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Product | Description | |
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Tacrolimus Quick inquiry Where to buy Suppliers range | Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the bodys learned (or adaptive) immune response.Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimuras disease, and the skin condition vitiligo.Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukuba. Group: Main Products. Alternative Names: (2-propenyl)-, (3s-(3r*(e(1s*, 3s*, 4s*)), 4s*, 5r*, 8s*, 9e, 12r*, 14r*, 15s*, 16r*, 18s*;, 19s*, 26ar*))-;16-dimethoxy-4, 10, 12, 18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2, 1-c)(1, 4)oxaazacyclotricosine-1, 7, 20, 21(4h, 23h)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14, 16-dim;6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-5;fr900506;prograf;tsukubaenolide. Grades: 98%+. CAS No. 104987-11-3. Product ID: ACM104987113. Molecular formula: C44H69NO12. Mole weight: 804.02. IUPAC Name: FK506(Tacrolimus). Appearance: White or off-white crystalline powder. Boiling Point: 871.7ºC at 760 mmHg. Melting Point: 113-115ºC. Flash Point: 481ºC. Density: 1.19 g/cm³. | |
Tacrolimus Quick inquiry Where to buy Suppliers range | FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Uses: Drug. Synonyms: Prograf; Fujimycin; FK506; Protopy. Grades: >98%. CAS No. 104987-11-3. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
Tacrolimus 15 DMT Quick inquiry Where to buy Suppliers range | Tacrolimus 15 DMT is a metabolite of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Synonyms: 15-O-Desmethyl Tacrolimus; 13-O-Demethyl-FK-506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 14, 19-trihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-16-methoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-, (3S, 4R, 5S, 8R, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-. Grades: >98%. CAS No. 151039-41-7. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
Tacrolimus 15-DMT Quick inquiry Where to buy Suppliers range | ||
Tacrolimus-19-Desmethyl Impurity Quick inquiry Where to buy Suppliers range | Tacrolimus-19-Desmethyl is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
Tacrolimus 21-Carboxy Acid Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: 21-Carboxy Acid Tacrolimus. Grades: > 95%. Molecular formula: C44H71NO13. Mole weight: 822.06. | |
Tacrolimus 31 DMT Quick inquiry Where to buy Suppliers range | Tacrolimus 31 DMT is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: O-desmethyl Tacrolimus; Hydroxy Tacrolimus; (18E)-17-Allyl-12-[(1E)-1-(3,4-dihydroxycyclohexyl)-1-propen-2-yl]-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone. Grades: >98%. CAS No. 135635-47-1. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
Tacrolimus 31-DMT Quick inquiry Where to buy Suppliers range | Tacrolimus 31-DMT is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: 12-[1-(3,4-Dihydroxycyclohexyl)prop-1-en-2-yl]-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; Tacrolimus 31 DMT; VHOPGJHKSPGXIZ-UHFFFAOYSA-N; 17-Allyl-1,14-dihydroxy-12-[2-(3,4-dihydroxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone. CAS No. 127984-76-3. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
Tacrolimus alpha-Hydroxy Acid Quick inquiry Where to buy Suppliers range | Tacrolimus alpha-Hydroxy Acid (TAC-H1) is an impuritie of Tacrolimus,which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: TAC-H1. Molecular formula: C45H73NO13. Mole weight: 836.06. | |
Tacrolimus C4-epimer Diene Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus C4-epimer Diene. Grades: > 95%. Molecular formula: C44H67NO11. Mole weight: 786.02. | |
Tacrolimus Diene Quick inquiry Where to buy Suppliers range | Cas No. 104987-16-8. | |
Tacrolimus EP Impurity A Quick inquiry Where to buy Suppliers range | Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Uses: Anti-bacterial agents. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-ethyl-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; FK-520; FR900520; FR-900520; FR 900520; L 683590; L-683590; L683590; Changchuanmycin; Immunomycin; Ascomycin; Tacrolimus Related Compound A USP; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-. Grades: ≥90% by HPLC. CAS No. 104987-12-4. Molecular formula: C43H69NO12. Mole weight: 792.00. | |
