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| Product | Description | |
|---|---|---|
| sphingosine kinase | The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species. Group: Enzymes. Synonyms: SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.91. CAS No. 50864-48-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3121; sphingosine kinase; EC 2.7.1.91; 50864-48-7; SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Cat No: EXWM-3121. |  |
| Sphingosine kinase 1a Active from mouse | recombinant, expressed in baculovirus, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Sphingosine kinase 1 Active human | recombinant, expressed in baculovirus, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Sphingosine Kinase 1 Inhibitor, SKI-178 (N'- (1E) -1- (3, 4-Dimethoxyphenyl) ethylidene) -3- (4-methoxyphenyl) -1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) | A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. |  Worldwide |
| Sphingosine kinase 2 Active from mouse | recombinant, expressed in baculovirus, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Sphingosine kinase 2 Active human | recombinant, expressed in baculovirus, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Sphingosine kinase 2 (long form) Active human | recombinant, expressed in baculovirus, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Sphingosine Kinase Inhibitor IV, CB5468139 (N-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-N-cyclohexylacetamide, SK Inhibitor IV, Sphingosine Kinase Inhibitor IV) | A cell-permeable naphthoquinone derivative that acts as an ATP-competitive inhibitior against sphingosine kinase 1 (IC50 = 2uM; [sphingosine] = 10uM & [ATP] = 100uM) and several protein kinases, including, but not limited to, TNK2, AURKB, Met, Syk, AURKC, Fyn, Flt2, PIM2, MST2, CLK1, Tie1, and Fak (IC50 <2uM), while exhibiting much reduced potency toward DAG Kinase and sphingosine kinase 2 (37% and no inhibition, respectively, at 100uM). Shown to be more potent than SK1/2 dual inhibitor against kidney adenocarcinoma A498 proliferation (GI50 = 10 and 20uM, respectively; 48h) and the two inhibitors are also reported to induce differential modulations of A498 cellular ceramides and S1P levels when applied at their respective GI50. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SKI-II, Sphingosine Kinase Inhibitor (4- [ [4- (4-Chlorophenyl) -2-thiazolyl] amino] phenol) | Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5uM, with no inhibition against ERK2, PI3-kinase, or PKCa at concentrations up to 60uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 312636-16-1. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| SKI-I, Sphingosine Kinase Inhibitor (5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide) | Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy. Group: Biochemicals. Grades: Highly Purified. CAS No. 306301-68-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| 1-(1-iodoethyl)-4-octylbenzene | 1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod, also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 15mg, 30mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 1-?(2-?Iodoethyl)?-?2-?octylbenzene | 1-?(2-?Iodoethyl)?-?2-?octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 162358-96-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 1,?3-?Bis(bromomethyl)?-?5-?methylbenzene | 1,?3-?Bis(bromomethyl)?-?5-?methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity. Group: Biochemicals. Grades: Highly Purified. CAS No. 19294-04-3. Pack Sizes: 1g, 5g. Molecular Formula: C9H10Br2, Molecular Weight: 277.98. US Biological Life Sciences. | Worldwide |
| 1,4-Bipiperidine | 1,4-Bipiperidine is used in the synthesis of selective sphingosine kinase 1 inhibitors used as a therapeutic agent for proliferative diseases. Also used in the synthesis of calcitonin gene-related (CGRP) receptor antagonists. Group: Biochemicals. Alternative Names: 4-(1-Piperidino)piperidine. Grades: Highly Purified. CAS No. 4897-50-1. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1-(4-Hydroxyphenyl)thiourea | 1-(4-Hydroxyphenyl)thiourea is an intermediate in the synthesis of (SKI II), a nonlipid inhibitor of sphingosine kinase. SKI II s orally bioavailable and has shown significant inhibition of tumor growth in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 1520-27-0. Pack Sizes: 1g, 5g. Molecular Formula: C7H8N2OS, Molecular Weight: 168.22. US Biological Life Sciences. | Worldwide |
| 1-? (4-? (Trifluoromethoxy) ?phenyl) ?-?2-?thiourea | 1-? (4-? (Trifluoromethoxy) ?phenyl) ?-?2-?thiourea Is used as a reagent in the synthesis of 2-aminothiazole derivatives which act as sphingosine kinase inhibitors. These 2-aminothiazole derivatives thus act as anticancer and anti-inflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 142229-74-1. Pack Sizes: 250mg, 1g. Molecular Formula: C8H7F3N2OS. US Biological Life Sciences. | Worldwide |
| 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol | 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol is a substrate for human sphingosine kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 136770-76-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H41NO2, Molecular Weight: 315.529999999999. US Biological Life Sciences. | Worldwide |
