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| Product | Description | |
|---|---|---|
| Poly(2-ethyl-2-oxazoline), α-benzyl, ω-thiol terminated | 2-Ethyl-2-oxazoline is an oxazoline which is used particularly as a monomer for the cationic ring-opening polymerization to poly(2-alkyloxazoline)s. This type of polymers are under investigation as readily water-soluble and biocompatible materials for biomedical applications. Uses: Poly(2-ethyl-2-oxazoline) is a hydrophilic polymer that is commonly used in biomedical s. this is a biocompatible polymer with one chain-end functionalized with a thiol group which is commonly used in ligation as well as in thiol-ene click chemistry. these polymers are commonly used as an amorphous alternative to pegs. Group: Hydrophilic polymers. Alternative Names: Polyoxazoline, PEtOx, POx. Pack Sizes: Packaging 5 g in glass bottle. Molecular formula: average Mn 10,000. Mole weight: C6H5CH2(C5H9NO)nSH. |  |
| Poly(ethylene oxide), 4-arm, thiol terminated | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 10000. | |
| Poly(L-lactide), thiol terminated | Poly(L-lactide) (PLLA) and its copolymers are among the most studied biodegradable polymers. PLLA is a crystalline polymer with good mechanical properties. The applications of PLLA are mainly concentrated in biomedical applications. Group: 3d printing materials biodegradable polymers. Alternative Names: thioPLA, mercapto PLLA, mercapto PLA. Molecular formula: average Mn 2,500. Mole weight: H(C3H4O2)nOC2H4SH. | |
| Polystyrene thiol terminated | Polystyrene is a colorless and transparent thermoplastic, among which expanded polystyrene is commonly known as Styrofoam. Uses: This is a well-defined polystyrene with thiol functionality on one end and cyano on the other. the thiol functionality is versatile and commonly used in surface modifying nanoparticles; attaching to au to form self assembled monolayers (sams); as well as thiol - ene click chemistry. Group: Hydrophobic polymers. Alternative Names: Mercaptopolystyrene, MercaptoPS, PS SH terminated. Pack Sizes: 1 g in glass bottle. Molecular formula: average Mn 5,000. Mole weight: CNC3H6(C8H8)nSH. | |
| Polystyrene thiol terminated (average Mn 11, 000, PDI ≤1.1) | Polystyrene thiol terminated (average Mn 11, 000, PDI ≤1.1). Group: Polystyrene (ps). | |
| 2',3'-Dideoxyguanosine-5'-O-(1-Thiotriphosphate) | 2',3'-Dideoxyguanosine-5'-O-(1-Thiotriphosphate), a potent nucleotide analog, serves as a promising biomedical product towards combatting multiple viral infections such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Not only does this chain-terminating inhibitor effectively target viral reverse transcriptase and RNA polymerase, but it also displays promising results in cancer treatment and cell signaling research. Its potential to revolutionize antiviral therapy warrants further exploration. Synonyms: Alpha Thiol ddGTP; 1-Thio-ddGTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H16N5O11P3S. Mole weight: 507.25. |  |
| 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-a-D-arabinouridine | 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-a-D-arabinouridine is a nucleoside analog used as an antiviral drug to treat hepatitis B and C virus infections. It inhibits viral replication by incorporating into viral DNA and terminating chain elongation. It also exhibits antitumor activity by inhibiting DNA synthesis in cancer cells. Synonyms: 1-[(2S,3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4-dione; 1-(2-Deoxy-2-fluoro-4-thio-alpha-D-arabino-pentofuranosyl)-5-methyluracil; 1-(2-Deoxy-2-fluoro-4-thio-alpha-D-arabinofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one; 1-(2-Deoxy-2-fluoro-4-thio-α-D-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 294868-24-9. Molecular formula: C10H13FN2O4S. Mole weight: 276.28. | |
| 3'-Azido-2',3'-dideoxythymidine-5'-O-(1-Thiotriphosphate) | 3'-Azido-2',3'-dideoxythymidine-5'-O-(1-Thiotriphosphate) is a potent antiviral nucleotide analog, inhibiting reverse transcriptase enzymes that is essential in the reserch of HIV and AIDS. Acting as a chain terminator, it prevents the replication of the viral genome, reducing viral load and inhibiting disease progression. Synonyms: Alpha Thiol-2',3'-Azido-ddTTP; 1-Thio-2',3'-Azido-ddTTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H16N5O12P3S. Mole weight: 523.25. | |
| 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase | The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain. Group: Enzymes. Synonyms: 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Enzyme Commission Number: EC 5.4.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5546; 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase; EC 5.4.4.5; 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Cat No: EXWM-5546. |  |
