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| Product | Description | |
|---|---|---|
| soluble epoxide hydrolase | Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism. It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76, lipid-phosphate phosphatase. Like EC 3.3.2.9, microsomal epoxide hydrolase, it is probable that the reaction involves...se). Group: Enzymes. Synonyms: epoxide hydrase (ambiguous); epoxide hydratase (ambiguous); arene-oxide hydratase (ambiguous); aryl epoxide hydrase (ambiguous); trans-stilbene oxide hydrolase; sEH; cytosolic epoxide hydrolase. Enzyme Commission Number: EC 3.3.2.10. CAS No. 9048-63-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3995; soluble epoxide hydrolase; EC 3.3.2.10; 9048-63-9; epoxide hydrase (ambiguous); epoxide hydratase (ambiguous); arene-oxide hydratase (ambiguous); aryl epoxide hydrase (ambiguous); trans-stilbene oxide hydrolase; sEH; cytosolic epoxide hydrolase. Cat No: EXWM-3995. |  |
| 1,3-Dicyclohexylurea | 1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 500 mg. Product ID: HY-W013989. |  |
| 1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester | 1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester is used to prepare azetidine compounds as soluble epoxide hydrolase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1330763-95-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H18N2O2, Molecular Weight: 198.26. US Biological Life Sciences. |  Worldwide |
| (±)17(18)-EpETE-Ethanolamide | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grade: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. |  |
| 1-Cyclohexyl-3-dodecyl urea | 1-Cyclohexyl-3-dodecyl urea is a potent and selective inhibitor of soluble epoxide hydrolase (sEH). Synonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND. CAS No. 402939-18-8. Molecular formula: C19H38N2O. Mole weight: 310.52. | |
| AR-9281 | AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APAU. CAS No. 913548-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111151. | |
| AUDA | AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC 50 s of 18 and 69 nM for the mouse and human sEH, respectively [1]. AUDA has anti-inflammatory activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108570. | |
| AUDA | AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grade: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6. | |
| AUNP-12 | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grade: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
| CAY10640 | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grade: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
| cholesterol-5,6-oxide hydrolase | The enzyme appears to work equally well with either epoxide as substrate. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase). Group: Enzymes. Synonyms: cholesterol-epoxide hydrolase; ChEH. Enzyme Commission Number: EC 3.3.2.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3996; cholesterol-5,6-oxide hydrolase; EC 3.3.2.11; cholesterol-epoxide hydrolase; ChEH. Cat No: EXWM-3996. | |
| CUDA | CUDA is an inhibitor of soluble epoxide hydrolase (sEH) which catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity with IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. Synonyms: 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid. Grade: ≥95%. CAS No. 479413-68-8. Molecular formula: C19H36N2O3. Mole weight: 340.5. | |
| CUDA | CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) , with IC 50 s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively [1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121538. | |
| Cyclohexylmethyl Mesylate | Cyclohexylmethyl Mesylate is a reactant used in the preparation of (adamantanylureido)cyclohexanol derivatives as orally bioavailable potent soluble epoxide hydrolase inhibitors. Synonyms: Cyclohexylmethyl Mesylate; Cyclohexanemethanol Methanesulfonate; Methanesulfonic Acid Cyclohexylmethyl Ester; Cyclohexanemethyl Methanesulfonate; Cyclohexylmethyl Mesylate; Cyclohexylmethyl Methanesulfonate. Grade: >95%. CAS No. 14100-97-1. Molecular formula: C8H16O3S. Mole weight: 192.28. | |
