Secreted Enzyme Suppliers USA
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Product | Description | |
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[(1S)-2-Phenyl-1-[(2R)-tetrahydro-5-oxo-2-furanyl]ethyl]carbamic Acid 1,1-Dimethyethyl Ester Quick inquiry Where to buy Suppliers range | [(1S)-2-Phenyl-1-[(2R)-tetrahydro-5-oxo-2-furanyl]ethyl]carbamic Acid 1,1-Dimethyethyl Ester is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (A β), the major causative agent in Alzheimer disease (AD). Group: Biochemicals. Grades: Highly Purified. CAS No. 135130-98-2. Pack Sizes: 100mg, 1g. Molecular Formula: C17H23NO4. US Biological Life Sciences. | Worldwide |
5-Bromo-4-chloro-1H-indol-3-yl-b-D-glucuronide Quick inquiry Where to buy Suppliers range | 5-Bromo-4-chloro-1H-indol-3-yl-b-D-glucuronide is a notable glucuronide derivation of 5-Bromo-4-chloro-1H-indole, meticulously utilized as a probe within drug metabolism studies. This compound is commonly harnessed to evaluate the engagement of glucuronidation in the metabolic processes of specific medications, or to unlock the secrets pertaining to UDP-glucuronosyltransferase enzymes within drug elimination pathways. Synonyms: X-Glucuronide X-GlcA. CAS No. 18656-89-8. Molecular formula: C14H13BrClNO7. Mole weight: 422.61. | |
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) Quick inquiry Where to buy Suppliers range | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp Quick inquiry Where to buy Suppliers range | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
Bexarotene (4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic Acid) Quick inquiry Where to buy Suppliers range | A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce AB40 and AB42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6h and 50% reduction in 72h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of AB proteases, insulin degrading enzyme, and neprilysin. Group: Biochemicals. Grades: Highly Purified. CAS No. 153559-49-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Bombesin Quick inquiry Where to buy Suppliers range | Bombesin is a neuropeptide with many biological effects such as hormone release, activation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM), and also to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM). Uses: Neurotransmitter agents. Synonyms: H-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; L-pyroglutamyl-L-glutaminyl-L-arginyl-L-leucyl-glycyl-L-asparagyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide; Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Grades: ≥95%. CAS No. 31362-50-2. Molecular formula: C71H110N24O18S. Mole weight: 1619.85. | |
BW-B 70C Quick inquiry Where to buy Suppliers range | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
CCK (26-30) (sulfated) Quick inquiry Where to buy Suppliers range | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (26-30) is an N-terminal fragment of CCK, the sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% at 0.1 mM. Synonyms: N-Acetyl cholecystokinin (26-30) (sulfated). Grades: ≥95%. CAS No. 89911-69-3. Molecular formula: C33H41N7O12S2. Mole weight: 791.85. | |
CCK (26-31) (sulfated) Quick inquiry Where to buy Suppliers range | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (26-31) is an N-terminal fragment of CCK, the sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% at 0.1 mM. Synonyms: N-Acetyl cholecystokinin (26-31) (sulfated). Grades: ≥95%. CAS No. 89911-65-9. Molecular formula: C38H50N8O13S3. Mole weight: 923.05. | |
CCK (27-33) (non-sulfated) Quick inquiry Where to buy Suppliers range | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (27-33) is a C-terminal fragment of CCK. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes with IC50 of 4 μM and inhibits electrically-stimulated contraction of isolated guinea pig ileum with IC50 of 17 μM. Synonyms: Cholecystokinin (27-33) (non-sulfated). Grades: ≥95%. CAS No. 47910-79-2. Molecular formula: C45H57N9O10S2. Mole weight: 948.12. | |
CCK Octapeptide (non-sulfated) Quick inquiry Where to buy Suppliers range | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK Octapeptide (non-sulfated) is the non-sulfated form of the C-terminal octapeptide of CCK. Synonyms: CCK-8 (desulfated); Cholecystokinin (CCK) (26-33); 2-desulfo-cholecystokinin-8 (swine). Grades: 98%. CAS No. 25679-24-7. Molecular formula: C49H62N10O13S2. Mole weight: 1063. | |
