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| Product | Description | |
|---|---|---|
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. |  |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| SN-38 Carboxylate Disodium Salt. | The active metabolite of. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SN-38 glucuronide | SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SN-38G. CAS No. 121080-63-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126373. | |
| SN-38 Glucuronide | A metabolite of Irinotecan. Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 121080-63-5. Molecular formula: C28H28N2O11. Mole weight: 568.53. |  |
| SN-38 tri-O-acetyl-b-D-glucuronic acid methyl ester | SN-38 tri-O-acetyl-b-D-glucuronic acid methyl ester: A potent prodrug used in the field of biomedicine for targeted chemotherapy. This compound is derived from irinotecan and is transformed into SN-38, an active metabolite, within the body. Synonyms: (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid methyl ester 2,3,4-triacetate. CAS No. 121098-77-9. Molecular formula: C35H36N2O14. Mole weight: 708.67. | |
| 10-O-Acetyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin; 10-Hydroxy-7-ethylcamptothecin 10-Acetate; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 946821-59-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Acetyl SN-38-d3 | 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin-d3; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 10-Hydroxy-7-ethylcamptothecin 10-Acetate-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Cerulenin | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3-Epoxy-4-oxo-7,10-dodecadienamide. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 17397-89-6. Molecular formula: C12H17NO3. Mole weight: 223.27. Purity: 0.98. IUPACName: (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide. Canonical SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N. Product ID: ACM17397896. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CHIR-124 | CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons. Synonyms: CHIR-124; CHIR 124; CHIR124. Grades: 0.98. CAS No. 405168-58-3. Molecular formula: C23H22ClN5O. Mole weight: 419.913. | |
| Firtecan pegol | Firtecan pegol, also known as EZN-2208,Pegylated SN-38, or PEG-SN38, is a water-soluble polyethyleneglycol-SN38 conjugate. In vitro, the IC50 of EZN-2208 ranged from 3-24 nM, which was 30- to 45-fold lower than CPT-11 or 2.5- to 3.5-fold higher than SN38. In both an early-disease Raji model and an advanced-disease Daudi model, treatment with multiple doses of EZN-2208 resulted in 90% and 100% cures of animals, respectively (cure defined as no sign of tumors by gross observations at the termination of study). The activity of EZN-2208 was dramatically superior to that of CPT-11 in all three models. The excellent therapeutic efficacy of EZN-2208 in several B-cell NHL xenograft models merits its evaluation in the clinic for lymphoid malignancies. Synonyms: EZN-2208 (Pegylated SN-38). PEG-SN38, Firtecan pegol. CAS No. 946062-05-1. Molecular formula: C118H122N12O37. Mole weight: 2300.321. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Synonyms: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. Grades: >98%. CAS No. 136572-09-3. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. | |
| Labetuzumab govitecan | Labetuzumab govitecan (IMMU 130) is an Anti- CEACAM5 / SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU 130; hMN-14-SN-38. CAS No. 1469876-18-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99681. | |
| (R)-7-Ethyl-10-Hydroxy Camptothecin | R-Enantiomer of SN-38. Used for making the bioconjugates and bifunctional isocyanate cross linking reagents. Synonyms: (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione. Grades: > 95%. CAS No. 647852-82-2. Molecular formula: C22H20N2O5. Mole weight: 392.42. | |
| Sacituzumab govitecan | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU-132. CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132254. | |
| Sacituzumab govitecan (solution) | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU-132 (solution). CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132254A. | |
| Tenifatecan | Tenifatecan, also known as SN2310, is an injectable emulsion composed of 7-ethyl-10-hydroxycamptothecin (SN-38) conjugate with vitamin E through a succinate linker. SN-38 is the active metabolite of irinotecan. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. SN2310 Injectable Emulsion is being developed with the objective of demonstrating improved anti-tumor activity as a result of increased exposure to SN-38 based on a longer half-life. Synonyms: SN 2300; SN2300; SN-2300; BEL2310; BEL 2310; BEL-2310. CAS No. 850728-17-5. Molecular formula: C53H68N2O8. Mole weight: 861.12. | |
| YHO-13177 | YHO-13177 is a potent and specific inhibitor of BCRP. It potentiated the cytotoxicity of SN-38 in cancer cells and had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells. Synonyms: YHO-13177; YHO 13177; YHO13177. Grades: >98%. CAS No. 912287-56-0. Molecular formula: C20H22N2O3S. Mole weight: 370.47. | |
| YHO-13351 free base | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. | |
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