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| Product | Description | |
|---|---|---|
| Streptozotocin | 100mg Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-100mg. Molecular Weight 265.22. See USA prepack pricing. |  |
| Streptozotocin | 1g Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-1g. Molecular Weight 265.22. See USA prepack pricing. | |
| Streptozotocin | Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic. Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter. O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) inhibitor. Genotoxic. Induces DNA damage. Produces DNA strand breaks. Cell death inducer. Antineoplastic. Anti-cancer agent used in chemotherapy. Induces cell cylce arrest at G2. Group: Biochemicals. Alternative Names: 2-Deoxy-2-[[ (methylnitrosoamino) carbonyl]amino]-D-glucose; D-2-Deoxy-2- (3-methyl-3-nitrosoureido) glucopyranose; Estreptozocin; NSC 37917; NSC 85998; STRZ; STZ; Streptozocin; Streptozoticin; U 9889; Zanosar. Grades: Highly Purified. CAS No. 18883-66-4. Pack Sizes: 50mg, 250mg, 1g. Molecular Formula: C?H??N?O?. US Biological Life Sciences. |  Worldwide |
| Streptozotocin | Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Streptozocin; NSC-85998; U 9889. CAS No. 18883-66-4. Pack Sizes: 100 mg; 500 mg. Product ID: HY-13753. |  |
| 1,2-Dilaurin | 1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981). Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: (Rac)-1,2-Didodecanoylglycerol. CAS No. 17598-94-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W127391. | |
| BBT | BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/ CaMK2 pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 445000-45-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 100 mg. Product ID: HY-Q40876. | |
| βARK1 Inhibitor | βARK1 inhibitor is an inhibitor of G protein-coupled receptor kinase 2/β-adrenergic receptor kinase 1 (GRK2/βARK1) with IC50 value of 126 μM. It has been shown to decrease systolic blood pressure in ob/ob and nicotinamide plus streptozotocin-induced mouse models of type 2 diabetes when administered at a dose of 200 μg/kg. Synonyms: betaARK1 Inhibitor; Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate; GRK2 Inhibitor. Grades: ≥95% (mixture of isomers). CAS No. 24269-96-3. Molecular formula: C12H9NO6. Mole weight: 263.2. |  |
| C-Peptide 1 (rat) | C-Peptide 1 (rat) specifically binds to G-protein-coupled membrane receptors in the nanomolar concentration range, and subsequently activates Ca2+-dependent intracellular signaling pathways. This leads to a stimulation of the activity of both Na+-K+-ATPase, and endothelial nitric oxide synthase. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover. Synonyms: Insulin 1 Precursor (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Pro-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Glu-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-prolyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-L-alpha-glutamyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine. Grades: ≥95%. CAS No. 41475-27-8. Molecular formula: C140H228N38O51. Mole weight: 3259.53. | |
| C-Peptide 2 (rat) | C-Peptide 2 (rat), a peptide composed of 31 amino acid residues, can effectively improve glucose utilization in streptozotocin induced diabetic rats. It is a component of proinsulin, and can inhibit glucose-induced insulin secretion. Synonyms: Preproinsulin 2 (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Ala-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-alanyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-glycyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine; Insulin 2 Precursor (57-87) (rat); Proinsulin 2 (33-63) (rat). Grades: ≥95% by HPLC. CAS No. 41594-08-5. Molecular formula: C135H222N38O49. Mole weight: 3161.43. | |
| [Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
| DL-α-Tocopherol acetate | DL-α-Tocopherol acetate. Synonyms: Vitamin E acetate, all-rac-α-Tocopheryl acetate. CAS No. 7695-91-2. Pack Sizes: 5, 25, 100 g in glass bottle. Product ID: CDC10-0088. Molecular formula: C31H52O3. Category: Antioxidant Cosmetic Chemicals. Product Keywords: Cosmetic Ingredients; Antioxidant Cosmetic Chemicals; DL-α-Tocopherol acetate; CDC10-0088; 7695-91-2; C31H52O3; Vitamin E acetate, all-rac-α-Tocopheryl acetate; 231-710-0; MFCD00072042; 7695-91-2. Purity: ≥96% (HPLC). Color: Colorless to dark yellow. EC Number: 231-710-0. Physical State: Viscous Liquid. Solubility: Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils. Quality Level: 200. Storage: 2-8°C. Application: DL-α-Tocopherol acetate has been used to study it effect on blood pressure and lipidic profile in streptozotocin-induced diabetes mellitus rats. It has also been used as a standard in α-tocopherol analysis using plasma sample and mature fresh tobacco leaves. Boiling Point: 224 °C0.3 mm Hg(lit.). Melting Point: -28°C. Density: 0.96 g/mL at 20 °C (lit.). Product Description: α-Tocopherol is a predominant form of vitamin E in human and animal tissues and also in leaf chloroplasts. It is the major form in supplements. DL-α-Tocopherol acetate is considered as the only storage form of vitamin E. |  |
| Noopept | Noopept is a nootropic and neuroprotective drug that normalizes the balance of the pro- and antioxidant systems. Noopept modulates a variety of physiological functions including cognition and anxiety. Noopept significantly weakens streptozotocin-Induced diabetes in rats. Synonyms: GVS-111; GVS111; GVS 111; SGS-111; SGS 111; SGS111. Grades: >98%. CAS No. 157115-85-0. Molecular formula: C17H22N2O4. Mole weight: 318.37. | |
| o-Phenanthroline | o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,10-Phenanthroline. CAS No. 66-71-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W004544. | |
| o-Phenanthroline monohydrate | o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,10-Phenanthroline monohydrate. CAS No. 5144-89-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y1841. | |
| R715 | R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice [1]. Uses: Scientific research. Group: Peptides. CAS No. 185052-09-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103290. | |
| TMPA | TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK&alpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258275-73-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18555. | |
| Tolrestat | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. | |
| UD-014 | UD-014 is a selective and long-acting inhibitor of semicarbazide-sensitive amine oxidase (SSAO; VAP-1) (IC50 = 3.2 nM), which shows a therapeutic effect of diabetic nephropathy in a streptozotocin rat model. Uses: The treatment of diabetic nephropathy. Synonyms: UD 014; UD014. | |
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