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| Product | Description | |
|---|---|---|
| Sodium Channel inhibitor 1 | Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatment, exhibiting concentration-dependent efficacy in studies. Uses: Sodium channel inhibitor1 is an effective voltage-gated sodium channel blocker that could be used for pain treatment. Synonyms: Sodium Channel inhibitor 1; CHEMBL2164368; 7-FLUORO-3-OXO-2-(2-(PYRIDIN-2-YL)ETHYL)-N-(4-(TRIFLUOROMETHOXY)BENZYL)ISOINDOLINE-1-CARBOXAMIDE; SCHEMBL3900840. Grades: 98%. CAS No. 1198117-23-5. Molecular formula: C24H19F4N3O3. Mole weight: 473.42. |  |
| Sodium Channel inhibitor 6 | Sodium Channel inhibitor 6 (compound I) is a sodium channel inhibitor that can be used in the study of neuropathic pain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2877755-11-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-171244. |  |
| 1-[5-Chloro-6-(2-methylpropoxy)-3-pyridinyl]-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide | 1-[5-Chloro-6-(2-methylpropoxy)-3-pyridinyl]-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide is an indazole derivative that can be used as a sodium channel inhibitor useful in the treatment of pain. Group: Biochemicals. Grades: Highly Purified. CAS No. 1387633-03-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H21ClN4O4S, Molecular Weight: 436.91. US Biological Life Sciences. |  Worldwide |
| 2-(3-Bromopropyl)-1,2,4-triazolo-pyridin-3-one | Used in the preparation of bicycloamine derivatives as sodium channel inhibitors for treatment of pain, epilepsy and insomnia. Group: Biochemicals. Alternative Names: 2-(3-Bromopropyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one. Grades: Highly Purified. CAS No. 1094305-62-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2-(4,4-Difluoro-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | 2-(4,4-Difluoro-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, is used as a reagent in the preparation of 4- (cycloalkanyloxy) benzenesulfonamide derivatives as inhibitors of voltage-gated sodium channel for prevention and treatment of pains. Group: Biochemicals. Grades: Highly Purified. CAS No. 1227068-84-9. Pack Sizes: 500mg, 5g. Molecular Formula: C12H19BF2O2, Molecular Weight: 244.09. US Biological Life Sciences. | Worldwide |
| (2-Fluoro-6-methylphenyl)hydrazine Hydrochloride | (2-Fluoro-6-methylphenyl)hydrazine Hydrochloride acts as a reagent in the preparation of amino-substituted heterocyclic derivatives as sodium channel inhibitors useful in treating diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1314927-22-4. Pack Sizes: 500mg, 1g. Molecular Formula: C7H9FN2 + (HCl), Molecular Weight: 140.16. US Biological Life Sciences. | Worldwide |
| 2-Piperidin-4-yl-1H-benzimidazole | 2-Piperidin-4-yl-1H-benzimidazole is used as a reagent in the synthesis of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of ischemic stroke. Also used as a reagent in the synthesis of 2,3,5-trisubstituted pyridine derivatives as potent Akt1/Akt2 dual inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 38385-95-4. Pack Sizes: 250mg, 1g. Molecular Formula: C12H15N3. US Biological Life Sciences. | Worldwide |
| 3'-Methoxydaidzein | 3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC 50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels [1]. Uses: Scientific research. Group: Natural products. CAS No. 21913-98-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1847. | |
| 8-[Fluo]-AHT-PET-cGMP | 8-[Fluo]-AHT-PET-cGMP is a fluorescent cGMP analogue (λexc494 nm, λem517 nm), which can be used for receptor studies. It has the potential to be a CNG channel inhibitor. Synonyms: 8-(6-[Fluoresceinyl]aminohexylthio)-β-phenyl-1,N2-ethenoguanosine-3',5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C45H39N7NaO12PS2. Mole weight: 987.9. | |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50 = 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM). Synonyms: 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide; AM-2099; AM2099; AM 2099. CAS No. 1443373-17-8. Molecular formula: C19H13F3N4O3S2. Mole weight: 466.46. | |
| Amiloride | Amiloride (MK-870) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870. CAS No. 2609-46-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285. | |
| Amiloride HCl | Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure. Uses: Acid sensing ion channel blockers. Synonyms: Amiloride HCl anhydrous; Amiloride (hydrochloride); Amiloride hydrochloride anhydrous; MK-870 hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grades: ≥ 98%. (HPLC). CAS No. 2016-88-8. Molecular formula: C6H9Cl2N7O. Mole weight: 266.09. | |
| Amiloride hydrochloride | Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride. CAS No. 2016-88-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0285A. | |
| Amiloride hydrochloride dihydrate | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride dihydrate. CAS No. 17440-83-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285B. | |
