Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Tacrolimus | FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Uses: Drug. Synonyms: Prograf; Fujimycin; FK506; Protopy. Grade: >98%. CAS No. 104987-11-3. Molecular formula: C44H69NO12. Mole weight: 804.02. |  |
| Tacrolimus | Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase , which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: FK506; Fujimycin; FR900506. CAS No. 104987-11-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13756. |  |
| Tacrolimus | Tacrolimus. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone. CAS No. 104987-11-3. Molecular formula: C44H69NO12. Mole weight: 804.02. Catalog: APB104987113. |  |
| Tacrolimus | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Tacrolimus-[13C,d2] | Tacrolimus-[13C,d2] is the labelled analogue of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Advagraf-13C,D2; Fujimycin-13C,D2; FK-506-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2. Grade: ≥85%. CAS No. 1356841-89-8. Molecular formula: C43[13C]H67D2NO12. Mole weight: 807.02. | |
| Tacrolimus 8-epimer | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Tacrolimus 8-propyl analog | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Tacrolimus Diene | Tacrolimus Diene. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Tacrolimus EP Impurity I; (3S,4R,5E,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-19-hydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone. CAS No. 104987-16-8. Molecular formula: C44H67NO11. Mole weight: 786.00. Catalog: APB104987168. | |
| Tacrolimus EP Impurity A | Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Uses: Anti-bacterial agents. Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; FK-520; FR900520; FR-900520; FR 900520; L 683590; L-683590; L683590; Changchuanmycin; Immunomycin; Ascomycin; Tacrolimus Related Compound A USP; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-. Grade: ≥90% by HPLC. CAS No. 104987-12-4. Molecular formula: C43H69NO12. Mole weight: 792.00. | |
| Tacrolimus EP Impurity A | Tacrolimus EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone. CAS No. 104987-12-4. Molecular formula: C43H69NO12. Mole weight: 792.01. Catalog: APB104987124. | |
| Tacrolimus EP Impurity C | Tacrolimus EP Impurity C is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,12,18-trimethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 10-Desmethyl tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,12,18-trimethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; Tacrolimus monohydrate EP impurity C; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Allyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14,16-dimethoxy-4,12,18-trimethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21-(4H,23H)-tetrone; Desmethyl tacrolimus. Grade: ≥95%. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
| Tacrolimus EP Impurity D | Tacrolimus EP Impurity D is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5S,8S,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 8-epi Tacrolimus; 8-Epitacrolimus; Tacrolimus anhydrous 8-epimer; Tacrol. Grade: ≥90% by HPLC. CAS No. 129212-35-7. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
| Tacrolimus EP Impurity E | Tacrolimus EP Impurity E is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; Dihydro Tacrolimus; Dihydro-FK 506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotr. Grade: ≥90% by HPLC. CAS No. 104987-30-6. Molecular formula: C44H71NO12. Mole weight: 806.06. | |
| Tacrolimus EP Impurity E | Tacrolimus EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone. CAS No. 104987-30-6. Molecular formula: C44H71NO12. Mole weight: 806.03. Catalog: APB104987306. | |
| Tacrolimus EP Impurity F | Tacrolimus EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,4R,5S,8R,12S,14S,15R,16S,18R,26aS,E)-8-allyl-5,15-dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,24,25,26,26a-hexadecahydro-1H-pyrido[2,1-c][1,4]oxaaz. CAS No. 1393890-33-9. Molecular formula: C44H69NO12. Mole weight: 804.02. Catalog: APB1393890339. | |
| Tacrolimus EP Impurity G | Tacrolimus EP Impurity G is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19S,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; Tacrolimus compound II; Tacrolimus anhydrous 19-epimer; 19-Epi FK-506; 1. Grade: ≥90% by HPLC. CAS No. 144490-63-1. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
| Tacrolimus EP Impurity H | Tacrolimus EP Impurity H is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (1E,3S,4R,5S,8R,9E,12S,14S)-5-hydroxy-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-14-methoxy-14-[(2R,3S,5R)-3-methoxy-5-methyl-6-oxooxan-2-yl]-2,4,10,12-tetramethyl-7-oxo-8-(prop-2-en-1-yl)tetradeca-1,9-dien-3-yl (2S)-1-formylpiperidine-2-carboxylate; Tacrolimus monohydrate impurity H [EP]; 2-Piperidinecarboxylic acid, 1-formyl-, (1S,2R,3S,6R,7E,10S,12S)-3-hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-. Grade: ≥95%. CAS No. 143210-33-7. Molecular formula: C43H69NO11. Mole weight: 776.01. | |
