Sphingosine Phosphate Suppliers USA
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Product | Description | |
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CAGED D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Quick inquiry Where to buy Suppliers range | CAGED D ERYTHRO SPHINGOSINE 1 PHOSPHATE. CAS No. 207516-11-8. | |
Caged D-erythro-sphingosine-1-phosphate (Caged SPP) Quick inquiry Where to buy Suppliers range | Caged SPP provides a method to elevate intracellular level of SPP upon ultraviolet irradiation and thus can be utilized as a new tool in studies of SPP-mediated intracellular events. Group: Biochemicals. Alternative Names: Caged SPP. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
D-erythro-Dihydro-D-sphingosine-1-phosphate Quick inquiry Where to buy Suppliers range | D-erythro-Dihydro-D-sphingosine-1-phosphate. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 19794-97-9. IUPAC Name: [(2S,3R)-2-amino-3-hydroxyoctadecyl] dihydrogen phosphate. Molecular formula: C18H40NO5P. Mole weight: 381.49. Catalog: APS19794979. SMILES: CCCCCCCCCCCCCCC[C@@H] (O)[C@@H] (N)COP (=O) (O)O. Format: Neat. | |
D-erythro-Dihydro-D-sphingosine-1-phosphate Quick inquiry Where to buy Suppliers range | May be used as a negative control for C2 Ceramide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
D-ERYTHRO-DIHYDRO-D-SPHINGOSINE-1-PHOSPHATE Quick inquiry Where to buy Suppliers range | D ERYTHRO DIHYDRO D SPHINGOSINE 1 PHOSPHATE. CAS No. 19794-97-9. | |
D-erythro-Sphingosine-1-phosphate Quick inquiry Where to buy Suppliers range | D-erythro-Sphingosine-1-phosphate. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 26993-30-6. IUPAC Name: [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate. Molecular formula: C18H38NO5P. Mole weight: 379.47. Catalog: APS26993306. SMILES: CCCCCCCCCCCCC\C=C\[C@@H] (O)[C@@H] (N)COP (=O) (O)O. Format: Neat. | |
D-erythro-Sphingosine-1-Phosphate Quick inquiry Where to buy Suppliers range | D-erythro-Sphingosine-1-Phosphate. Alternative Names: Sphingosine 1-phosphate. Grades: 98%+. Product ID: ACM26993306. Molecular formula: C18H38NO5P. Mole weight: 379.47. Boiling Point: 548.8±60.0 °C(Predicted). Melting Point: 179-189 °C. Storage: Freezer. | |
D-Erythro-Sphingosine 1-Phosphate Quick inquiry Where to buy Suppliers range | D-Erythro-Sphingosine 1-Phosphate. Group: Biochemicals. Grades: Highly Purified. CAS No. 26993-30-6. Pack Sizes: 1mg, 2mg. US Biological Life Sciences. | Worldwide |
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Quick inquiry Where to buy Suppliers range | D ERYTHRO SPHINGOSINE 1 PHOSPHATE. CAS No. 26993-30-6. | |
D-erythro-Sphingosine-1-Phosphate (SPN-1-P) Quick inquiry Where to buy Suppliers range | A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Alternative Names: SPN-1-P. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
N-Biotinyl D-erythro-Sphingosine-1-phosphate Quick inquiry Where to buy Suppliers range | A biotinylated substrate conjugate used for performing ELISA on water-soluble ligands. Used for ceramide phosphate sphingosine synthesis. Group: Biochemicals. Alternative Names: (3aS,4S,6aR)-. Grades: Highly Purified. CAS No. 1093733-24-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1-phosphate Dicyanoethyl Ester Quick inquiry Where to buy Suppliers range | Intermediate in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-9-Cyano-6-(2-cyanoethoxy)-3-(1-hydroxyhexadecyl)-5,7-dioxa-2-aza-6-phosphanonanoic Acid 6-Oxide 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 169528-22-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Sphingosine 1-phosphate Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Synonyms: D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate. Grades: ≥98% by HPLC. CAS No. 26993-30-6. Molecular formula: C18H38NO5P. Mole weight: 379.48. | |
Sphingosine-1-phosphate Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate. Group: Biochemicals. Grades: Purified. CAS No. 26993-30-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Sphingosine-1-phosphate (d16:1) Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate (d16:1). Alternative Names: 2(S)-amino-1-(dihydrogen phosphate), 4(E)-hexadecene-1,3(R)-diol, C16 S1P, C16 Sphingosine-1-phosphate, S1P (d16:1). Grades: 95%+. Product ID: ACM709026608. Molecular formula: C16H34NO5P. Mole weight: 351.4. Storage: Freezer. | |
