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| Product | Description | |
|---|---|---|
| Bis(2-cyanoethoxy)-1-(N-t-boc-sphingosine-1-Phosphate-13C2,D2 | Intermediate for a labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Caged D-erythro-sphingosine-1-phosphate (Caged SPP) | Caged SPP provides a method to elevate intracellular level of SPP upon ultraviolet irradiation and thus can be utilized as a new tool in studies of SPP-mediated intracellular events. Group: Biochemicals. Alternative Names: Caged SPP. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Dihydro-D-sphingosine-1-phosphate | May be used as a negative control for C2 Ceramide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| D-Erythro-Dihydro-d-sphingosine-1-phosphate | Heterocyclic Organic Compound. Alternative Names: dihydro-S1P; Dihydro-sphingosin-1-phosphat; dihydrorhaponticin; sphinganine-1-phosphate; 3.3.5-trihydroxy-4-methoxy-bibenzyl. CAS No. 108126-32-5. Molecular formula: C18H40NO5P. Mole weight: 381.49. Appearance: White Powder. Purity: ≥98%. IUPACName: [(2S,3R)-2-amino-3-hydroxyoctadecyl] dihydrogen phosphate. Density: 1.08g/cm³. Catalog: ACM108126325. |  |
| D-erythro-Dihydrosphingosine 1-phosphate | Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors. Negative control for intracellular effects of sphingosine 1-phosphate. Induces chemotaxis. Antifibrotic. Group: Biochemicals. Alternative Names: (2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P. Grades: Highly Purified. CAS No. 19794-97-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H40NO5P. US Biological Life Sciences. | Worldwide |
| D-Erythro-Sphingosine 1-Phosphate | D-Erythro-Sphingosine 1-Phosphate. Group: Biochemicals. Grades: Highly Purified. CAS No. 26993-30-6. Pack Sizes: 1mg, 2mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine-1-Phosphate-13C2,D2 | A labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine-1-Phosphate (SPN-1-P) | A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Alternative Names: SPN-1-P. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Biotinyl D-erythro-sphingosine-1-phosphate | Heterocyclic Organic Compound. Alternative Names: (3aS,4S,6aR)-. CAS No. 1093733-24-4. Molecular formula: C28H52N3O7PS. Mole weight: 605.77. Purity: 0.96. IUPACName: [(E,3R)-2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-hydroxyoctadec-4-enyl] dihydrogen phosphate. Canonical SMILES: CCCCCCCCCCCCCC=CC (C (COP (=O) (O)O)NC (=O)CCCCC1C2C (CS1)NC (=O)N2)O. Catalog: ACM1093733244. | |
| N-Biotinyl D-erythro-Sphingosine-1-phosphate | A biotinylated substrate conjugate used for performing ELISA on water-soluble ligands. Used for ceramide phosphate sphingosine synthesis. Group: Biochemicals. Alternative Names: (3aS,4S,6aR)-. Grades: Highly Purified. CAS No. 1093733-24-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1,3-di-O-(phosphate Dicyanoethyl Ester) | Side product in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1-phosphate Dicyanoethyl Ester | Intermediate in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-9-Cyano-6-(2-cyanoethoxy)-3-(1-hydroxyhexadecyl)-5,7-dioxa-2-aza-6-phosphanonanoic Acid 6-Oxide 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 169528-22-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sphingosine 1-phosphate | Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Synonyms: D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate. Grades: ≥98% by HPLC. CAS No. 26993-30-6. Molecular formula: C18H38NO5P. Mole weight: 379.48. |  |
| Sphingosine-1-phosphate | Sphingosine-1-phosphate. Group: Biochemicals. Grades: Purified. CAS No. 26993-30-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Sphingosine-1-phosphate | Sphingosine-1-phosphate (S1P) is an agonist of S1P 1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors [1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids [2]. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration [4]. Uses: Scientific research. Group: Natural products. Alternative Names: S1P. CAS No. 26993-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108496. |  |
| Sphingosine-1-phosphate (d16:1) | Sphingosine-1-phosphate (d16:1) is an unsaturated derivative of sphingosine-1-phosphate (S1P) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors. Synonyms: C16 S1P; C16 Sphingosine-1-phosphate; S1P (d16:1); Hexadecasphing-4-enine-1-phosphate; [(E,2S,3R)-2-amino-3-hydroxyhexadec-4-enyl] dihydrogen phosphate. Grades: ≥95%. CAS No. 709026-60-8. Molecular formula: C16H34NO5P. Mole weight: 351.4. | |