Tacrolimus EP Impurity C Quick inquiry Where to buy Suppliers range | Tacrolimus EP Impurity C is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 12, 18-trimethyl-8-(prop-2-en-1-yl)-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; 10-Desmethyl tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 12, 18-trimethyl-8-(2-propen-1-yl)-, (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; Tacrolimus monohydrate EP impurity C; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Allyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14, 16-dimethoxy-4, 12, 18-trimethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone; Desmethyl tacrolimus. Grades: ≥95%. Molecular formula: C43H67NO12. Mole weight: 789.99. | |
Tacrolimus EP Impurity D Quick inquiry Where to buy Suppliers range | Tacrolimus EP Impurity D is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8S, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(prop-2-en-1-yl)-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; 8-epi Tacrolimus; 8-Epitacrolimus; Tacrolimus anhydrous 8-epimer; Tacrolimus 8-epimer [USP-RS]; Tacrolimus monohydrate impurity D [EP]; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8R*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-; (-)-8-epi-Tacrolimus; (3S, 4R, 5S, 8S, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Allyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-{(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: ≥90% by HPLC. CAS No. 129212-35-7. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
Tacrolimus EP Impurity E Quick inquiry Where to buy Suppliers range | Tacrolimus EP Impurity E is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; Dihydro Tacrolimus; Dihydro-FK 506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-, (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-; Tsukubamycin B; USP Tacrolimus 8-propyl Analog; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-{(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-8-propyl-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: ≥90% by HPLC. CAS No. 104987-30-6. Molecular formula: C44H71NO12. Mole weight: 806.06. | |
Tacrolimus EP Impurity G Quick inquiry Where to buy Suppliers range | Cas No. 144490-63-1. | |
Tacrolimus EP Impurity H Quick inquiry Where to buy Suppliers range | Tacrolimus EP Impurity H is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (1E,3S,4R,5S,8R,9E,12S,14S)-5-hydroxy-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-14-methoxy-14-[(2R,3S,5R)-3-methoxy-5-methyl-6-oxooxan-2-yl]-2,4,10,12-tetramethyl-7-oxo-8-(prop-2-en-1-yl)tetradeca-1,9-dien-3-yl (2S)-1-formylpiperidine-2-carboxylate; Tacrolimus monohydrate impurity H [EP]; 2-Piperidinecarboxylic acid, 1-formyl-, (1S,2R,3S,6R,7E,10S,12S)-3-hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propen-1-yl)-12-[(2R,3S,5R)-tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl]-7-dodecen-1-yl ester, (2S)-; (1S,2R,3S,6R,7E,10S,12S)-3-Hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propen-1-yl)-12-[(2R,3S,5R)-tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl]-7-dodecen-1-yl (2S)-1-formyl-2-piperidinecarboxylate; 2-Piperidinecarboxylic acid, 1-formyl-, (1S,2R,3S,6R,7E,10S,12S)-3-hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propenyl)-12-[(2R,3S,5R)-tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl]-7-dodecenyl ester, (2S)-; 2-Piperidinecarboxylic acid, 1-formyl-, 3-hydroxy-1-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propenyl)-12-(tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl)-7-dodecenyl ester, [2R-[2α[1S*[[E(1R*, 3R*, 4R*)], (S*)], 2R*, 3S*, 6R*, 7E, 10S*, 12S*], 3β, 5β]]-. Grades: ≥95%. CAS No. 143210-33-7. Molecular formula: C43H69NO11. Mole weight: 776.01. | |
Tacrolimus EP Impurity I Quick inquiry Where to buy Suppliers range | Tacrolimus EP Impurity I is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5E, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-19-hydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(prop-2-en-1-yl)-3, 4, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; Tacrolimus diene; 23,24-Anhydro Tacrolimus; Δ23-FK-506; Tacrolimus Impurity I; Tacrolimus monohydrate impurity I [EP]; 15,19-Epoxy(5E,9E)-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-tetradecahydro-19-hydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-, (3S, 4R, 8R, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-tetradecahydro-19-hydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5E, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-. Grades: ≥90% by HPLC. CAS No. 104987-16-8. Molecular formula: C44H67NO11. Mole weight: 786.02. | |
