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Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1682653-80-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130551.
1,4-Dihydro-[1,2,4,5]tetrazine-3,6-dicarboxylic acid,disodium salt
1,4-Dihydro-[1,2,4,5]tetrazine-3,6-dicarboxylic acid,disodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,4-DIHYDRO-[1,2,4,5]TETRAZINE-3,6-DICARBOXYLIC ACID, DISODIUM SALT. Product Category: Heterocyclic Organic Compound. CAS No. 96898-32-7. Molecular formula: C4H2N4Na2O4. Mole weight: 216.06. Purity: 0.96. IUPACName: disodium 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylate. Product ID: ACM96898327. Alfa Chemistry ISO 9001:2015 Certified.
Also known as 5-carboxyfluorescein-PEG4-Tetrazine. A pegylated FAM dye with enhanced water solubility and containing a tetrazine moiety for Tetrazine-TCO ligation. Uses: For industrial and laboratory use. Product Category: Fluorescein Dyes. Appearance: Red solid. Molecular formula: C41H40N6O11. Mole weight: 792.79 g/mol. Purity: 0.95. Product ID: DYE-FLU-0064. Alfa Chemistry ISO 9001:2015 Certified.
BDP TR methyltetrazine
BDP TR methyltetrazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[4-(2,2-Difluoro-12-thiophen-2-yl-1,3-diaza-2-boranuidatricyclo[7.3.0.03,7]dodeca-5,7,9,11-tetraen-4-yl)phenoxy]-N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]acetamide. Product Category: BODIPY Fluorophores. CAS No. 2183473-54-1. Molecular formula: C31H24BF2N7O2S. Mole weight: 607.5. Purity: 0.98. IUPACName: 2-[4-(2,2-difluoro-12-thiophen-2-yl-1,3-diaza-2-boranuidatricyclo[7.3.0.03,7]dodeca-5,7,9,11-tetraen-4-yl)phenoxy]-N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]acetamide. Canonical SMILES: [B-]1(N2C(C=CC2=CC3=CC=C(N31)C4=CC=CS4)C5=CC=C(C=C5)OCC(=O)NCC6=CC=C(C=C6)C7=NN=C(N=N7)C)(F)F. Product ID: ACM2183473541-1. Alfa Chemistry ISO 9001:2015 Certified.
Janelia Fluor® 646, Tetrazine
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging [1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF646, Tetrazine. CAS No. 2042192-00-5. Pack Sizes: 200 μg; 500 μg; 1 mg. Product ID: HY-138659.
Methyltetrazine-Amine
Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345955-28-3. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135140.
Methyltetrazine-amine hydrochloride
Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1596117-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135140A.
Methyltetrazine-PEG4-maleimide
Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1802908-02-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-141278.
Sulfo-Cy3-Methyltetrazine
Sulfo-Cy3-Methyltetrazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-Methyl-Tetrazine-Sulfo-Cy3. Product Category: Cyanine Fluorophores. CAS No. 1801924-47-9. Molecular formula: C42H49N7O10S3. Mole weight: 908.1. Purity: 0.95. Product ID: ACM1801924479-1. Alfa Chemistry ISO 9001:2015 Certified.
Sulfo-Cy3-Tetrazine
Sulfo-Cy3-Tetrazine. Uses: Designed for use in research and industrial production. Product Category: Cyanine Fluorophores. CAS No. 2055138-86-6. Molecular formula: C41H47N7O10S3. Mole weight: 894.1. Purity: 0.9. Product ID: ACM2055138866-1. Alfa Chemistry ISO 9001:2015 Certified.
Sulfo-Cy5-tetrazine
Sulfo Cy5-tetrazine is a tetrazine-coupled Cy5 (HY-D0821) derivative dye with fluorescence properties similar to CY5 (Ex/Em=633/647 nm). Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1801695-57-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D1482.
Sulfo-Cy5-Tetrazine
Sulfo-Cy5-Tetrazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cy5tetrazine. Product Category: Cyanine Fluorophores. CAS No. 1801695-57-7. Molecular formula: C43H49N7O10S3. Mole weight: 920.1. Purity: 0.9. IUPACName: 2-[(1E,3E,5E)-5-[3,3-dimethyl-1-[6-oxo-6-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methylamino]hexyl]-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethyl-1-(3-sulfopropyl)indol-1-ium-5-sulfonate. Canonical SMILES: CC1(C2=C(C=CC(=C2)S(=O)(=O)[O-])[N+](=C1/C=C/C=C/C=C/3\C(C4=C(N3CCCCCC(=O)NCC5=CC=C(C=C5)C6=NN=CN=N6)C=CC(=C4)S(=O)(=O)O)(C)C)CCCS(=O)(=O)O)C. Product ID: ACM1801695577-1. Alfa Chemistry ISO 9001:2015 Certified.
