Streptozotocin Suppliers USA
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Product | Description | |
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Streptozotocin Quick inquiry Where to buy Suppliers range | Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic. Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter. O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) inhibitor. Genotoxic. Induces DNA damage. Produces DNA strand breaks. Cell death inducer. Antineoplastic. Anti-cancer agent used in chemotherapy. Induces cell cylce arrest at G2. Group: Biochemicals. Alternative Names: 2-Deoxy-2-[[ (methylnitrosoamino) carbonyl]amino]-D-glucose; D-2-Deoxy-2- (3-methyl-3-nitrosoureido) glucopyranose; Estreptozocin; NSC 37917; NSC 85998; STRZ; STZ; Streptozocin; Streptozoticin; U 9889; Zanosar. Grades: Highly Purified. CAS No. 18883-66-4. Pack Sizes: 50mg, 250mg, 1g. Molecular Formula: C?H??N?O?. US Biological Life Sciences. | Worldwide |
Streptozotocin Quick inquiry Where to buy Suppliers range | Streptozotocin. Group: Heterocyclic Organic Compound. CAS No. 18884-66-4. Product ID: ACM18884664. Molecular formula: C8H15N3O7. | |
Streptozotocin Quick inquiry Where to buy Suppliers range | 1g Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-1g. Molecular Weight 265.22. See USA prepack pricing. | |
Streptozotocin Quick inquiry Where to buy Suppliers range | 100mg Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-100mg. Molecular Weight 265.22. See USA prepack pricing. | |
Streptozotocin Quick inquiry Where to buy Suppliers range | 1g Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-1g. Molecular Weight 265.22. See USA prepack pricing. | |
Streptozotocin Quick inquiry Where to buy Suppliers range | 100mg Pack Size. Group: Bioactive Small Molecules, Organics, Research Organics & Inorganics. Formula: C8H15N3O7. CAS No. 18883-66-4. Prepack ID 11074846-100mg. Molecular Weight 265.22. See USA prepack pricing. | |
βARK1 Inhibitor Quick inquiry Where to buy Suppliers range | βARK1 inhibitor is an inhibitor of G protein-coupled receptor kinase 2/β-adrenergic receptor kinase 1 (GRK2/βARK1) with IC50 value of 126 μM. It has been shown to decrease systolic blood pressure in ob/ob and nicotinamide plus streptozotocin-induced mouse models of type 2 diabetes when administered at a dose of 200 μg/kg. Synonyms: betaARK1 Inhibitor; Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate; GRK2 Inhibitor. Grades: ≥95% (mixture of isomers). CAS No. 24269-96-3. Molecular formula: C12H9NO6. Mole weight: 263.2. | |
Cenupatide Quick inquiry Where to buy Suppliers range | Cenupatide is an urokinase plasminogen activator receptor (uPAR) inhibitor drug candidate. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of streptozotocin (STZ)-induced diabetes. Cenupatide was found to revert STZ-induced up-regulation of uPA levels and activity, while uPAR on podocytes and (s)uPAR were unaffected. In glomeruli, Cenupatide inhibited FPR2 expression suggesting that the drug may act downstream uPAR, and recovered the increased activity of the αvβ3 integrin/Rac-1 pathway indicating a major role of uPAR in regulating podocyte function. Uses: Peptide Inhibitors. CAS No. 1006388-38-0. Product ID: R1917. | |
C-Peptide 1 (rat) Quick inquiry Where to buy Suppliers range | C-Peptide 1 (rat) specifically binds to G-protein-coupled membrane receptors in the nanomolar concentration range, and subsequently activates Ca2+-dependent intracellular signaling pathways. This leads to a stimulation of the activity of both Na+-K+-ATPase, and endothelial nitric oxide synthase. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover. Synonyms: Insulin 1 Precursor (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Pro-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Glu-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-prolyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-L-alpha-glutamyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine. Grades: ≥95%. CAS No. 41475-27-8. Molecular formula: C140H228N38O51. Mole weight: 3259.53. | |
C-Peptide 2 (rat) Quick inquiry Where to buy Suppliers range | C-Peptide 2 (rat), a peptide composed of 31 amino acid residues, can effectively improve glucose utilization in streptozotocin induced diabetic rats. It is a component of proinsulin, and can inhibit glucose-induced insulin secretion. Synonyms: Preproinsulin 2 (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Ala-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-alanyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-glycyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine; Insulin 2 Precursor (57-87) (rat); Proinsulin 2 (33-63) (rat). Grades: ≥95% by HPLC. CAS No. 41594-08-5. Molecular formula: C135H222N38O49. Mole weight: 3161.43. | |
[Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt Quick inquiry Where to buy Suppliers range | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
Noopept Quick inquiry Where to buy Suppliers range | Noopept is a nootropic and neuroprotective drug that normalizes the balance of the pro- and antioxidant systems. Noopept modulates a variety of physiological functions including cognition and anxiety. Noopept significantly weakens streptozotocin-Induced diabetes in rats. Synonyms: GVS-111; GVS111; GVS 111; SGS-111; SGS 111; SGS111. Grades: >98%. CAS No. 157115-85-0. Molecular formula: C17H22N2O4. Mole weight: 318.37. | |
Tolrestat Quick inquiry Where to buy Suppliers range | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. | |
UD-014 Quick inquiry Where to buy Suppliers range | UD-014 is a selective and long-acting inhibitor of semicarbazide-sensitive amine oxidase (SSAO; VAP-1) (IC50 = 3.2 nM), which shows a therapeutic effect of diabetic nephropathy in a streptozotocin rat model. Uses: The treatment of diabetic nephropathy. Synonyms: UD 014; UD014. |