| Sphingosine-1-phosphate (d17:1) | Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-erythro-Sphingosine-C17-1-phosphate. CAS No. 474923-27-8. Pack Sizes: 1 mg. Product ID: HY-141630. | |
| Sphingosine-1-phosphate-d7 | Sphingosine-1-phosphate-d 7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: S1P-d7. CAS No. 2260670-15-1. Pack Sizes: 1 mg; 5 mg; 500 μg. Product ID: HY-108496S. | |
| 1-(3,5-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propylpyrazolo[3,4-b]pyridin-6-yl)amino]urea | JTE 013 has been found to be an antagonist of Sphingosine-1-Phosphate Receptor-2 (S1P2R). Synonyms: JTE 013; JTE013; JTE-013; 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide; N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 547756-93-4. Molecular formula: C17H19N7OCl2. Mole weight: 408.29. | |
| (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride | (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307231-02-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
| (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride | (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307873-37-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
| 2-Acetyl-4-tetrahydroxybutyl imidazole | 2-Acetyl-4-tetrahydroxybutyl imidazole is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Uses: Immunosuppressive agents. Synonyms: 2-Athbi; THI; (1R,2S,3R)-2-acetyltetrahydroxybutylimidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole. Grades: >99%. CAS No. 94944-70-4. Molecular formula: C9H14N2O5. Mole weight: 230.22. | |
| 3-Bromo-1,1,1-trifluoropropane | 3-Bromo-1,1,1-trifluoropropane is used in the discovery of potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 460-32-2. Pack Sizes: 250mg, 1g. Molecular Formula: C3H4BrF3, Molecular Weight: 176.96. US Biological Life Sciences. | Worldwide |
| (3-Carboxypropyl)triphenylphosphonium Bromide | (3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used for the preparation of sphingosine 1-phosphate-1 receptor antagonists, as well as for the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Synonyms: (4-Hydroxy-4-oxobutyl)triphenylphosphonium Bromide; Phosphonium, (3-carboxypropyl)triphenyl-, bromide (1:1). Grades: ≥95%. CAS No. 17857-14-6. Molecular formula: C22H22BrO2P. Mole weight: 429.29. | |
| A - 971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
| A-971432 | A-971432 is a potent, selective and orally active sphingosine-1-phosphate (S1P) receptor 5 agonist with IC 50 s of.362, >10, 0.006 μM for S1P1, S1P3, S1P5 respectively. A-971432 protects blood - brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimers disease or multiple sclerosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1240308-45-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110291. | |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Synonyms: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. Grades: 0.98. CAS No. 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. | |
| Amiselimod HCl | Amiselimod, formerly known as MT-1303, is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases. And it also is a potent and selective immunosuppressant and sphingosine 1 phosphate receptor modulator, as an investigational therapy for people with relapsing-remitting muscular sclerosis (RRMS), inflammatory bowel disease (IBD), and other autoimmune diseases. Synonyms: 2-amino-2-{2-[4- (heptyloxy) -3- (trifluoromethyl) phenyl]ethyl}propane-1, 3-diol hydrochloride; MT-1303; MT1303; MT 1303; Amiselimod HCl. CAS No. 942398-84-7. Molecular formula: C19H31ClF3NO3. Mole weight: 413.91. | |
| Amiselimod hydrochloride | Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 ( S1P1 ) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MT-1303 hydrochloride. CAS No. 942398-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16734A. | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grades: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| azido-FTY720 | Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down-regulating sphingosine-1 phosphate receptor (S1PR). Phosphorylation of FTY270 by sphingosine kinase can cause S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. It is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). Synonyms: azido-FTY720; 881914-35-8; 2-Amino-2-[2-(3-azido-4-octylphenyl)ethyl]-1,3-propanediol; 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]propane-1,3-diol; 1,3-Propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-; AKOS040755896; HY-134976; CS-0168486. Grades: ≥98%. CAS No. 881914-35-8. Molecular formula: C19H32N4O2. Mole weight: 348.5. | |