| 2-(Acetyloxy)-3-nitrobenzoic Acid Methyl Ester | 2-(Acetyloxy)-3-nitrobenzoic Acid Methyl Este is disubsituted benzoic acid derivative used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 22621-42-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H9NO6. US Biological Life Sciences. | Worldwide |
| (2R,4R)-4-Hydroxy-2-pyrrolidinemethanol Hydrochloride | (2R,4R)-4-Hydroxy-2-pyrrolidinemethanol hydrochloride is used as a reagent to synthesize various pharmaceutical compounds such as sphingosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1009335-36-7. Pack Sizes: 50mg, 500mg. Molecular Formula: C5H12ClNO2, Molecular Weight: 153.61. US Biological Life Sciences. | Worldwide |
| 3-(Acetylamino)-2-hydroxybenzoic Acid Methyl Ester | 3-(Acetylamino)-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 184151-07-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H11NO4. US Biological Life Sciences. | Worldwide |
| 3-Amino-2-hydroxybenzoic Acid Methyl Ester | 3-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 35748-34-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H9NO3. US Biological Life Sciences. | Worldwide |
| 4-Amino-3-hydroxybenzoic acid | 4-Amino-3-hydroxybenzoic acid (CAS# 2374-03-0) is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. Synonyms: benzoic acid, 4-amino-3-hydroxy-; 3-hydroxy-4-aminobenzoic acid. Grade: 98.0%. CAS No. 2374-03-0. Molecular formula: C7H7NO3. Mole weight: 153.1. |  |
| 4-Amino-3-hydroxybenzoic Acid | 4-Amino-3-hydroxybenzoic Acid is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. Group: Biochemicals. Alternative Names: (4-Carboxy-2-hydroxyphenyl)amine; 3-Hydroxy-4-aminobenzoic Acid; 3-Hydroxy-PABA; 3-Hydroxy-p-aminobenzoic Acid; NSC 407243. Grades: Highly Purified. CAS No. 2374-03-0. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Synonyms: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. Grade: 0.98. CAS No. 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. | |
| Amgen-23 | Amgen-23 is a potent sphingosine kinases (SPHK) inhibitor. Grade: 98% by HPLC. CAS No. 1448706-15-7. Molecular formula: C23H25Cl2N3O2S. Mole weight: 478.4. | |
| Amiselimod HCl | Amiselimod, formerly known as MT-1303, is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases. And it also is a potent and selective immunosuppressant and sphingosine 1 phosphate receptor modulator, as an investigational therapy for people with relapsing-remitting muscular sclerosis (RRMS), inflammatory bowel disease (IBD), and other autoimmune diseases. Synonyms: 2-amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}propane-1,3-diol hydrochloride; MT-1303; MT1303; MT 1303; Amiselimod HCl. CAS No. 942398-84-7. Molecular formula: C19H31ClF3NO3. Mole weight: 413.91. | |
| Amiselimod hydrochloride | Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 ( S1P1 ) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MT-1303 hydrochloride. CAS No. 942398-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16734A. |  |
| azido-FTY720 | Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down-regulating sphingosine-1 phosphate receptor (S1PR). Phosphorylation of FTY270 by sphingosine kinase can cause S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. It is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). Synonyms: azido-FTY720; 881914-35-8; 2-Amino-2-[2-(3-azido-4-octylphenyl)ethyl]-1,3-propanediol; 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]propane-1,3-diol; 1,3-Propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-; AKOS040755896; HY-134976; CS-0168486. Grade: ≥98%. CAS No. 881914-35-8. Molecular formula: C19H32N4O2. Mole weight: 348.5. | |
| B-5354a | B-5354a is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 21 μmol/L. Molecular formula: C19H29NO3. Mole weight: 319.44. | |
| B-5354b | B-5354b is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 58 μmol/L. Molecular formula: C21H31NO3. Mole weight: 345.47. | |
| B-5354c | B-5354c is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 38 μmol/L. Molecular formula: C21H33NO3. Mole weight: 347.49. | |
| Biotin S1P | Sphingosine 1-phosphate biotin is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with biotin. Biotin S1P is produced by the phosphorylation of biotinyl sphingosine by recombinant human sphingosine kinase 1 and 2 (hSK1 and hSK2). Synonyms: omega-biotinyl D-erythro-sphingosine-1-phosphate; (2S,3R,4E)-2-Azaniumyl-3-hydroxy-18-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octadec-4-en-1-yl hydrogen phosphate. Grade: >99%. CAS No. 799812-63-8. Molecular formula: C28H53N4O7PS. Mole weight: 620.78. | |
| C16 Ceramide (N-Palmitoyl-D-Sphingosine, N-Hexadecanoyl-D-sphingosine, Palmitoyl Ceramide) | A predominant, rather hydrophobic natural ceramide. Activates a cytosolic serine/threonine protein phosphatase in T9 cells; induces EGF receptor phosphorylation in A-431 cells; stimulates ceramide-activated protein kinase. Group: Biochemicals. Alternative Names: N-Palmitoyl-D-Sphingosine; N-Hexadecanoyl-D-sphingosine; Palmitoyl Ceramide. Grades: Highly Purified. CAS No. 24696-26-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| C2 Ceramide (N-Acetyl-D-sphingosine, Acetyl Ceramide) | A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]acetamide; N-Acetyl-D-sphingosine; Acetyl Ceramide; N-Acetylsphingosine. Grades: Highly Purified. CAS No. 3102-57-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 341.53. US Biological Life Sciences. | Worldwide |
