inhibitor III, 4u8C (8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III) | A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50=550 and 45nM, respectively, with 0 and 16min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50=6.9 and 4.1uM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin treatment. Comparing to STF083010, 4u8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4u8C from targeting IRE1 Lys599 intracellularly. Group: Biochemicals. Grades: Highly Purified. CAS No. 14003-96-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| KIRA6 | KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. Synonyms: KIRA6; KIRA-6; KIRA 6; 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea; 1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea; KIRA analog, 2. CAS No. 1589527-65-0. Molecular formula: C28H25F3N6O. Mole weight: 518.53. | |
| KIRA-7 | KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase ( IC 50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1937235-76-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124646. | |
| Kira8 | Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC 50 of 5.9 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMG-18. CAS No. 1630086-20-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114368. | |
| MKC-8866 | MKC-8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity. MKC8866 strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. Group: Inhibitors. Alternative Names: MKC-8866; MKC 8866; MKC8866; IRE1-IN-8866; IRE1IN8866; IRE1 IN 8866; IRE1-IN8866; IRE1-IN 8866; IRE1IN-8866; IRE1IN 8866. CAS No. 1338934-59-0. Molecular formula: C18H19NO7. Mole weight: 361.35. Appearance: Solid powder. Purity: >98%. IUPACName: 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde. Canonical SMILES: O=CC1=C (O)C (OC)=CC2=C1OC (C (CC (N3CCOCC3)=O)=C2C)=O. Catalog: ACM1338934590. | |
| N1-MethylpseudoUridine-5'-Triphosphate Sodium | It is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA. The product has passed the functionality test in transcription reaction. The solution is free of DNase and RNase contamination. Synonyms: 1-Methylpseudouridine-5'-Triphosphate sodium salt; N1-Methylpseudo-UTP sodium salt; 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy (phosphonooxy) phosphinyl]oxy]phosphinyl]-β -D-ribofuranosyl]-1-methyl-, sodium salt; 1-Methylpseudo-UTP sodium salt; 1-Methylpseudouridine-5'-Triphosphate; N1-Methylpseudo-UTP. Grades: 99%, 100mM sodium salt solution. Molecular formula: C10H17N2O15P3.xNa. Mole weight: 498.17 (free acid). | |
| Native Aspergillus oryzae Ribonuclease T1 | Ribonuclease T1 (RNase T1) from Aspergillus oryzae is an endoribonuclease that hydrolyzes after G residues. Cleavage occurs between the 3-phosphate group of a guanidine ribonucleotide and 5-hydroxyl of the adjacent nucleotide. The initial product is a 2:3 cyclic phosphate nucleoside that is hydrolyzed to the corresponding 3-nucleoside phosphate. It differs from Pancreatic RNase in that it attacks the guanine sites specifically to yield 3'-GMP and oligonucleotides with a 3'-GMP terminal group. Applications: Ribonuclease t1 (rnase t1) from aspergillus oryzae is used to digest denatured rna prior to sequencing and is used for protein folding studies. Group: Enzymes. Synonyms: Ribonuclease T1; EC 3.1.27.3; g. Enzyme Commission Number: EC 3.1.27.3. CAS No. 9026-12-4. Rnase. Activity: 300,000-600,000 units/mg protein. Storage: -20°C. Form: ammonium sulfate suspension; Suspension in 2.8 M (NH4)2SO4 solution. Source: Aspergillus oryzae. Ribonuclease T1; EC 3.1.27.3; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1; 9026-12-4. Cat No: NATE-0658. | |
| Native Bovine Ribonuclease A | Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3 phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2'-OH groups essential for the formation of cyclic intermediates. RNase can hydrolyze RNA from protein samples. Pancreatic RNase A specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds. Ribonucleases do not hydrolyze dna, because the dna lacks 2?-oh groups essential for the formation of cyclic intermediates. rnase can hydrolyze rna from protein samples. pancreatic rnase a specifically cleaves at the 3?-side of pyrimidine (uracil or cytosine) phosphate bon...y to investigate particle-based and monolithic columns for cation exchange protein displacement chromatography. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3.1.27.5; RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3.1.27.5. CAS No. 9001-99-4. Rnase. Mole weight: mol wt ~13.7 kDa. Activity: Type I, 50-150 Kunitz units/mg solid; Type | |