| C11 Ceramide-1-Phosphate | C11 Ceramide-1-Phosphate. Group: Others. Synonyms: N-[11-undecanoyl]-D-ceramide-1-phosphate (ammonium salt). Purity: >99%. Mole weight: 810.842. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; N-[11-undecanoyl]-D-ceramide-1-phosphate (ammonium salt); C11 Ceramide-1-Phosphate; N-[11-(Dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt). Cat No: FLBZ-189. |  |
| C4 Ceramide-1-phosphate | Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. Group: Biochemicals. Alternative Names: N- [ (1S, 2R, 3E) -2-Hydroxy-1- [ (phosphonooxy) methyl] -3-heptadecenyl] butanamide; N-Butyl-D-sphingosine-1-phosphate; Butyl Ceramide-1-phosphate; N-Butanoyl-D-erythro-sphingosine-1-phosphate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CAY10444 | CAY10444 is a family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned. It is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 μM. Synonyms: BML-241; CAY 10444; CAY-10444; BML 241. Grades: ≥98%. CAS No. 298186-80-8. Molecular formula: C15H29NO2S. Mole weight: 287.5. | |
| CAY10621 | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grades: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. | |
| CAY10734 | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) with IC50=0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. Synonyms: CAY 10734; CAY-10734. Grades: ≥98%. CAS No. 635701-59-6. Molecular formula: C23H25N3O3. Mole weight: 391.5. | |
| CAY10739 | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1) with IC50=25.12 nM in a β-arrestin recruitment assay, which was designed to prevent systemic effects following topical application. It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively). Synonyms: CAY 10739; CAY-10739. Grades: ≥98%. Molecular formula: C23H24N2O3S. Mole weight: 408.51. | |
| Ceralifimod | Ceralifimod (ONO-4641) is a selective agonist of sphingosine 1-phosphate (S1P) receptor 1 and 5 (EC50 = 0.0273 and 0.334?nM). In animal experiment, ONO-4641 prevented relapse of disease in a non-obese diabetic mouse model of relapsing-remitting EAE. ONO-4641 had been developed for the treatment of multiple sclerosis (MS) and undergone a phase II clinical trial by Merck KGaA and Ono, therefore, the study were terminated in Dec 2014. Uses: Ceralifimod (ono-4641) is a selective agonist of sphingosine 1-phosphate (s1p) receptor 1 and 5 (ec50 = 0.0273 and 0.334?nm) developed for the treatment of multiple sclerosis (ms). Synonyms: ONO-4641; ONO 4641; ONO4641; Ceralifimod. UNII-BZ2O8A84A4; 891859-12-4; AK173892; Ceralifimod [INN]; SCHEMBL465051; 1-[[6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid. Grades: ≥98%. CAS No. 891859-12-4. Molecular formula: C27H33NO4. Mole weight: 435.564. | |
| ceramidase | Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). Group: Enzymes. Synonyms: acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Enzyme Commission Number: EC 3.5.1.23. CAS No. 37289-06-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4413; ceramidase; EC 3.5.1.23; 37289-06-8; acylsphingosine deacylase; glycosphingolipid ceramide deacylase. Cat No: EXWM-4413. | |
| Ceranib 1 | Ceranib 1 is a ceramidase inhibitor. It inhibits proliferation in SKOV3 ovarian carcinoma cells. It decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells and induces accumulation of ceramide species. It is a useful research chemical and has an antiproliferative effect. Synonyms: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone; 6-Methyl-3-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone. Grades: ≥98% by HPLC. CAS No. 328076-61-5. Molecular formula: C26H21NO3. Mole weight: 395.45. | |
| Ceranib-2 | Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Ceranib-2 decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation. Grades: ≥98%. CAS No. 1402830-75-4. Molecular formula: C25H19NO3. Mole weight: 381.4. | |
