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1,4-Anhydro-1,5-dihydroxy Canagliflozin is an impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H25FO5S, Molecular Weight: 444.52. US Biological Life Sciences.
Worldwide
1-Benzyl-3-bromobenzene
1-Benzyl-3-bromobenzene is used in the synthesis of inhibitors of HIV-1 integrase. It is also used to prepare C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2. Group: Biochemicals. Grades: Highly Purified. CAS No. 27798-39-6. Pack Sizes: 250mg, 2.5g. Molecular Formula: C13H11Br. US Biological Life Sciences.
Worldwide
1-benzyl-4-ethoxybenzene
1-benzyl-4-ethoxybenzene is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Benzene,1-ethoxy-4-(phenylmethyl)-; 1-benzyl-4-ethoxy-benzene. Grade: 98%. CAS No. 35672-52-7. Molecular formula: C15H16O. Mole weight: 212.29.
1-bromo-3-(4-ethoxybenzyl)benzene
1-bromo-3-(4-ethoxybenzyl)benzene is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 1-bromo-3-(4-ethoxybenzyl)benzene; SCHEMBL1539283; NZKWIAVSCANBMU-UHFFFAOYSA-N; 898538-17-5; CS-0165479; 1-bromo-3-(4-ethoxybenzyl)benzene? (Dapagliflozin Impurity pound(c). CAS No. 898538-17-5. Molecular formula: C15H15BrO. Mole weight: 291.19.
1-C-[4-Chloro-3-[(4-ethoxyphenyl)?methyl]?phenyl]?-D-Glucopyranose is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 461432-27-9. Molecular formula: C21H25ClO7. Mole weight: 424.87.
1-chloro-2-(2-ethoxybenzyl)-4-iodobenzene
1-chloro-2-(2-ethoxybenzyl)-4-iodobenzene is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 2305949-36-2. Molecular formula: C15H14ClIO. Mole weight: 372.63.
1-Hydroxy Dapagliflozin 3-O-β-D-Glucuronide
1-Hydroxy Dapagliflozin 3-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C27H33ClO13. Mole weight: 600.99.
1-Keto Dapagliflozin 3-O-β-D-Glucuronide
1-Keto Dapagliflozin 3-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C27H31ClO13. Mole weight: 598.98.
1-Methoxy Canagliflozin
1-Methoxy Canagliflozin is an impurity in the synthesis of the drug Canagliflozin (C175190). Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1358581-37-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H27FO6S, Molecular Weight: 474.54. US Biological Life Sciences.
Worldwide
(1R)-1,5-Dihydroxy Canagliflozin
(1R)-1,5-Dihydroxy Canagliflozin is an impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H27FO6S, Molecular Weight: 462.53. US Biological Life Sciences.
Worldwide
1R-Dapagliflozin
1R-Dapagliflozin is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin alfa-Isomer; (2R,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grade: >95%. CAS No. 1373321-04-0. Molecular formula: C21H25ClO6. Mole weight: 408.87.
2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-lactone
2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-lactone is used as a reactant to synthesize various glucoside containing compounds as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 13096-62-3. Pack Sizes: 1mg. Molecular Formula: C34H34O6, Molecular Weight: 538.63. US Biological Life Sciences.
2-(4-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Canagliflozin Impurity 27; Thiophene, 2-[(4-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)-. CAS No. 2265214-89-7. Molecular formula: C18H14BrFS. Mole weight: 361.27.
2- (4-Fluorophenyl) -5-[ (5-iodo-2-methylphenyl) methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 898566-17-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C18H14FIS, Molecular Weight: 408.27. US Biological Life Sciences.
Worldwide
2-(4-Fluorophenyl)-thiophene
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 58861-48-6. Pack Sizes: 250mg, 1g. Molecular Formula: C10H7FS, Molecular Weight: 178.23. US Biological Life Sciences.
2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene; Thiophene, 2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)-; Canagliflozin Impurity 29. CAS No. 1030825-20-7. Molecular formula: C18H14BrFS. Mole weight: 361.27.
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 1030825-20-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H14BrFS. US Biological Life Sciences.
Worldwide
(2,5-dibromophenyl)(4-ethoxyphenyl)methanone
(2,5-dibromophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 1713015-63-4. Molecular formula: C15H12Br2O2. Mole weight: 384.07.
(2,5-dichlorophenyl)(4-ethoxyphenyl)methanone
(2,5-dichlorophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 1097076-93-1. Molecular formula: C15H12Cl2O2. Mole weight: 295.16.
