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| Product | Description | |
|---|---|---|
| TGR5 | A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222. |  |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. |  |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Betulinic Acid | Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. Group: Biochemicals. Alternative Names: Mairin; (+)-Betulinic acid; 3 β-Hydroxylup-20(29)-en-28-oic Acid; Betulic Acid; Lupatic Acid; NSC 113090; β-Betulinic Acid; (3 β)-3-HydroxyLup-20(29)-en-28-oic Acid. Grades: Highly Purified. CAS No. 472-15-1. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C??H??O?, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
| Cholic acid 7-sulfate | Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Sulfocholic acid. CAS No. 60320-05-0. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-126855. | |
| Cloxacillin EP Impurity D | 3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic Acid is used in the preparation of isoxazolecarboxamides as a class of TGR5 agonists. It is also used in the preparation of β-lactamase inhibitors. Synonyms: 3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic Acid. Grades: > 95%. CAS No. 23598-72-3. Molecular formula: C11H8ClNO3. Mole weight: 237.64. | |
| Deoxycholic acid | Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptor TGR5 [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Cholanoic Acid; Desoxycholic acid. CAS No. 83-44-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0593. | |
| Deoxycholic acid | Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is specifically responsible for activating the G-protein-coupled bile acid receptor TGR5, stimulating the thermogenic activity of brown adipose tissue (BAT). Uses: Hypotensive. Synonyms: Cholanoic Acid; Desoxycholic acid; 3α,12α-dihydroxy-5β-cholanate; Deoxycholate; Cholerebic; Degalol; Droxolan; Pyrochol; 5β-cholanic acid-3α,12α-diol; 7-Deoxycholic acid; 5β-Deoxycholic Acid; NSC 8797; Septocholl; Ursodeoxycholic Acid EP Impurity E. Grades: >98%. CAS No. 83-44-3. Molecular formula: C24H40O4. Mole weight: 392.58. | |
| Deoxycholic acid sodium salt | Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptor TGR5 [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium deoxycholate. CAS No. 302-95-4. Pack Sizes: 100 mg; 500 mg. Product ID: HY-N0593A. | |
| EP-024297 | EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid (OCA). EP-024297 is selective for FXR over TGR5. It promisingly becomes a new treatment of NASH. Uses: The potential treatment of nash. Synonyms: EP-024297; EP 024297; EP024297. | |
| Hyocholic Acid | Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 547-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121238. | |
| Hyodeoxycholic acid | Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC 50 of 31.6 μM in CHO cells. Uses: Scientific research. Group: Natural products. Alternative Names: HDCA. CAS No. 83-49-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0169. | |
| Hyodeoxycholic acid (HDCA) | Hyodeoxycholic acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. It is a TGR5 (GPCR19) agonist, with an EC50 of 31.6 μM in CHO cells. Synonyms: Iodeoxycholic acid; 7-Deoxyhyocholic acid; 3α,6α-Dihydroxy-5β-cholan-24-oic acid; 5β-cholan-24-oic acid-3α,6α-Diol; α-Hyodeoxycholic acid; 3α,6α-Dihydroxy-5β-cholanic acid. Grades: >98%. CAS No. 83-49-8. Molecular formula: C24H40O4. Mole weight: 392.57. | |
| INT-767 | INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was just planed a Phase II trial for Hepatic fibrosis. IC50: 30 nM(EC50, FXR), 630 nM(EC50, TGR5). Uses: Int-767 has been found to be a inhibitor of fxr and tgf5 and could have probable effect against some liver and metabolic diseases. Synonyms: INT-767; INT 767; INT767; CS-5007; CS 5007; CS5007; HY-12434; HY 12434; HY12434; Sulfuric acid sodium 3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholane-23-yl ester salt. Grades: 98%. CAS No. 1000403-03-1. Molecular formula: C25H43NaO6S. Mole weight: 494.66. | |
| INT-777 | INT-777(S-EMCA) is a novel potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 uM). Synonyms: INT-777; INT 777; INT777; 6-EMCA; S-EMCA; ?HY-15677. Grades: >98%. CAS No. 1199796-29-6. Molecular formula: C27H46O5. Mole weight: 450.65. | |
| Lithocholic Acid | A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol; 3-Hydroxycholan-24-oic Acid; 3α-Hydroxy-5 β-cholan-24-oate; 3α-Hydroxy-5 β-cholan-24-oic Acid; 3α-Hydroxy-5 β-cholanic Acid; 3α-Hydroxy-5 β-cholanoic Acid; 3α-Hydroxycholanic Acid; NSC 683770. Grades: Highly Purified. CAS No. 434-13-9. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Lithocholic Acid | A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3α-Hydroxy-5β-cholanic acid. Product Category: Steroidal Compounds. Appearance: White to off-white powder. CAS No. 434-13-9. Molecular formula: C24H40O3. Mole weight: 376.57. Purity: 0.98. IUPACName: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. Canonical SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C. Density: 1.0454 g/cm³. ECNumber: 207-099-1. Product ID: ACM434139. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Lithocholic Acid 24-Ac-O-β-D-Glucuronide | Lithocholic Acid 24-Ac-O-β-D-Glucuronide is an impurity of Lithocholic Acid (L469180), a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Synonyms: 1-[(3α,5β)-3-Hydroxycholan-24-oate] β-D-Glucopyranuronic Acid. CAS No. 142780-61-8. Molecular formula: C30H48O9. Mole weight: 552.7. | |
| Lithocholic Acid 3-O-Glucuronide | Lithocholic Acid 3-O-Glucuronide is an impurity of Lithocholic Acid, a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Synonyms: (3α,5β)-23-Carboxy-24-norcholan-3-yl β-D-Glucopyranosiduronic Acid; Lithocholic Acid 3-Glucuronide. Grades: 98%. CAS No. 75239-91-7. Molecular formula: C30H48O9. Mole weight: 552.7. | |