| Native Bovine Ribonuclease B | Native RNase BS generated by subtilisin digestion of native RNase B comprising of amino acid residues 21-124 of RNase B, is sensitive to PNGase F digestion. Intramolecular N-glycans of bovine pancreatic RNase B function like chaperone. RNase B is found to be much faster than RNase A, while RNase A is liable to aggregate during regeneration. The stimulatory effect of Asn-oligosaccharide (which corresponds to the most predominant sugar chain of RNase B) reveals that the N-glycans of RNase B facilitates the transformation of bulky intermediates into folded, compact species. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3.1.27. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3.1.27.5. CAS No. 9001-99-4. Purity: > 80% (SDS-PAGE). Rnase. Activity: > 50 Kunitz units/mg protein. Storage: -20°C. Source: Bovine pancreas. Species: Bovine. Pancreatic ribonucleases; EC 3.1.27.5; RNase; RNase I; RNase B; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Pack: Package size based on protein content. Cat No: NATE-0656. | |
| Native Swine (Bovine) Ribonuclease | Pancreatic Ribonuclease (RNase I) catalyzes cleavage of the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group attached to the 3'-ribose of an adjacent pyrimidine nucleotide forming a 2',3'-cyclic phosphate which may then be hydrolyzed to the corresponding 3'-nucleoside phosphate. Ribonuclease A has a molecular weight of 13,700 daltons. It operates in an optimum pH range of 7.0-7.5. The high purity Ribonuclease is purified by re-crystallization, and then by Ion Exchange Chromatography and ultra-filtration. Applications: As a laboratory analysis reagent, is scientific research institutions widely used. Group: Enzymes. Synonyms: RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endo. Rnase. Mole weight: 13.7 kDa. Activity: No less than 50Kunitz units/mg, calculated on the dried basis. Appearance: White or pale yellow lyophilized powder. Storage: Sealed, Dark, at temperature 2-8 centigrade. Source: Bovine (Swine) Pancrease. Species: Swine (Bovine). RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-assocd; glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase. Cat No: PHAM-240. | |
| Native Tritirachium album limber Proteinase K | Proteinase K (PROK) is a serine protease with broad specificity towards aliphatic, aromatic and other hydrophobic amino acids. PROK has a molecular weight of 27,000 daltons and is Ca2+ dependent. It is not inactivated by metal ion chelating agents such as EDTA, sulfhydryl reagents, PCMB, TLCK, or TPCK. It also retains activity in 0.5% SDS. It can be inhibited by PMSF or DFP. Applications: Useful for the proteolytic inactivation of nucleases during the isolation of dna and rna. removes endotoxins that bind to cationic proteins such as lysozyme and ribonuclease a. reported useful for the isolation of hepatic, yeast, and mung bean mit ochondria determination of enzyme l o...oteinase; Tritirachium album proteinase K; endopeptidase K; 39450-01-6; protease K. Enzyme Commission Number: EC 3.4.21.64. CAS No. 39450-01-6. Purity: Purified to remove DNase and RNase. Proteinase K. Mole weight: 27 kDa. Activity: Type I, > 20 units per mg dry weight; Type II, > 400 u/ml. Storage: Powder: 2-8°C; Liquid: -20°C. Form: Type I, powder; Type II, Liquid in 20mg/ml in 10mM Tris-HCl, 1mM calcium acetate, pH 7.5 containing 50% glycerol. Source: Tritirachium album limber. Proteinase K; EC 3.4.21.64; Tritirachium alkaline proteinase; Tritirachium album serine proteinase; Tritirachium album proteinase K; endopeptidase K; 39450-01-6; protease K. Cat No: NATE-0637. | |
| pancreatic ribonuclease | Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the RNA helix by complexing with single-stranded RNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the nucleotides. Group: Enzymes. Synonyms: RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gen. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase. Enzyme Commission Number: EC 3.1.27.5. CAS No. 9001-99-4. Rnase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3603; pancreatic ribonuclease; EC 3.1.27.5; 9001-99-4; RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase. Cat No: EXWM-3603. | |
