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| Product | Description | |
|---|---|---|
| Sorafenib | Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRβ , FLT3 and c-Kit , respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay 43-9006. CAS No. 284461-73-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-10201. |  |
| Sorafenib | Sorafenib Inhibitor. Uses: Scientific use. Product Category: T0093L. CAS No. 284461-73-0. |  |
| Sorafenib 2-Chloro Isomer | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4- [4- [ [ [ [2-Chloro-3- (trifluoromethyl) ?phenyl] ?amino] ?carbonyl] ?amino] ?phenoxy] ?-N-methyl-2-pyridinecarboxamide; 4-Deschloro-2-chloro-Sorafenib. Grades: > 95%. CAS No. 1431697-81-2. Molecular formula: C21H16ClF3N4O3. Mole weight: 464.83. |  |
| Sorafenib-beta-D-Glucuronide | Sorafenib-beta-D-Glucuronide is one of Sorafenib metabolites. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-[(4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]-beta-D-glucopyranuronosylamine; 1- [ [4-Chloro-3- (trifluoroMethyl) phenyl] [ [ [4- [ [2- [ (MethylaMino) carbonyl] -4-pyridinyl] oxy] phenyl] aMino] carbonyl] aMino] -1-deoxy-Beta-D-glucopyranuronic Acid; Sorafenib Beta-D-Glucuronide. Grades: ≥95%. CAS No. 1130164-93-0. Molecular formula: C27H24ClF3N4O9. Mole weight: 640.95. | |
| Sorafenib-d3 | Cas No. 1130115-44-4. | |
| Sorafenib ?-D-Glucuronide | Sorafenib ?-D-Glucuronide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1130164-93-0. Molecular formula: C27H24ClF3N4O9. Mole weight: 640.95. Catalog: APB1130164930. |  |
| Sorafenib Hemitosylate | Sorafenib Hemitosylate is the salt of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-[4-[[[[4-chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino] phenoxy]-N-methyl-2-pyridinecarboxamide, 4-methylbenzenesulfonate (2:1). CAS No. 2056030-06-7. Molecular formula: C21H16ClF3N4O3.1/2(C7H8O3S). Mole weight: 550.92. | |
| Sorafenib Impurity 1 | Sorafenib Impurity 1 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Molecular formula: C28H25N7O6. Mole weight: 555.54. | |
| Sorafenib Impurity 10 | Sorafenib Impurity 10 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: SORAFENIB IMPURITY 10; 2206827-14-5; propan-2-yl N-[4-[2-(methylcarbamoyl)pyridin-4-yl]oxyphenyl]carbamate; SORAFENIBIMPURITY10; EN300-6494528; Z3064469246; Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate; propan-2-yl N-(4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamate. Molecular formula: C24H24F3N5O4. Mole weight: 503.47. | |
| Sorafenib Impurity 4 | Sorafenib Impurity 4 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Molecular formula: C7H7NO2. Mole weight: 137.14. | |
| Sorafenib Impurity 5 | Sorafenib Impurity 5 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Molecular formula: C14H13ClN4O2. Mole weight: 304.73. | |
| Sorafenib Impurity 7 | Sorafenib Impurity 7 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4-Hydroxy-phenylhydroxylamine. Grades: ≥ 95%. CAS No. 3505-87-1. Molecular formula: C6H7NO2. Mole weight: 125.13. | |
| Sorafenib Impurity 8 | Sorafenib Impurity 8 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: Flucofuron; 370-50-3; Flucofuron [ISO]; TCMDC-137559; 1,3-bis[4-chloro-3-(trifluoromethyl)phenyl]urea; CHEBI:59242; 1,3-Bis(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)urea; 1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)urea; N,N'-bis[4-chloro-3-(trifluoromethyl)phenyl]urea; U3V3S70655; Mitin N; 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea; N,N'-BIS(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)UREA. Molecular formula: C25H25F3N6O3. Mole weight: 514.50. | |
| Sorafenib Impurity 84 | Sorafenib Impurity 84. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1403469-80-6. Molecular formula: C7H6Cl2N2O. Mole weight: 205.04. Catalog: APB1403469806. | |
