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| Product | Description | |
|---|---|---|
| thermolysin | A thermostable extracellular metalloendopeptidase containing four calcium ions. Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. Type example of peptidase family M4. Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. Group: Enzymes. Synonyms: Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN. Enzyme Commission Number: EC 3.4.24.27. CAS No. 9073-78-3. TLN. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4308; thermolysin; EC 3.4.24.27; 9073-78-3; Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN. Cat No: EXWM-4308. |  |
| Native Bacillus thermoproteolyticus Thermolysin | Thermolysin is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacteria Bacillus thermoproteolyticus. It requires one zinc ion for enzyme activity and four calcium ions for structural stability. Thermolysin specifically catalyzes the hydrolysis of peptide bonds containing hydrophobic amino acids. However thermolysin is also widely used for peptide bond formation through the reverse reaction of hydrolysis. Thermolysin is the most stable member of a family of metalloproteinases produced by various Bacillus species. These enzymes are also termed 'neutral' proteinases or thermolysin-like proteinases (TLPs). Group: Enzymes. Synonyms: thermolysin; Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN; EC 3.4.24.27. Enzyme Commission Number: EC 3.4.24.27. CAS No. 9073-78-3. TLN. Mole weight: 36.2kDa. Activity: Reverse-phase HPLC analysis shows <30% of undigested insulin after 10 minutes of incubation with Thermolysin at 75°C using a 1:20 thermolysin:insulin ratio. Form: Lyophilized. Source: Bacillus thermoproteolyticus. thermolysin; Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN; EC 3.4.24.27. Cat No: NATE-0705. | |
| Native Geobacillus stearothermophilus Thermolysin | Thermolysin is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacteria Bacillus thermoproteolyticus. It requires one zinc ion for enzyme activity and four calcium ions for structural stability. Thermolysin specifically catalyzes the hydrolysis of peptide bonds containing hydrophobic amino acids. However thermolysin is also widely used for peptide bond formation through the reverse reaction of hydrolysis. Thermolysin is the most stable member of a family of metalloproteinases produced by various Bacillus species. These enzymes are also termed 'neutral' proteinases or thermolysin-like proteinases (TLPs). Suitable for cell culture. Applica... of n-terminal to phe which is preferred over the others. often used to do limited proteolysis for peptide mapping and studies of protein structure and conformational changes. Group: Enzymes. Synonyms: thermolysin; Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN; EC 3.4.24.27. Enzyme Commission Number: EC 3.4.24.27. CAS No. 9073-78-3. TLN. Activity: 30-175 units/mg protein (E1%/280). Storage: -20°C. Form: lyophilized powder containing calcium and sodium acetate buffer salts. Source: Geobacillus stearothermophilus. thermolysin; Bacillus thermoproteolyticus neutral proteinase; thermoase; thermoase Y10; TLN; EC 3.4.24.27. Cat No: NATE-0704. | |
| bacillolysin | Variants of this enzyme have been found in species of Bacillus including B. subtilis, B. amyloliquefaciens, B. megaterium (megateriopeptidase,), B. mesentericus, B. cereus and B. stearothermophilus. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: Bacillus metalloendopeptidase; Bacillus subtilis neutral proteinase; anilozyme P 10; Bacillus metalloproteinase; Bacillus neutral proteinase; megateriopeptidase. Enzyme Commission Number: EC 3.4.24.28. CAS No. 9080-56-2. Neutral Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4309; bacillolysin; EC 3.4.24.28; 9080-56-2; Bacillus metalloendopeptidase; Bacillus subtilis neutral proteinase; anilozyme P 10; Bacillus metalloproteinase; Bacillus neutral proteinase; megateriopeptidase. Cat No: EXWM-4309. | |
| coccolysin | A 30 kDa endopeptidase found intracellularly in S. thermophilus and S. diacetilactis and in the medium of S. faecalis. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: Streptococcus thermophilus intracellular proteinase; EM 19000. Enzyme Commission Number: EC 3.4.24.30. CAS No. 156859-08-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4312; coccolysin; EC 3.4.24.30; 156859-08-4; Streptococcus thermophilus intracellular proteinase; EM 19000. Cat No: EXWM-4312. | |
| FA-Gly-Abu-NH2 | FA-Gly-Abu-NH2 can be used as substrate in a substrate specificity study of thermolysin. Synonyms: 3-(2-Furyl)acryloyl-Gly-Abu-NH2. Grades: ≥ 98%. CAS No. 67607-48-1. Molecular formula: C13H17N3O4. Mole weight: 279.30. |  |
