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(E)-N'- (9- ( (2R, 3R, 4R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-3- ( (tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6, 9-dihydro-1H-purin-2-yl)-N, N-dimethylformimidamide, a novel molecule with potential applications in cancer therapy, has been shown to act by selectively inhibiting certain proteins critical to cancer cell proliferation and survival. Studies performed in preclinical models demonstrated promising results, and efforts to further develop this compound are currently underway. Defining a precise mechanism of action will require more detailed studies of this complex therapeutic candidate. Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, (4ξ)-; (4ξ)-5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-[(dimethylamino)methylen]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]guanosine. Molecular formula: C40H50N6O7Si. Mole weight: 754.95.
Methyl (3R) -3- (tert-butyldi methyl silyloxy) -5-oxo-6-tri phenylphosphoranylide ne hexanoate
Methyl (3R) -3- (tert-butyldi methyl silyloxy) -5-oxo-6-tri phenylphosphoranylide ne hexanoate. Group: Biochemicals. Grades: Highly Purified. CAS No. 147118-35-2. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C31H39O4PSi. US Biological Life Sciences.
It is used for nucleoside modification and nucleic acid synthesis. Synonyms: 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidine; N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine; N4-acetyl-2'-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)cytidine; 5'-O-(4,4'-Dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl]-N4-acetylcytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]cytidine. Grades: ≥95%. CAS No. 121058-85-3. Molecular formula: C38H47N3O8Si. Mole weight: 701.88.
2'-O-(tert-Butyldimethylsilyl)-6α-hydroxy 7-epi-Paclitaxel is one of Paclitaxel impurities. Paclitaxel is a tetracyclic diterpenoid isolated originally from the Pacific yew tree Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. It has a role as a microtubule-stabilising agent, a metabolite, a human metabolite and an antineoplastic agent. Uses: 6α-hydroxypaclitaxel derivative. Synonyms: (3xi, 5beta, 6alpha, 7alpha, 10beta, 13alpha)-4, 10-Bis(acetyloxy)-13-{[(2R, 3S)-3-benzamido-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpropanoyl]oxy}-1, 6, 7-trihydroxy-9-oxo-5, 20-epoxytax-11-en-2-yl benzoate; 2-tert-Pentylcyclopentanon; 2-(1,1-dimethyl-propyl)-cyclopentan-1-one; 2'-NOR THIAMINE; 2-t-Amyl-cyclopentanon; (2aR, 3S, 4S, 4aS, 6S, 9S, 11S, 12S, 12aR, 12bS)-9-(((2R, 3S)-3-benzamido-2-((tert-butyldimethylsilyl)oxy)-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-3, 4, 11-trihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-d3, 4]benzo[1, 2-b]oxete-6, 12b-diyl diacetate. Grades: > 98%. CAS No. 165065-08-7. Molecular formula: C53H65NO15Si. Mole weight: 984.16.
2'-O-(tert-Butyldimethylsilyl) Paclitaxel
2'-O-(tert-Butyldimethylsilyl) Paclitaxel is one of Paclitaxel impurities. Paclitaxel is a tetracyclic diterpenoid isolated originally from the Pacific yew tree Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. It has a role as a microtubule-stabilising agent, a metabolite, a human metabolite and an antineoplastic agent. Uses: Paclitaxel derivative as antitumor agent. Synonyms: 2'-O-(tert-Butyldimethylsilyl)taxol; (3xi,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-benzamido-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 2'-O-TBS-paclitaxel. Grades: 98%. CAS No. 114655-02-6. Molecular formula: C53H65NO14Si. Mole weight: 968.16.
3'-O-(t-Butyldiphenylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidine, a highly complex and intricately designed nucleoside analog, serves as a paramount tool within the realm of biomedical research. Its profound versatility lies in its crucial role as a precursor in the synthesis of diverse modified oligonucleotides and nucleic acids. By embodying the epitome of precision through advanced molecular engineering techniques, this compound exhibits immense potential in the realm of biomedicine, thereby presenting promising therapeutic applications in combating viral infections and malignancies. Synonyms: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-; 3'-O-(tert-butyldiphenylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]thymidine; 5'-O-[Bis (4-methoxyphenyl) phenylmethyl]-3'-O-[ (1, 1-dimethylethyl) diphenylsilyl]thymidine. Grades: ≥95%. CAS No. 289681-49-8. Molecular formula: C47H50N2O7Si. Mole weight: 782.99.
3'-O-tert-Butyldimethylsilyl-2'-deoxy-5'-O-DMT-adenosine, an intricate and multifaceted compound, finds its utility within the biomedical industry with diverse and intriguing applications. Primarily deployed in drug synthesis and research, this compound assumes a pivotal role as a fundamental constituent for the synthesis of nucleoside analogs. This process bears immense significance in the advancement of antiviral drug development, illustrating its profound impact on therapeutic interventions. Synonyms: 3'-O-(t-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine; 9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-yl]purin-6-amine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]adenosine. Grades: ≥95%. CAS No. 89947-86-4. Molecular formula: C37H45N5O5Si. Mole weight: 667.87.