| retroviral ribonuclease H | Comments: Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third. The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites. Group: Enzymes. Synonyms: RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Enzyme Commission Number: EC 3.1.26.13. CAS No. 9050-76-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3589; retroviral ribonuclease H; EC 3.1.26.13; 9050-76-4; RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Cat No: EXWM-3589. | |
| ribonuclease α | Specific for O-methylated RNA. Group: Enzymes. Synonyms: 2'-O-methyl RNase. Enzyme Commission Number: EC 3.1.26.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3590; ribonuclease α; EC 3.1.26.2; 2'-O-methyl RNase. Cat No: EXWM-3590. | |
| ribonuclease D | Requires divalent cations for activity (Mg2+, Mn2+ or Co2+). Alteration of the 3'-terminal base has no effect on the rate of hydrolysis whereas modification of the 3'-terminal sugar has a major effect. tRNA terminating with a 3'-phosphate is completely inactive. This enzyme can convert a tRNA precursor into a mature tRNA. Group: Enzymes. Synonyms: RNase D. Enzyme Commission Number: EC 3.1.13.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3540; ribonuclease D; EC 3.1.13.5; RNase D. Cat No: EXWM-3540. | |
| ribonuclease E | RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication. The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction. 2'-O-Methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus. In Escherichia coli, the enzyme is found in the RNA degradosome. The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, enolase (EC 4.1.1.11) and polynucleotide phosphorylase (EC 2.7.7.8). Group: Enzymes. Synonyms: endoribonuclease E; RNase E; Rne protein. Enzyme Commission Number: EC 3.1.26.12. CAS No. 76106-82-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3588; ribonuclease E; EC 3.1.26.12; 76106-82-6; endoribonuclease E; RNase E; Rne protein. Cat No: EXWM-3588. | |
| Ribonuclease from Rana Pipiens, Recombinant | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. Group: Enzymes. Synonyms: Ribonuclease; Rana Pipiens. Rnase. Source: E. coli. Species: Rana Pipiens. Ribonuclease; Rana Pipiens. Cat No: NATE-1913. | |
| ribonuclease H | Acts on RNA-DNA hybrids. Group: Enzymes. Synonyms: endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H. Enzyme Commission Number: EC 3.1.26.4. CAS No. 9050-76-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3592; ribonuclease H; EC 3.1.26.4; 9050-76-4; endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H. Cat No: EXWM-3592. | |
| Ribonuclease H from Escherichia coli, Recombinant | Ribonuclease H (RNase H) is a family of non-sequence-specific endonucleases that catalyze the cleavage of RNA via a hydrolytic mechanism. Members of the RNase H family can be found in nearly all organisms, from bacteria to archaea to eukaryotes. RNase Hs ribonuclease activity cleaves the 3-O-P bond of RNA in a DNA/RNA duplex substrate to produce 3-hydroxyl and 5-phosphate terminated products. In DNA replication, RNase H is responsible for removing the RNA primer, allowing completion of the newly synthesized DNA. Applications: Ribonuclease h from escherichia coli has been used in a study to assess metallobi ochemistry of the magnesium ion. ribonuclease h has also been used in a study to investigate selective inhibitors of hiv-1 reverse transcriptase ass ociated rnase h activity. Group: Enzymes. Synonyms: Ribonuclease H; RNase H; EC 3.1.4.34; 9050-76-4. Enzyme Commission Number: EC 3.1.4.34. CAS No. 9050-76-4. Rnase. Activity: 1,000-4,000 units/mL. Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 20 mM Tris-HCl, pH 7.5, 100 mM KCl, 10 mM MgCl2, 0.1 mM EDTA, 0.1 mM DTT and 0.05 mg BSA per ml. Source: E. coli. Species: Escherichia coli. Ribonuclease H; RNase H; EC 3.1.4.34; 9050-76-4. Pack: vial of ~30 units. Cat No: NATE-0657. | |