Sphingosine-1-phosphate (d16:1) Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate (d16:1) is an unsaturated derivative of sphingosine-1-phosphate (S1P) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors. Synonyms: C16 S1P; C16 Sphingosine-1-phosphate; S1P (d16:1); Hexadecasphing-4-enine-1-phosphate; [(E,2S,3R)-2-amino-3-hydroxyhexadec-4-enyl] dihydrogen phosphate. Grades: ≥95%. CAS No. 709026-60-8. Molecular formula: C16H34NO5P. Mole weight: 351.4. | |
Sphingosine-1-phosphate (d17:1) Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate (d17:1). Alternative Names: 2(S)-amino-4(E)-heptadecene-1,3(R)-diol, 1-(dihydrogen phosphate), D-erythro-Sphingosine C17-phosphate, S1P (d17:1). Grades: 95%+. Product ID: ACM474923278. Molecular formula: C17H36NO5P. Mole weight: 365.5. Storage: Freezer. | |
Bis(2-cyanoethoxy)-1-(N-t-boc-sphingosine-1-Phosphate-13C2,D2 Quick inquiry Where to buy Suppliers range | Intermediate for a labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
D-erythro-Sphingosine-1-phosphate-13C2,D2 Quick inquiry Where to buy Suppliers range | D-erythro-Sphingosine-1-phosphate-13C2,D2. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS001473. Format: Neat. Product Type: Stable Isotope Labelled. | |
D-erythro-Sphingosine-1-Phosphate-13C2,D2 Quick inquiry Where to buy Suppliers range | A labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1,3-di-O-(phosphate Dicyanoethyl Ester) Quick inquiry Where to buy Suppliers range | Side product in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
1-(3,5-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propylpyrazolo[3,4-b]pyridin-6-yl)amino]urea Quick inquiry Where to buy Suppliers range | JTE 013 has been found to be an antagonist of Sphingosine-1-Phosphate Receptor-2 (S1P2R). Synonyms: JTE 013; JTE013; JTE-013; 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide; N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 547756-93-4. Molecular formula: C17H19N7OCl2. Mole weight: 408.29. | |
(1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride Quick inquiry Where to buy Suppliers range | (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307231-02-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
(1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride Quick inquiry Where to buy Suppliers range | (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307873-37-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
2-Acetyl-4-tetrahydroxybutyl imidazole Quick inquiry Where to buy Suppliers range | 2-Acetyl-4-tetrahydroxybutyl imidazole is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Uses: Immunosuppressive agents. Synonyms: 2-Athbi; THI; (1R,2S,3R)-2-acetyltetrahydroxybutylimidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole. Grades: >99%. CAS No. 94944-70-4. Molecular formula: C9H14N2O5. Mole weight: 230.22. | |
3-Bromo-1,1,1-trifluoropropane Quick inquiry Where to buy Suppliers range | 3-Bromo-1,1,1-trifluoropropane is used in the discovery of potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 460-32-2. Pack Sizes: 250mg, 1g. Molecular Formula: C3H4BrF3, Molecular Weight: 176.96. US Biological Life Sciences. | Worldwide |
(3-Carboxypropyl)triphenylphosphonium Bromide Quick inquiry Where to buy Suppliers range | (3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used for the preparation of sphingosine 1-phosphate-1 receptor antagonists, as well as for the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Synonyms: (4-Hydroxy-4-oxobutyl)triphenylphosphonium Bromide; Phosphonium, (3-carboxypropyl)triphenyl-, bromide (1:1). Grades: ≥95%. CAS No. 17857-14-6. Molecular formula: C22H22BrO2P. Mole weight: 429.29. | |
A - 971432 Quick inquiry Where to buy Suppliers range | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
ABC294640 Quick inquiry Where to buy Suppliers range | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Synonyms: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. Grades: 0.98. CAS No. 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. | |