| Tacrolimus EP Impurity I | Tacrolimus EP Impurity I is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5E,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-19-hydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; Tacrolimus diene; 23,24-Anhydro Tacrolimus; Δ23-FK-506; Tacrolimus Impurity I; Tacrolimus monohydrate impurity I [EP]; 15,19-Epoxy(5E,9E)-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8,11,12,13,14,15,16,17,18,19,24,25,26,26a-tetradecahydro-19-hydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,8R,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8,11,12,13,14,15,16,17,18,19,24,25,26,26a-tetradecahydro-19-hydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5E,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-. Grade: 95%. CAS No. 104987-16-8. Molecular formula: C44H67NO11. Mole w | |
| Tacrolimus Impurity 13 | Tacrolimus Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026775-21-2. Molecular formula: C44H69NO12. Mole weight: 804.03. Catalog: APB1026775212. | |
| Tacrolimus Impurity 22 | Tacrolimus Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1700657-83-5. Molecular formula: C44H71NO13. Mole weight: 822.05. Catalog: APB1700657835. | |
| Tacrolimus Impurity 23 | Tacrolimus Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133941-75-0. Molecular formula: C56H97NO12Si2. Mole weight: 1032.56. Catalog: APB133941750. | |
| Tacrolimus Impurity 26 | Tacrolimus Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 104987-25-9. Molecular formula: C50H83NO12Si. Mole weight: 918.29. Catalog: APB104987259. | |
| Tacrolimus Impurity 29 | Tacrolimus Impurity 29. Uses: For analytical and research use. Group: Impurity standards. CAS No. 131944-48-4. Molecular formula: C44H69NO12. Mole weight: 804.02. Catalog: APB131944484. | |
| Tacrolimus Impurity 53 | Tacrolimus Impurity 53. Uses: For analytical and research use. Group: Impurity standards. CAS No. 123719-19-7. Molecular formula: C43H69NO11. Mole weight: 776.02. Catalog: APB123719197. | |
| Tacrolimus Impurity 54 | Tacrolimus Impurity 54. Uses: For analytical and research use. Group: Impurity standards. CAS No. 139958-51-3. Molecular formula: C43H67NO12. Mole weight: 790. Catalog: APB139958513. | |
| Tacrolimus Impurity 7 | Tacrolimus Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 124554-37-6. Molecular formula: C44H69NO13. Mole weight: 820.03. Catalog: APB124554376. | |
| Tacrolimus Impurity (Methyl Acryl Aldehyde) | Tacrolimus Impurity (Methyl Acryl Aldehyde) is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (E)-3-[[(1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl]-2-methylacrylaldehyde; [1R-[1α(E),3α,4β]]-3-(4-Hydroxy-3-methoxycyclohexyl)-2-methyl-2-propenal; Tacrolimus Methylacryl Aldehyde; 3-((1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl)-2-methylacrylaldehyde, (E)-; (2E)-3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methylprop-2-enal; (2E)-3-[(1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl]-2-methylacrylaldehyde; 2-Propenal, 3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methyl-, (2E)-. Grade: ≥90% by HPLC. CAS No. 109466-74-2. Molecular formula: C11H18O3. Mole weight: 198.26. | |
| Tacrolimus Methylacryl Aldehyde | Tacrolimus Methyl Acryl Aldehyde is the degradation product of Tacrolimus, a novel macrocyclic lactone isolated from Streptomyces tsukubaensis, having immunosuppressant activity. Group: Biochemicals. Alternative Names: [1R-[1α(E), 3α, 4 β]]-3-(4-Hydroxy-3-methoxycyclohexyl)-2-methyl-2-propenal. Grades: Highly Purified. CAS No. 109466-74-2. Pack Sizes: 10mg. Molecular Formula: C??H??O?, Molecular Weight: 198.26. US Biological Life Sciences. |  Worldwide |
| Tacrolimus monohydrate | Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase , which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate. CAS No. 109581-93-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13756A. | |
| Tacrolimus monohydrate | Tacrolimus monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 109581-93-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C44H69NO12·H2O. US Biological Life Sciences. | Worldwide |
| Tacrolimus monohydrate | Tacrolimus monohydrate is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Synonyms: Tacrolimus Hydrate; Tsukubaenolide hydrate; (3S,?4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine?-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-hydrate. Grade: >98%. CAS No. 109581-93-3. Molecular formula: C44H71NO13. Mole weight: 822.03. | |