| Sorafenib Impurity 85 | Sorafenib Impurity 85. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1021077-12-2. Molecular formula: C7H6Cl2N2O. Mole weight: 205.04. Catalog: APB1021077122. | |
| Sorafenib Impurity 9 | Sorafenib Impurity 9 is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4- (4- (3- (4-Hydroxy-3- (trifluoromethyl) phenyl) ureido) phenoxy) -N-methylpicolinamide. CAS No. 862875-16-9. Molecular formula: C21H17F3N4O4. Mole weight: 446.38. | |
| Sorafenib Impurity C | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Grades: > 95%. Molecular formula: C27H23N5O6. Mole weight: 513.51. | |
| Sorafenib Impurity G | Sorafenib Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate. CAS No. 18585-06-3. Molecular formula: C10H9ClF3NO2. Mole weight: 267.63. Catalog: APB18585063. | |
| Sorafenib Impurity I | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 1,3-bis-(4-Chloro-α,α,α-trifluoro-m-tolyl)urea. Grades: > 95%. CAS No. 370-50-3. Molecular formula: C15H8Cl2F6N2O. Mole weight: 417.13. | |
| Sorafenib Impurity INT-1-F | Sorafenib Impurity INT-1-F. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1065074-98-7. Molecular formula: C8H11N3O. Mole weight: 165.2. Catalog: APB1065074987. | |
| Sorafenib Impurity INT-1-N | Sorafenib Impurity INT-1-N. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1863331-80-9. Molecular formula: C9H13N3O. Mole weight: 179.22. Catalog: APB1863331809. | |
| Sorafenib-methyl-d3 | Labeled Sorafenib, a potent Raf kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Sorafenib N-oxide | Sorafenib N-oxide. Group: Biochemicals. Alternative Names: 4- [4- [ [ [ [4-Chloro-3- (trifluoromethyl) phenyl] amino] carbonyl] amino] phenoxy] -N-methyl-2-pyridinecarboxamide 1-oxide. Grades: Highly Purified. CAS No. 583840-03-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H16ClF3N4O4. US Biological Life Sciences. | Worldwide |
| Sorafenib-N-oxide | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Uses: Protein kinase inhibitors. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide 1-oxide. Grades: > 95%. CAS No. 583840-03-3. Molecular formula: C21H16ClF3N4O4. Mole weight: 480.82. | |
| Sorafenib, p-Toluenesulfonate Salt | Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50=6nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-b, c-KIT, and Flt3. However, sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 475207-59-1. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H16ClF3N4O3 C7H8O3S, Molecular Weight: 637.03. US Biological Life Sciences. | Worldwide |
| Sorafenib Related Compound | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-methyl-4-phenoxy-2-Pyridinecarboxamide. Grades: > 95%. CAS No. 2004659-85-0. Molecular formula: C13H12N2O2. Mole weight: 228.25. | |
| Sorafenib related compound 10 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic Acid; 4- (4- (3- (4-Chloro-3- (trifluoromethyl) phenyl) ureido) phenoxy) picolinic Acid; Sorafenib Hydroxydemethylamine. Grades: > 95%. CAS No. 1012058-78-4. Molecular formula: C20H13ClF3N3O4. Mole weight: 451.79. | |
| Sorafenib related compound 10 | Sorafenib related compound 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1012058-78-4. Molecular formula: C20H13ClF3N3O4. Mole weight: 451.79. Catalog: APB1012058784. | |
| Sorafenib related compound 11 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-Methyl-4-[4-[[2-[(methylamino)carbonyl]-4-pyridinyl]amino]phenoxy]-2-pyridinecarboxamide. Grades: > 95%. CAS No. 2004659-83-8. Molecular formula: C20H19N5O3. Mole weight: 377.40. | |
| Sorafenib Related Compound 12 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-[4-(formylamino)phenoxy]-N-methyl-2-Pyridinecarboxamide. Grades: > 95%. CAS No. 2004659-84-9. Molecular formula: C14H13N3O3. Mole weight: 271.27. | |