1,2,3-Triaminoguandine Hydrochloride
1,2,3-Triaminoguandine is used to prepare 3-arylamino-6-benzylamino-1,2,4,5-tetrazines with antimalarial activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5329-29-3. Pack Sizes: 250mg, 1g. Molecular Formula: CH9ClN6, Molecular Weight: 140.58. US Biological Life Sciences.
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Clofentezine
Clofentezine. Group: Biochemicals. Alternative Names: NC 21314; 3,6-Bis(2-chlorophenyl)-1,2,4,5-tetrazine; Acaristop; Apollo; Apollo (pesticide); Apollo 50W; Apollo SOSC; Bisclofentezin; Bisclofentezine; 3,6-Bis(2-chlorophenyl)-1,2,4,5-tetrazine. Grades: Highly Purified. CAS No. 74115-24-5. Pack Sizes: 1g. Molecular Formula: C14H8Cl2N4, Molecular Weight: 303.149999999999. US Biological Life Sciences.
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Clofentezine
Clofentezine is an active substance of plant protection product used as pesticide, acaricide. It belongs to the chemical family of quinoxalines. It is used in agriculture for the protection of ornamentals, food and non-food crops in the field. It has sublethal effects on life-table parameters of Tetranychus urticae Koch females. Uses: Clofentezine is used as a pesticide, acaricide. it is used in agriculture for the protection of ornamentals, food and non-food crops in the field. Synonyms: NC 21314; 3, 6-Bis(2-chlorophenyl)-1, 2, 4, 5-tetrazine; Acaristop; Apollo; Bisclofentezin. Grades: 98%. CAS No. 74115-24-5. Molecular formula: C14H8Cl2N4. Mole weight: 303.15.
TCO-NHS ester
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191901-33-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-141165.
TCO-PEG3-FITC
A FITC probe functionalized with a TCO moiety for tetrazine-TCO ligation and a PEG3 spacer. Uses: For industrial and laboratory use. Product Category: Other Fluorescent Dyes. Appearance: Orange solid. Molecular formula: C38H43N3O10S. Mole weight: 733.83 g/mol. Purity: 0.95. Product ID: DYE-FLU-0102. Alfa Chemistry ISO 9001:2015 Certified.
TCO-PEG4-NHS ester
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1621096-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141167A.
Temozolomide
Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, Methazolastone, M&B 39831, Temodal, Temodar; CCRG 81045, TMZ; NSC 362856. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 10mg, 25mg, 100mg. US Biological Life Sciences.
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Temozolomide Acid
A metabolite of Temozolomide as antitumor agent. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid. Grades: Highly Purified. CAS No. 113942-30-6. Pack Sizes: 10mg. US Biological Life Sciences.
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Temozolomide Acid
Temozolomide acid is an active metabolite of temozolomide(T017775) with anticancer activity in vitro. Temozolomide is an alkylating agent used as a treatment of some brain cancer, a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.In Apr 2016, Stanford University and Merck suspended enrolment in a phase II trial for Acute myeloid leukaemia (Combination therapy, Newly diagnosed, Second-line therapy or greater) in USA. In 14 Jul 2016, Medivation planed a phase II trial for Endometrial cancer in USA (NCT02836028) After two days, M.D. Anderson Cancer Center completed a phase II trial in Malignant melanoma (Late-stage disease, Neoadjuvant therapy, Monotherapy, Combination therapy) in USA. Uses: As an antitumor agent. Synonyms: 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxylic Acid; Temozolomide-8-carboxylic Acid; TMZA. Grades: 98%. CAS No. 113942-30-6. Molecular formula: C6H5N5O3. Mole weight: 195.14.
Temozolomide Cyano Impurity
One impurity of Temozolomide, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 8-Descarboxamido-8-cyano Temozolomide; 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carbonitrile; Cyanotemozolomide; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile. Grades: > 95%. CAS No. 114601-31-9. Molecular formula: C6H4N6O. Mole weight: 176.14.
MOF&Benzenemethanamine, 4-(6-methyl-1,2,4,5-tetrazin-3-yl)-. Group: Organic-linker blocks- other linker blocks.
NEO 212
NEO 212 is a novel DNA alkylating agent that causes DNA damage and cancer cell apoptosis. It has the potent activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 μM for cytotoxicity on glioma cell lines). NEO212 is a conjugate of temozolomide (TMZ) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas. Uses: Dna alkylating agent. Synonyms: NEO 212; NEO212; NEO-212; [(4S)-4-Isopropenyl-1-cyclohexen-1-yl]methyl [(3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazin-8-yl)carbonyl]carbamate. Grades: 99%. CAS No. 1361198-79-9. Molecular formula: C17H20N6O4. Mole weight: 372.38.
Labeled Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 1mg. US Biological Life Sciences.
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