| Ilomastat | Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor, displaying potential anticancer activity. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Ilomastat inhibits enzymes including thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. Synonyms: GM6001; GM-6001; GM 6001; Ilomastat; galardin; (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanedia. Grades: 98%. CAS No. 142880-36-2. Molecular formula: C20H28N4O4. Mole weight: 388.468. | |
| Metalloproteinase from Staphylococcus aureus | A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example of this would be meltrin which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt. The metal ion is coordinated to the protein via three ligands. The ligands co-ordinating the metal ion can vary with histidine, glutamate, aspartate, lysine, and arginine. The fourth coordination position is taken up by a labile water molecule. Treatment with chelating agents such as EDTA leads to complete inactivation. EDTA is a metal chelator that rem...tial for activity. They are also inhibited by the chelator orthophenanthroline. Applications: Enzyme used for structural and enzymological studies. specificity similar to that of thermolysin with preference to hydrophobic p1' residues. Group: Enzymes. Synonyms: Aureolysin. Enzyme Commission Number: EC 3.4.24.29. CAS No. 39335-13-2. Purity: > 95 % (SDS-PAGE). Metalloproteinase. Mole weight: 28000. Storage: at -15 °C to -25 °C. Form: Lyophilized from 20 mM Tris/HCl pH 7.8, containing 5-10 mM CaCl2. Source: Staphylococcus aureus. Aureolysin; EC 3.4.24.29; Metalloproteinase; Staphylococcus aureus neutral proteinase; Staphylococcus aureus neutral protease. Cat No: NATE-1617. | |
| mycolysin | From Streptomyces griseus, S. naraensis, and S. cacaoi. Specificity similar to that of thermolysin, but much more sensitive to inhibition by mercaptoacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family M5. Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: pronase component; Streptomyces griseus neutral proteinase; actinase E; SGNPI. Enzyme Commission Number: EC 3.4.24.31. CAS No. 153190-34-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4313; mycolysin; EC 3.4.24.31; 153190-34-2; pronase component; Streptomyces griseus neutral proteinase; actinase E; SGNPI. Cat No: EXWM-4313. | |
| Phosphoramidon disodium | Phosphoramidon disodium, a microbial metabolite , is a specific metalloprotease thermolysin inhibitor with an IC 50 of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme ( ECE ), neutral endopeptidase ( NEP ), and angiotensin-converting enzyme ( ACE ) with IC 50 values of 3.5, 0.034, and 78 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 164204-38-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2021A. |  |
| Phosphoramidon Disodium Salt | Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. Synonyms: N-(alpha-Rhamno-pyranosyl-phos-phono)-L-leucyl-L-tryptophan disodium salt; L-Tryptophan, N- ( ( (6-deoxy-alpha-L-mannopyranosyl) oxy) hydroxyphosphinyl) -L-leucyl-, disodium salt. Grades: >98%. CAS No. 164204-38-0. Molecular formula: C23H32N3Na2O10P. Mole weight: 587.47. | |
| pseudolysin | In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage. Group: Enzymes. Synonyms: Pseudomonas elastase; Pseudomonas aeruginosa neutral metalloproteinase. Enzyme Commission Number: EC 3.4.24.26. CAS No. 171715-23-4. ELA1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4307; pseudolysin; EC 3.4.24.26; 171715-23-4; Pseudomonas elastase; Pseudomonas aeruginosa neutral metalloproteinase. Cat No: EXWM-4307. | |
| TDSP5 | TDSP5, a low molecular weight protamine as a nontoxic heparin/low molecular weight heparin antidote, is a homogeneous 1880-d peptide fragment derived directly from protamine by enzymatic digestion of protamine with thermolysin. TDSP5 neutralizes the anticoagulant effects of heparin and commercial low molecular-weight heparin preparations. TDSP5 shows significantly reduced crossreactivity toward mouse sera containing antiprotamine antibodies. TDSP5 exhibits a decrease in its potential in activating the complement system. Synonyms: LMWP-TDSP5; Low molecular weight protamine-TDSP5. | |
| vibriolysin | Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: Aeromonas proteolytica neutral proteinase; aeromonolysin. Enzyme Commission Number: EC 3.4.24.25. CAS No. 69598-88-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4306; vibriolysin; EC 3.4.24.25; 69598-88-5; Aeromonas proteolytica neutral proteinase; aeromonolysin. Cat No: EXWM-4306. | |
| Z-L-phenylalanine | An inhibitor of thermolysin. Synonyms: Z-L-Phe-OH; N-Carbobenzoxy-L-phenylalanine. Grades: ≥ 98% (HPLC). CAS No. 1161-13-3. Molecular formula: C17H17NO4. Mole weight: 299.30. | |
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