Tacrolimus Impurity 1 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 1 is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: Tacrolimus Impurity 1. Grades: ≥95%. Molecular formula: C43H69NO11. Mole weight: 776.03. | |
Tacrolimus Impurity 11 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 11 is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Molecular formula: C44H73NO13. Mole weight: 824.05. | |
Tacrolimus Impurity 12 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 12 is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-15, 19-Epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-19-dehydroxy-20, 21, 22-oxazolidinone-1, 7, 20, 21(4H, 23H)-tetrone. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
Tacrolimus Impurity 13 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 13 is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
Tacrolimus Impurity 14 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 14 is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. CAS No. 1260758-24-4. Molecular formula: C10H15NO4S. Mole weight: 245.29. | |
Tacrolimus Impurity 18 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 18 is an impuritie of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. CAS No. 129039-81-2. Molecular formula: C43H65NO12. Mole weight: 787.97. | |
Tacrolimus Impurity 2 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacroliums Impurity D; [3R-[3R*(1R*, 3R*, 4R*), 4E, 6S*, 7S*, 10R*, 11E, 14S*, 16S*, 17R*, 18S*, 20R*, 21R*, 28aS*]]-7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 26, 27, 28, 28a-Hexadecahydro-7, 21-dihydroxy-3-(4-hydroxy-3-methoxycyclohexyl)-16, 18-dimethoxy-4, 6, 12, 14, 20-pentamethyl-10-(2-propenyl)-7, 21-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclopentacosine-1, 9, 22, 23(6H, 25H)-tetrone. Grades: > 95%. CAS No. 131944-48-4. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
Tacrolimus Impurity 3 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 3. Grades: > 95%. Molecular formula: C43H69NO11. Mole weight: 776.03. | |
Tacrolimus Impurity 4 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 4. Grades: > 95%. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
Tacrolimus Impurity 5 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 5. Grades: > 95%. Molecular formula: C44H71NO13. Mole weight: 822.06. | |
Tacrolimus Impurity 6 Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity 6 is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: Pyrido[2,1-c][1,4]oxaazacyclodocosine-19-carboxylic acid, 1, 3, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 25a-docosahydro-5, 15, 19-trihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-1, 7, 20-trioxo-8-(2-propen-1-yl)-, (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 25aS)-; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 25aS)-1, 3, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 25a-Docosahydro-5, 15, 19-trihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-1, 7, 20-trioxo-8-(2-propen-1-yl)pyrido[2, 1-c][1, 4]oxaazacyclodocosine-19-carboxylic acid; Tacrolimus α-hydroxy acid; Tacrolimus hydroxy acid. Grades: >95%. CAS No. 1700657-83-5. Molecular formula: C44H71NO13. Mole weight: 822.06. | |
Tacrolimus Impurity 7 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 7. Grades: > 95%. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
Tacrolimus Impurity 8 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 8. Grades: > 95%. Molecular formula: C44H71NO13. Mole weight: 822.06. | |