| CS-0777-P | CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent development was reported. Uses: Multiple sclerosis. Synonyms: CS-0777; CS0777; CS 0777. 1-(5-((3R)-3-amino-3-methyl-4-(phosphonooxy)butyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-1-Butanone. Grades: 98%. CAS No. 840523-39-9. Molecular formula: C21H31N2O5P. Mole weight: 422.45. | |
| CYM-5541 | CYM-5541, also called as ML249, is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM) that less effectively activates S1P1 (EC50 = 28-38 μM) and does not disrupt S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters. Synonyms: N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide; CYM-5541; CYM 5541; CYM5541; N,N-dicyclohexyl(5-cyclopropylisoxazol-3-yl)carboxamide. CAS No. 945128-26-7. Molecular formula: C19H28N2O2. Mole weight: 316.44. | |
| Etrasimod | Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 ( S1P 1 ) receptor with an IC 50 value of 1.88 nM in CHO cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APD334. CAS No. 1206123-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12789. | |
| Ex26 | Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 ( S1P 1 ) antagonist ( IC 50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P 1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1P1-IN-Ex26. CAS No. 1233332-37-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117213. | |
| Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate ( S1P ) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720 free base. CAS No. 162359-55-9. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-11063. | |
| Fingolimod-d4 | Fingolimod-d 4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: FTY720 free based-d4. CAS No. 1346747-38-3. Pack Sizes: 500 μg; 1 mg. Product ID: HY-11063S. | |
| Fingolimod-d4 hydrochloride | Fingolimod-d 4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: FTY720-d4. CAS No. 1346604-90-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-11063S1. | |
| Fingolimod hydrochloride | Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate ( S1P ) antagonist with IC 50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720. CAS No. 162359-56-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-12005. | |
| Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride) | Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Fingolimod phosphate | Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720 phosphate. CAS No. 402615-91-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15381. | |
| Fingolimod (Standard) | Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162359-55-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11063R. | |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| FTY720 phenoxy-biotin | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, which means that it would likewise be phosphorylated in vivo. Synonyms: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-N-biotinoyl-1,5-diampentane. Grades: ≥95%. Molecular formula: C27H44N4O5S·HCl. Mole weight: 573.2. | |
| FTY720 Phosphate | FTY720 is a derivative of ISP-1 (myriocin). FTY720 phosphate is a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5, IC50 values = 0.2-6 nM). Synonyms: FTY720P; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate). Grades: ≥98%. CAS No. 402615-91-2. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
| FTY720 (R)-Phosphate | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate. Synonyms: (2R)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol. Grades: ≥98%. CAS No. 402616-23-3. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
| FTY720 (S)-Phosphate | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-phosphate is the single stereoisomer of FTY720. FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R enantiomer binds with 5 to 130-fold lower affinity. Synonyms: (S)-FTY 720P; (2S)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol. Grades: ≥98%. CAS No. 402616-26-6. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
