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| Product | Description | |
|---|---|---|
| Thapsigargin | ?98% (HPLC), solid film. Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. |  |
| Thapsigargin | A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels. Group: Biochemicals. Alternative Names: Octanoic Acid (3S, 3aR, 4S, 6S, 6aR, 7S, 8S, 9bS)-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester; (-)-Thapsigargin; Octanoic Acid [3S-[3α,3a β,4α,6 β,6a β,7 β, 8α(Z), 9bα]]-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b-decahydro-3, 3a-dihydroxy-3, 6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4, 5-b]furan-7-yl Ester. Grades: Highly Purified. CAS No. 67526-95-8. Pack Sizes: 2.5mg. US Biological Life Sciences. |  Worldwide |
| Thapsigargin | Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations. In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects. Uses: Enzyme inhibitors. Synonyms: Octanoic acid. Grade: >99%. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. |  |
| Thapsigargin | Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca 2+ -ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 67526-95-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13433. |  |
| Thapsigargin | Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types. Uses: Designed for use in research and industrial production. Additional or Alternative Names: THAPSIGARGIN;Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester;(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azul. Product Category: Inhibitors. Appearance: liquid or film. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. Purity: 0.95. IUPACName: [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl]octanoate. Canonical SMILES: CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O. ECNumber: 614-076-3. Product ID: ACM67526958. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Thapsigargin | Thapsigargin Inhibitor. Uses: Scientific use. Product Category: TQ0302. CAS No. 67526-95-8. |  |
| Thapsigargin Ready Made Solution | ?98% (HPLC), 10 mM in DMSO. Group: Fluorescence/luminescence spectroscopy. | |
| 11-Aminoundecanoic acid | 11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1'as matrix metalloproteinase inhibitors. Synonyms: ω-Aminoundecanoic acid; Undecanoic acid, 11-amino-; 11-Aminoundecylic acid; 11-amino-undecanoic acid; H-11-Aun-OH. Grade: ≥ 99% (Titration). CAS No. 2432-99-7. Molecular formula: C11H23NO2. Mole weight: 201.31. | |
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