Tacrolimus Impurity (Methyl Acryl Aldehyde) Quick inquiry Where to buy Suppliers range | Tacrolimus Impurity (Methyl Acryl Aldehyde) is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (E)-3-[[(1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl]-2-methylacrylaldehyde; [1R-[1α(E),3α,4β]]-3-(4-Hydroxy-3-methoxycyclohexyl)-2-methyl-2-propenal; Tacrolimus Methylacryl Aldehyde; 3-((1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl)-2-methylacrylaldehyde, (E)-; (2E)-3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methylprop-2-enal; (2E)-3-[(1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl]-2-methylacrylaldehyde; 2-Propenal, 3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methyl-, (2E)-. Grades: ≥90% by HPLC. CAS No. 109466-74-2. Molecular formula: C11H18O3. Mole weight: 198.26. | |
Tacrolimus Lactone Isomer Quick inquiry Where to buy Suppliers range | One of the isomer impurities of Tacrolimus Lactone, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Iso-FK-506 (iso-Tacrolimus); [3S-[3R*[1R*, 2R*, 4(1S*, 3S*, 4S*)], 6S*, 10R*, 12R*, 13R*, 14R*, 16S*, 17S*, 24aR*]]-6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 22, 23, 24, 24a-tetradecahydro-17-hydroxy-3-[2-hydroxy-4-(4-hydroxy-3-methoxycyclohexyl)-1, 3-dimethyl-3-butenyl]-12, 14-dimethoxy-8, 10, 16-trimethyl-6-(2-propenyl)-13, 17-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacycloheneicosine-1, 5, 18, 19(4H, 21H)-tetrone. Grades: >95%. CAS No. 134590-88-8. Molecular formula: C44H69NO12. Mole weight: 804.02. | |
Tacrolimus Methylacryl Aldehyde Quick inquiry Where to buy Suppliers range | Tacrolimus Methyl Acryl Aldehyde is the degradation product of Tacrolimus, a novel macrocyclic lactone isolated from Streptomyces tsukubaensis, having immunosuppressant activity. Group: Biochemicals. Alternative Names: [1R-[1α(E), 3α, 4 β]]-3-(4-Hydroxy-3-methoxycyclohexyl)-2-methyl-2-propenal. Grades: Highly Purified. CAS No. 109466-74-2. Pack Sizes: 10mg. Molecular Formula: C??H??O?, Molecular Weight: 198.26. US Biological Life Sciences. | Worldwide |
Tacrolimus Methyl Acryl Aldehyde Quick inquiry Where to buy Suppliers range | Tacrolimus Methyl Acryl Aldehyde. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: 2-Propenal, 3-(4-hydroxy-3-methoxycyclohexyl)-2-methyl-, [1R-[1α(E),3α,4β]]- (9CI). CAS No. 109466-74-2. Pack Sizes: 10MG. IUPAC Name: (E)-3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methylprop-2-enal. Molecular formula: C11H18O3. Mole weight: 198.26. Catalog: APS109466742. SMILES: CO[C@@H]1C[C@@H] (CC[C@H]1O)\C=C (/C)\C=O. Format: Neat. Shipping: Dry ice. | |
Tacrolimus monohydrate Quick inquiry Where to buy Suppliers range | Tacrolimus monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 109581-93-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C44H69NO12·H2O. US Biological Life Sciences. | Worldwide |
Tacrolimus regioisomer Quick inquiry Where to buy Suppliers range | Tacrolimus regioisomer is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (4E, 11E)-10-Allyl-7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 26, 22, 28, 28a-hexadecahydro-7, 21-dihydroxy-3-(4-hydroxy-3-methoxycyclohexyl)-16, 18-dimethoxy-4, 6, 12, 14, 20-pentamethyl-17, 21-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclopentacosine-1, 9, 22, 23(6H, 25H)-tetrone. Molecular formula: C44H69NO12. Mole weight: 804.03. | |
Tacrolimus Ring-opening Impurity Quick inquiry Where to buy Suppliers range | One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Ring-opening Impurity. Grades: > 95%. Molecular formula: C44H69NO12. Mole weight: 804.04. | |
Tacrolimus System Suitability Mixture Quick inquiry Where to buy Suppliers range | It is a mixture of tacrolimus, ascomycin and tacrolimus 8-propyl analog. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone mix. with (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Ethyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone mix. with (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-{(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-8-propyl-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone. Molecular formula: C44H69NO12.C43H69NO12.C44H71NO12. Mole weight: 2402.10. | |
Tacrolimus USP Related Compound A Quick inquiry Where to buy Suppliers range | Tacrolimus USP Related Compound A is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: USP Tacrolimus Related Compound A; (E)-8-Ethyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone. Grades: ≥95%. Molecular formula: C43H69NO12. Mole weight: 792.01. | |