| ribonuclease III | This is an endoribonuclease that cleaves double-stranded RNA molecules. The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. RNase III is involved in both rRNA processing and mRNA processing and decay. Group: Enzymes. Synonyms: RNase III; ribonuclease 3. Enzyme Commission Number: EC 3.1.26.3. CAS No. 9073-62-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3591; ribonuclease III; EC 3.1.26.3; 9073-62-5; RNase III; ribonuclease 3. Cat No: EXWM-3591. | |
| ribonuclease M5 | Converts the 5S-rRNA precursor from Bacillus subtilis into 5S-rRNA, with 5'-phosphate and 3'-hydroxy groups. Group: Enzymes. Synonyms: RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Enzyme Commission Number: EC 3.1.26.8. CAS No. 62253-00-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3596; ribonuclease M5; EC 3.1.26.8; 62253-00-3; RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Cat No: EXWM-3596. | |
| ribonuclease P | An RNA-containing enzyme, essential for tRNA processing; generates 5'-termini or mature tRNA molecules. Group: Enzymes. Synonyms: RNase P. Enzyme Commission Number: EC 3.1.26.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3593; ribonuclease P; EC 3.1.26.5; RNase P. Cat No: EXWM-3593. | |
| ribonuclease [poly-(U)-specific] | Forms oligonucleotides with chain lengths of 6 to 12. Group: Enzymes. Synonyms: ribonuclease (uracil-specific); uracil-specific endoribonuclease; uracil-specific RNase. Enzyme Commission Number: EC 3.1.26.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3597; ribonuclease [poly-(U)-specific]; EC 3.1.26.9; ribonuclease (uracil-specific); uracil-specific endoribonuclease; uracil-specific RNase. Cat No: EXWM-3597. | |
| Ribonuclease R from E. coli | RNase R is an 3'-->5' exoribonuclease closely related to RNase II, which has been shown to be involved in selective mRNA degradation, particularly of non stop mRNAs in bacteria. RNase R has homologues in many other organisms. When a part of another larger protein has a domain that is very similar to RNase R, this is called an RNase R domain. Rnase r is provided as a 250 u size (20 u/μl; 1 μg/μl) and is supplied with a 10x rnase r reaction buffer. Applications: O alternative splicing studieso gene expression studieso intron cdna productiono intronic screening of cdna librarieso isolation of splicing intermediates and lariats. Group: Enzymes. Synonyms: RNase R; Ribonuclease. Enzyme Commission Number: EC 3.1.13.1. Activity: 20 U/μl. Storage: Store only at -20°C in a freezer without a defrost cycle. Source: E. coli. RNase R; Ribonuclease; Ribonuclease R. Cat No: NATE-1636. | |
| ribonuclease T1 | Formerly EC 2.7.7.26 and EC 3.1.4.8. Group: Enzymes. Synonyms: guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1. Enzyme Commission Number: EC 3.1.27.3. CAS No. 9026-12-4. Rnase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3601; ribonuclease T1; EC 3.1.27.3; 9026-12-4; guanyloribonuclease; Aspergillus oryzae ribonuclease; RNase N1; RNase N2; ribonuclease N3; ribonuclease U1; ribonuclease F1; ribonuclease Ch; ribonuclease PP1; ribonuclease SA; RNase F1; ribonuclease C2; binase; RNase Sa; guanyl-specific RNase; RNase G; RNase T1; ribonuclease guaninenucleotido-2'-transferase (cyclizing); ribonuclease N3; ribonuclease N1. Cat No: EXWM-3601. | |
| ribonuclease T2 | This enzyme catalyses the following chemical reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. Group: Enzymes. Synonyms: ribonuclease II; base-non-specific ribonuclease; nonbase-specific RNase; RNase (non-base specific); non-base specific ribonuclease; nonspecific RNase; RNase Ms; RNase M; RNase II; Escherichia coli ribonuclease II; ribonucleate nucleotido-2'-transferase (cyclizing); acid ribonuclease; RNAase CL; Escherichia coli ribonuclease I' ribonuclease PP2; . Enzyme Commission Number: EC 3.1.27.1. CAS No. 37278-25-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3598; ribonuclease T2; EC 3.1.27.1; 37278-25-4; ribonuclease II; base-non-specific ribonuclease; nonbase-specific RNase; RNase (non-base specific); non-base specific ribonuclease; nonspecific RNase; RNase Ms; RNase M; RNase II; Escherichia coli ribonuclease II; ribonucleate nucleotido-2'-transferase (cyclizing); acid ribonuclease; RNAase CL; Escherichia coli ribonuclease I' ribonuclease PP2; ribonuclease N2; ribonuclease M; acid RNase; ribonnuclease (non-base specific); ribonuclease (non-base specific); RNase T2; ribonuclease PP3; ribonucleate 3'-oligonucleotide hydrolase; RNase II; ribonuclease U4. Cat No: EXWM-3598. | |