| C6 Ceramide-13C2,d2 | A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway. Group: Biochemicals. Alternative Names: N-Hexanoy-D-sphingosine-13C2,d2; N-Caproyl-D-sphingosine-13C2,d2; Caproyl Ceramide-13C2,d2. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| C8-Ceramide | C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Octanoyl-D-erythro-sphingosine. CAS No. 74713-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108391. | |
| CAY10621 | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grade: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. | |
| ceramidase | Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). Group: Enzymes. Synonyms: acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Enzyme Commission Number: EC 3.5.1.23. CAS No. 37289-06-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4413; ceramidase; EC 3.5.1.23; 37289-06-8; acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Cat No: EXWM-4413. | |
| Defensamide | Defensamide (MHP) can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production. It is an activator of sphingosine kinase (SPHK1). Synonyms: MHP; N-Hexanoyltyrosine methyl ester; UNII-8GJP2KSJ0T; 8GJP2KSJ0T. CAS No. 1104874-94-3. Molecular formula: C16H23NO4. Mole weight: 293.36. | |
| D-erythro-Dihydro-D-sphingosine (Sphinganine) | Biosynthetic precursor of sphingosine. Inhibits protein kinase C. Group: Biochemicals. Alternative Names: Sphinganine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine | D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC 50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine. CAS No. 123-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101047. | |
| D-erythro-Sphingosine | D-erythro-Sphingosine is a natural isomer of sphingosine and acts as an inhibitor of protein kinase C and calmodulin-dependent enzymes with no effects on protein kinase A or myosin light chain kinase. It may stimulate mast cells by activation of protein kinase C. Synonyms: Sphingosine (d18:1); sphingosine; D-Sphingosine; 4-Sphingenine; 2S, 3R(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediolsphing-4-enine. Grade: >99%. CAS No. 123-78-4. Molecular formula: C18H37NO2. Mole weight: 299.49. | |
| D-erythro-Sphingosine-d7 | D-erythro-Sphingosine-d 7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7. CAS No. 1246304-34-6. Pack Sizes: 500 μg. Product ID: HY-101047S. | |
| erythro-ω-Amino Sphingosine Biotinamide | Biotin Sphingosine is a derivative of sphingosine. It contains a biotin moiety linked to the ω-terminal of its fatty-acid chain. Biotin Sphingosine plays a key role in identifying sphingosine interaction with acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A). It is used in an assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Synonyms: omega-biotinyl D-erythro-sphingosine; Biotin Sphingosine; (3aS,4S,6aR)-N-[(14E,16R,17S)-17-Amino-16,18-dihydroxy-14-octadecen-1-yl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide. Grade: >99%. CAS No. 752987-57-8. Molecular formula: C28H52N4O4S. Mole weight: 540.80. | |
| F-12509A | It is produced by the strain of Trichopezizella barbata SANK 25395. F-12509A has competitive inhibitory activity against sphingosine kinase, and the Ki value is 18μmol/L. Synonyms: F12509A. CAS No. 191608-64-7. Molecular formula: C21H28O4. Mole weight: 344.44. | |
| Fmoc-4-phenylpiperidine-4-carboxylic acid | Fmoc-4-phenylpiperidine-4-carboxylic acid. Uses: Fmoc-ppca is mainly used as a protecting group in peptide synthesis to prevent unwanted reactions from occurring during the reaction. it is also used as a precursor in the synthesis of various peptides such as sphingosine-1-phosphate receptor antagonists, vla-4 antagonists, and mer receptor tyrosine kinase inhibitors. Additional or Alternative Names: Fmoc-PPCA. Product Category: Amino Acids. CAS No. 215190-19-5. Molecular formula: C27H25NO4. Mole weight: 427.5. Purity: Peak Area by HPLC ≥95%. IUPACName: 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid. Canonical SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35. Density: 1.278 g/cm3. Product ID: ACM215190195-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fmoc-erythro-Sphingosine ( (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol) | The N-Fmoc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| FTY720 Hydrochloride | FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Alternative Names: 2-Amino-2- (2- (4-octylphenyl) ethyl) propane-1, 3-diol Hydrochloride; Fingolimod Hydrochloride. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| FTY720 phenoxy-biotin | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, which means that it would likewise be phosphorylated in vivo. Synonyms: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-N-biotinoyl-1,5-diampentane. Grade: ≥95%. Molecular formula: C27H44N4O5S·HCl. Mole weight: 573.2. | |
| MHP | MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase ( SPHK1 ), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methyl caprooyl tyrosinate. CAS No. 1104874-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101572. | |