Amiselimod HCl Quick inquiry Where to buy Suppliers range | Amiselimod, formerly known as MT-1303, is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases. And it also is a potent and selective immunosuppressant and sphingosine 1 phosphate receptor modulator, as an investigational therapy for people with relapsing-remitting muscular sclerosis (RRMS), inflammatory bowel disease (IBD), and other autoimmune diseases. Synonyms: 2-amino-2-{2-[4- (heptyloxy) -3- (trifluoromethyl) phenyl]ethyl}propane-1, 3-diol hydrochloride; MT-1303; MT1303; MT 1303; Amiselimod HCl. CAS No. 942398-84-7. Molecular formula: C19H31ClF3NO3. Mole weight: 413.91. | |
APD334 Quick inquiry Where to buy Suppliers range | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
AUY954 Quick inquiry Where to buy Suppliers range | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grades: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
azido-FTY720 Quick inquiry Where to buy Suppliers range | Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down-regulating sphingosine-1 phosphate receptor (S1PR). Phosphorylation of FTY270 by sphingosine kinase can cause S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. It is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). Synonyms: azido-FTY720; 881914-35-8; 2-Amino-2-[2-(3-azido-4-octylphenyl)ethyl]-1,3-propanediol; 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]propane-1,3-diol; 1,3-Propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-; AKOS040755896; HY-134976; CS-0168486. Grades: ≥98%. CAS No. 881914-35-8. Molecular formula: C19H32N4O2. Mole weight: 348.5. | |
C16 Ceramide (N-Palmitoyl-D-Sphingosine, N-Hexadecanoyl-D-sphingosine, Palmitoyl Ceramide) Quick inquiry Where to buy Suppliers range | A predominant, rather hydrophobic natural ceramide. Activates a cytosolic serine/threonine protein phosphatase in T9 cells; induces EGF receptor phosphorylation in A-431 cells; stimulates ceramide-activated protein kinase. Group: Biochemicals. Alternative Names: N-Palmitoyl-D-Sphingosine; N-Hexadecanoyl-D-sphingosine; Palmitoyl Ceramide. Grades: Highly Purified. CAS No. 24696-26-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
C17 Sphinganine-1-phosphate (d17:0) Quick inquiry Where to buy Suppliers range | C17 Sphinganine-1-phosphate (d17:0). Alternative Names: 2(S)-amino-1,3(R)-heptadecanediol, 1-(dihydrogen phosphate), C17 Sphinganine-1-phosphate, D-erythro-Sphinganine-C17-1-phosphate, dihydro-D-erythro-Sphingosine-C17-1-phosphate, Sphinganine-1-phosphate (d17:0). Grades: 95%+. Product ID: ACM474923290. Molecular formula: C17H38NO5P. Mole weight: 367.5. Boiling Point: 537.7±60.0 °C(Predicted). Storage: Freezer. | |
C2 Ceramide (N-Acetyl-D-sphingosine, Acetyl Ceramide) Quick inquiry Where to buy Suppliers range | A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]acetamide; N-Acetyl-D-sphingosine; Acetyl Ceramide; N-Acetylsphingosine. Grades: Highly Purified. CAS No. 3102-57-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 341.53. US Biological Life Sciences. | Worldwide |
C4 Ceramide-1-phosphate Quick inquiry Where to buy Suppliers range | Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. Group: Biochemicals. Alternative Names: N- [ (1S, 2R, 3E) -2-Hydroxy-1- [ (phosphonooxy) methyl] -3-heptadecenyl] butanamide; N-Butyl-D-sphingosine-1-phosphate; Butyl Ceramide-1-phosphate; N-Butanoyl-D-erythro-sphingosine-1-phosphate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
C6 Ceramide-13C2,d2 Quick inquiry Where to buy Suppliers range | A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway. Group: Biochemicals. Alternative Names: N-Hexanoy-D-sphingosine-13C2,d2; N-Caproyl-D-sphingosine-13C2,d2; Caproyl Ceramide-13C2,d2. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
CAY10444 Quick inquiry Where to buy Suppliers range | CAY10444 is a family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned. It is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 μM. Synonyms: BML-241; CAY 10444; CAY-10444; BML 241. Grades: ≥98%. CAS No. 298186-80-8. Molecular formula: C15H29NO2S. Mole weight: 287.5. | |
CAY10621 Quick inquiry Where to buy Suppliers range | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grades: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. | |
CAY10734 Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) with IC50=0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. Synonyms: CAY 10734; CAY-10734. Grades: ≥98%. CAS No. 635701-59-6. Molecular formula: C23H25N3O3. Mole weight: 391.5. | |