| Sorafenib Related Compound 13 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 6-Chloro-N-methylpicolinamide; 6-Chloro-N-methyl-2-pyridinecarboxamide. Grades: > 95%. CAS No. 845306-04-9. Molecular formula: C7H7ClN2O. Mole weight: 170.6. | |
| Sorafenib Related Compound 14 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide; BAY 43-9007; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-(2-carbamoyl-4-pyridyloxy)phenyl]urea; N-Desmethyl Sorafenib. Grades: > 95%. CAS No. 284461-74-1. Molecular formula: C20H14ClF3N4O3. Mole weight: 450.81. | |
| Sorafenib Related Compound 15 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4,4'-[Carbonylbis(imino-4,1-phenyleneoxy)]bis[N-methyl-2-pyridinecarboxamide]; PAPE-urea; N,N'-Bis[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea. Grades: > 95%. CAS No. 284670-98-0. Molecular formula: C27H24N6O5. Mole weight: 512.53. | |
| Sorafenib related compound 16 | Sorafenib related compound 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1256817-30-7. Molecular formula: C8H10N2O2. Mole weight: 166.18. Catalog: APB1256817307. | |
| Sorafenib related compound 19 | Sorafenib related compound 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1012058-77-3. Molecular formula: C12H10N2O3. Mole weight: 230.22. Catalog: APB1012058773. | |
| Sorafenib related compound 2 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; [4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; 4-Chloro-3-(trifluoromethyl)carbanilic Acid Ethyl Ester; Ethyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate. Grades: > 95%. CAS No. 18585-06-3. Molecular formula: C10H9ClF3NO2. Mole weight: 267.64. | |
| Sorafenib Related Compound 26 HCl | Sorafenib Related Compound 26 HCl is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Molecular formula: C11H11F3N2O2.HCl. Mole weight: 296.67. | |
| Sorafenib related compound 3 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-Methyl-4-[4-[[[[3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide; Deschloro Sorafenib. Grades: > 95%. CAS No. 1285533-84-7. Molecular formula: C21H17F3N4O3. Mole weight: 430.39. | |
| Sorafenib related compound 4 | Sorafenib related compound 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1129683-83-5. Molecular formula: C14H10ClF3N2O2. Mole weight: 330.69. Catalog: APB1129683835. | |
| Sorafenib related compound 5 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Grades: > 95%. Molecular formula: C14H16N4O2. Mole weight: 272.31. | |
| Sorafenib related compound 8 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 2-Pyridinecarboxamide, 4-[4-[(aminocarbonyl)?amino]?phenoxy]?-N-methyl-. Grades: > 95%. CAS No. 1129683-88-0. Molecular formula: C14H14N4O3. Mole weight: 286.29. | |
| Sorafenib related compound 8 | Sorafenib related compound 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1129683-88-0. Molecular formula: C14H14N4O3. Mole weight: 286.29. Catalog: APB1129683880. | |
| Sorafenib tosylate | inhibits cancer cells similar to paclitaxel effective against paclitaxel-resistant tumours. CAS No. 284461-73-0. Product ID: 8-04403. Molecular formula: C21H11N4O3ClF3. Mole weight: 464.83. Reference: J. Antibiot., 55, 41, 2002. |  |
| Sorafenib tosylate | Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib tosylate is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRβ , FLT3 and c-Kit , respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay 43-9006 tosylate. CAS No. 475207-59-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-10201A. | |
| Des-(4-chloro-3-trifluoromethyl)-4-(methyl-4-hydroxypicolinate) Sorafenib | Des-(4-chloro-3-trifluoromethyl)-4-(methyl-4-hydroxypicolinate) Sorafenib is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4- [4- [ [ [ [4- [ [2- [ (Methylamino) carbonyl] -4-pyridinyl] oxy] phenyl] amino] carbonyl] amino] phenoxy] -methyl ester-2-pyridinecarboxylic Acid; Sorafenib Impurity C; Sorafenib Impurity 6. Grades: > 98%. CAS No. 2204442-52-2. Molecular formula: C27H23N5O6. Mole weight: 513.50. | |
