Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Ryanodine | Ryanodine. Group: Biochemicals. Grades: Purified. CAS No. 15662-33-6. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Ryanodine | Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa. Uses: Scientific research. Group: Natural products. CAS No. 15662-33-6. Pack Sizes: 1 mg. Product ID: HY-103306. |  |
| RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) | A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences. | Worldwide |
| 1-Methylcyclopentanol | 1-Methylcyclopentanol is used as a reagent in the synthesis of cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV. It is also used in the preparation of Lomifylline (L470200) which is a methylxanthine analog that induces Ca2+-release from intracellular stores via the ryanodine receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1462-03-9. Pack Sizes: 1g, 5g. Molecular Formula: C6H12O. US Biological Life Sciences. | Worldwide |
| 2,2',3,5',6-Pentachlorobiphenyl | 2,2',3,5',6-Pentachlorobiphenyl is an environmental neurotoxicant that promotes synaptogenesis through ryanodine receptor-dependent miR132 upregulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 38379-99-6. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H5Cl5, Molecular Weight: 326.43. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-iodo-3-methylbenzoic Acid | 2-Amino-5-iodo-3-methylbenzoic acid is an intermediate in the synthesis of highly potent and selective activator of insect ryanodine receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 108857-24-5. Pack Sizes: 1g, 5g. Molecular Formula: C8H8INO2. US Biological Life Sciences. | Worldwide |
| 2-Aminoethyl Methanethiosulfonate, Hydrobromide (MTSEA-Bromide) | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: MTSEA-Bromide. Grades: Highly Purified. CAS No. 16599-33-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 2-Aminoethyl Methanethiosulfonate, Hydrochloride (MTSEA-Chloride) | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: Methanesulfonothioic Acid S-(2-Aminoethyl) Ester Hydrochloride; MTSEA-Chloride. Grades: Highly Purified. CAS No. 37597-96-9. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C?H??ClNO?S?, Molecular Weight: 191.7. US Biological Life Sciences. | Worldwide |
| 2-Bromoethyl Methanethiosulfonate | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Chloroethyl Methanethiosulfonate | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3,5-Di-t-butyl-2-hydroxybenzaldehyde | 3,5-Di-t-butyl-2-hydroxybenzaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-t-butyl-2-hydroxybenzaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC). Group: Biochemicals. Alternative Names: 2-Hydroxy-3,5-di-tert-butylbenzaldehyde; 3,5-tert-Butyl-2-hydroxybenzaldehyde; 3,5-Bis(1,1-dimethylethyl)-2-hydroxybenzaldehyde; 3,5-Bis(tert-butyl)salicylaldehyde; 3,5-Di-t-butyl-2-hydroxybenzaldehyde; 3,5-Di-t-butylsalicylaldehyde; 3,5-Di-tert-butylsalicylaldehyde; 3,5-Di-tert-butylsalicylic Aldehyde. Grades: Highly Purified. CAS No. 37942-07-7. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 3-Bromopyrazole | 3-Bromopyrazole is a useful synthetic intermediate in the synthesis of Rynaxypyr (C325380); an insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Group: Biochemicals. Grades: Highly Purified. CAS No. 14521-80-3. Pack Sizes: 1g, 5g. Molecular Formula: C3H3BrN2, Molecular Weight: 146.97. US Biological Life Sciences. | Worldwide |
| 4-Pentynyl Methanethiosulfonate | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: Methanesulfonothioic Acid S-4-Pentyn-1-yl Ester. Grades: Highly Purified. CAS No. 1076199-31-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 84-F2 | 84-F2 is a lead compound that can inhibit calmodulin (CaM)-deficient cardiac ryanodine receptor 2 (RyR2) activity and arrhythmia. Study indicated that it was potentially used to treat arrhythmia via targeting RyR2. Uses: The potential treatment of arrhythmia. Synonyms: 84 F2. |  |
| Aladorian | Aladorianis is a ryanodine receptor calcium release channel modulator. It is an antiarrhythmic agent. Clinical development for Chronic heart failure and Ventricular tachycardia was discontinued. Uses: Chronic heart failure; ventricular tachycardia. Synonyms: 2,3-Dihydro-7-methoxy-α-oxo-1,4-benzothiazepine-4(5H)-acetic Acid; ARM036; ARM-036; ARM 036; S36; S44121-1; Aladorian; Aladorian; S 36; S 44121-1. Grades: 98%. CAS No. 865433-00-7. Molecular formula: C12H13NO4S. Mole weight: 267.30. | |
| cADP-Ribose (cADPR) Ammonium Salt | Cyclic ADP-ribose ammonium is a potent calcium-mobilized second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and extracellular influx through the opening of TRPM2 channels. Synonyms: cADP-Ribose Ammonium Salt; cADPR Ammonium Salt; cyclic ADP-ribose ammonium salt; Cyclic Adenosine Diphosphate Ribose ammonium salt; Cyclic adenosine 5'-diphosphate ribose ammonium salt. Grades: 90%. Molecular formula: C15H21N5O13P2.x(NH3). Mole weight: 541.30 (free base). | |
| Chlorantraniliprole | Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor , with EC 50 s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ~300-fold more potent than that in the mouse myoblast cell line, C2C12 ( EC 50 , 14 μM). Uses: Scientific research. Group: Signaling pathways. CAS No. 500008-45-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112820. | |
| Cyclic ADP-?ribose | Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor -mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: cADPR. CAS No. 119340-53-3. Pack Sizes: 500 μg. Product ID: HY-N7395. | |
