Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| STING agonist-1 | STING agonist-1 (G10) is a novel human-specific STING agonist (IC90 = 24.57 μM), exhibits no direct binding affinity for STING. Uses: Activator of sting-dependent signaling; exhibits no direct binding affinity for sting. Synonyms: G10; G10; G-10; G 10; STING agonist G10;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide. Grades: ≥98%. CAS No. 702662-50-8. Molecular formula: C21H16ClFN2O3S. Mole weight: 430.88. |  |
| STING agonist-1 | STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC 90 of 24.57 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: G10. CAS No. 702662-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19711. |  |
| STING agonist-20 | STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2591300-72-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148068. | |
| STING agonist-26 | STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING , TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β , IL-6 , CXCL-10 , TNF-α , ISG-15 , and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2868261-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152959. | |
| STING agonist-3 | STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103665. | |
| STING agonist-3-trihydrochloride | STING agonist-3-trihydrochloride is an agonist of stimulator of interferon genes (STING) for treating cancer. Grades: ≥98%. Molecular formula: C37H45Cl3N12O6. Mole weight: 860.19. | |
| STING Agonist-4 | STING agonist-4 is a new type of potent and selective STING agonist, which can induce phosphorylation of IRF3 and IFN-β secretion, and promote the production of IFN-γ inducible protein 10 (IP-10), IL-6 and TNF&alpha. Synonyms: 1,1'-(1,4-Butanediyl)Bis[2-[[(1-Ethyl-3-Methyl-1H-Pyrazol-5-Yl)Carbonyl]Amino]-1H-Benzimidazole-5-Carboxamide; diABZI STING agonist-2. Grades: ≥98% by HPLC. CAS No. 2138300-40-8. Molecular formula: C34H38N12O4. Mole weight: 678.7. | |
| STING Agonist C11 | STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. It activates IFN-dependent signaling and induces secretion of IFN from human cells. Synonyms: N-(Methylcarbamoyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-phenylacetamide. Grades: ≥95%. CAS No. 875863-22-2. Molecular formula: C19H18N4O3S. Mole weight: 382.44. | |
| diABZI STING agonist-1 | diABZI STING agonist-1 is a selective agonist of stimulator of interferon genes (STING) receptor, with EC50s of 130, 186 nM for human and mouse, respectively. Synonyms: 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-; (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide; STING agonist compound 3; 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide. Grades: >98%. CAS No. 2138299-33-7. Molecular formula: C42H51N13O7. Mole weight: 849.94. | |
| diABZI STING agonist-1 | diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-33-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-112921A. | |
| diABZI STING agonist-1 trihydrochloride | diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-34-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112921B. | |
| diABZI STING agonist-1-trihydrochloride | Cas No. 2138299-34-8. | |
| STING-agonist-3 | STING-agonist-3 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: (E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-5-carboxamide. Grades: 99%. CAS No. 2138299-29-1. Molecular formula: C37H42N12O6. Mole weight: 750.8. | |
| STING-agonist-4 | STING-agonist-4 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: 1,1'-(butane-1,4-diyl)bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1H-benzimidazole-5-carboxamide}. Grades: 99%. CAS No. 213830-40-8. Molecular formula: C34H38N12O4. Mole weight: 678.74. | |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R, 3R, 3aS, 7aR, 9R, 10R, 10aS, 14aR)-2, 9-bis(6-amino-9H-purin-9-yl)-3, 5, 10, 12-tetrahydroxyoctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecine 5,12-dioxide. Grades: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| c-di-AMP disodium | c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyclic diadenylate disodium; Cyclic-di-AMP disodium. CAS No. 2734909-87-4. Pack Sizes: 10 mM * 1 mL; 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12326A. | |
| c-di-GMP Fluorinated | A STING agonist. CAS No. 1334145-18-4. Molecular formula: C20H20F2N10O12P2.2Na. Mole weight: 738.36. | |
| c-di-UMP | A STING agonist negative control. Synonyms: Cyclic di-uridine monophosphate, c-di-UMP sodium salt. CAS No. 73120-97-5. Molecular formula: C18H20N4O16P2.2Na. Mole weight: 656.3. | |
| CL656 | CL656 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: c-[2'FdAMP(S)-2'FdIMP(S)]; cAIM(PS)2 Difluor (Rp/Sp); Adenosine, 2'-deoxy-2'-fluoro-5'-O-(hydroxymercaptophosphinyl)-P-thioinosinylyl-(3'?5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; CL 656; CL-656; (Rp/Sp) c-[2'FdAM(PS)-2'FdIM(PS]); 9-((2R, 3R, 3aR, 7aR, 9R, 10R, 10aR, 14aR)-9-(6-amino-9H-purin-9-yl)-3, 10-difluoro-12-hydroxy-5-mercapto-5-oxido-12-sulfidooctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecin-2-yl)-1, 9-dihydro-6H-purin-6-one. Grades: >98%. CAS No. 1951464-79-1. Molecular formula: C20H21F2N9O9P2S2. Mole weight: 695.51. | |