| Tacrolimus Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Tacrolimus solution | 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| Tacrolimus System Suitability Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 12-hydroxytacrolimus | 12-hydroxytacrolimus is an impurity of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Molecular formula: C44H69NO13. Mole weight: 820.02. | |
| 13-O-Desmethyl Tacrolimus | 13-O-Desmethyl Tacrolimus is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S,4R,5S,8R,9E,12S,14S,15S,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26-Hexadecahydro-5,16,19-trihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-16,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone. Grade: ≥95%. CAS No. 139958-51-3. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
| 19-epi Tacrolimus | 19-epi Tacrolimus is an impurity of Tacrolimus. Tacrolimus is an immunosuppressant that can inhibit the activity of FK-506 binding protein. Grade: ≥90% by HPLC. Molecular formula: C43H69NO12. Mole weight: 792.01. | |
| 8-Epitacrolimus | 8-Epitacrolimus is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. 8-Epitacrolimus is also an Epimer of Tacrolimus. Group: Biochemicals. Alternative Names: (-)-8-epi-Tacrolimus; [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8R*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: Highly Purified. CAS No. 129212-35-7. Pack Sizes: 500ug. Molecular Formula: C??H??NO??, Molecular Weight: 804.02. US Biological Life Sciences. | Worldwide |
| Desmethyl Tacrolimus | Desmethyl Tacrolimus. Uses: For analytical and research use. Group: Impurity standards. CAS No. 132172-14-6. Molecular formula: C43H67NO12. Mole weight: 790. Catalog: APB132172146. | |
| FK-506 (Fujimycin, Tacrolimus) | FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Group: Biochemicals. Alternative Names: Advagraf; FR 900506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide. Grades: Highly Purified. CAS No. 104987-11-3. Pack Sizes: 50mg, 100mg, 500mg, 1g. Molecular Formula: C44H69NO12, Molecular Weight: 804.02. US Biological Life Sciences. | Worldwide |
| FK-506 (Fujimycin, Tacrolimus)-13C,D2 | FK-506 (Fujimycin, Tacrolimus)-13C,D2. Group: Biochemicals. Alternative Names: FK-506-13C,D2. Grades: Highly Purified. CAS No. 104987-11-3forunlabelled. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Iso-FK-506 (iso-Tacrolimus) | An isomer of FK-506 from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Alternative Names: [3S-[3R*[1R*, 2R*, 4(1S*, 3S*, 4S*)], 6S*, 10R*, 12R*, 13R*, 14R*, 16S*, 17S*, 24aR*]]. Grades: Highly Purified. CAS No. 134590-88-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Oxacyclohexane open ring tacrolimus | Oxacyclohexane open ring tacrolimus is an impurity of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: Tacrolimus Open Ring Impurity; Tacrolimus related compound, tacrolimus open ring; 3H-Pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone, 5,6,11,13,14,15,16,17,18,20,24,25,26,26a-tetradecahydro-5,15,20,20-tetrahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,26aS)-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,26aS)-5,6,11,13,14,15,16,17,18,20,24,25,26,26a-Tetradecahydro-5,15,20,20-tetrahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone; 3H-Pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,20H,23H)-tetrone, 5,6,11,12,13,14,15,16,17,18,24,25,26,26a-tetradecahydro-5,15,20,20-tetrahydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,26aR*]]-. Grade: ≥90% by HPLC. CAS No. 144432-23-5. Molecular formula: C44H71NO13. Mole weight: 822.03. | |
| 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 | 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C50H85NO12Si, Molecular Weight: 920.29. US Biological Life Sciences. | Worldwide |
| 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 | 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Synonyms: [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,7R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-3-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-4,5,6,7,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-5,7,19-trihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,20,21(23H)-trione; 22-Hydroxy 33-tert-Butyldimethylsilyloxy-Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,20,21(23H)-trione, 3-[2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-4,5,6,7,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-5,7,19-trihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,7R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-. CAS No. 134556-80-2. Molecular formula: C50H85NO12Si. Mole weight: 920.29. | |