| Ribonuclease T2 from Aspergillus oryzae, Recombinant | Aspergillus oryzae Ribonuclease T2 is a member of the RNase T2 family of endonucleases that are present in a wide variety of microbial, plant and animal species. In contrast to Aspergillus oryzae Ribonuclease T1, which is an exclusively guanylic-acid specific endonuclease, all RNase T2-like enzymes are essentially base non-specific. However, RNase T2 endonucleases from different species can show slight base preferences. The fungal enzymes, including Aspargillus oryzae RNaseT2, show slight base preference in the following order: A>G>C, U. RNase T2 cleaves between the 3-phosphate residue of one base and the 5-OH residue of the adjacent nucleotide forming a 2, 3-cyclic phosphate intermediate followed by the generation of oligonucleotides with 3-phosphate residues. This enzyme is also used as a non-mammalian source of RNase in various applications. Group: Enzymes. Synonyms: Ribonuclease T2; RNase T2; Ribonuclease. Enzyme Commission Number: EC 3.1.27.1. Rnase. Mole weight: 36 kDa. Activity: ≥10,000 units per mg protein. Stability: Stable at 12-18 months at 2-8°C. Storage: Store at 2-8°C. Form: Lyophilized powder. Source: Pichia pastoris. Species: Aspergillus oryzae. Ribonuclease T2; RNase T2; Ribonuclease. Cat No: NATE-1930. | |
| Ribonuclease T2 from Human, Recombinant | Pancreatic Ribonuclease (RNase I) catalyzes cleavage of the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group attached to the 3'-ribose of an adjacent pyrimidine nucleotide forming a 2',3'-cyclic phosphate which may then be hydrolyzed to the corresponding 3'-nucleoside phosphate. Rnaset2 (ribonuclease t2) is an enzyme which belongs to the rnase t2 family. it is highly expressed in the temporal lobe and fetal brain. rnaset2 gene is a novel member of the rh/t2/s-glycoprotein class of extracellular ribonucleases. it is a single copy gene that maps to 6q27, aregion associated with human malignancies and chromosomal rearrangement. defects in rna...ase; nonspecific RNase; RNase Ms; RNase M; RNase II; ribonucleate nucleotido-2'-transferase (cyclizing); acid ribonuclease; RNAase CL; ribonuclease N2; ribonuclease M; acid RNase; ribonnuclease (non-base specific); ribonuclease (non-base specific); RNase T2; ribonuclease PP3; ribonucleate 3'-oligonucleotide hydrolase; ribonuclease U4. Purity: 95% (SDS-PAGE test). Rnase. Mole weight: 36-42 kDa. Storage: 4°C, store at -20°C for long-term preservation. Form: Lipuid. Source: HEK293 cells. Species: Human. Ribonuclease T2; EC 3.1.27.1; ribonuclease II; base-non-specific ribonuclease; nonbase-specific RNase; RNase (non-base specific); non-base specific ribonuclease; nonspecific R | |
| ribonuclease U2 | This enzyme catalyses the following chemical reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates. Group: Enzymes. Synonyms: purine specific endoribonuclease; ribonuclease U3; RNase U3; RNase U2; purine-specific ribonuclease; purine-specific RNase; Pleospora RNase; Trichoderma koningi RNase III; ribonuclease (purine). Enzyme Commission Number: EC 3.1.27.4. CAS No. 37205-57-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3602; ribonuclease U2; EC 3.1.27.4; 37205-57-5; purine specific endoribonuclease; ribonuclease U3; RNase U3; RNase U2; purine-specific ribonuclease; purine-specific RNase; Pleospora RNase; Trichoderma koningi RNase III; ribonuclease (purine). Cat No: EXWM-3602. | |
| Rugulosin ((+) form) | An intense yellow pigment produced by some species of penicillium, aspergillus and the fungal symbiotants of some lichens; shows antibacterial and insecticidal activity; an inhibitor of RNA Polymerase and Rnase. Synonyms: (+)-Rugulosin; Radicalisin; NSC 160880; 5H,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-. Grades: >98% by HPLC. CAS No. 23537-16-8. Molecular formula: C30H22O10. Mole weight: 542.49. | |