| CMA | CMA is a murine-selective agonist of STING. It triggers type I IFN response in murine macrophages, without effect on human STING signaling. Synonyms: 9-Oxo-10(9H)-acridineacetic acid. Grades: ≥98% by HPLC. CAS No. 38609-97-1. Molecular formula: C15H11NO3. Mole weight: 253.25. | |
| Cyclic-di-GMP disodium | Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4]. Uses: Scientific research. Group: Natural products. Alternative Names: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium. CAS No. 2222132-40-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-110382. | |
| Dazostinag disodium | Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-676. CAS No. 2553413-93-5. Pack Sizes: 100 ?g; 500 ?g; 1 mg; 5 mg; 10 mg. Product ID: HY-148029. | |
| diABZI-V/C-DBCO | diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 ?M, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035557-60-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-162874. | |
| DMXAA | DMXAA is a STING agonist that induces antitumor immunological responses. Uses: Antineoplastic agents. Synonyms: 9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo-; 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid; 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid; 5,6-Dimethyl-9-oxo-9H-xanthen-4-ylacetic acid; 5,6-Dimethylxanthenone-4-acetic acid; ASA404; ASA 404; ASA404; AS1404; AS 1404; AS1404; D5817; NSC 640488; Vadimezan. Grades: ≥95%. CAS No. 117570-53-3. Molecular formula: C17H14O4. Mole weight: 282.29. | |
| E7766 diammonium salt | E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242635-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111999A. | |
| IACS-8779 | IACS-8779 is a highly potent agonist of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. IACS-8779 shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds. Synonyms: SCHEMBL23046679; 2243079-26-5; AKOS040733407. Grades: >98%. CAS No. 2243079-26-5. Molecular formula: C21H25N9O10P2S2. Mole weight: 689.56. | |
| IACS-8803 | IACS-8803 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. Compared to one of the clinical benchmark compounds, it shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma. Synonyms: CHEMBL4596454; SCHEMBL22930678; SCHEMBL23710564; 2095690-70-1; AKOS040733408. Grades: >98%. CAS No. 2095690-70-1. Molecular formula: C20H23FN10O9P2S2. Mole weight: 692.53. | |
| MSA-2 | An orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. Grades: >98%. CAS No. 294425-81-6. Molecular formula: C14H14O5S. Mole weight: 294.32. | |
| MSA-2 | MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 ?M for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-? secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129425-81-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-136927. | |
| pGpA | A STING agonist negative control (pGpA). Synonyms: 3'5'-pGpA sodium salt; 3'3'-cGAMP Control. CAS No. 20137-01-3. Molecular formula: C20H23N10O14P2.3Na. Mole weight: 758.38. | |
| pGpG | pGpG is a STING agonist negative control and c-diGMP metabolite. Synonyms: P; -(5'-Guanosyl)-P; -(5'-guanosyl)-(3'?5')-diphosphate, Sodium salt. Grades: ≥ 95 % by HPLC. CAS No. 33008-99-0. Molecular formula: C20H26N10O15P2(free acid). Mole weight: 708.43 (free acid). | |
| SNX281 | SNX281 is a systemically active non-CDN STING agonist that binds to the STING protein. SNX281 promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 activates STING and leads to the production of type I IFNs and proinflammarory cytokines, ultimately stimulating the infilatration of immune cells into the tumor microenvironment. SNX281 enhances anti-tumor immunity, potentially overcoming resistance to checkpoint inhibitors in some cancer. SNX281 can be used in the research for anti-tumor immunity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2332803-84-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160406. | |
| SR-717 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 ?M and 2.2 ?M in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375421-09-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131454. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-717 lithium; SR 717 lithium; SR717 lithium. Product Category: Agonists. Appearance: Solid powder. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Purity: >98%. IUPACName: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate. Canonical SMILES: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]. Product ID: ACM2375421091. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: SR 717 lithium; SR717 lithium. Grades: >98%. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. | |
| Vadimezan | Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes ( STING ) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DMXAA; ASA-404. CAS No. 117570-53-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-10964. | |
Our database is helping our users find suppliers everyday.