c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 Quick inquiry Where to buy Suppliers range | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grades: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
Compound E Quick inquiry Where to buy Suppliers range | Compound E is a cell-permeable inhibitor of γ-secretase (GSI), which is a multifunctional transmembrane protein complex enzymatically catalyzing the cleavage of single-pass transmembrane proteins. Compound E can inhibit Notch processing (IC50 = 2.2 nM in SupT1 cells) and β-ammyloid production in cell culture (IC50 = 0.3 nM). Synonyms: γ-Secretase Inhibitor; Gamma-Secretase Inhibitor XXI; (S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide; (2S)-2-{[(3,5-Difluorophenyl)acetyl]amino}-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide; N2-[(3,5-difluorophenyl)acetyl]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-L-alaninamide. Grades: 99%. CAS No. 209986-17-4. Molecular formula: C27H24F2N4O3. Mole weight: 490.5. | |
Deserpidine Quick inquiry Where to buy Suppliers range | Deserpidine is an antihypertensive drug related to Reserpine. It is naturally found in Rauvolfia spp. Deserpidine is a competitive ACE (angiotensin converting enzyme) inhibitor. Deserpidine can block the conversion of angiotensin I to angiotensin II as a potent vasoconstrictor through competing with angiotensin I for ACE. Reduced level of serum angiotensin II leads to a decrease in blood pressure. Deserpidine can also decrease angiotensin II-induced aldosterone secretion by the adrenal cortex. Uses: Antihypertensive drug. Synonyms: (3β, 16β, 17α, 18β, 20α)-17-methoxy-18-[(3, 4, 5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester; Deserpidic Acid Methyl Ester 3,4,5-Trimethoxybenzoate; Deserpidin; 1-Demethoxyreserpine; 11-Desmethoxyreserpine; Canescin; Canescine; Canescine (Rauwolfia); Harmonyl; NSC 72138; Raunormin; Raunormine; Recanescin; Recanescine; Reserpidine. Grades: 95%. CAS No. 131-01-1. Molecular formula: C32H38N2O8. Mole weight: 578.66. | |
HA-155 Quick inquiry Where to buy Suppliers range | HA-155 is an autotaxin inhibitor. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), which is responsible for tumor cell motility stimulation. Synonyms: HA 155; HA155; Autotaxin Inhibitor IV; Boronic acid, B- [4- [ [4- [ [3- [ (4-fluorophenyl) methyl] -2, 4-dioxo-5-thiazolidinylidene] methyl] phenoxy] methyl] phenyl] -. Grades: ≥95%. CAS No. 1229652-22-5. Molecular formula: C24H19BFNO5S. Mole weight: 463.3. | |
HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
Loxiglumide Quick inquiry Where to buy Suppliers range | Loxiglumide is an orally active, potent and selective small-molecule antagonist of the cholecystokinin receptor CCKA. It stimulates calorie intake and hunger feelings in humans. It could antagonize the CCK-induced reduction of gastric emptying in rats, accelerate the intestinal transport and accelerate the gallbladder emptying in mice. It inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying. Uses: Loxiglumide stimulates calorie intake and hunger feelings in humans. it inhibits pancreatic secretion of digestive enzymes. Synonyms: CR-1505; CR 1505; CR1505; D,L-4-(3,4-dichlorobenzoylamino)-5-(n-3-methoxypropylpentylamino)-5-oxo-pentanoicacid;Pentanoicacid,4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino);CR-1505;CR1505;4-(3,4-Dichlorobenzamido)-5-((3-methoxypropyl)(pentyl)amino)-5-oxopentanoic acid. Grades: 95%. CAS No. 107097-80-3. Molecular formula: C21H30Cl2N2O5. Mole weight: 461.38. | |
LX2343 Quick inquiry Where to buy Suppliers range | LX2343 is an inhibitor of β-site amyloid protein cleaving enzyme 1 (BACE1/β-secretase) with IC50 = 11.43 μM. It also acts as a non-ATP competitive PI3K inhibitor (IC50 = 15.99 μM). LX2343 was shown to ameliorate the cognitive dysfunction of AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy. Synonyms: LX-2343; LX 2343; 2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide. Grades: ≥98%. CAS No. 333745-53-2. Molecular formula: C22H19ClN2O6S. Mole weight: 474.91. | |
marinobufagenin Quick inquiry Where to buy Suppliers range | Marinobufagenin (marinobufagin) is a cardiotonic bufadienolide steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis. Uses: Enzyme inhibitors; vasoconstrictor agents. Synonyms: Marinobufagin; (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide; NSC-234205. Grades: ≥ 98.0%. CAS No. 470-42-8. Molecular formula: C24H32O5. Mole weight: 400.52. | |