19-epi Tacrolimus Quick inquiry Where to buy Suppliers range | 19-epi Tacrolimus is an impurity of Tacrolimus. Tacrolimus is an immunosuppressant that can inhibit the activity of FK-506 binding protein. Grades: ≥90% by HPLC. Molecular formula: C43H69NO12. Mole weight: 792.01. | |
8-epi Tacrolimus Quick inquiry Where to buy Suppliers range | Cas No. 129212-35-7. | |
Desmethyl Tacrolimus Quick inquiry Where to buy Suppliers range | Cas No. 132172-14-6. | |
Dihydro Tacrolimus Quick inquiry Where to buy Suppliers range | Cas No. 104987-30-6. | |
Everolimus, Cyclosporine and Tacrolimus Mix Standard Quick inquiry Where to buy Suppliers range | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
FK-506 (Fujimycin, Tacrolimus) Quick inquiry Where to buy Suppliers range | FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Group: Biochemicals. Alternative Names: Advagraf; FR 900506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide. Grades: Highly Purified. CAS No. 104987-11-3. Pack Sizes: 50mg, 100mg, 500mg, 1g. Molecular Formula: C44H69NO12, Molecular Weight: 804.02. US Biological Life Sciences. | Worldwide |
FK-506 (Fujimycin, Tacrolimus)-13C,D2 Quick inquiry Where to buy Suppliers range | FK-506 (Fujimycin, Tacrolimus)-13C,D2. Group: Biochemicals. Alternative Names: FK-506-13C,D2. Grades: Highly Purified. CAS No. 104987-11-3forunlabelled. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Iso-FK-506 (iso-Tacrolimus) Quick inquiry Where to buy Suppliers range | Iso-FK-506 (iso-Tacrolimus). Uses: For analytical and research use. Group: Chiral Molecules. Catalog: APS002012. Format: Neat. | |
Iso-FK-506 (iso-Tacrolimus) Quick inquiry Where to buy Suppliers range | An isomer of FK-506 from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Alternative Names: [3S-[3R*[1R*, 2R*, 4(1S*, 3S*, 4S*)], 6S*, 10R*, 12R*, 13R*, 14R*, 16S*, 17S*, 24aR*]]. Grades: Highly Purified. CAS No. 134590-88-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 Quick inquiry Where to buy Suppliers range | 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C50H85NO12Si, Molecular Weight: 920.29. US Biological Life Sciences. | Worldwide |
22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 Quick inquiry Where to buy Suppliers range | 22-Hydroxy 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Synonyms: [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 7R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-3-[2-[4-[[(1, 1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-5, 7, 19-trihydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 20, 21(23H)-trione; 22-Hydroxy 33-tert-Butyldimethylsilyloxy-Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,20,21(23H)-trione, 3-[2-[4-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-5, 7, 19-trihydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 7R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-. CAS No. 134556-80-2. Molecular formula: C50H85NO12Si. Mole weight: 920.29. | |
23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 Quick inquiry Where to buy Suppliers range | 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C53H91NO12Si2. US Biological Life Sciences. | Worldwide |
23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 Quick inquiry Where to buy Suppliers range | 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-FK-506 is an analog of Tacrolimus, an immunosuppressant that inhibits the activity of FK-506-binding protein. Synonyms: 23-Hydroxy-33-O-tert-butyldimethylsilyloxy-27-O-trimethylsilyl-iso-Tacrolimus; [3S-[3R*[1R*, 2R*, 4(1S*, 3S*, 4S*)], 5R*, 6S*, 10R*, 12R*, 13R*, 14R*, 16S*, 17S*, 24aR*]]-3-[4-[4-[[(1, 1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1, 3-dimethyl-2-[(trimethylsilyl)oxy]-3-butenyl]-4, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 22, 23, 24, 24a-hexadecahydro-5, 17-dihydroxy-12, 14-dimethoxy-8, 10, 16-trimethyl-6-(2-propenyl)-13, 17-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacycloheneicosine-1, 18, 19(21H)-trione; 13,17-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacycloheneicosine-1,18,19(21H)-trione, 3-[4-[4-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1, 3-dimethyl-2-[(trimethylsilyl)oxy]-3-butenyl]-4, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 22, 23, 24, 24a-hexadecahydro-5, 17-dihydroxy-12, 14-dimethoxy-8, 10, 16-trimethyl-6-(2-propenyl)-, [3S-[3R*[1R*, 2R*, 4(1S*, 3S*, 4S*)], 5R*, 6S*, 10R*, 12R*, 13R*, 14R*, 16S*, 17S*, 24aR*]]-. Grades: ≥90%. CAS No. 134556-85-7. Molecular formula: C53H93NO12Si2. Mole weight: 992.48. | |