| Lithocholic Acid-d4 | A labeled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid-d4; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol-d4; 3-Hydroxycholan-24-oic Acid-d4; 3α-Hydroxy-5 β-cholan-24-oate-d4; 3α-Hydroxy-5 β-cholan-24-oic Acid-d4; 3α-Hydroxy-5 β-cholanic Acid-d4; 3α-Hydroxy-5 β-cholanoic Acid-d4; 3α-Hydroxycholanic Acid-d4; NSC 683770-d4. Grades: Highly Purified. CAS No. 83701-16-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Lithocholic Acid-d5 | A labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid-d5; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol-d5; 3-Hydroxycholan-24-oic Acid-d5; 3α-Hydroxy-5 β-cholan-24-oate-d5; 3α-Hydroxy-5 β-cholan-24-oic Acid-d5; 3α-Hydroxy-5 β-cholanic Acid-d5; 3α-Hydroxy-5 β-cholanoic Acid-d5; 3α-Hydroxycholanic Acid-d5; NSC 683770-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Methyl Isolithocholate-d7 | Methyl Isolithocholate-d7 is a labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: Methyl 3 β-Hydroxy-5 β-cholanoate; 3 β-Hydroxy-5 β-cholanic Acid Methyl Ester-d7; (3 β,5 β)-3-Hydroxycholan-24-oic Acid Methyl Ester-d7. Grades: Highly Purified. CAS No. 5405-42-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Methyl Lithocholate | Methyl Lithocholate is an derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: Lithocholic Acid Methyl Ester-d7; Methyl 3α-Hydroxy-5 β-cholan-24-oate-d7; Methyl 3α-Hydroxy-5 β-cholanoate-d7; 3α-Hydroxy-5 β-cholanic Acid-d7; 3α-Hydroxy-5 β-cholan-24-oic Acid Methyl Ester-d7; (3α,5 β)-3-Hydroxycholan-24-oic Acid Methyl Ester-d7. Grades: Highly Purified. CAS No. 1249-75-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Methyl Lithocholate-d7 | Isotope labelled derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: Lithocholic Acid Methyl Ester-d7; Methyl 3α-Hydroxy-5 β-cholan-24-oate-d7; Methyl 3α-Hydroxy-5 β-cholanoate-d7; 3α-Hydroxy-5 β-cholanic Acid-d7; 3α-Hydroxy-5 β-cholan-24-oic Acid Methyl Ester-d7; (3α,5 β)-3-Hydroxycholan-24-oic Acid Methyl Ester-d7. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Milbemycin oxime | Milbemycin oxime is a semi-synthetic macrolide. As a nematocide and insecticide in veterinary medicine, it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50=2.6 μM (Plasmodium falciparum 3D7); Bile acid transporter: IC50=3.6 μM (human); TGR5: IC50=36.4 μM (human); HCT-116: IC50 >50 μM (human); GBM: IC50 >50 μM (human). Uses: A broad spectrum insecticide; used for treatment and prevention of heartworm in dogs and cats. Synonyms: Milbemycin A 5-oxime; Milbemite; Trifexis; Interceptor; Milbe Mite. Grades: ≥98%. CAS No. 129496-10-2. Molecular formula: C126H176N4O28. Mole weight: 2194.78. | |
| SB756050 | SB756050 is a selective TGR5 agonist currently undergone testing in a phase 1 clinical trials study in the treatment of type 2 diabetes. Synonyms: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane; SB756050; F1018-1711; 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane; SB-756050; SB 756050; SB756050. CAS No. 447410-57-3. Molecular formula: C21H28N2O8S2. Mole weight: 500.59. | |
| Sulfolithocholic Acid Trimethylamine Salt | Sulfolithocholic Acid is an derivative of Lithocholic Acid (L469180), a cholic acid derivative and TGR5 modulator found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: 3α-Sulfate-5 β-cholan-24-oic Acid Trimethylamine Salt; Lithocholic Acid 3-O-Sulfate Trimethylamine Salt ; Lithocholic Acid 3α-Sulfate Trimethylamine Salt; (3α,5 β)-3-(Sulfooxy)-cholan-24-oic Acid Trimethylamine Salt. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Taurodeoxycholic acid sodium hydrate | Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium taurodeoxycholate monohydrate. CAS No. 110026-03-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1899A. | |
| TC-G 1005 | TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5) that selectively activates TGR5 over FXR (farnesoid X receptor). TC-G 1005 has been shown to increase plasma GLP-1 level and lower blood glucose level in mice. Synonyms: TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005; (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone. Grades: ≥98% by HPLC. CAS No. 1415407-60-1. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| Triamterene | Triamterene blocks epithelial Na + channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 396-01-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0575. | |
| Triamterene (Standard) | Triamterene (Standard) is the analytical standard of Triamterene. This product is intended for research and analytical applications. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 396-01-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B0575R. | |
| Ursodeoxycholic acid | Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 ( TGR5 , GPCR19 ) and the farnesoid X receptor ( FXR ). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Ursodeoxycholate; Ursodiol; UDCA. CAS No. 128-13-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-13771. | |
| Ursodeoxycholic acid-2,2,4,4-d4 | Ursodeoxycholic acid-2,2,4,4-d 4 is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 347841-46-7. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-113478S. | |
| Ursodeoxycholic acid sodium | Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 ( TGR5 , GPCR19 ) and the farnesoid X receptor ( FXR ). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium. CAS No. 2898-95-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-13771A. | |
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