| Amiloride (hydrochloride) (Standard) | Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride (Standard). CAS No. 2016-88-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B0285AR. | |
| AMTB hydrochloride | AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC 50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels ( Na V ) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 926023-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100345. | |
| ARCA Sodium | ARCA Sodium, a potent inhibitor of the Nav1.5 cardiac sodium channel, is adeptly utilized in mitigating arrhythmias, such as atrial fibrillation. Additionally, it exhibits promise as a therapeutic agent for the management of chronic pain conditions. Molecular formula: C22H29N10Na2O18P3. Mole weight: 860.42. | |
| AVE-0118 | AVE 0118 is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to the anti-AF property of AVE0118. Synonyms: [1,1'-Biphenyl]-2-carboxamide, 2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[2- (4-Methoxyphenyl) acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide; AVE 0118; AVE0118. Grades: ≥95%. CAS No. 498577-53-0. Molecular formula: C30H29N3O3. Mole weight: 479.57. | |
| AVE 0118 hydrochloride | AVE 0118 hydrochloride is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to anti-AF property of AVE0118. Synonyms: Benzeneacetamide, 4-methoxy-N-[[2'-[[[2-(3-pyridinyl)ethyl]amino]carbonyl][1,1'-biphenyl]-2-yl]methyl]-, hydrochloride (1:1); 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide hydrochloride; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-, hydrochloride; 2'-[[2- (4-Methoxyphenyl) acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide hydrochloride; AVE 0118 hydrochloride; AVE0118 hydrochloride. Grades: 99%. CAS No. 2108821-80-1. Molecular formula: C30H29N3O3.HCl. Mole weight: 516.03. | |
| Benzamil | Benzamil is a Na+/Ca2+ exchanger (NCX) inhibitor and epithelial sodium channel (ENaC) blocker. Benzamil has been developed as a promising treatment for cystic fibrosis. Synonyms: Benzylamiloride. CAS No. 2898-76-2. Molecular formula: C13H14ClN7O. Mole weight: 319.75. | |
| Benzamil hydrochloride | Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na + /Ca 2+ exchanger (NCX) inhibitor ( IC 50 ~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca 2+ -activated currents, with an IC 50 of 1.1 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Benzylamiloride hydrochloride. CAS No. 161804-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1546A. | |
| Benzamil hydrochloride | Benzamil hydrochloride is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM) and an epithelial sodium channel (ENaC) blocker. Benzamil is an analogue of amiloride, and it is potentially used for the treatment of cystic fibrosis. Uses: Potential treatment of cystic fibrosis. Synonyms: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 161804-20-2. Molecular formula: C13H14ClN7O.HCl. Mole weight: 356.21. | |
| Bupivacaine | Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium , L-calcium , and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC 50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 38396-39-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0405. | |
| Bupivacaine hydrochloride | Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium , L-calcium , and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC 50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18010-40-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0405A. | |
| Bupivacaine (hydrochloride) (Standard) | Bupivacaine (hydrochloride) (Standard) is the analytical standard of Bupivacaine (hydrochloride). This product is intended for research and analytical applications. Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium , L-calcium , and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC 50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18010-40-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0405AR. | |
| Carbamazepine | Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC 50 of 131 μM. Carbamazepine blocks voltage gated Na + , Ca 2+ , and K + channels, and is also a HDAC inhibitor ( IC 50 : 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CBZ; NSC 169864. CAS No. 298-46-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0246. | |
| CGP 37157 | CGP 37157 is a a selective sodium-calcium exchanger inhibitor with IC50 value of 0.36 μM in isolated mitochondria. It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum. CGP 37157 can be used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis. Synonyms: Cgp 37157; Cgp-37157; Cgp37157. 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one. Grades: 98%. CAS No. 75450-34-9. Molecular formula: C15H11Cl2NOS. Mole weight: 289.78. | |