| sgRNA Screening Kit | sgRNA Screening Kit. Sgrna screening kit provides a simple, reliable, and rapid method for assessing sgrna efficiency before cell transduction, allowing you to identify the highly effective crispr sgrna. cas9 nuclease nls is an rna-guided endonuclease that catalyzes site-specific cleavage of double stranded dna. the location of the break is within the target sequence 3 bases from the ngg pam (protospacer adjacent motif). the design of single guide rna (sgrna) is dependent on the target region close to the pam site. even if you pick a target sequence that fulfills all of the described requirements, sgrna specificity and activity is unpredictable. therefore, it is often recommended that multiple, different sgrnas be designed to target a gene of interest. components. gencrispr cas9 nuclease. 10x reaction buffer. positive control sgrna. positive control substrate. rnase-free water. Group: Cloning Enzymes. Purity: 30 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3509. | |
| S Tag Peptide | S Tag Peptide, a 15 amino acid peptide derived from RNase A, is an oligopeptide used for improving protein solubility. Synonyms: Lys-Glu-Thr-Ala-Ala-Ala-Lys-Phe-Glu-Arg-Gln-His-Met-Asp-Ser; L-lysyl-L-alpha-glutamyl-(3xi)-L-threonyl-L-alanyl-L-alanyl-L-alanyl-L-lysyl-L-phenylalanyl-L-alpha-glutamyl-L-arginyl-L-glutaminyl-L-histidyl-L-methionyl-L-alpha-aspartyl-L-serine; S Tag. Grades: ≥95%. Molecular formula: C73H117N23O25S. Mole weight: 1748.91. | |
| Sunitinib | Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC 50 s of 80 nM and 2 nM for VEGFR2 and PDGFRβ , respectively [1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU 11248. CAS No. 557795-19-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10255A. | |
| Sunitinib Malate | Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC 50 s of 80 nM and 2 nM for VEGFR2 and PDGFRβ , respectively [1]. Sunitinib Malate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU 11248 Malate. CAS No. 341031-54-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10255. | |
| Thermitase from Bacillus cereus, Recombinant | Thermitase from Bacillus cereus is a protease that inactivates Rnases, Dnases and enzymes in reactions. Thermitase from bacillus cereus is a protease that inactivates rnases, dnases and enzymes in reactions. Applications: Thermitase is used for the isolation of rna and dna (plasmid and genomic). thermitase has been used in a study to assess the development and application of 15n-tracer substances for measuring the whole-body protein turnover rates. thermitase has also been used in a study to investigate a computational pr ocedure for transferring a binding site onto an existing protein scaffold. Group: Enzymes. Synonyms: Thermitase; thermophilic Streptomyces serine proteinase; Thermoactinomyces vulgaris serine proteinase. CAS No. 69772-87-8. Thermitase. Mole weight: mol wt 33 kDa. Activity: > 5.0 unit/mg protein. Storage: -20°C. Form: Supplied as a solution in 20mM Tris-HCl (pH 7.4), 1mM CaCl2 and 50% glycerol. Source: Bacillus cereus. Thermitase; thermophilic Streptomyces serine proteinase; Thermoactinomyces vulgaris serine proteinase. Cat No: NATE-0694. | |
| Trimethyltin Hydroxide | Trimethyltin Hydroxide is a reagent used in the synthesis of modified thymines used as inhibitors of RNase A. Also used in the preparation of Ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes. Group: Biochemicals. Alternative Names: Hydroxytri methyl stannane; Hydroxytrimethyltin; Trimethylhydroxytin; Trimethylstannanol; Trimethylstannyl Hydroxide. Grades: Purified. CAS No. 56-24-6. Pack Sizes: 1g, 5g. Molecular Formula: C?H??OSn, Molecular Weight: 180.82. US Biological Life Sciences. | Worldwide |
| tRNA nucleotidyltransferase | Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase. Group: Enzymes. Synonyms: phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Enzyme Commission Number: EC 2.7.7.56. CAS No. 116412-36-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3267; tRNA nucleotidyltransferase; EC 2.7.7.56; 116412-36-3; phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Cat No: EXWM-3267. | |
| Valoneic Acid Dilactone | Valoneic Acid Dilactone is a polyphenol natural product. It shows an inhibitory effect on 5α-reductase. It also has selectively inhibited RNase L and shows antibacterial activity. Synonyms: Valoneic acid bilactone. Grades: 90% by HPLC. CAS No. 60202-70-2. Molecular formula: C21H10O13. Mole weight: 470.3. | |
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