| 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 | 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 is an analog of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Synonyms: 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-Tacrolimus; [3S-[3R*[1R*,2R*,4(1S*,3S*,4S*)],5R*,6S*,10R*,12R*,13R*,14R*,16S*,17S*,24aR*]]-3-[4-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1,3-dimethyl-2-[(trimethylsilyl)oxy]-3-butenyl]-4,5,6,9,10,11,12,13,14,15,16,17,22,23,24,24a-hexadecahydro-5,17-dihydroxy-12,14-dimethoxy-8,10,16-trimethyl-6-(2-propenyl)-13,17-epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,18,19(21H)-trione; 13,17-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,18,19(21H)-trione, 3-[4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1,3-dimethyl-2-[(trimethylsilyl)oxy]-3-butenyl]-4,5,6,9,10,11,12,13,14,15,16,17,22,23,24,24a-hexadecahydro-5,17-dihydroxy-12,14-dimethoxy-8,10,16-trimethyl-6-(2-propenyl)-, [3S-[3R*[1R*,2R*,4(1S*,3S*,4S*)],5R*,6S*,10R*,12R*,13R*,14R*,16S*,17S*,24aR*]]-. Grade: ≥90%. CAS No. 134556-85-7. Molecular formula: C53H93NO12Si2. Mole weight: 992.48. | |
| 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 | 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C53H91NO12Si2. US Biological Life Sciences. | Worldwide |
| 24,32-Bis-O-(tert-butyldimethylsilyl)-fk-506 | 24,32-Bis-O-(tert-butyldimethylsilyl)-fk-506. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 24,32-Bis-O-(tert-butyldimethylsilyl) Tacrolimus. Product Category: Heterocyclic Organic Compound. Appearance: Pale Yellow Solid (Foam). CAS No. 133941-75-0. Molecular formula: C56H97NO12Si2. Mole weight: 1032.54. Purity: 0.96. IUPACName: 24,33-Bis-(t.butyl-dimethylsilyl)-FK 506. Canonical SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O[Si](C)(C)C(C)(C)C)C)C(=CC4CCC(C(C4)OC)O[Si](C)(C)C(C)(C)C)C)O)C)OC)OC. Product ID: ACM133941750. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 | 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506. Group: Biochemicals. Alternative Names: 24,32-Bis-O-(tert-butyldimethylsilyl) tacrolimus. Grades: Highly Purified. CAS No. 133941-75-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C56H97NO12Si2. US Biological Life Sciences. | Worldwide |
| 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 | 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 is protected form of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: Protected form of fk-506 (tacrolimus). Synonyms: 24,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus; Tacrolimus Impurity 16; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-. Grade: 95%. CAS No. 133941-75-0. Molecular formula: C56H97NO12Si2. Mole weight: 1032.54. | |
| 24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) | 24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) is an intermediate of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: 24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-(2,3-dihydroxypropyl)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; Tacrolimus Impurity 17. Grade: ≥90%. CAS No. 1356932-17-6. Molecular formula: C56H99NO14Si2. Mole weight: 1066.55. | |
| 25,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy Tacrolimus. Grades: Highly Purified. CAS No. 1356932-17-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 25,33-Bis-O-(tert-butyldimethylsilyl)-FK-506 | Protected form of FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus. Grades: Highly Purified. CAS No. 133941-75-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 25,33-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major) | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus-13CD2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 33-tert-Butyldimethylsilyloxy-FK 506 | 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate of iso-Tacrolimus. Synonyms: [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-3-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; 33-tert-Butyldimethylsilyloxy-Tacrolimus; Tacrolimus Impurity 26; Tacrolimus Impurity 15. Grade: ≥95%. CAS No. 104987-25-9. Molecular formula: C50H83NO12Si. Mole weight: 918.28. | |
| 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 | 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 is an intermediate of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: An intermediate in the preparation of labelled fk-506 (tacrolimus). Synonyms: 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-fk-506; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-8-acetaldehyde, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-1,4,5,6,7,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-1,7,20,21-tetraoxo-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; FK-506 analogue; 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-8-acetaldehyde, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[2-[4-[(1,1-dimethylethyl)dimethylsilyl]-3-methoxycyclohexyl]-1-methylethenyl]-1,4,5,6,7,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-1,7,20,21-tetraoxo-, [3S-[3R*[E(1S*,3S*,4S*)],4R*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-. Grade: ≥90%. CAS No. 155684-96-1. Molecular formula: C55H95NO13Si2. Mole weight: 1034.51. | |