24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 Quick inquiry Where to buy Suppliers range | 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506. Group: Biochemicals. Alternative Names: 24,32-Bis-O-(tert-butyldimethylsilyl) tacrolimus. Grades: Highly Purified. CAS No. 133941-75-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C56H97NO12Si2. US Biological Life Sciences. | Worldwide |
24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 Quick inquiry Where to buy Suppliers range | 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 is protected form of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: Protected form of fk-506 (tacrolimus). Synonyms: 24,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus; Tacrolimus Impurity 16; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R, 3R, 4R)-4-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-19-hydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-, (3S, 4S, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-. Grades: 95%. CAS No. 133941-75-0. Molecular formula: C56H97NO12Si2. Mole weight: 1032.54. | |
24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) Quick inquiry Where to buy Suppliers range | 24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) is an intermediate of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Synonyms: 24,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-(2, 3-dihydroxypropyl)-5-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R, 3R, 4R)-4-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-19-hydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-, (3S, 4S, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; Tacrolimus Impurity 17. Grades: ≥90%. CAS No. 1356932-17-6. Molecular formula: C56H99NO14Si2. Mole weight: 1066.55. | |
25,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (mixture of diastereomers) Quick inquiry Where to buy Suppliers range | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy Tacrolimus. Grades: Highly Purified. CAS No. 1356932-17-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
25,33-Bis-O-(tert-butyldimethylsilyl)-FK-506 Quick inquiry Where to buy Suppliers range | Protected form of FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus. Grades: Highly Purified. CAS No. 133941-75-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
25,33-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major) Quick inquiry Where to buy Suppliers range | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 25,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus-13CD2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
33-tert-Butyldimethylsilyloxy-FK 506 Quick inquiry Where to buy Suppliers range | 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate of iso-Tacrolimus. Synonyms: [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-3-[2-[4-[[(1, 1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone; 33-tert-Butyldimethylsilyloxy-Tacrolimus; Tacrolimus Impurity 26; Tacrolimus Impurity 15. Grades: ≥95%. CAS No. 104987-25-9. Molecular formula: C50H83NO12Si. Mole weight: 918.28. | |
37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 Quick inquiry Where to buy Suppliers range | 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 is an intermediate of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: An intermediate in the preparation of labelled fk-506 (tacrolimus). Synonyms: 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-fk-506; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-8-acetaldehyde, 5-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-[(E)-2-[(1R, 3R, 4R)-4-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-1, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 26a-docosahydro-19-hydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-1, 7, 20, 21-tetraoxo-, (3S, 4S, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; FK-506 analogue; 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo Tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-8-acetaldehyde, 5-[[(1, 1-dimethylethyl)dimethylsilyl]oxy]-3-[2-[4-[(1, 1-dimethylethyl)dimethylsilyl]-3-methoxycyclohexyl]-1-methylethenyl]-1, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 26a-docosahydro-19-hydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-1, 7, 20, 21-tetraoxo-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4R*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-. Grades: ≥90%. CAS No. 155684-96-1. Molecular formula: C55H95NO13Si2. Mole weight: 1034.51. | |
