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| Product | Description | |
|---|---|---|
| Telaprevir | Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Highly Purified. CAS No. 402957-28-2. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. |  Worldwide |
| Telaprevir | Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). Telaprevir forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of Telaprevir and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with Telaprevir, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, Telaprevir exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, Telaprevir showed excellent inhibition of HCV NS3-4A protease activity in the liver. Uses: Oligopeptides. Synonyms: Telavic; VRT 111950; VX 950; Incivek; Incivo; LY 570310; MP 424; S-Telaprevir; (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl]butyl]octahydrocyclopenta [c]pyrrole-1-carboxamide. Grades: ≥98% (HPLC). CAS No. 402957-28-2. Molecular formula: C36H53N7O6. Mole weight: 679.85. |  |
| Telaprevir | Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease , the steady-state inhibitory constant ( K i ) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide [1] [2] [3]. Telaprevir inhibits SARS-CoV-2 3CL pro activity [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-950. CAS No. 402957-28-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10235. |  |
| Telaprevir-d4 | A labeled peptidomimetic inhibitor of hepatitis C virus protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- [ (cyclopropyl-d4) amino] -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Telaprevir impurity 6 | Telaprevir impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1033882-31-3. Molecular formula: C19H28N4O4. Mole weight: 376.46. Catalog: APB1033882313. |  |
| Des [N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] carboxamido] 1-tert-Butyloxycarbonyl Telaprevir | Intermediate in the preparation of Telaprevir. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) -2-[ (2S) -2-[[ (2S) -2-Cyclohexyl-2-[ (2-pyrazinylcarbonyl) amino]acetyl]amino]-3, 3-dimethyl-1-oxobutyl]octahydro-cyclopenta[c]pyrrole-1-carboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 926276-19-9. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Hydroxy Telaprevir | Telaprevir. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -1-hydroxy-2-oxoethyl] butyl] octahydro-cyclopenta [c] pyrrole-1-carboxamide-d4. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| (R)-Telaprevir | (R)-Telaprevir is an enantiomer of Telaprevir , an inhibitor of the hepatitis C virus NS3-4A protease. Group: Biochemicals. Alternative Names: (1S, 3aR, 6aS) -2- [ (2S) -2- [ [ (2S) -2-cyclohexyl-2- [ (2-pyrazinylcarbonyl) amino] acetyl] amino] -3, 3-dimethyl-1-oxobutyl] -N- [ (1R) -1- [2- (cyclopropylamino) -2-oxoacetyl] butyl] octahydrocyclopenta [c] pyrrole-1-carboxamide. Grades: Purified. CAS No. 923270-50-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Chlorcyclizine hydrochloride | Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A. Synonyms: NSC 169496; Chlorcyclizine HCl; 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine monohydrochloride. Grades: ≥98%. CAS No. 14362-31-3. Molecular formula: C18H21ClN2·HCl. Mole weight: 337.3. | |
| L-Cyclohexylglycine methyl ester hydrochloride | L-Cyclohexylglycine methyl ester hydrochloride (CAS# 14328-63-3) is an intermediate used in the synthesis of telaprevir and other pharmaceutical excipients. Synonyms: H-Chg-OMe HCl; H-Phg(hexahydro)-OMe HCl; Hexahydro-L-phenylglycine methyl ester hydrochloride. Grades: ≥ 98 %. CAS No. 14328-63-3. Molecular formula: C9H18ClNO2. Mole weight: 207.70. | |
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