| Chlorpromazine-d6 hydrochloride | Chlorpromazine-d 6 (hydrochloride) is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, sodium channel. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1228182-46-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-B0407AS. | |
| Conquinine | Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. Uses: Conquinine is an alkaloid with class 1a antiarrhythmic and antimalarial effects. it also blocks muscarinic and alpha-adrenergic neurotransmission. Synonyms: Quinidine;Chinidin;Pitayine;(+)-Quinidine;Quinidex;Chinidin;(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol. Grades: 98%. CAS No. 56-54-2. Molecular formula: C20H24N2O2. Mole weight: 324.42. | |
| D-3263 | D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer. Synonyms: 3-(2-Aminoethyl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbonyl)-5-methoxy-1H-benzo[d]imidazol-2(3H)-one; 2H-Benzimidazol-2-one, 3-(2-aminoethyl)-1,3-dihydro-5-methoxy-1-(((1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl)carbonyl)-; 3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥95%. CAS No. 947257-66-1. Molecular formula: C21H31N3O3. Mole weight: 373.49. | |
| Dantrolene sodium | Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 440. CAS No. 14663-23-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14657. | |
| Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dantrolene sodium hydrate. CAS No. 24868-20-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12542A. | |
| DCA | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
| Dibucaine | Dibucaine (Cinchocaine) is a sodium channel inhibitor. Dibucaine is a potent SChE inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cinchocaine. CAS No. 85-79-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0552. | |
| Dibucaine hydrochloride | Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cinchocaine hydrochloride. CAS No. 61-12-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0552A. | |
| EIPA | EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE). Uses: Epithelial sodium channel blockers. Synonyms: Ethylisopropylamiloride; L 593754; MH 12-43; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1154-25-2. Molecular formula: C11H18ClN7O. Mole weight: 299.76. | |
| Eslicarbazepine acetate | Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIA 2-093. CAS No. 236395-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0703. | |
| ETHOTOIN | Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Uses: Anticonvulsant drug. Synonyms: (±)-Ethotoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; AC-695; AC 695; AC695; Accenon; Peganone; 3-Ethyl-5-phenyl-2,4-Imidazolidinedione. Grades: 95%. CAS No. 86-35-1. Molecular formula: C11H12N2O2. Mole weight: 204.23. | |
| Funapide | Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials. Uses: Chronic painconditions. Synonyms: UNII-A5595LHJ2L; A5595LHJ2L; XEN-401-S; TV-45070; TV 45070; TV45070; XEN402; XEN-402; XEN 402; Funapide.(7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one. Grades: 98%. CAS No. 1259933-16-8. Molecular formula: C22H14F3NO5. Mole weight: 429.35. | |
| Funapide | Funapide (TV 45070; XEN402) is a potent inhibitor of the sodium channel Nav1.7 , Nav1.8 and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TV 45070; XEN402. CAS No. 1259933-16-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16723. | |
| Halazone | Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K d value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80-13-7. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-B1386. | |
| HMR 1098 | HMR 1098 is a KATP channel antagonist inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels. Synonyms: HMR 1098; HMR1098; HMR-1098; 5-chloro-2-methoxy-n-[2-[4-methoxy-3- (3-methylthioureidosulfonyl) phenyl]ethyl]benzamide sodium salt. Grades: 98%. CAS No. 261717-22-0. Molecular formula: C19H21ClN3NaO5S2. Mole weight: 493.96. | |
| HUN51998 | HUN51998, also known as CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. HUN51998 was first reported in patent WO 2018144900, which functioned as a antagonist of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2)? with potential application for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and?/or pain (e.g., neuropathic pain). Uses: Designed for use in research and industrial production. Additional or Alternative Names: CRMP2-Ubc9-NaV1.7 inhibitor; HUN51998; HUN-51998; HUN 51998. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2241651-99-8. Molecular formula: C34H31F2N3O3. Mole weight: 567.64. Purity: >98%. IUPACName: (4-(1-(3-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(3-fluorobenzyloxy)-3-methoxyphenyl)methanone. Canonical SMILES: O=C(N1CCC(C2=NC3=CC=CC=C3N2CC4=CC=CC(F)=C4)CC1)C5=CC=C(OCC6=CC=CC(F)=C6)C(OC)=C5. Product ID: ACM2241651998. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ICA-121431 | ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant sodium channels like human Nav1.5 or Nav1.7 channels. Synonyms: ICA-121431; ICA 121431; ICA121431. 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamideICA-121431; ICA 121431; ICA121431. CAS No. 313254-51-2. Molecular formula: C23H19N3O3S2. Mole weight: 449.54. | |