| 37-Desmethylene 25,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 37-Desmethylene 25,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo Tacrolimus; (3S, 4S, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-. Grades: Highly Purified. CAS No. 155684-96-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-FK-506 | 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-FK-506. Group: Biochemicals. Alternative Names: 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo tacrolimus. Grades: Highly Purified. CAS No. 155684-96-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C55H95NO13Si2. US Biological Life Sciences. | Worldwide |
| (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,15,19-trihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-16,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: 16,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,15,19-trihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25. Grade: ≥95%. CAS No. 132172-14-6. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
| 5-Hydroxy-33-tert-butyldimethylsilyloxy-iso-FK-506 | 5-Hydroxy-33-tert-butyldimethylsilyloxy-iso-FK-506 is an analog of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Uses: Analog of iso-fk-506. Synonyms: 13,17-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,18,19(21H)-trione, 3-[4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-2-hydroxy-1,3-dimethyl-3-butenyl]-4,5,6,9,10,11,12,13,14,15,16,17,22,23,24,24a-hexadecahydro-5,17-dihydroxy-12,14-dimethoxy-8,10,16-trimethyl-6-(2-propenyl)-, [3S-[3R*[1R*,2R*,3E,4(1S*,3S*,4S*)],5R*,6S*,7E,10R*,12R*,13R*,14R*,16S*,17S*,24aR*]]-; [3S-[3R*[1R*,2R*,3E,4(1S*,3S*,4S*)],5R*,6S*,7E,10R*,12R*,13R*,14R*,16S*,17S*,24aR*]]-3-[4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-2-hydroxy-1,3-dimethyl-3-butenyl]-4,5,6,9,10,11,12,13,14,15,16,17,22,23,24,24a-hexadecahydro-5,17-dihydroxy-12,14-dimethoxy-8,10,16-trimethyl-6-(2-propenyl)-13,17-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,18,19(21H)-trione. Grade: 95%. CAS No. 134556-79-9. Molecular formula: C50H85NO12Si. Mole weight: 920.29. | |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grade: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
| Ascomycin | Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Immunomycin; FR-900520; FK520. CAS No. 104987-12-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-13557. | |
| Ascomycin | Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Moll...the compounds." J. Infect. Dis. 191: 1342-1349 (2005).FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994). Group: Biochemicals. Alternative Names: Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C43H69NO12, Molecular Weight: 792.01. US Biological Life Sciences. | Worldwide |
| Dihydro FK-506 | A novel analog of FK-506 macrocycle. Group: Biochemicals. Alternative Names: Tsukubamycin B; Dihydro Tacrolimus; [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-15, 19-Epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-15, 19-Epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: Highly Purified. CAS No. 104987-30-6. Pack Sizes: 1mg, 2.5mg, 5mg. Molecular Formula: C??H??NO??, Molecular Weight: 806.03. US Biological Life Sciences. | Worldwide |
| (E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 2; Tacrolimus Regioisomer; Tacrolimus Allylic Ester Rearrangement Impurity. Grade: 95%. CAS No. 131944-48-4. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
| FK-506-13C,D2 (Major) | A labeled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Group: Biochemicals. Alternative Names: Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FK-506 3'-Methyl Ether | It is a fermentation process impurity of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: It is a fermentation process impurity. it is formed during tacrolimus ((f370000) fermentation using strain of streptomyces tsukubaensis. Synonyms: 3-[2-(3,4-Dimethoxycyclohexyl)-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone. Grade: 95%. CAS No. 124554-16-1. Molecular formula: C45H71NO12. Mole weight: 818.04. | |
| Umirolimus | A semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group. It is one of the most hydrophobic tacrolimus analogues. It binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Synonyms: Biolimus; Biolimus A9; TRM 986; 42-O-(2-Ethoxyethyl)rapamycin. Grade: >95% by HPLC. CAS No. 851536-75-9. Molecular formula: C55H87NO14. Mole weight: 986.28. | |
Our database is helping our users find suppliers everyday.
