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Product | Description | |
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Staurosporine Quick inquiry Where to buy Suppliers range | Staurosporine is a cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective inhibitor of protein kinases, including protein kinase C. This agent induces apoptosis by an undetermined mechanism. Uses: Microbial Fermentation Products. CAS No. 62996-74-1. Product ID: MFP-013. | |
Staurosporine Quick inquiry Where to buy Suppliers range | Staurosporine Inhibitor. Uses: Scientific use. Product Category: T6680. CAS No. 62996-74-1. | |
Staurosporine, streptomyces staurosporeus Quick inquiry Where to buy Suppliers range | 5mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C28H26N4O3. CAS No. 62996-74-1. Prepack ID 16881725-5mg. Molecular Weight 466.53. See USA prepack pricing. | |
Staurosporine, streptomyces staurosporeus Quick inquiry Where to buy Suppliers range | 5mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C28H26N4O3. CAS No. 62996-74-1. Prepack ID 16881725-5mg. Molecular Weight 466.53. See USA prepack pricing. | |
1,1',2,2',3,3',4,4'-Octahydro staurosporine Quick inquiry Where to buy Suppliers range | 1,1',2,2',3,3',4,4'-Octahydro staurosporine. Group: Biochemicals. Alternative Names: (9S, 10R, 11R, 13R)-2, 3, 4, 5, 6, 7, 10, 11, 12, 13, 15, 16, 17, 18-Tetradecahydro-10-methoxy-9-methyl-11-(methylamino)-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonin-1-one. Grades: Highly Purified. CAS No. 220038-18-6. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C28H34N4O3. US Biological Life Sciences. | Worldwide |
1,1,2,2,3,3,4,4-Octahydro Staurosporine Quick inquiry Where to buy Suppliers range | Hydrogenated Staurosporine. Group: Biochemicals. Alternative Names: (9S, 10R, 11R, 13R)-2, 3, 4, 5, 6, 7, 10, 11, 12, 13, 15, 16, 17, 18-Tetradecahydro-10-methoxy-9-methyl-11-(methylamino)-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonin-1-one. Grades: Highly Purified. CAS No. 220038-18-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetrahydro Staurosporin Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetrahydro Staurosporin. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 220038-19-7. Molecular formula: C28H26N4O3. Mole weight: 466.53. Catalog: APS220038197. SMILES: CN[C@@H]1C[C@H]2O[C@@] (C) ([C@@H]1OC)n3c4ccccc4c5c6CNC (=O)c6c7c8ccccc8n2c7c35. Format: Neat. | |
1,2,3,4-Tetrahydro Staurosporine Quick inquiry Where to buy Suppliers range | Staurosporine derivative for use as isoenzyme PKCα inhibitors and anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 220038-19-7. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
7-Oxo staurosporine Quick inquiry Where to buy Suppliers range | 7-Oxo staurosporine. Group: Biochemicals. Alternative Names: (9S,10R,11R,13R)-10,11,12,13-Tetrahydro-10-methoxy-9-methyl-11-(methylamino)- 9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,3(2H)-dione; 7-Oxostaurosporine; BMY 41950. Grades: Highly Purified. CAS No. 125035-83-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C28H24N4O4. US Biological Life Sciences. | Worldwide |
7-Oxo staurosporine Quick inquiry Where to buy Suppliers range | 7-Oxo staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). Synonyms: BMY 41950; RK-1409; 7-oxostaurosporine. Grades: ≥98%. CAS No. 125035-83-8. Molecular formula: C28H24N4O4. Mole weight: 480.5. | |
Staurosporin Quick inquiry Where to buy Suppliers range | Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurospores and is a super-potent, cell permeable PKC inhibitor (IC50=0.7); at higher concentrations Staurosporine inhibits other protein kinases: CDK2/cyclin A (IC50=7uM) and CDK4/cyclin D (IC50=3-10uM). At a concentration of 50-100nM it is a functional neurotrophins agonist promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. Staurosporine inhibits a variety of kinases including PKA, PKG, MLCK, CaMK, tyrosine kinases, and phosphorylase kinase. This compound displays selectivity toward the PKC isoforms, inhibiting PKCα, PKC β, PKCγ, PKCδ, and PKCε, but not PKC?, and induces PKC translocation. Staurosporine also inhibits topoisomerase II directly by interaction with the ATP binding site, augments PMA-induced ornithine decarboxylase, and activates a bcl-2-regulated apoptosis pathway. Source:Streptomyces staurosporeus. Group: Biochemicals. Alternative Names: Antibiotic AM2282; Antibiotic 230; CCRIS 3272. Grades: Highly Purified. CAS No. 62996-74-1. Pack Sizes: 100ug, 1mg, 5mg, 10mg. Molecular Formula: C28H26N4O3, Molecular Weight: 466.53. US Biological Life Sciences. | Worldwide |
2,3-Dichloro-6-nitrobenzaldehyde Quick inquiry Where to buy Suppliers range | 2,3-Dichloro-6-nitrobenzaldehyde is a reactant used in the synthesis of Staurosporinone (K000510) analogues. Staurosporinone acts as a protein kinase C inhibitor of microbial origin. Group: Biochemicals. Grades: Highly Purified. CAS No. 75618-41-6. Pack Sizes: 2.5g, 5g. Molecular Formula: C7H3Cl2NO3, Molecular Weight: 220.01. US Biological Life Sciences. | Worldwide |
3'-Demethylstaurosporine Quick inquiry Where to buy Suppliers range | 3'-Demethoxy-3'-hydroxystaurosporine is a staurosporine homolog produced by the mutant strain M14 of Streptomycin longisporoflavus R19. The activity of inhibiting protein kinase C (PKC) is lower than that of staurosporine. Synonyms: 3'-Demethoxy-3'-hydroxystaurosporine; (5S,6R,7R,9R)-6-hydroxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one. CAS No. 161743-35-7. Molecular formula: C27H24N4O3. Mole weight: 452.50. | |