| Native Streptomyces sp. Phospholipase D | Phospholipase D (PLD) is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Applications: Phospholipase d (pld) has been used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to yield the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld has been used in purification and kinetic studies. the enzyme has been used in the translocation of sphingosine kinase 1 (sk1) to membrane fractions under in vitro conditions. it has also been used to produce phosphatidic acid (pa) from phosphatidylcholine (pc) in hl60 permeabilized cells. Group: Enzymes. Synonyms: phospholipase D; lipophosphodiesterase II; lecithinase D;. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 150 units/mg solid. Storage: -20°C. Form: Type VII, lyophilized powder. Source: Streptomyces sp. phospholipase D; lipophosphodiesterase II; lecithinase D; choline phosphatase; phosphatidylcholine phosphatidohydrolase; EC 3.1.4.4; 9001-87-0; PLD. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0597. | |
| NBD Sphingosine | NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1449370-25-5. Pack Sizes: 50 μg (523.45 μM * 200 μL in Ethanol). Product ID: HY-130433. | |
| N-Boc-erythro-sphingosine-13C2,D2 | Labelled N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Boc-erythro-sphingosine ((2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol) | The N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyltamoxifen hydrochloride | N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15917-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129099A. | |
| N,N-Dimethylsphingosine ((2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol) | Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1beta and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism. Group: Biochemicals. Grades: Highly Purified. CAS No. 119567-63-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine | Protected D-erythro-C18-Dihydro-D-sphingosine. Biosynthetic precursor of Sphingosine. Inhibits protein kinase C. Group: Biochemicals. Alternative Names: N-[ (1S, 2R) -2-Hydroxy-1- (hydroxymethyl) heptadecyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 140408-14-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Opaganib | Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 ( SK2 ) inhibitor with K i of 9.8 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABC294640. CAS No. 915385-81-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16015. | |
| Peretinoin | Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 [1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC 50 of 9 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIK333. CAS No. 81485-25-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100008. | |
| PF-543 | PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II. CAS No. 1415562-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15425. | |
| PF-543 Citrate | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 Citrate induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II Citrate. CAS No. 1415562-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15425A. | |
| S-15183a | S-15183a is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. It also inhibited endogenous SPH kinase activity in intact platelets. Synonyms: S-15183 a. Molecular formula: C25H36O5. Mole weight: 416.5. | |
| S-15183b | S-15183b is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. Synonyms: S-15183 b. Molecular formula: C27H40O5. Mole weight: 444.6. | |
| SKI-178 | SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). SKI-178 induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. SKI-178 is a novel therapeutic agent for the treatment of AML, including multidrug-resistant/recurrent AML subtypes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKI-178; SKI 178; SKI178. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.43. Purity: >98%. IUPACName: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Canonical SMILES: O=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C. Product ID: ACM1259484973. Alfa Chemistry ISO 9001:2015 Certified. | |
| SKI-I | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK) , with an IC 50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 ( IC 50 =11 μM). SKI-I induces apoptosis in tumor cell lines [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 306301-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115735. | |
| SKI II | SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC 50 values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 312636-16-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13822. | |
| SKI V | SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC 50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC 50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24418-86-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12895. | |
| SLM6031434 hydrochloride | SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with K i s of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1897379-34-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120268A. | |
| Sphingosine (D-erythro-Sphingosine) | Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine. Group: Biochemicals. Alternative Names: (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol; trans-D-erythro-2-Amino-4-octadecene-1,3-diol; 4-Sphingenine; D-erythro-Sphingosine. Grades: Highly Purified. CAS No. 123-78-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??NO?, Molecular Weight: 299.49. US Biological Life Sciences. | Worldwide |
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