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Heterocyclic Organic Compound. Alternative Names: methyl 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate. CAS No. 1041430-21-0. Catalog: ACM1041430210.
1, ?2, ?3, ?4-?Tetrahydrocyclopent [b]?indole
1, 2, 3, 4-Tetrahydrocyclopent [b]indole is used in the synthesis of BACE inhibitors. Also used to synthesize benzazocinecarboxylic acids as potential antiinflammatory agents. Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydrocyclopent [b]indole; 1, 2, 3, 4-Tetrahydrocyclopenta [b]indole; 2,3-(1,3-Propanediyl)-1H-Indole; 2,3-Trimethyleneindole; NSC 112674. Grades: Highly Purified. CAS No. 2047-91-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C11H11N. US Biological Life Sciences.
A potent mutagenic product from the dry distillation of L-lysine. Group: Biochemicals. Alternative Names: 1, 2, 3, 8-Tetrahydrocyclopenta [c]pyrido [3, 2-a]carbazole; Lys-P1. Grades: Highly Purified. CAS No. 69477-66-3. Pack Sizes: 10mg. US Biological Life Sciences.
It is produced by the strain of Aspergillus flavus, Asp. parasiticus. The compound of aflatoxin has the activity of anti-gram-positive bacteria, inhibits cell mitosis, has the effect of liver necrosis and carcinogenesis, and is a mycotoxin which contaminates food. Synonyms: AFLATOXIN M1; 4-Hydroxyaflatoxin B1; 3020O28I3; CCRIS 15; (6aR, 9aR)-9a-hydroxy-4-methoxy-2, 3, 6a, 9a-tetrahydrocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h]chromene-1, 11-dione; (6aR-cis)-2, 3, 6a, 9a-tetrahydro-9a-hydroxy-4-methoxycyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h][1]benzopyran-1, 11-dione; CHEBI:78576; Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-,(6ar,9ar)-. Grades: ≥95%. CAS No. 6795-23-9. Molecular formula: C17H12O7. Mole weight: 328.27.
Aflatoxin Q1
Aflatoxin Q1 is a metabolite of Aflatoxin B1. It is created in human body as a in-vivo detoxification process of Aflatoxin B1. Uses: A metabolite of aflatoxin b1; a hepatocarcinogen in many animal models and probably a human carcinogen. it is produced by the predominant forms of cytochrome p 450 enzymes responsible for the biotransformation of afb1. it shows potential predictive value. Synonyms: Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S,6aR,9aS)-; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S-(3-alpha,6a-alpha,9a-alpha))-; (3S, 6aR, 9aS)-3-hydroxy-4-methoxy-2, 3, 6a, 9a-tetrahydrocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h]chromene-1, 11-dione. Grades: ≥98%. CAS No. 52819-96-2. Molecular formula: C17H12O7. Mole weight: 328.27.
This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49.
Asperulosidic acid
Asperulosidic acid is a naturally occurring compound abundant in diverse plants, garnering immense interest due to its remarkable pharmacological activities. Its anti-inflammatory and antioxidant attributes have propelled its prominence in the biomedical research. Synonyms: (1S,4aS,5S,7aS)-7-[(acetyloxy)methyl]-1-(beta-D-glucopyranosyloxy)-5-hydroxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid. Grades: >98%. CAS No. 25368-11-0. Molecular formula: C18H24O12. Mole weight: 432.4.
Bay 36-7620
BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Synonyms: (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one; BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B. Grades: >98 %. CAS No. 232605-26-4. Molecular formula: C19H18O2. Mole weight: 278.349.
MK-0354 is a partial agonist of Niacin receptor, G-protein coupled receptor 109a. Its EC50 value is 1.65/1.08 μM for hGPR109a/ mGPR109a, which show no activation of GPR109b in the cAMP assay at any concentration up to 100 μM. It demonstrated clear and statistically significant partial agonism in the cAMP assays for both the mouse and human receptors with efficacy approximately 60-70% of that of either nicotinic acid or β-hydroxy butyrate in vitro. It appeared to be somewhat unique among the members of the pyrazole tetrazole series in having reasonable receptor activity. It retained the plasma free fatty acid lowering effects in mice, but did not induce vasodilation at the maximum feasible dose in vivo. It could activate the antilipolytic pathway in adipocytes. It was developed by Arena pharmaceuticals and Merck Serono together. It had been in the two phase of clinical and been used for the treatment of atherosclerosis, but it was terminated in 2006. Uses: Mk-0354 could activate the antilipolytic pathway in adipocytes. had been used for the treatment of atherosclerosis. Synonyms: MK-0354; MK0354; MK 0354; 3-(1H-tetrazol-5-yl)-1, 4, 5, 6-tetrahydrocyclopenta[c]pyrazole;1, 4, 5, 6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole. Grades: >98%. CAS No. 851776-28-8. Molecular formula: C7H8N6. Mole weight: 176.18.
Sch59498
Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c) with antihypertensive and antiplatelet effect. Synonyms: Sch59498; Sch 59498; Sch-59498; 2-hexyl-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one; 2-Hexyl-5-methyl-7,8-propano-1,4,7beta,8beta-tetrahydro-5H-imidazo[2,1-b]purine-4-one; (6aR,9aS)-2-Hexyl-5,6a,7,8,9,9a-hexahydro-5-methylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one; DYIUKMSMAJWWAT-NEPJUHHUSA-N. CAS No. 224157-99-7. Molecular formula: C17H25N5O. Mole weight: 315.41.
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