37-Desmethylene 25,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 Quick inquiry Where to buy Suppliers range | An intermediate in the preparation of labeled FK-506 (Tacrolimus). Group: Biochemicals. Alternative Names: 37-Desmethylene 25,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo Tacrolimus; (3S, 4S, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-. Grades: Highly Purified. CAS No. 155684-96-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-FK-506 Quick inquiry Where to buy Suppliers range | 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo-FK-506. Group: Biochemicals. Alternative Names: 38-Desmethylene 24,32-bis-O-(tert-butyldimethylsilyl)-38-oxo tacrolimus. Grades: Highly Purified. CAS No. 155684-96-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C55H95NO13Si2. US Biological Life Sciences. | Worldwide |
8-Epitacrolimus Quick inquiry Where to buy Suppliers range | 8-Epitacrolimus is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. 8-Epitacrolimus is also an Epimer of Tacrolimus. Group: Biochemicals. Alternative Names: (-)-8-epi-Tacrolimus; [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8R*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: Highly Purified. CAS No. 129212-35-7. Pack Sizes: 500ug. Molecular Formula: C??H??NO??, Molecular Weight: 804.02. US Biological Life Sciences. | Worldwide |
AP1903 Quick inquiry Where to buy Suppliers range | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grades: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
Ascomycin Quick inquiry Where to buy Suppliers range | Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Mollison, K.W., et al. "A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases." J. Invest. Dermatol. 112: 729-738 (1999).Antimalarial effects of ascomycin appear to be independent of its immunosuppressive properties. Monaghan, P., et al. "Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds." J. Infect. Dis. 191: 1342-1349 (2005).FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994). Group: Biochemicals. Alternative Names: Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C43H69NO12, Molecular Weight: 792.01. US Biological Life Sciences. | Worldwide |
Dihydro FK-506 Quick inquiry Where to buy Suppliers range | A novel analog of FK-506 macrocycle. Group: Biochemicals. Alternative Names: Tsukubamycin B; Dihydro Tacrolimus; [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-15, 19-Epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-15, 19-Epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: Highly Purified. CAS No. 104987-30-6. Pack Sizes: 1mg, 2.5mg, 5mg. Molecular Formula: C??H??NO??, Molecular Weight: 806.03. US Biological Life Sciences. | Worldwide |
FK-506-13C,D2 (Major) Quick inquiry Where to buy Suppliers range | A labeled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Group: Biochemicals. Alternative Names: Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
FK-506 3'-Methyl Ether Quick inquiry Where to buy Suppliers range | It is a fermentation process impurity of Tacrolimus, which is a macrolide drug that is widely used as a potent immunosuppressant. Uses: It is a fermentation process impurity. it is formed during tacrolimus ((f370000) fermentation using strain of streptomyces tsukubaensis. Synonyms: 3-[2-(3, 4-Dimethoxycyclohexyl)-1-methylethenyl]-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: 95%. CAS No. 124554-16-1. Molecular formula: C45H71NO12. Mole weight: 818.04. | |
Umirolimus Quick inquiry Where to buy Suppliers range | A semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group. It is one of the most hydrophobic tacrolimus analogues. It binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Synonyms: Biolimus; Biolimus A9; TRM 986; 42-O-(2-Ethoxyethyl)rapamycin. Grades: >95% by HPLC. CAS No. 851536-75-9. Molecular formula: C55H87NO14. Mole weight: 986.28. |