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine
It is used for special nucleoside or RNA modification. Synonyms: 5'-O-DMT-3'-O-TBDMS adenosine; 5'-O-(4,4'-Dimethoxytrityl)-3'-O-t-butyldimethylsilyl adenosine; (2R, 3R, 4S, 5R) -2- (6-Amino-9H-purin-9-yl) -5- ( (bis (4-methoxyphenyl) (phenyl) methoxy) methyl) -4- ( (tert-butyldimethylsilyl) oxy) tetrahydrofuran-3-ol; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]adenosine; 5'-O-[Bis (4-methoxyphenyl) phenylmethyl]-3'-O-[ (1, 1-dimethylethyl) dimethylsilyl]adenosine. Grades: ≥95%. CAS No. 81794-12-9. Molecular formula: C37H45N5O6Si. Mole weight: 683.87.
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine
It is used for special nucleoside or RNA modification. Synonyms: 5'-O-DMT-3'-O-TBDMS uridine; 5'-O-(4,4'-Dimethoxytrityl)-3'-O-t-butyldimethylsilyl uridine; 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)uridine; 1- ( (2R, 3R, 4S, 5R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4- ( (tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2, 4 (1H, 3H)-dione; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]uridine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine. Grades: ≥95%. CAS No. 81246-81-3. Molecular formula: C36H44N2O8Si. Mole weight: 660.83.
5'-DMT-2'-TBDMS-N6-Me-rA is an extraordinary modified RNA nucleoside, allowing for unrivaled applications in the intricate domain of drug research and development, explicitly targeting RNA-based ailments encompassing malignant neoplasms, viral afflictions is as well as hereditary anomalies. Synonyms: 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N6-methyladenosine; N6-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-Adenosine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-methyladenosine. Grades: ≥98% by HPLC. CAS No. 588698-75-3. Molecular formula: C38H47N5O6Si. Mole weight: 697.91.
5'-DMT-3'-O-TBDMS-N1-Methyl-PseudoUridine
5'-DMT-3'-O-TBDMS-N1-Methyl-PseudoUridine, an essential compound in the field of biomedical research, holds immense significance for studying RNA modifications. Its role as a powerful tool in unraveling the impact of modified nucleosides on RNA structure and function is undeniable. Furthermore, its potential therapeutic implications in combating RNA dysregulation-associated ailments, such as cancer and neurodegenerative disorders, make it a promising avenue worth exploring. Synonyms: 3'-O-tert-butyldimethylsilyl-5'-O-DMT-N1-methylpseudoUridine; 5'-O-(4,4'-Dimethoxytrityl)-3'-O-tert-butyldimethylsilyl-N1-methylpseudouridine; 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1-methyl-; 5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine; 5-[(2S,3S,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-1-methylpyrimidine-2,4-dione. Grades: ≥95%. CAS No. 875302-43-5. Molecular formula: C37H46N2O8Si. Mole weight: 674.86.
5'-O-DMT-2'-O-TBDMS-5-Methyl-L-Uridine 3'-CE phosphoramidite is a DNA synthesis building block with a 5'-dimethoxy trityl group. Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-uridine-3'-cyanoethyl phosphoramidite; 5-O-(4,4'-dimethoxytrityl)-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-2-O-(tert-butyl-dimethyl-silyl)-1-deoxy-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5'-O-[Bis (4-methoxyphenyl) (phenyl)methyl]-3'-O-[ (2-cyanoethoxy) (diisopropylamino)phosphino]-2'-O-[dimethyl (2-methyl-2-propanyl)silyl]-5-methyluridine; DMT-2'-O-TBDMS-5-Me-rU Phosphoramidite. Grades: ≥98% by HPLC. CAS No. 159639-78-8. Molecular formula: C46H63N4O9PSi. Mole weight: 875.09.
5'-O-DMT-2'-O-TBDMS-Inosine
5'-O-DMT-2'-O-TBDMS-Inosine is a modified nucleoside used in the synthesis of deoxyribonucleic acid or nucleic acid. Synonyms: 5'-DMT-2'-TBDMS-rI; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-purin-6-one; 2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)inosine. Grades: ≥98% by HPLC. CAS No. 127212-34-4. Molecular formula: C37H44N4O7Si. Mole weight: 684.85.
Antiviral and anticancer drug for cells infected with influenza A virus, herpes simplex virus type 2, and human lymphocytic leukemia cells. Synonyms: 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-inosine 3'-CE phosphoramidite; 2'-O-(tert-Butyldimethylsilyl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)inosine; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis (4-methoxyphenyl) (phenyl)methyl]-3'-O-[ (2-cyanoethoxy) (diisopropylamino)phosphino]-2'-O-[dimethyl (2-methyl-2-propanyl)silyl]inosine. Grades: ≥97% by HPLC. CAS No. 261518-12-1. Molecular formula: C46H61N6O8PSi. Mole weight: 885.07.
