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| Product | Description | |
|---|---|---|
| Telaprevir | Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Highly Purified. CAS No. 402957-28-2. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. |  Worldwide |
| Telaprevir | Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease , the steady-state inhibitory constant ( K i ) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide [1] [2] [3]. Telaprevir inhibits SARS-CoV-2 3CL pro activity [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-950. CAS No. 402957-28-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10235. |  |
| Telaprevir-d4 | A labeled peptidomimetic inhibitor of hepatitis C virus protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- [ (cyclopropyl-d4) amino] -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Telaprevir-[d4] | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. Synonyms: (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-[(cyclopropyl-d4)amino]-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide; LY 570310-d4; MP 424-d4; VRT 111950-d4; VX 950-d4. Grade: >98%. Molecular formula: C36H49D4N7O6. Mole weight: 683.87. |  |
| Telaprevir impurity 6 | Telaprevir impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1033882-31-3. Molecular formula: C19H28N4O4. Mole weight: 376.46. Catalog: APB1033882313. |  |
| Des [N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] carboxamido] 1-tert-Butyloxycarbonyl Telaprevir | Intermediate in the preparation of Telaprevir. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) -2-[ (2S) -2-[[ (2S) -2-Cyclohexyl-2-[ (2-pyrazinylcarbonyl) amino]acetyl]amino]-3, 3-dimethyl-1-oxobutyl]octahydro-cyclopenta[c]pyrrole-1-carboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 926276-19-9. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Hydroxy Telaprevir | Telaprevir. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -1-hydroxy-2-oxoethyl] butyl] octahydro-cyclopenta [c] pyrrole-1-carboxamide-d4. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| (R)-Telaprevir | (R)-Telaprevir is an enantiomer of Telaprevir , an inhibitor of the hepatitis C virus NS3-4A protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) -2- [ (2S) -2- [ [ (2S) -2-cyclohexyl-2- [ (2-pyrazinylcarbonyl) amino] acetyl] amino] -3, 3-dimethyl-1-oxobutyl] -N- [ (1R) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Purified. CAS No. 923270-50-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| L-Cyclohexylglycine methyl ester hydrochloride | L-Cyclohexylglycine methyl ester hydrochloride (CAS# 14328-63-3) is an intermediate used in the synthesis of telaprevir and other pharmaceutical excipients. Synonyms: H-Chg-OMe HCl; H-Phg(hexahydro)-OMe HCl; Hexahydro-L-phenylglycine methyl ester hydrochloride. Grade: ≥ 98 %. CAS No. 14328-63-3. Molecular formula: C9H18ClNO2. Mole weight: 207.70. | |
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