| Acetyl-Coenzyme A acetyltransferase 2 from Human, Recombinant | ACAT2 enzyme participates in lipid metabolism. ACAT2 takes part in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. ACAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. ACAT2 deficiency contributes to severe mental retardation and hypotonus. Acat2 recombinant human produced in e. coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-397 a.a.) and having a molecular mass of 45.4 kda. the acat2 is fused to 36 amino acid his-tag at n-terminus and purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Purity: Greater than 95.0% as determined by SDS-PAGE. ACAT-2. Mole weight: 45.4 kDa. Stability: ACAT2 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Cat No: NATE-0798. | |
| Cys(Npys)-TAT (47-57), FAM-labeled | It corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. It is synthesized with C(Npys) at the N-terminus for applications requiring specific conjugation reactions and has a fluorophore labeled with FAM having Abs/Em=494/518 nm. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Synonyms: Cys(Npys)-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys(FAM)-NH2. Grades: ≥95%. Molecular formula: C99H148N38O23S2. Mole weight: 2302.61. | |
| γ-glutamyl hydrolase | A lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. Commonly studied with folylpoly-γ-glutamate as substrate, with which the initial cleavage may release glutamate or poly-γ-glutamate of two or more residues, according to the species of origin of the enzyme. Final products are pteroyl-α-glutamate (folic acid) and free glutamate. Highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid (leaving group). Action on γ-glutamyl bonds is independent of an N-terminal pteroyl moiety, but it is not known whether an N-terminal γ-Glu residue can be hydrolysed. Type example of peptidase family C26. Group: Enzymes. Synonyms: conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptid. Enzyme Commission Number: EC 3.4.19.9. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4092; γ-glutamyl hydrolase; EC 3.4.19.9; 9074-87-7; conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptidase; γ-Glu-X carboxypeptidase; pteroyl-poly-γ-glutamate hydrolase; carboxypeptidase G; folic acid conjugase; poly(γ-glutamic acid) endohydrolase; polyglutamate hydrolase; poly(glutamic acid) hydrolase II; pteroylpoly-γ-glutamyl hydrolase. Cat No: EXWM-4092. | |
| linoleate 8R-lipoxygenase | The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P-450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase). The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase). Group: Enzymes. Synonyms: linoleic acid 8R-dioxygenase; 5,8-LDS (bifunctional enzyme); 7,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctio. Enzyme Commission Number: EC 1.13.11.60. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0580; linoleate 8R-lipoxygenase; EC 1.13.11.60; linoleic acid 8R-dioxygenase; 5,8-LDS (bifunctional enzyme); 7,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 7,8-linoleate diol synthase (bifunctional enzyme); PpoA. Cat No: EXWM-0580. | |
| Native Bovine Protein Disulfide Isomerase | Protein Disulfide Isomerase (PDI) has the C-terminal ER retention sequence Lys-Asp-Glu-Leu. It has active, intracellular traffic to different cell compartments. PDI supports internalization of Chlamydia, cholera and diphtheria toxins in some hosts. PDI is required for Sindbis virus infection and aids in reducing HIV gp120 protein thiols. PDI facilitates formation of the correct disulfide bonds by promoting rapid reshuffling of disulfide pairings. Protein disulfide isomerase (pdi) from bovine liver is a homodimer with a molecular weight of 107 kda (gel filtration) and the molecular weight of the monomer has been reported at 57 kda (sds-page). the enzyme is a glycoprotein ... is mainly l ocated in the er, where it assists in protein-folding and thiol-disulfide exchanges. it is used to study functional role of pdi in parasite infection and the interaction between macrophage pdi and l. chagasi. Group: Enzymes. Synonyms: Protein disulfide isomerase; PDI; EC 5.3.4.1; 37318-49-3; S-S rearrangase. Enzyme Commission Number: EC 5.3.4.1. CAS No. 37318-49-3. Purity: >95% (SDS-PAGE). PDI. Activity: 100-400 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing potassium phosphate buffer salts and stabilizer. Source: Bovine liver. Species: Bovine. Protein disulfide isomerase; PDI; EC 5.3.4.1; 37318-49-3; S-S rearrangase. Cat No: NATE-0533. | |