| GLPG2938 | GLPG2938 is an antagonists of sphingosine-1-phosphate (S1P) receptor for prophylaxis and?/or treatment of diseases including fibrotic, inflammatory, autoimmune, metabolic, cardiovascular, and?/or proliferative diseases. GLPG2938 displayed S1P inhibitory activity.with EC50 value of 9.5 nM (S1P2 antagonist EC50)?. Group: Antagonists. Alternative Names: MUN96006; MUN-96006; MUN 96006; GLPG2938; GLPG-2938; GLPG 2938. CAS No. 2130996-00-6. Molecular formula: C20H19F6N7O2. Mole weight: 503.41. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(2-ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea. Canonical SMILES: O=C (NCC1=NN=C (C2=CN (C)N=C2C (F) (F)F)C (C)=C1)NC3=CC (OCC)=NC (C (F) (F)F)=C3. Catalog: ACM2130996006. | |
| GSK-2018682 | GSK-2018682 is a potent and selective agonist of sphingosine-1-phosphate receptor (S1PR) subtype 1 that has the potential to treat multiple sclerosis (MS). Synonyms: GSK2018682; GSK 2018682; GSK-2018682. UNII-NJL503AIJA; NJL503AIJA; 4-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid. Grades: ≥98%. CAS No. 1034688-30-6. Molecular formula: C22H21ClN4O4. Mole weight: 440.884. | |
| JTE-013 | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Synonyms: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
| JTE-013 | JTE-013 is a potent and specific S1P 2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P 2 with IC 50 s of 17 nM and 22 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100675. | |
| K6PC-5 | K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Uses: Potential treatment of skin disorders with abnormal differentiation and proliferation. Synonyms: K6PC-5; K6PC 5; K6PC5; Dihydroxyisopropyl capryloylcaprylamide; Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo. Grades: 98%. CAS No. 756875-51-1. Molecular formula: C19H37NO4. Mole weight: 343.5. | |
| KRP-203 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
| L-threo Lysosphingomyelin (d18:1) | L-threo Lysosphingomyelin (d18:1) is an endogenous bioactive sphingolipid and an agonist of sphingosine-1-phosphate (S1P) receptors 1-3. Synonyms: L-threo Lyso SM (18:1); L-threo Lysosphingomyelin (18:1); L-threo Sphingosine-1-Phosphocholine (d18:1); L-threo-Sphingosylphosphorylcholine; [(E,2S,3S)-2-amino-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Grades: ≥98%. CAS No. 105615-55-2. Molecular formula: C23H49N2O5P. Mole weight: 464.62. | |
| MK-571 | MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711. CAS No. 115104-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19989. | |
| MK-571 sodium | MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711 sodium. CAS No. 115103-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19989A. | |
| Mocravimod hydrochloride | Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KRP-203. CAS No. 509088-69-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13660. | |
| Native Streptomyces sp. Phospholipase D | Phospholipase D (PLD) is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid. Applications: Phospholipase d (pld) has been used to hydrolyze the phosphate bonds of phospholipids and sphingomyelin to yield the corresponding phosphatidic acid. it has also been used to study metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-cho incorporation. furthermore, pld has been used in purification and kinetic studies. the enzyme has been used in the translocation of sphingosine kinase 1 (sk1) to membrane fractions under in vitro conditions. it has also been used to produce phosphatidic acid (pa) from phosphatidylcholine (pc) in hl60 permeabilized cells. Group: Enzymes. Synonyms: phospholipase D; lipophosphodiesterase II; lecithinase D;. Enzyme Commission Number: EC 3.1.4.4. CAS No. 9001-87-0. PLD. Activity: > 150 units/mg solid. Storage: -20°C. Form: Type VII, lyophilized powder. Source: Streptomyces sp. phospholipase D; lipophosphodiesterase II; lecithinase D; choline phosphatase; phosphatidylcholine phosphatidohydrolase; EC 3.1.4.4; 9001-87-0; PLD. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0597. | |
| NBD Lyso SM | Fluorescent Lipids. Alternative Names: Omega(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine-1-phosphocholine. CAS No. 1246303-02-5. Molecular formula: C29H51N6O8P. Mole weight: 642.72. Appearance: Powder. Purity: >99%. IUPACName: [(E,2S,3R)-2-amino-3-hydroxy-18-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: C[N+] (C) (C)CCOP (=O) ([O-])OC[C@@H] ([C@@H] (/C=C/CCCCCCCCCCCCCNC1=CC=C (C2=NON=C12)[N+] (=O)[O-])O)N. Catalog: ACM1246303025. | |
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