| Diflapolin | Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It is selective for FLAP and sEH over other arachidonic acid metabolism enzymes. Diflapolin (1, 3, and 10 mg/kg) decreases inflammation in a mouse model of peritonitis induced by zymosan, reducing the production of LTB4 and LTC4 and inhibiting leukocyte recruitment. Grade: ≥98%. CAS No. 724453-98-9. Molecular formula: C22H17Cl2N3O2S. Mole weight: 458.36. | |
| EC5026 | EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPN-19186. CAS No. 1809885-32-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135653. | |
| EC5026 | EC5026 is an inhibitor of soluble epoxide hydrolase (sEH). Inhibition of sEH increases epoxides of polyunsaturated fatty acids (EpFA) in vivo and confers beneficial effects. Synonyms: EC-5026; EC 5026. Grade: 98% by HPLC. CAS No. 1809885-32-2. Molecular formula: C18H23F4N3O3. Mole weight: 405.4. | |
| GSK2256294A | GSK2256294A, an effective inhibitor of human soluble epoxide hydrolase(sEH), was developed by GSK and still under Phase I trial in Chronic obstructive pulmonary disease. IC50: 27pM. Uses: Gsk2256294a is an effective inhibitor of human soluble epoxide hydrolase(seh). Synonyms: GSK2256294; GSK-2256294; GSK 2256294; GSK-2256294A; GSK 2256294A. Grade: 98%. CAS No. 1142090-23-0. Molecular formula: C21H24F3N7O. Mole weight: 447.46. | |
| GSK2256294A | GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 2256294. CAS No. 1142090-23-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19644. | |
| hepoxilin-epoxide hydrolase | Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase). Group: Enzymes. Synonyms: hepoxilin epoxide hydrolase; hepoxylin hydrolase; hepoxilin A3 hydrolase. Enzyme Commission Number: EC 3.3.2.7. CAS No. 122096-98-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4004; hepoxilin-epoxide hydrolase; EC 3.3.2.7; 122096-98-4; hepoxilin epoxide hydrolase; hepoxylin hydrolase; hepoxilin A3 hydrolase. Cat No: EXWM-4004. | |
| leukotriene-A4 hydrolase | This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase). Group: Enzymes. Synonyms: LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase. Enzyme Commission Number: EC 3.3.2.6. CAS No. 90119-07-6. LTA4H. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4003; leukotriene-A4 hydrolase; EC 3.3.2.6; 90119-07-6; LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase. Cat No: EXWM-4003. | |
| limonene-1,2-epoxide hydrolase | Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. The enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC 3.3.2.4 (trans-epoxysuccinate hydrolase), EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase) and EC 3.3.2.10 (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline. Both enantiomers of menth-8-ene-1,2-diol [i.e. (1R,2R,4S)-menth-8-ene-1,2-diol and (1S,2S,4R)-menth-8-ene-1,2-diol] are metabolized. Group: Enzymes. Synonyms: limonene oxide hydrolase. Enzyme Commission Number: EC 3.3.2.8. CAS No. 216503-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4005; limonene-1,2-epoxide hydrolase; EC 3.3.2.8; 216503-88-7; limonene oxide hydrolase. Cat No: EXWM-4005. | |
| lipid-phosphate phosphatase | Requires Mg2+ for maximal activity. The enzyme from mammals is a bifunctional enzyme: the N-terminal domain exhibits lipid-phosphate-phosphatase activity and the C-terminal domain has the activity of EC 3.3.2.10, soluble epoxide hydrolase (sEH). The best substrates for this enzyme are 10-hydroxy-9-(phosphonooxy)octadecanoates, with the threo- form being a better substrate than the erythro- form. The phosphatase activity is not found in plant sEH or in EC 3.3.2.9, microsomal epoxide hydrolase, from mammals. Group: Enzymes. Synonyms: hydroxy fatty acid phosphatase; dihydroxy fatty acid phosphatase; hydroxy lipid phosphatase; sEH (ambiguous); soluble epoxide hydrolase (ambiguous). Enzyme Commission Number: EC 3.1.3.76. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3681; lipid-phosphate phosphatase; EC 3.1.3.76; hydroxy fatty acid phosphatase; dihydroxy fatty acid phosphatase; hydroxy lipid phosphatase; sEH (ambiguous); soluble epoxide hydrolase (ambiguous). Cat No: EXWM-3681. | |
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