| Idrevloride | Idrevloride is an epithelial sodium channel (ENaC) inhibitor. Synonyms: 3, 5-diamino-6-chloro-N-{[4- (4-{2-[ (1-deoxy-D-glucitol-1-yl) (hexyl) amino]ethoxy}phenyl) butyl]carbamimidoyl} pyrazine-2-carboxamide; 3, 5-diamino-6-chloro-N- [N'- [4- [4- [2- [hexyl- [ (2S, 3R, 4R, 5R) -2, 3, 4, 5, 6-pentahydroxyhexyl] amino] ethoxy] phenyl] butyl] carbamimidoyl] pyrazine-2-carboxamide. CAS No. 1416973-63-1. Molecular formula: C30H49ClN8O7. Mole weight: 669.22. | |
| Ion Channel Inhibitor Library | A unique collection of 946 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include potassium channel, calcium channel, sodium channel, Proton pump, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2300. Categories: Ion Channel Inhibitor Libraries. |  |
| KC 12291 hydrochloride | KC 12291 hydrochloride is the hydrochloride salt of KC 12291, which is an orally active atypical inhibitor of voltage-gated sodium channels in ischemia. It inhibits sustained sodium currents and delays myocardial sodium overload, thus prevents diastolic contracture in isolated atria in vitro. It shows bradycardic, cardioprotective and anti-ischemic activity in vivo. Synonyms: KC 12291 hydrochloride; KC12291 hydrochloride; KC-12291 hydrochloride; 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride. Grades: ≥97% by HPLC. CAS No. 181936-98-1. Molecular formula: C22H28N3O3SCl. Mole weight: 449.99. | |
| Lidocaine hydrochloride | Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence [1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lignocaine hydrochloride. CAS No. 73-78-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0185A. | |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| Native Human Plasmin | Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products. Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Applications: A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. it has also been used in a study to investigate activation of human epithelial sodium channel (enac) by plasmin and chymotrypsin. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Enzyme Commission Number: EC 3.4.21.7. CAS No. 9001-90-5. PLG. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing sodium phosphate, mannitol, and NaCl. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Cat No: NATE-0598. |  |
| Nav1.7 inhibitor | Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia. Uses: Nav1.7 inhibitor is a voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia. Synonyms: Nav1.7 inhibitor; NAV1.7-INHIBITOR; 1355631-24-1; 5-Chloro-4-((3,4-dichlorophenoxy)methyl)-2-fluoro-N-(methylsulfonyl)benzamide; 5-Chloro-4-[(3,4-dichlorophenoxy)methyl]-2-fluoro-N-(methylsulfonyl)benzamide; C15H11Cl3FNO4S. Grades: 98%. CAS No. 1355631-24-1. Molecular formula: C15H11Cl3FNO4S. Mole weight: 426.67. | |
| Nisoxetine | Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET) , with a K d of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53179-07-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1704. | |
| Nisoxetine hydrochloride | Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET) , with a K d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57754-86-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1704A. | |
| Permethrin | Permethrin is a medication and chemical widely used as an insecticide, acaricide, and insect repellent. Permethrin is a first-line treatment for scabies. It is used as a cream.It belongs to the family of synthetic chemicals called pyrethroids and functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation. It is not known to rapidly harm most mammals or birds, but is toxic to fish and cats. In cats it may induce hyperexcitability, tremors, seizures, and death. In general, it has a low mammalian toxicity and is poorly absorbed by skin.It is on the World Health Organizations List of Essential Medicines, the most important medications needed in a basic health system. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-dichloroacetyl-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline;(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate;3-phenoxybenzyl (1RS,3RS;3-phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropanecarboxylate;Permethrin (isomers). Product Category: Inhibitors. Appearance: Colourless crystals. CAS No. 52645-53-1. Molecular formula: C21H20Cl2O3. Mole weight: 391.29. Purity: ≥98.0%. Canonical SMILES: O=C(C1C(C)(C)C1/C=C(Cl)\Cl)OCC2=CC=CC(OC3=CC=CC=C3)=C2. Density: 1.19. Product ID: ACM52645531. Alfa Chemistry ISO 9001:2015 Certified. | |