5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-methyl-adenosine 3'-CE phosphoramidite is a vital compound used in the biomedical industry for synthesizing RNA molecules. This phosphoramidite aids in the incorporation of modified adenosine bases during RNA synthesis, enabling researchers to study specific drug targets or diseases related to N6-methyladenosine methylation. By providing precise adenosine modifications, this product facilitates the investigation of gene expression and regulatory mechanisms, leading to potential breakthroughs in drug discovery and disease understanding. Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Me-rA phosphoramidite; 5'-O-[Bis (4-methoxyphenyl) (phenyl)methyl]-3'-O-[ (2-cyanoethoxy) (diisopropylamino)phosphino]-2'-O-[dimethyl (2-methyl-2-propanyl)silyl]-N-methyladenosine. Grades: ≥98% by HPLC. CAS No. 588698-79-7. Molecular formula: C47H64N7O7PSi. Mole weight: 898.11.
5'-O-DMT-3'-O-tert-Butyldimethylsilyl-uridine-2'-CE phosphoramidite is a modified nucleoside used in DNA synthesis. Synonyms: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite; 3'-TBDMS-ibu-rG Phosphoramidite; 5-O-(4,4'-dimethoxytrityl)-2-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-3-O-(tert-butyl-dimethyl-silyl)-1-deoxy-1-uracil-1-yl-beta-D-ribo-pentofuranose; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]. Grades: ≥97% by HPLC. CAS No. 129451-77-0. Molecular formula: C45H61N4O9PSi. Mole weight: 861.05.
7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl-2-debenzoyl Paclitaxel is a derivative of Paclitaxel, which is a chemotherapy medication used to treat a number of types of cancer. Synonyms: (αR,βS)-β-(Benzoylamino)-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[(triethylsilyl)oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester; 2'-(Tert-butyldimethylsilyl)-2-debenzoyl-7-(triethylsilyl)paclitaxel; (2α, 5β, 7β, 10β, 13α)-4, 10-Diacetoxy-1, 2-dihydroxy-9-oxo-7-[(triethylsilyl)oxy]-5, 20-epoxytax-11-en-13-yl (2R,3S)-3-(benzoylamino)-2-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-3-phenylpropanoate. Grades: ≥95%. CAS No. 162459-94-1. Molecular formula: C52H75NO13Si2. Mole weight: 978.32.
(S,E)-2-(3-((tert-Butyldimethylsilyl)oxy)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoic Acid Methyl Ester is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Synonyms: methyl 2-[(3S)-3-[tert-butyl(dimethyl)silyl]oxy-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]propyl]benzoate; (S,E)-2-(3-((tert-Butyldimethylsilyl)oxy)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoic; (S,E)-2-(3-((tert-Butyldimethylsilyl)oxy)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoic Acid Methyl Ester. CAS No. 1772578-77-4. Molecular formula: C34H38ClNO3Si. Mole weight: 572.21.
N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a valuable compound extensively used in the biomedical industry acting as a key intermediate for the synthesis of nucleotides and nucleosides. This product finds application in the development of antiviral drugs targeting various diseases caused by viral infections. Synonyms: 5'-DMT-2'-TBDMS-Bz-rC; 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine; N- (1- ( (2R, 3R, 4R, 5R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-3- ( (tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)benzamide; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoylcytidine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]cytidine; N4-Benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)cytidine. Grades: ≥98% by HPLC. CAS No. 81256-87-3. Molecular formula: C43H49N3O8Si. Mole weight: 763.95.
Tetra-O-(tert-butyldimethyl)silyl cis-Piceatannol. Group: Biochemicals. Alternative Names: (Z) - [ [4- [2- [3, 5-bis [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] phenyl] ethenyl] -1, 2-phenylene] bis (oxy) ] bis [ (1, 1-dimethylethyl) dimethylsilane. Grades: Highly Purified. CAS No. 106325-84-2. Pack Sizes: 10mg. US Biological Life Sciences.
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Zebularine 3'-CE phosphoramidite
Zebularine 3'-CE phosphoramidite is a key compound widely used in biomedical field playing a crucial role in the synthesis of oligonucleotides and specifically designed for the modification of nucleic acids. It enables the research of various diseases, including cancer, by targeting specific gene sequences and regulating gene expression. Synonyms: Zebularine CEP; 155831-90-6; 2/'-O-T-BUTYLDIMETHYLSILYL-3/'-O-[(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINO]-5/'-O-(4,4/'-DIMETHOXY; 3-[[ (2R, 3R, 4R, 5R) -2-[[bis (4-methoxyphenyl) -phenylmethoxy]methyl]-4-[tert-butyl (dimethyl) silyl]oxy-5- (2-oxopyrimidin-1-yl) oxolan-3-yl]oxy-[di (propan-2-yl) amino]phosphanyl]oxypropanenitrile; W-201408; (2R, 3R, 4R, 5R)-2- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4- ( (tert-butyldimethylsilyl)oxy)-5- (2-oxopyrimidin-1 (2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. Grades: 95%. CAS No. 155831-90-6. Molecular formula: C45H61N4O8PSi. Mole weight: 845.04.