Moexipril Quick inquiry Where to buy Suppliers range | Moexipril is a potent orally active nonsulfhydryl angiotensin converting enzyme(ACE) inhibitor with antihypertensive activity. It is used for the treatment of hypertension and congestive heart failure. It prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. lt was developed by Schwarz Pharma and has been listed. Uses: Moexipri is used for the treatment of hypertension and congestive heart failure. Synonyms: 2-[2-[(1-Ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;RS 10085; RS-10085;SPM-925;CI-925; RS 10085;SPM 925;CI 925; RS10085;SPM925;CI925. Grades: 98%. CAS No. 103775-10-6. Molecular formula: C27H34N2O7. Mole weight: 498.57. | |
Nafazatrom Quick inquiry Where to buy Suppliers range | Nafazatrom is a pyrazolinone derivative. It increases endogenous prostacyclin (PGI2) and has potential antimetastatic activities. It is used an antithrombotic drug that increases PGI2 levels. It inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of PGI2 and prevents intravascular coagulation. It also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. It is a lipoxygenase inhibitor, reduces stimulated Prolactin secretion. It also reduces the incidence of accompanying arrhythmias in myocardial injuries. Uses: Nafazatrom is used an antithrombotic drug. Synonyms: 2,4-Dihydro-5-methyl-2-[2-(2-naphthalenyloxy)ethyl]-3H-pyrazol-3-one; Bay-g-6575; BAY g 6575; 3-methyl-1-(2-(naphthalen-2-yloxy)ethyl)-1H-pyrazol-5(4H)-one. Grades: 98%. CAS No. 59040-30-1. Molecular formula: C16H16N2O2. Mole weight: 268.32. | |
N-hydroxypipecolic acid Quick inquiry Where to buy Suppliers range | N-Hydroxypipecolic acid, a pivotal biochemical component of drug synthesis for treatment of Alzheimer's and other neurodegenerative diseases, remarkably inhibits gamma-secretase enzyme leading to decreased amyloid beta production, a hallmark of Alzheimer's. Synonyms: 1-hydroxy-2-piperidinecarboxylic acid; 2-Piperidinecarboxylic acid, 1-hydroxy-; hydroxypipecolic acid. Grades: 95%. CAS No. 115819-92-6. Molecular formula: C6H11NO3. Mole weight: 145.16. | |
Omeprazole Quick inquiry Where to buy Suppliers range | Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia. It binds to the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) and inhibits its activity and the parietal cell secretion of H+ ions into the gastric lumen. Uses: Anti-ulcer agents; enzyme inhibitors. Synonyms: OMEP; OMP; OMZ; 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; Antra; Losec; Gastrogard; Gastroloc; Mepral; Mopral; Omepral; Prilosec; Zoltum; (±)-Omeprazole. Grades: >98%. CAS No. 73590-58-6. Molecular formula: C17H19N3O3S. Mole weight: 345.42. | |
Omeprazole S-Isomer Quick inquiry Where to buy Suppliers range | Omeprazole S-Isomer is an impurity of Omeprazole. Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia. It binds to the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) and inhibits its activity and the parietal cell secretion of H+ ions into the gastric lumen. Uses: Anti-ulcer agents; enzyme inhibitors. Synonyms: Esomeprazole; (S)-Omeprazole; (-)-Omeprazole; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole. Grades: 95%. CAS No. 119141-88-7. Molecular formula: C17H19N3O3S. Mole weight: 345.42. | |
Oxyntomodulin (human, mouse, rat) Quick inquiry Where to buy Suppliers range | Oxyntomodulin (human, mouse, rat) can effectively inhibit gastric acid secretion and pancreatic enzyme secretion when infused iv. Furthermore, Oxyntomodulin injection into the intraventricular and hypothalamic paraventricular nucleus effectively and consistently inhibits food intake in both fasted and non-fasted animals. Synonyms: OXM (human, mouse, rat); H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Arg-Asn-Asn-Ile-Ala-OH; Preproglucagon (53-89) (human, mouse, rat); Proglucagon (33-69) (human, mouse, rat); Glucagon-37 (human, mouse, rat); L-histidyl-L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threonyl-L-lysyl-L-arginyl-L-asparagyl-L-arginyl-L-asparagyl-L-asparagyl-L-isoleucyl-L-alanine. Grades: 95%. CAS No. 159002-68-3. Molecular formula: C192H295N61O60S. Mole weight: 4449.83. | |