| Native Clostridium perfringens (C. welchII) Choloylglycine Hydrolase | Choloylglycine hydrolase (EC 3.5.1.24) is an N-terminal nucleophilic (Ntn) hydrolase that catalyzes the hydrolysis of amide bonds, libeRates the glycine/taurine moiety from the steroid core and eventually yields unconjugated bile acids. Agents that oxidize thiol groups (e.g., p-mercuribenzoate, iodoacetamide, Hg2+, Cu2+, and Cd2+) have been shown to strongly inhibit bile salt hydrolase (BSH) activity in Clostridium perfringens. Applications: The enzyme from creative enzymes has been used in the analysis of bile samples in various studies. Group: Enzymes. Synonyms: EC 3.5.1.24; glycocholase; bile salt hydrolase; choloyltaurine hydrolase; 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase; 37289-07-9. Enzyme Commission Number: EC 3.5.1.24. CAS No. 37289-07-9. Choloylglycine Hydrolase. Activity: > 100 units/mg protein. Storage: -20°C. Form: lyophilized powder. Partially purified lyophilized powder containing buffer salts and stabilizer. Source: Clostridium perfringens (C. welchII). EC 3.5.1.24; glycocholase; bile salt hydrolase; choloyltaurine hydrolase; 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase; 37289-07-9. Cat No: NATE-0129. | |
| Native Pseudomonas sp. Carboxypeptidase G | Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group.1 Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions. Applications: Carboxypeptidase g from pseudomonas sp., or γ-glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin cooh-terminus in p-450cam (cytochrome m) hydroxylations. carboxypeptidase g from pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via no-cgmp signaling in lung adenocarcinoma cells. Group: Enzymes. Synonyms: γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidas. Enzyme Commission Number: EC 3.4.17.11. CAS No. 9074-87-7. Carboxypeptidase G. Activity: > 3 units/mg protein. Storage: -20°C. Form: lyophilized powder contains sodium acetate salt. Source: Pseudomonas sp. γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidase; carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Cat No: NATE-0102. | |
| Poly(L-lactide), acrylate terminated | Poly(L-lactide) (PLLA) and its copolymers are among the most studied biodegradable polymers. PLLA is a crystalline polymer with good mechanical properties. The applications of PLLA are mainly concentrated in biomedical applications. Uses: This poly(l-lactide) is a well-defined biodegradable polymer which is functionalized with an alcohol on one end and an acrylate on the other. acrylates are commonly used in polymerizations or in ligatation to thiols with thiol-ene click chemistry. polylactide is commonly used in several applications including drug delivery, compatibilizer, emulsifier, thermoplastic elastomer or impact-resistant plastic. Group: 3d printing materials biodegradable polymers. Alternative Names: acrylate-PLA-OH, PLA, PLLA acrylate. Pack Sizes: 1 g in glass bottle. Molecular formula: average Mn 2,500. Mole weight: (C3H4O2)nC5H8O3. | |
| sulfur carrier protein ThiS adenylyltransferase | Binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.The enzyme shows significant structural similarity to ubiquitin-activating enzyme. In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide. Group: Enzymes. Synonyms: thiF (gene name). Enzyme Commission Number: EC 2.7.7.73. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3285; sulfur carrier protein ThiS adenylyltransferase; EC 2.7.7.73; thiF (gene name). Cat No: EXWM-3285. | |
| TAT (47-57) GGG-Cys(Npys) | It corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. The N-terminus is rendered free for applications requiring certain conjugation reactions with a free N-terminal end, and a linker GGG is placed at the C-terminal end, and the peptide has been synthesized with the C(Npys) group. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Cys(Npys)-NH2. Grades: ≥95%. Molecular formula: C78H135N39O19S2. Mole weight: 1987.29. | |
| ubiquitinyl hydrolase 1 | Links to polypeptides smaller than 60 residues are hydrolysed more readily than those to larger polypeptides. Isoforms exist with quantitatively different specificities, amongst the best known being UCH-L1 and UCH-L3, which are major proteins of the brain of mammals. Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). Ubiquitinyl hydrolase 1 is the type example of peptidase family C12, with a similar protein fold to papain and catalytic amino acids Cys, His and Asp. There is a separate family (C19) of enzymes that also hydrolyse ubiquitinyl bonds, and it is thought that all the ubiquitinyl hydrolases are also ubiquitin thiolesterases (EC 3.1.2.15). Group: Enzymes. Synonyms: ubiquitin C-terminal hydrolase; yeast ubiquitin hydrolase. Enzyme Commission Number: EC 3.4.19.12. CAS No. 86480-67-3, 189642-63-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4084; ubiquitinyl hydrolase 1; EC 3.4.19.12; 86480-67-3, 189642-63-5; ubiquitin C-terminal hydrolase; yeast ubiquitin hydrolase. Cat No: EXWM-4084. | |
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