7-Oxostaurosporine (Antibiotic BMY 41950, Antibiotic RK 1409) Quick inquiry Where to buy Suppliers range | 7-Oxostaurosporine is the oxidised and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumor cells lines to Antibiotic UCN-01. Despite its close relationship to Antibiotic UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties. Group: Biochemicals. Alternative Names: Antibiotic BMY 41950, Antibiotic RK 1409. Grades: Highly Purified. CAS No. 141196-69-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Antibiotic K252A (Antibiotic SF 2370) Quick inquiry Where to buy Suppliers range | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Antibiotic UCN-02 (UCN 02) Quick inquiry Where to buy Suppliers range | UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. Group: Biochemicals. Alternative Names: UCN 02. Grades: Highly Purified. CAS No. 121569-61-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
AZ 10417808 Quick inquiry Where to buy Suppliers range | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
Bax inhibitor peptide V5 Quick inquiry Where to buy Suppliers range | BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet, and anti-cancer drug. Uses: Peptide Inhibitors. CAS No. 579492-81-2. Product ID: R1852. | |
Bisindolylmaleimide I hydrochloride Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide I hydrochloride (BMI) is a water soluble form of Bisindolylmaleimide I. It is a staurosporine inspired molecule, which has been shown to display equally potent inhibition. BIM I is a highly selective, cell-permeable, and reversible PKC inhibitor with Ki of 14 nM that is structurally similar to the poorly selective PKC inhibitor staurosporine. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It can inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Synonyms: BIM I; GF109203X; Gö 6850. Grades: ≥98%. CAS No. 176504-36-2. Molecular formula: C25H24N4O2·HCl. Mole weight: 449. | |
Bisindolylmaleimide III Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1. Synonyms: BIM III. Grades: ≥98%. CAS No. 137592-43-9. Molecular formula: C23H20N4O2. Mole weight: 384.4. | |
K-252b Quick inquiry Where to buy Suppliers range | A staurosporine analogue isolated from a nocardiopsis strain; a potent inhibitor of protein kinase C. K-252b exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents; also active against other kinases, notably myosin light chain kinase, camp-dependent protein kinase (PKA), protein kinase C (PKC) and cgmp-dependent protein kinase (PKG). Synonyms: (9r,10s,12s)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid. Grades: >98% by HPLC. CAS No. 99570-78-2. Molecular formula: C26H19N3O5. Mole weight: 453.45. | |
K-252c Quick inquiry Where to buy Suppliers range | K252c, a metabolite product of Nocardiopsis Sp., has been found to be a protein kinase C inhibitor and exhibit antiviral activities against GCV-sensitive and-resistant strains at some extent. Uses: K252c inhibits protein kinase c. its reported ic50 value of 214 nm on rat brain enzyme k252c is cytotoxic for a549 and p388 cancer celllines showing ic50 = 2-3 μm. Synonyms: Staurosporine aglycone; K252C; 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one. Grades: ≥97%. CAS No. 85753-43-1. Molecular formula: C20H13N3O. Mole weight: 311.34. | |
Necrosis Inhibitor, Necrox-2 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine) Quick inquiry Where to buy Suppliers range | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
Necrosis Inhibitor, Necrox-5 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, Dihydrochloride) Quick inquiry Where to buy Suppliers range | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
Rebeccamycin Quick inquiry Where to buy Suppliers range | Rebeccamycin is a weak topoisomerase I inhibitor isolated from Nocardia sp. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. It shows significant antitumor properties in vitro. Uses: Microbial Fermentation Products. CAS No. 93908-02-2. Product ID: MFP-026. | |
Rebeccamycin (NSC 359079, BRN 4732638) Quick inquiry Where to buy Suppliers range | Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 93908-02-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
Stauprimide (N-Benzoyl-7-oxostaurosporine) Quick inquiry Where to buy Suppliers range | Stauprimide, a cell-permeable analog of Staurosporine, increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs). Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc. Group: Biochemicals. Grades: Highly Purified. CAS No. 154589-96-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
UCN-01 Quick inquiry Where to buy Suppliers range | KRX-0601, also known as UCN-01, is a synthetic derivative of staurosporine with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting apoptosis. Uses: Antineoplastic agents. Synonyms: Antibiotic UCN 01; UCN01; Staurosporine; 7-hydroxystaurosporine; KW-2401; KW 2401; KW2401; (3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; (+)-UCN-01; KRX 0601; NSC 638850. Grades: >99% by HPLC. CAS No. 112953-11-4. Molecular formula: C28H26N4O4. Mole weight: 482.53. | |
UCN-02 Quick inquiry Where to buy Suppliers range | UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. Synonyms: Antibiotic UCN 02; UCN02; GNF-Pf-3072; 7-hydroxy-staurosporine; 7-epi-Hydroxystaurosporine; (3S,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; [3S-(3α, 9α, 10β, 11β, 13α)]-2, 3, 10, 11, 12, 13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonin-1-one. Grades: >95% by HPLC. CAS No. 121569-61-7. Molecular formula: C28H26N4O4. Mole weight: 482.53. |