| Cysteine, S-Nitrosylated (SNO-Cys) (BSA) | Nitric oxide (NO), generated by cell type-specific NO- synthase (NOS) isoforms, is a freely diffusible intercellular messenger that functions in target cells in NOS-dependent signaling. S-nitrosylation of cysteine thiols in proteins by the highly labile NO radical has been identified as an important effector of NO-related bioactivity both in NOS- containing cells and intercellular signaling. Most cells contain low levels of nitrosylated proteins that are thought to be regulated by S-nitrosylation and denitrosylation. S-nitrosylation of proteins serves as a ubiquitous post- translational modification that dynamically regulates a broad functional spectrum of proteins. The majority of these proteins are regulated by S-nitrosylation on a single critical cysteine residue within an acidic/basic or hydrophobic structural motif that may also be subject to oxygen- or glutathione-dependent modification. NO- sensitive ion channels including the cardiac and skeletal muscle ryanodine receptor (RyR1 Group: Biochemicals. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| DHBP dibromide | DHBP dibromide blocks calcium release from sarcoplasmic reticulum by direct interaction with the ryanodine receptor. Synonyms: Diheptylviologen dibromide; 1,1'-Diheptyl-4,4'-bipyridinium Dibromide; Diheptylviologen Bromide; Heptylviologen Bromide; Heptylviologen Dibromide; N,N'-Diheptyl-4,4'-bipyridinium Dibromide; N,N'-Diheptyl-4,4'-dipyridinium Dibromide; 1,1'-Diheptyl-[4,4'-bipyridine]-1,1'-diium bromide. Grades: ≥98%. CAS No. 6159-5-3. Molecular formula: C24H38Br2N2. Mole weight: 514.39. | |
| JTV 519 fumarate | The fumarate salt form of JTV 519, which has been found to be a Ryanodine receptor (RyR) inhibitor and also could be a useful intermediate. Synonyms: JTV 519 fumarate; JTV519 fumarate; JTV-519 fumarate; 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate. Grades: ≥98% by HPLC. CAS No. 1883549-36-7. Molecular formula: C25H32N2O2.C4H4O4. Mole weight: 540.67. | |
| JTV-519 hemifumarate | JTV-519 hemifumarate (K201 hemifumarate) is a Ca 2+ -dependent blocker of sarcoplasmic reticulum Ca 2+ -stimulated ATPase ( SERCA ) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K201 hemifumarate. CAS No. 1435938-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15293B. | |
| Maurocalcine | Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. It is an activator of Ca2+ release channel and a Ryanodine receptors agonist. It is a 33-mer basic peptide cross-linked by three disulfide bridges. Synonyms: MCa. Grades: >97%. | |
| Methyl Methanethiosulfonate-13C | Labeled Methyl Methanethiosulfonate. Used for the rapid and selective modification of sulfhydryl groups of enzymes. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: Methanesulfonothioic Acid S-Methyl Ester-13C; Thiomethanesulfonic Acid S-Methyl Ester-13C; MMTS-13C; NSC 21545-13C; S-Methyl Methanesulfonothioate-13C; S-Methyl Methanethiosulfonate-13C. Grades: Highly Purified. CAS No. 1309943-60-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Methyl Methanethiosulfonate (MMTS) | Used for the rapid and selective modification of sulfhydryl groups of enzymes. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: Methanesulfonothioic Acid S-Methyl Ester; Thiomethanesulfonic Acid S-Methyl Ester; MMTS; NSC 21545; S-Methyl Methanesulfonothioate; S-Methyl Methanethio-sulfonate. Grades: Highly Purified. CAS No. 2949-92-0. Pack Sizes: 100mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| P1,P5-Di(adenosine-5')pentaphosphate trilithium salt | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5?-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. Group: Biochemicals. Alternative Names: P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, 94108-02-8, A(5)P5(5)A, AC1O4WDE, D6392_SIGMA, CTK8G2238, EINECS 302-339-2, AP5A lithium salt P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, AG-H-86941, Diadenosine pentaphosphate trilithium salt, Diadenosine pentaphosphate pentalithium salt, K00187, A(5 inverted exclamation marka)P5(5 inverted exclamation marka)A trilithium sal. Grades: Highly Purified. CAS No. 75522-97-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H26N10O22P5Li3, Molecular Weight: 934.17. US Biological Life Sciences. | Worldwide |
| Paraxanthine | Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. Uses: Scientific research. Group: Natural products. CAS No. 611-59-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W016498. | |
| Propargyl Methanethiosulfonate | Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor. Group: Biochemicals. Alternative Names: Thiomethanesulfonic Acid S-2-Propynyl Ester. Grades: Highly Purified. CAS No. 7651-65-2. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| S107 | S107 is a type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. S107 increased FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. Synonyms: 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride; S107; S-107; S 107. CAS No. 927871-76-9. Molecular formula: C11H15NOS. Mole weight: 209.31. | |
| (-)-Xestospongin C | (-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-induced Ca2+ release in PC12 cells and attenuate PHP-induced IL-2 production in Jurkat T cells, but exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Synonyms: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine; Xestospongin C. CAS No. 88903-69-9. Molecular formula: C28H50N2O2. Mole weight: 446.71. | |
Our database is helping our users find suppliers everyday.