CAY10739 Quick inquiry Where to buy Suppliers range | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1) with IC50=25.12 nM in a β-arrestin recruitment assay, which was designed to prevent systemic effects following topical application. It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively). Synonyms: CAY 10739; CAY-10739. Grades: ≥98%. Molecular formula: C23H24N2O3S. Mole weight: 408.51. | |
Ceralifimod Quick inquiry Where to buy Suppliers range | Ceralifimod (ONO-4641) is a selective agonist of sphingosine 1-phosphate (S1P) receptor 1 and 5 (EC50 = 0.0273 and 0.334?nM). In animal experiment, ONO-4641 prevented relapse of disease in a non-obese diabetic mouse model of relapsing-remitting EAE. ONO-4641 had been developed for the treatment of multiple sclerosis (MS) and undergone a phase II clinical trial by Merck KGaA and Ono, therefore, the study were terminated in Dec 2014. Uses: Ceralifimod (ono-4641) is a selective agonist of sphingosine 1-phosphate (s1p) receptor 1 and 5 (ec50 = 0.0273 and 0.334?nm) developed for the treatment of multiple sclerosis (ms). Synonyms: ONO-4641; ONO 4641; ONO4641; Ceralifimod. UNII-BZ2O8A84A4; 891859-12-4; AK173892; Ceralifimod [INN]; SCHEMBL465051; 1-[[6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid. Grades: ≥98%. CAS No. 891859-12-4. Molecular formula: C27H33NO4. Mole weight: 435.564. | |
Ceranib 1 Quick inquiry Where to buy Suppliers range | Ceranib 1 is a ceramidase inhibitor. It inhibits proliferation in SKOV3 ovarian carcinoma cells. It decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells and induces accumulation of ceramide species. It is a useful research chemical and has an antiproliferative effect. Synonyms: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone; 6-Methyl-3-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone. Grades: ≥98% by HPLC. CAS No. 328076-61-5. Molecular formula: C26H21NO3. Mole weight: 395.45. | |
Ceranib-2 Quick inquiry Where to buy Suppliers range | Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Ceranib-2 decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation. Grades: ≥98%. CAS No. 1402830-75-4. Molecular formula: C25H19NO3. Mole weight: 381.4. | |
CS-0777-P Quick inquiry Where to buy Suppliers range | CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent development was reported. Uses: Multiple sclerosis. Synonyms: CS-0777; CS0777; CS 0777. 1-(5-((3R)-3-amino-3-methyl-4-(phosphonooxy)butyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-1-Butanone. Grades: 98%. CAS No. 840523-39-9. Molecular formula: C21H31N2O5P. Mole weight: 422.45. | |
CYM-5541 Quick inquiry Where to buy Suppliers range | CYM-5541, also called as ML249, is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM) that less effectively activates S1P1 (EC50 = 28-38 μM) and does not disrupt S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters. Synonyms: N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide; CYM-5541; CYM 5541; CYM5541; N,N-dicyclohexyl(5-cyclopropylisoxazol-3-yl)carboxamide. CAS No. 945128-26-7. Molecular formula: C19H28N2O2. Mole weight: 316.44. | |
D-erythro-Dihydrosphingosine 1-phosphate Quick inquiry Where to buy Suppliers range | Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors. Negative control for intracellular effects of sphingosine 1-phosphate. Induces chemotaxis. Antifibrotic. Group: Biochemicals. Alternative Names: (2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P. Grades: Highly Purified. CAS No. 19794-97-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H40NO5P. US Biological Life Sciences. | Worldwide |
Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride) Quick inquiry Where to buy Suppliers range | Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) Quick inquiry Where to buy Suppliers range | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
FTY720 phenoxy-biotin Quick inquiry Where to buy Suppliers range | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, which means that it would likewise be phosphorylated in vivo. Synonyms: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-N-biotinoyl-1,5-diampentane. Grades: ≥95%. Molecular formula: C27H44N4O5S·HCl. Mole weight: 573.2. | |