| Permethrin | Permethrin (NRDC-143) is an insecticide , acaricide and a high selectively inhibitor of the Mitochondrial complex I , found in sediment and water samples. Permethrin shows estrogenic in vivo and anti- estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka ( Oryzias latipes ) [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NRDC-143. CAS No. 52645-53-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0887. | |
| PF-04856264 | This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting with the S1-S4 voltage sensor segment of homologous domain 4 which is unlike other known NaV inhibitors. PF-04856264 interaction with the region of the channel which controls voltage sensitivity enables subtype selective modulation and may be applicated as an efficient tool for drug development. Synonyms: PF-04856264; PF04856264; PF 04856264; PF-4856264; PF4856264; PF 4856264. 3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide. Grades: 98%. CAS No. 1235397-05-3. Molecular formula: C20H15N5O3S2. Mole weight: 437.49. | |
| PF 05089771 tosylate | PF 05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. It exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Synonyms: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate; PF-05089771; PF05089771; PF 05089771 Tosylate. Grades: ≥98% by HPLC. CAS No. 1430806-04-4. Molecular formula: C18H12Cl2FN5O3S2.C7H8O3S. Mole weight: 672.56. | |
| PF-05241328 | PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50 = 31nM) for the treatment of pain. But PF-05241328 is studied to have poor solubility and likely solubility limited absorption. Synonyms: PF-05241328; PF 05241328; PF05241328; PF-5241328; PF 5241328; PF5241328. 1-(5-Chloro-6-(2-methylpropoxy)-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide; 1H-Indazole-5-carboxamide, 1-(5-chloro-6-(2-methylpropoxy)-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-. CAS No. 1387633-03-5. Molecular formula: C19H21ClN4O4S. Mole weight: 436.9179. | |
| PH-064 | PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1. Synonyms: BIM-46187; BIM 46187; BIM46187; PH-064; PH 064; PH064; (2R)-2-amino-3-[[(2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]-3-oxopropyl]disulfanyl]-1-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]propan-1-one;Imidazo[1,2-a]pyrazine, 7,7'-[dithiobis[(2R)-2-aMino-1-oxo-3,1-propanediyl]]bis[8-(cyclohexylMethyl)-5,6,7,8-tetrahydro-2-phenyl-, (8S,8'S)- (9CI). Grades: >98 %. CAS No. 892546-37-1. Molecular formula: C44H58N8O2S2. Mole weight: 795.11. | |
| Phenamil methanesulfonate | Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC 50 of 400 nM [2]. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca 2+ transport with an IC 50 of 140 nM in a Ca 2+ uptake assay [1]. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway [4]. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161-94-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108464A. | |
| Primidone | Primidone is the orally active inhibitor for TRPM3 ( IC 50 = 0.6 μM), RIP kinase and voltage-gated sodium channel , and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 125-33-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0339. | |
| Procaine | Procaine is a sodium channel blocker and inhibitor of a variety of processes. Group: Biochemicals. Grades: Highly Purified. CAS No. 59-46-1. Pack Sizes: 500mg, 1g. Molecular Formula: C13H20N2O2, Molecular Weight: 236.31. US Biological Life Sciences. | Worldwide |
| Ralfinamide mesylate | Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents. It displays analgesic effects in animal models of inflammatory and neuropathic pain. Synonyms: (2S) -2-[[[4-[ (2-Fluorophenyl) methoxy]phenyl]methyl]amino]-propanamide methanesulfonate. Grades: ≥99% by HPLC. CAS No. 202825-45-4. Molecular formula: C17H19FN2O2.CH3SO3H. Mole weight: 398.45. | |
| Ropivacaine | Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is used for the research of neuropathic pain management [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84057-95-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563. | |
| Ropivacaine hydrochloride | Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is widely used for neuropathic pain management in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 98717-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563B. | |
| Ropivacaine hydrochloride monohydrate | Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132112-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563A. | |
| Ropivacaine mesylate | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>[1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 854056-07-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563C. | |
| Rp-8-Br-PET-cGMPS | Rp-8-Br-PET-cGMPS is a selective inhibitor of cGMP-dependent protein kinase I a and I β and of retinal cGMP-gated ion channels. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-pCPT-cGMPS, it is much more lipophilic and membrane-permeant. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-20-1. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
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