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| Product | Description | |
|---|---|---|
| SLF | SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 195513-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114872. |  |
| SLF1081851 | SLF1081851 is a Spns2 inhibitor, inhibits S1P release ( IC 50 =1.93 μM). SLF1081851 plays a key role in development and immune system [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763730-97-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149004. | |
| SLF TFA | SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2378802-47-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114872A. | |
| BAY2666605 | BAY2666605 induces the formation of the SLFN12-PDE3A complex, leading to stabilization of SLFN12 and alteration of gene expression patterns, potentially resulting in suppression of cell cycle progression and induction of apoptosis in tumor cells. Molecular formula: C17H12F4N2O2. Mole weight: 352.28. |  |
| dFKBP-1 | dFKBP-1, a potent and PROTAC-based FKBP12 degrader, contains the FKBP12 ligand SLF, the thalidomide based Cereblon ligand, and a linker. Synonyms: (1R)-3-(3,4-Dimethoxyphenyl)-1-(3-{[4-({4-[({[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetyl)amino]butyl}amino)-4-oxobutanoyl]amino}phenyl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-piperidinecarboxylate; 2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[[4-[[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]amino]-1,4-dioxobutyl]amino]phenyl]propyl ester, (2S)-. Grade: ≥98%. CAS No. 1799711-22-0. Molecular formula: C53H64N6O14. Mole weight: 1009.11. | |
| H-Arg(Pmc)-OtBu | H-Arg(Pmc)-OtBu. Synonyms: Nomega-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine t-butyl ester; tert-butyl(2S)-2-amino-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)slfonyl]carbamimidamido}pentanoate; H-arg(PMC)-OtBu. Grade: ≥ 99% (Elemental Analysis). CAS No. 169543-81-1. Molecular formula: C24H40N4O5S. Mole weight: 496.68. | |
| Imatinib | Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with an IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib is an oral chemotherapy agent used to treat cancers. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Synonyms: CGP057148B; STI571; Gleevec; Glivec; N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide. Grade: >98%. CAS No. 152459-95-5. Molecular formula: C29H31N7O. Mole weight: 493.60. | |
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