FTY720 Phosphate Quick inquiry Where to buy Suppliers range | FTY720 is a derivative of ISP-1 (myriocin). FTY720 phosphate is a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5, IC50 values = 0.2-6 nM). Synonyms: FTY720P; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate). Grades: ≥98%. CAS No. 402615-91-2. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
FTY720 (R)-Phosphate Quick inquiry Where to buy Suppliers range | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate. Synonyms: (2R)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol. Grades: ≥98%. CAS No. 402616-23-3. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
FTY720 (S)-Phosphate Quick inquiry Where to buy Suppliers range | FTY720 is a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-phosphate is the single stereoisomer of FTY720. FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R enantiomer binds with 5 to 130-fold lower affinity. Synonyms: (S)-FTY 720P; (2S)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol. Grades: ≥98%. CAS No. 402616-26-6. Molecular formula: C19H34NO5P. Mole weight: 387.5. | |
GSK-2018682 Quick inquiry Where to buy Suppliers range | GSK-2018682 is a potent and selective agonist of sphingosine-1-phosphate receptor (S1PR) subtype 1 that has the potential to treat multiple sclerosis (MS). Synonyms: GSK2018682; GSK 2018682; GSK-2018682. UNII-NJL503AIJA; NJL503AIJA; 4-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid. Grades: ≥98%. CAS No. 1034688-30-6. Molecular formula: C22H21ClN4O4. Mole weight: 440.884. | |
JTE-013 Quick inquiry Where to buy Suppliers range | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Synonyms: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
K6PC-5 Quick inquiry Where to buy Suppliers range | K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Uses: Potential treatment of skin disorders with abnormal differentiation and proliferation. Synonyms: K6PC-5; K6PC 5; K6PC5; Dihydroxyisopropyl capryloylcaprylamide; Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo. Grades: 98%. CAS No. 756875-51-1. Molecular formula: C19H37NO4. Mole weight: 343.5. | |
KRP-203 Quick inquiry Where to buy Suppliers range | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
L-threo Lysosphingomyelin (d18:1) Quick inquiry Where to buy Suppliers range | L-threo Lysosphingomyelin (d18:1) is an endogenous bioactive sphingolipid and an agonist of sphingosine-1-phosphate (S1P) receptors 1-3. Synonyms: L-threo Lyso SM (18:1); L-threo Lysosphingomyelin (18:1); L-threo Sphingosine-1-Phosphocholine (d18:1); L-threo-Sphingosylphosphorylcholine; [(E,2S,3S)-2-amino-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Grades: ≥98%. CAS No. 105615-55-2. Molecular formula: C23H49N2O5P. Mole weight: 464.62. | |
NIBR0213 Quick inquiry Where to buy Suppliers range | NIBR0213 is an orally bioavailable and selective antagonist of sphingosine-1-phosphate receptor-1 (S1P1). NIBR0213 is identified as a promising agent for autoimmune disease therapy. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: NIBR-0213; NIBR 0213; GTPL6997; (2S)-2-[[4-[3-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]phenyl]-2,6-dimethylbenzoyl]amino]propanoic acid. Grades: ≥98%. CAS No. 1233332-14-3. Molecular formula: C27H29ClN2O3. Mole weight: 465. | |
Palmitoyl coenzyme A potassium salt Quick inquiry Where to buy Suppliers range | A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis. Palmitoyl CoA is a fatty acyl CoA thioether used in the synthesis of sphingosine. Synonyms: palmitoyl-CoA; Coenzyme A S-hexadecanoate; S-palmitoylcoenzyme A; PALMITOYL COENZYME A,K SALT; potassium [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[(3R)-4-[[3-(2-hexadecanoylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] hydrogen phosphate. Grades: ≥ 95%. CAS No. 1763-10-6. Molecular formula: C37H65N7O17P3SK. Mole weight: 1044.03. | |