P1,P5-Di(adenosine-5')pentaphosphate trilithium salt Quick inquiry Where to buy Suppliers range | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5?-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. Group: Biochemicals. Alternative Names: P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, 94108-02-8, A(5)P5(5)A, AC1O4WDE, D6392_SIGMA, CTK8G2238, EINECS 302-339-2, AP5A lithium salt P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, AG-H-86941, Diadenosine pentaphosphate trilithium salt, Diadenosine pentaphosphate pentalithium salt, K00187, A(5 inverted exclamation marka)P5(5 inverted exclamation marka)A trilithium salt, Adenosine 5-(hexahydrogen pentaphosphate), 5.5-ester with adenosine, pentalithium salt, P1,P5-Di(adenosine-5 inverted exclamation marka) pentaphosphate trilithium salt, 75522-97-3, pentalithium bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate. Grades: Highly Purified. CAS No. 75522-97-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H26N10O22P5Li3, Molecular Weight: 934.17. US Biological Life Sciences. | Worldwide |
PD 135158 Quick inquiry Where to buy Suppliers range | PD 135158 is a nonpeptide CCK2 receptor antagonist. It also exhibits agonist activity at the rat pancreatic CCKA receptor to stimulate pancreatic enzyme secretion. Uses: Anti-anxiety agents. Synonyms: 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[[[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid. Grades: ≥98% by HPLC. CAS No. 130285-87-9. Molecular formula: C35H44N4O6. Mole weight: 616.76. | |
PLD Inhibitor, FIPI Quick inquiry Where to buy Suppliers range | A cell-permeable, PLD1/2 inhibitor (IC50=1nM and 10nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50=20nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic b-cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 421.2. US Biological Life Sciences. | Worldwide |
RO4929097 Quick inquiry Where to buy Suppliers range | RO4929097, a small-molecule inhibitor of γ secretase (IC50 = 4 nM, EC50 = 5 nM), inhibits cellular processing of Aβ40 (EC50 = 14 nM) and Notch (EC50 = 5 nM). It was shown to decrease the levels of Notch transcriptional target HES1 in human primary melanoma cell lines. Uses: Enzyme inhibitors. Synonyms: RO-4929097; 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide. Grades: >98%. CAS No. 847925-91-1. Molecular formula: C22H20F5N3O3. Mole weight: 469.4. | |
Saxagliptin monohydrate Quick inquiry Where to buy Suppliers range | Saxagliptin hydrate is a selective and reversible DPP4 inhibitor. It demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes. It reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion. Synonyms: BMS-477118 hydrate; BMS 477118 hydrate; BMS477118 hydrate; Onglyza hydrate. Grades: >98%. CAS No. 945667-22-1. Molecular formula: C18H27N3O3. Mole weight: 333.43. | |
Secretin (33-59), rat Quick inquiry Where to buy Suppliers range | Secretin (33-59), rat is a 27-aa peptide, acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas. Uses: Peptide Inhibitors. CAS No. 121028-49-7. Product ID: R1670. | |
Secretin (human) Hydrochloride Quick inquiry Where to buy Suppliers range | Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin. Uses: API. Product ID: 10-101-29. | |
Secretin (porcine) Hydrochloride Quick inquiry Where to buy Suppliers range | Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin. Uses: API. Product ID: 10-101-99. | |
Semagacestat Quick inquiry Where to buy Suppliers range | Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (A β), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). Group: Biochemicals. Alternative Names: (2S) -2-Hydroxy-3-methyl-N- [ (1S) -1-methyl-2-oxo-2- [ [ (1S) -2, 3, 4, 5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl] amino] ethyl] butanamide; LY 450139. Grades: Highly Purified. CAS No. 425386-60-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(Thr2)-Amyloid β-Protein (1-42) Quick inquiry Where to buy Suppliers range | This is a mutation very close to the APP β-secretase cleavage site. The pathogenicity of Aβ42 Icelandic mutation A2T is lower than the native sequence. The precursor APP A673T is the first variant of APP found to reduce the risk of Alzheimer's disease in humans. A2T also affects the cleavage of γ-secretase, and the mutant is an inefficient substrate in a cell-based enzyme assay. Synonyms: Amyloid β-Protein (1-42) lcelandic mutation; H-Asp-Thr-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. Molecular formula: C204H313N55O61S. Mole weight: 4544.13. | |
Varespladib Quick inquiry Where to buy Suppliers range | Varespladib is a potent and selective inhibitor of secretory phospholipase A2 (sPLA2). The compound Varespladib inhibits both human and mouse sPLA2 group IIA, V, and X enzymes at low nM concentrations. Synonyms: LY315920; LY-315920; LY 315920; A-002; A002; A 002; Varespladib. Grades: >98%. CAS No. 172732-68-2. Molecular formula: C21H20N2O5. Mole weight: 380.39. |