| N-Desmethyl Sorafenib (Pyridine)-N-oxide | N-Desmethyl Sorafenib (Pyridine)-N-oxide is one of Sorafenib metabolites. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide 1-Oxide; BAY 68-7769; N'-desmethylsorafenib N-oxide; N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-1-oxo-(4-pyridyloxy)]phenyl}urea. Grades: 98%. CAS No. 583840-04-4. Molecular formula: C20H14ClF3N4O4. Mole weight: 466.80. | |
| 1,3-Bis(6-chloro-2',3'-difluoro-[1,1'-biphenyl]-3-yl)urea | 1,3-Bis(6-chloro-2',3'-difluoro-[1,1'-biphenyl]-3-yl)urea is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Molecular formula: C25H14Cl2F4N2O. Mole weight: 505.29. | |
| 1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea | 1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea is an impurity of Sorafenib (S676850), a kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1129683-83-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C14H10ClF3N2O2, Molecular Weight: 330.69. US Biological Life Sciences. | Worldwide |
| 1- (4-Chloro-3- (trifluoromethyl) phenyl) urea | 1- (4-Chloro-3- (trifluoromethyl) phenyl) urea is an impurity of Sorafenib (S676850); a multiple kinase inhibitor targeting both RAF and receptor tyrosine kinases that promote angiogenesis. Also antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H6ClF3N2O, Molecular Weight: 238.59. US Biological Life Sciences. | Worldwide |
| 1-(4-Chloro-3-(trifluoromethyl)phenyl)urea | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]urea; Sorafenib Impurity 1; Sorafenib related compound 1; 1-[3-(Trifluoromethyl)-4-chlorophenyl]urea; Sorafenib Related Compound 9. Grades: > 95%. CAS No. 343247-69-8. Molecular formula: C8H6ClF3N2O. Mole weight: 238.59. | |
| 3-? (Trifluoromethyl) ?phenyl Isocyanate | 3-? (Trifluoromethyl) ?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 329-01-1. Pack Sizes: 500mg, 1g. Molecular Formula: C8H4F3NO, Molecular Weight: 187.12. US Biological Life Sciences. | Worldwide |
| 4-(4-Aminophenoxy)-2-pyridinecarboxamide | 4-(4-Aminophenoxy)-2-pyridinecarboxamide is one of Sorafenib intermediates. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4-(2-Carbamoyl-4-pyridyloxy)aniline; 4-(4-Aminophenoxy)picolinamide; 4-(4-amino-phenoxy)-pyridine-2-carboxylic acid amide; 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-; Sorafenib tosylate Impurity 8; 4-(2-carbamoyl-pyridin-4-yloxy)aniline. Grades: 95%. CAS No. 284462-80-2. Molecular formula: C12H11N3O2. Mole weight: 229.23. | |
| 4-(4-Aminophenoxy)picolinic Acid | 4-(4-Aminophenoxy)picolinic Acid is used in the synthesis of sorafenib analogs. Synonyms: 4-(4-Aminophenoxy)-2-pyridinecarboxylic Acid; Sorafenib Related Compound 19. Grades: 98%. CAS No. 1012058-77-3. Molecular formula: C12H10N2O3. Mole weight: 230.22. | |
| 4-Chloro-3-(trifluoromethyl)aniline | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-chloro-3-(trifluoromethyl)aniline. Grades: 97 %. CAS No. 320-51-4. Molecular formula: C7H5ClF3N. Mole weight: 195.57. | |
| 4-Chloro-N-ethyl-2-pyrimidinamine | 4-Chloro-N-ethyl-2-pyrimidinaminee is used as a reactant in the preparation of sorafenib analogs. Synonyms: 4-Chloro-2-(ethylamino)pyrimidine; N-(4-Chloropyrimidin-2-yl)-N-ethylamine; N-(4-Chloropyrimidin-2-yl)ethylamine; 2-(4-Chloropyrimidin-2-yl)ethanamine. Grades: ≥95%. CAS No. 86575-65-7. Molecular formula: C6H8ClN3. Mole weight: 157.60. | |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Synonyms: AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925. Grades: >98%. CAS No. 1401033-86-0. Molecular formula: C26H29N7O2. Mole weight: 471.55. | |