Ponesimod Quick inquiry Where to buy Suppliers range | Ponesimod is an orally active and selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator that acts as a functional antagonist. It has potential immunomodulating activity. It may be used as a new therapeutic approach in lymphocyte-mediated autoimmune diseases. It is also an experimental drug for the treatment of multiple sclerosis (MS) and psoriasis. It protects against lymphocyte-mediated tissue inflammation. It activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity in vitro. It prevented edema formation, inflammatory cell accumulation and cytokine release in the skin of mice with delayed-type hypersensitivity. It also prevented the increase in paw volume and joint inflammation in rats with adjuvant-induced arthritis. It reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues by preventing egress of lymphocytes. It was developed by Actelion. It is in Clinical stage three. Uses: Ponesimod acts as a functional antagonist. it has potential immunomodulating activity. it may be used as a new therapeutic approach in lymphocyte-mediated autoimmune diseases. it is also an experimental drug for the treatment of multiple sclerosis (ms) and psoriasis. Synonyms: ACT-128800; ACT 128800; ACT128800; Ponesimod. (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propyliMino)-3-(o-tolyl)thiazolidin-4-one;4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]Methylene]-3-(2-Methylphenyl)-2-(propyliMino)-, (2Z,5Z)-;ACT-128800;5-[3-Chloro-4-[((2R)-2,3-dihydroxypropyl)oxy]benz-(Z)-ylidene]-2-((Z)-propylimino)-3-(o-tolyl)thiazolidin-4-one;(5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one. Grades: ≥ 95.0%. CAS No. 854107-55-4. Molecular formula: C23H25ClN2O4S. Mole weight: 460.97. | |
rac FTY720 Phosphate Quick inquiry Where to buy Suppliers range | rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Group: Biochemicals. Alternative Names: 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol 1-(Dihydrogen Phosphate); 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester; FTY720-P; FTY-P; Fingolimod phosphate. Grades: Highly Purified. CAS No. 402615-91-2. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. | Worldwide |
S1P4 Receptor Antagonist (CYM50358) Quick inquiry Where to buy Suppliers range | An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) antagonist (IC50=25nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC50 = 6.4uM, 3.9uM, 5.5uM, and 25uM for S1P1, S1P2, S1P5, and S1P3 (95% inhibition), respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
S1PR-MO-1 Quick inquiry Where to buy Suppliers range | The modulator of sphingosine-1-phosphate receptor. Synonyms: Cyclobutanecarboxylic acid, 3-[[1-[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]ethyl]amino]-. CAS No. 1149727-61-6. Molecular formula: C25H29N3O3. Mole weight: 419.52. | |
SEW 2871 Quick inquiry Where to buy Suppliers range | SEW 2871 is a potent, cell-permeable and selective sphingosine-1-phosphate type 1 receptor agonist (EC50= 13 nM). SEW 2871 suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole; SEW2871; SEW2871; SEW2871. Grades: >98%. CAS No. 256414-75-2. Molecular formula: C20H16N2OS. Mole weight: 332.419. | |
(S) FTY720 Phosphate (2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester, (S)-FTY720-P) Quick inquiry Where to buy Suppliers range | A sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. It is the active metabolite of FTY720-phosphate. Group: Biochemicals. Alternative Names: 2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester; (S)-FTY720-P. Grades: Highly Purified. CAS No. 402616-26-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
SKI-I, Sphingosine Kinase Inhibitor (5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide) Quick inquiry Where to buy Suppliers range | Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy. Group: Biochemicals. Grades: Highly Purified. CAS No. 306301-68-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Sphinganine-1-phosphate (d18:0) Quick inquiry Where to buy Suppliers range | Sphinganine-1-phosphate is an antagonist of the sphingosine-1-phosphate (S1P1/EDG-1) receptor with Ki value of 15 nM. It is a lipid mediator particularly for HDL. Synonyms: D-erythro-sphinganine-1-phosphate; C18-dihydro Sphingosine-1-phosphate; Dihydro-D-erythro-Sphingosine-1-phosphate; D-erythro-Dihydro-D-sphingosine-1-phosphate; [R-(R*,S*)]-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate); (2S,3R)-Sphinganine 1-Phosphate; C18-Dihydrosphingosine 1-Phosphate; Dihydrosphingosine-1-phosphate; (2S,3R)-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate). Grades: ≥95%. CAS No. 19794-97-9. Molecular formula: C18H40NO5P. Mole weight: 381.49. | |
Sphingosine Kinase 1 Inhibitor, SKI-178 (N'- (1E) -1- (3, 4-Dimethoxyphenyl) ethylidene) -3- (4-methoxyphenyl) -1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |