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| Product | Description | |
|---|---|---|
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. |  |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| SN-38 Carboxylate Disodium Salt. | The active metabolite of. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SN-38-d3 | SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 ?M, respectively[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: NK012-d3. CAS No. 718612-49-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-13704S. | |
| SN-38-[d3] | SN-38-[d3] is a labelled analogue of SN-38. SN-38 is the active metabolite of irinotecan. Uses: Labelled sn-38, a metabolite of irinotecan, a dna topoisomerase inhibitor. Synonyms: SN-38 D3. Grade: 95% atom D. CAS No. 718612-49-8. Molecular formula: C22H17D3N2O5. Mole weight: 395.42. |  |
| SN-38 glucuronide | SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SN-38G. CAS No. 121080-63-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126373. | |
| 10-O-Acetyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin; 10-Hydroxy-7-ethylcamptothecin 10-Acetate; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 946821-59-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Acetyl SN-38-d3 | 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin-d3; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 10-Hydroxy-7-ethylcamptothecin 10-Acetate-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| CL2A-SN-38 | CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1279680-68-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128946. | |
| Irinotecan EP Impurity E (SN-38) | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. Uses: The treatment of colorectal cancer. Synonyms: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 10-Hydroxy-7-ethylcamptothecin; SN 38 Lactone; Irinotecan EP Impurity E; SN-38; USP Irinotecan Related Compound B; Irinotecan Related Compound B; Irinotecan EP Impurity E; NSC-673596. Grade: ≥95%. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.40. | |
| (R)-SN-38 | R-Enantiomer of SN-38. Used for making the bioconjugates and bifunctional isocyanate cross linking reagents. Synonyms: (R)-7-Ethyl-10-Hydroxy Camptothecin; (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (R)-4,11-diethyl-4,9-dihydroxy-1H-benzo[f]pyrano[4',3':4,5]pyrido[2,1-a]isoindole-3,14(4H,12H)-dione. Grade: 95%. CAS No. 647852-82-2. Molecular formula: C22H20N2O5. Mole weight: 392.41. | |
| Cerulenin | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies[1][2][3][4]. Uses: Scientific research. Group: Natural products. CAS No. 17397-89-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0210. | |
| Cerulenin | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3-Epoxy-4-oxo-7,10-dodecadienamide. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 17397-89-6. Molecular formula: C12H17NO3. Mole weight: 223.27. Purity: 0.98. IUPACName: (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide. Canonical SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N. Product ID: ACM17397896. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CHIR-124 | CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons. Synonyms: CHIR-124; CHIR 124; CHIR124. Grade: 0.98. CAS No. 405168-58-3. Molecular formula: C23H22ClN5O. Mole weight: 419.913. | |
| CL2-MMT-SN38 | CL2-MMT-SN38 is a derivative of SN-38, an anticancer drug that is an active metabolite of the topoisomerase I inhibitor Irinotecan. Synonyms: 4-((2S,5S)-5-benzyl-38-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(4-(((4-methoxyphenyl)diphenylmethyl)amino)butyl)-4,7,11-trioxo-9,15,18,21,24,27,30,33,36-nonaoxa-3,6,12-triazaoctatriacontanamido)benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate. Grade: ≥90%. CAS No. 1084888-82-3. Molecular formula: C102H122N12O24. Mole weight: 1900.13. | |
| Firtecan pegol | Firtecan pegol, also known as EZN-2208,Pegylated SN-38, or PEG-SN38, is a water-soluble polyethyleneglycol-SN38 conjugate. In vitro, the IC50 of EZN-2208 ranged from 3-24 nM, which was 30- to 45-fold lower than CPT-11 or 2.5- to 3.5-fold higher than SN38. In both an early-disease Raji model and an advanced-disease Daudi model, treatment with multiple doses of EZN-2208 resulted in 90% and 100% cures of animals, respectively (cure defined as no sign of tumors by gross observations at the termination of study). The activity of EZN-2208 was dramatically superior to that of CPT-11 in all three models. The excellent therapeutic efficacy of EZN-2208 in several B-cell NHL xenograft models merits its evaluation in the clinic for lymphoid malignancies. Synonyms: EZN-2208 (Pegylated SN-38). PEG-SN38, Firtecan pegol. CAS No. 946062-05-1. Molecular formula: C118H122N12O37. Mole weight: 2300.321. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Labetuzumab govitecan | Labetuzumab govitecan (IMMU 130) is an Anti- CEACAM5 / SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU 130; hMN-14-SN-38. CAS No. 1469876-18-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99681. | |
| Sacituzumab govitecan | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU-132. CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132254. | |
| Sacituzumab govitecan | Sacituzumab govitecan is an antibody-drug conjugate with an SN-38 payload targeting trophoblast cell-surface antigen 2, an epithelial antigen expressed in breast cancer. Synonyms: IMMU-132; IMMU 132; IMMU132. CAS No. 1491917-83-9. | |
| Sacituzumab govitecan (solution) | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU-132 (solution). CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132254A. | |
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