(2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone
(2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone; 2305949-33-9; CS-0165465; (2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone? (Dapagliflozin Impurity pound(c). CAS No. 2305949-33-9. Molecular formula: C15H12ClIO2. Mole weight: 386.61.
(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone; 1103738-26-6; (5-Iodo-2-chlorophenyl)(4-ethoxyphenyl)methanone; (2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone; (2-chloro-5-iodophenyl)-(4-ethoxyphenyl)methanone; MFCD18642360; C15H12ClIO2; SCHEMBL1934926; BGRJXWMKCUZBIG-UHFFFAOYSA-N; AMY20632; AKOS030527184; AC-31118; DS-19445; SY126110; W13129; A894908; (2-chloro-5-iodophenyl) (4-ethoxyphenyl)methanone. CAS No. 1103738-26-6. Molecular formula: C15H12ClIO2. Mole weight: 386.61.
2-Methoxy Canagliflozin
2-Methoxy Canagliflozin is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Methyl 1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-α-D-glucopyranoside; 2-Methoxytetrahydro-2H-pyran-3,4,5-triol, (2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl); Canagliflozin impurity 10. CAS No. 1358581-37-9. Molecular formula: C25H27FO6S. Mole weight: 474.54.
(2R,3R,4R,5R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 2271248-78-1. Molecular formula: C21H25ClO6. Mole weight: 408.88.
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(2-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 2040305-09-5. Molecular formula: C29H33ClO10. Mole weight: 577.02.
((2R,3S,4R,5R,6S)-2-Propionate Dapagliflozin
((2R,3S,4R,5R,6S)-2-Propionate Dapagliflozin is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C23H27ClO7. Mole weight: 450.91.
(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)phenyl)-6-(hydroxyl methyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 2452300-89-7; Deschloro Dapagliflozin; Dapagliflozin Deschloro Impurity; CS-0011227; (1S)-1,5-Anhydro-1-C-[3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3S,4R,5R,6R)-2-{m-[(p-Ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 2452300-89-7. Molecular formula: C21H26O6. Mole weight: 374.43.
(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl) (hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Tetrahydro-2H-pyran-3,4,5-triol, (2S,3R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)(hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl); Canagliflozin impurity 08. CAS No. 1951467-29-0. Molecular formula: C24H25FO6S. Mole weight: 460.52.
(2S,3R,4R,5S,6R)-2-(4-Bromo-2-(4-ethoxyphenethyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C22H27BrO6. Mole weight: 467.35.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(methoxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Grade: 95%. CAS No. 1318794-28-3. Molecular formula: C22H27ClO7. Mole weight: 438.90.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-isopropoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-[4-chloro-3-(4-isopropoxybenzyl)phenyl]-D-glucitol. CAS No. 946525-39-9. Molecular formula: C22H27ClO6. Mole weight: 422.90.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-methoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 333359-90-3. Molecular formula: C20H23ClO6. Mole weight: 394.85.
(2S,3R,4S,5R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C20H23ClO5. Mole weight: 378.85.
(2S,3S,4R,5S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C29H33ClO10. Mole weight: 577.02.
(2S,3S,4S,5S,6R)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C29H33ClO10. Mole weight: 577.02.
3-(4-Fluorophenyl)thiophene
3-(4-Fluorophenyl)thiophene is an impurity of Canagliflozin (C175190), a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 119492-73-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H7FS, Molecular Weight: 178.23. US Biological Life Sciences.
Worldwide
3-(4-Fluorophenyl)-Thiophene
An impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Synonyms: 3-(4-fluorophenyl)thiophene; 119492-73-8; 3-(4-Fluoro-phenyl)-thiophene3-(4-Fluorophenyl)-Thiophene; SCHEMBL1046660. Grade: > 95%. CAS No. 119492-73-8. Molecular formula: C10H7FS. Mole weight: 178.23.
3-(4-Fluorophenyl)thiophene-d4
3-(4-Fluorophenyl)thiophene-d4 is labelled 3-(4-Fluorophenyl)thiophene (F596255) which is an impurity of Canagliflozin (C175190), a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H3D4FS, Molecular Weight: 182.25. US Biological Life Sciences.
Worldwide
4-Aminophlorizin
4-Aminophlorizin is an indispensible compound in the realm of diabetes research, acting as a noteworthy inhibitor of sodium/glucose cotransporter 1 (SGLT1) and SGLT2. Synonyms: 3-(4-Aminophenyl)-1-[2-(b-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-1-propanone. CAS No. 82628-89-5. Molecular formula: C21H25NO9. Mole weight: 435.42.
4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene
4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 5-Bromo-2-chloro-4'-ethoxydiphenylmethane. CAS No. 461432-23-5. Molecular formula: C15H14BrClO. Mole weight: 325.63.
4-chloro-3-(4-ethoxybenzyl)phenol
4-chloro-3-(4-ethoxybenzyl)phenol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 4-chloro-3-[(4-ethoxyphenyl)methyl]-Phenol. CAS No. 1408077-50-8. Molecular formula: C15H15ClO2. Mole weight: 262.73.
Atigliflozin
Atigliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor. It has antihyperglycemic activity and is used as an antihyperglycaemic drug candidate. Uses: Atigliflozin has antihyperglycemic activity and is used as an antihyperglycaemic drug candidate. Synonyms: β-D-Glucopyranoside, 2-[(4-methoxyphenyl)methyl]-3-thienyl; 2-((4-Methoxyphenyl)methyl)thiophen-3-yl-beta-d-glucopyranoside; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-[(4-methoxyphenyl)methyl]thiophen-3-yl]oxyoxane-3,4,5-triol. Grade: 98%. CAS No. 647834-15-9. Molecular formula: C18H22O7S. Mole weight: 382.43.
Canagliflozin
Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise. Alternative Names: Invokana;Canagliflozin anhydrous;TA-7284. CAS No. 842133-18-0. Product ID: API842133180. Molecular formula: C24H25FO5S. Mole weight: 444.5. EINECS: 695-192-1. SMILES: CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F. Appearance: White to Light Yellow Solid. Standard: Facility GMP. Category: Hypoglycemic APIs.
Canagliflozin
Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Alternative Names: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol. Grades: Highly Purified. CAS No. 842133-18-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Canagliflozin
Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-; JNJ-24831754; TA-7284; JNJ 24831754; TA 7284; JNJ24831754; TA7284; (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thien-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene; Invokana; JNJ 24831754ZAE; JNJ 28431754AAA. Grade: >98%. CAS No. 842133-18-0. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin
Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC 50 s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ 28431754. CAS No. 842133-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10451.
Canagliflozin 3-O-β-D-glucuronide
Canagliflozin 3-O-β-D-glucuronide is an impurity of Canagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol. Molecular formula: C30H33FO11S. Mole weight: 620.64.
Canagliflozin alpha-Isomer Impurity
epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1R)-1,5-Anhydro-1-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-D-glucitol; epi-Canagliflozin; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1R)-; (1R)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2R,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; Canagliflozin alpha-Isomer; Canagliflozin α-isomer. Grade: ≥95%. CAS No. 1589590-87-3. Molecular formula: C24H25FO5S. Mole weight: 444.53.
Canagliflozin Defluoro Impurity
Defluoro-Canagliflozin is an impurity of Canagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: Canagliflozin Impurity A; Canagliflozin Desfluoro Impurity; D-Glucitol, 1,?5-anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-, (1S)?-; (1S)-1,?5-Anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-D-glucitol; Desfluoro Canagliflozin; (2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(4-methyl-3-((5-phenylthiophen-2-yl)methyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol. Grade: ≥95%. CAS No. 842133-16-8. Molecular formula: C24H26O5S. Mole weight: 426.54.
Canagliflozin Furanose Form (Mixture of Anomers)
Canagliflozin Furanose Form (Mixture of Anomers) is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Galactitol, 1,4-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; Canagliflozin-10; Canagliflozin Impurity 17; (2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol. CAS No. 2161394-94-9. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin hemihydrate
Canagliflozin hemihydrate is a highly potent and selective inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. It is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes. Uses: The potential treatment of type 2 diabetes. Synonyms: (3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate; JNJ 28431754 hemihydrate; TA 7284 hemihydrate; JNJ-24831754-ZAE hemihydrate; JNJ-28431754-AAA hemihydrate; (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1); Cagliflozin hydrate; Invokana hemihydrate; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate. Grade: >98%. CAS No. 928672-86-0. Molecular formula: C24H25FO5S.1/2H2O. Mole weight: 453.53.
Canagliflozin hemihydrate
Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC 50 s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ 28431754 hemihydrate. CAS No. 928672-86-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-I0383.