| Angiogenesis related Compound Library | A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS); - Targets include angiogenesis signaling, and related targets such as S1P, VEGFR, PDGF, etc. ; - Includes approved drugs targeting angiogenesis, such as Sunitinib Malate, Lenalidomide, sorafenib, Erlotinib; drugs in clinical development with the most potential targeting angiogenesis, such as Vatalanib, Orantinib, 2-Methoxyestradiol (Panzem), Celecoxib; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4800. Categories: Angiogenesis related Compounds Libraries. | |
| BAY-721973 | BAY-721973 is a bio-active chemical,but few detailed information has been published yet. Synonyms: BAY-721973; BAY 721973; BAY721973; Sorafenib metabolite M3; UNII-83F1Z938Q0; 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) phenoxy) -N- (hydroxymethyl) -2-Pyridinecarboxamide. Grades: 98%. CAS No. 1380310-94-0. Molecular formula: C21H16ClF3N4O4. Mole weight: 480.83. | |
| Dimiracetam | Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NT-11624. CAS No. 126100-97-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-106856. | |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: PAPE-ethyl Carbamate; Sorafenib related compound 7. Grades: > 98%. CAS No. 2206827-12-3. Molecular formula: C16H17N3O4. Mole weight: 315.32. | |
| Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate | Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: Sorafenib related compound 6. Grades: > 95%. Molecular formula: C17H19N3O4. Mole weight: 329.35. | |
| N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea | N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea is one of Sorafenib impurities. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: Sorafenib Impurity 3. Grades: 98%. CAS No. 1129683-83-5. Molecular formula: C14H10ClF3N2O2. Mole weight: 330.69. | |
| N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide | N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-Pyridinecarboxamide, N-methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-, Deschloro Sorafenib, N-Methyl-4-[4-[[3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide. CAS No. 1285533-84-7. Pack Sizes: 10MG. IUPAC Name: N-methyl-4-[4-[[3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide. Molecular formula: C21H17F3N4O3. Mole weight: 430.38. Catalog: APS1285533847. SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)ccn1. Format: Neat. Shipping: Room Temperature. | |
| N,N'-bis[3-(4-Cyanophenoxy)-4-methylphenyl]urea | N,N'-bis[3-(4-Cyanophenoxy)-4-methylphenyl]urea is a derivative of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: Urea, N,N'-bis[3-(4-cyanophenoxy)-4-methylphenyl]-. Grades: 98%. CAS No. 1421677-31-7. Molecular formula: C29H22N4O3. Mole weight: 474.51. | |
| Phenyl (2-Chloro-3-(trifluoromethyl)phenyl)carbamate | Phenyl (2-Chloro-3-(trifluoromethyl)phenyl)carbamate is one of Sorafenib intermediates. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. CAS No. 2518227-67-1. Molecular formula: C14H9ClF3NO2. Mole weight: 315.67. | |
| Questiomycin A | Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Phx-3. CAS No. 1916-59-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N8439. | |
| Regorafenib | Inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Group: Biochemicals. Alternative Names: 4- [4- [ [ [ [4-Chloro-3- (trifluoromethyl) phenyl] amino] carbonyl] amino] -3-fluorophenoxy] -N-methyl-2-pyridinecarboxamide; 4-[4-[N- (4-Chloro-3-trifluoromethylphenyl) ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; BAY 73-4506; Fluoro-Sorafenib; Stivarga. Grades: Highly Purified. CAS No. 755037-03-7. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 482.82. US Biological Life Sciences. | Worldwide |
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