Canagliflozin Impurity 14
Canagliflozin Impurity 14 is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(3-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-; (2S,3R,4R,5S,6R)-2-(3-((5-(3-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 842133-17-9. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin Impurity 17
Canagliflozin Impurity 17 is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: Methanone, [5-(4-fluorophenyl)-2-thienyl](5-β-D-glucopyranosyl-2-methylphenyl)-; Methanone, (5-(4-fluorophenyl)-2-thienyl)(5-beta-D-glucopyranosyl-2-methylphenyl)-; Canagliflozin impurity 12; (5-(4-Fluorophenyl)thiophen-2-yl)(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanone; [5-(4-Fluorophenyl)-2-thienyl](5-β-D-glucopyranosyl-2-methylphenyl)methanone; Canagliflozin Impurity 2; Canagliflozin Keto Impurity. Grade: ≥95%. CAS No. 1951467-28-9. Molecular formula: C24H23FO6S. Mole weight: 458.50.
Canagliflozin Monoacetyl Impurity
Canagliflozin Monoacetyl Impurity is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: ((2R,3S,4R,5R,6S)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl acetate; Canagliflozin impurity 03. CAS No. 2146135-87-5. Molecular formula: C26H27FO6S. Mole weight: 486.55.
Canagliflozin Related Impurity 14
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. Synonyms: Thiophene, 2-(4-fluorophenyl)?-. Grade: > 95%. CAS No. 58861-48-6. Molecular formula: C10H7FS. Mole weight: 178.23.
Canagliflozin Ring Opening Impurity
Canagliflozin Ring Opening Impurity is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: (2S,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)hexane-1,2,3,4,5,6-hexaol; D-Glucitol, 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; 1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol. Molecular formula: C24H27FO6S. Mole weight: 462.53.
Canagliflozin Tetraacetate
Canagliflozin Tetraacetate is an intermediate in the synthesis of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-Tetraacetate; Canagliflozin impurity 05; Tetra Acetyl Canagliflozin. Grade: 98%. CAS No. 866607-35-4. Molecular formula: C32H33FO9S. Mole weight: 612.66.
Dapagliflozin
Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 ( SGLT2 ) inhibitor, which results in excretion of glucose into the urine [1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-512148. CAS No. 461432-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10450.
Dapagliflozin
Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; BMS 512148. Grade: >98%. CAS No. 461432-26-8. Molecular formula: C21H25ClO6. Mole weight: 408.87.
Dapagliflozin 2-O-β-D-glucuronide
Dapagliflozin 2-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-2-O-β-D-glucopyranuronosyl-D-glucitol. Grade: >95%. CAS No. 2078003-84-4. Molecular formula: C27H33ClO12. Mole weight: 585.00.
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-512148 (2S)-1,2-propanediol, hydrate. CAS No. 960404-48-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10450A.
Dapagliflozin-3-O-β-D-glucuronide
Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2 , that can be used to improve glycemic control and attenuate type 2 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-801576. CAS No. 1351438-75-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-125156.
Dapagliflozin 3-O-β-D-Glucuronide
Dapagliflozin 3-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol; D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-O-β-D-glucopyranuronosyl-, (1S)-; (2S,3S,4S,5R,6R)-6-(((2S,3S,4R,5R,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; Dapagliflozin M-15 metabolite; Dapagliflozin 3-O-glucuronide. Grade: ≥95%. CAS No. 1351438-75-9. Molecular formula: C27H33ClO12. Mole weight: 585.00.
Dapagliflozin C1,C2 Epimer
Dapagliflozin C1,C2 Epimer is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C21H25ClO6. Mole weight: 408.87.
Dapagliflozin C1,C2 Epimer Tetraacetate
Dapagliflozin C1,C2 Epimer Tetraacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C29H33ClO10. Mole weight: 577.02.
Dapagliflozin C2 Epimer Tetraacetate
Dapagliflozin C2 Epimer Tetraacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C29H33ClO10. Mole weight: 577.02.
Dapagliflozin Dimer
Dapagliflozin Dimer is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin Sugar Dimer. CAS No. 2452300-79-5. Molecular formula: C42H48Cl2O12. Mole weight: 815.73.
Dapagliflozin Furanose Isomer
Dapagliflozin Furanose Isomer is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin 1,4-Anhydro impurity; (1S)-1,4-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. Grade: >95%. CAS No. 1469910-70-0. Molecular formula: C21H25ClO6. Mole weight: 408.87.
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