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| Product | Description | |
|---|---|---|
| thioredoxin-disulfide reductase | A flavoprotein (FAD). Group: Enzymes. Synonyms: NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase. Enzyme Commission Number: EC 1.8.1.9. CAS No. 9074-14-0. TrxR. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1653; thioredoxin-disulfide reductase; EC 1.8.1.9; 9074-14-0; NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase. Cat No: EXWM-1653. |  |
| Thioredoxin reductase | Thioredoxin reductase (TrxR) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TrxR. CAS No. 9074-14-0. Pack Sizes: 50 μg. Product ID: HY-P2759. |  |
| Thioredoxin Reductase (NADPH) from Yeast, Recombinant | Thioredoxin reductase (TrxR/NTR), an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases. Thioredoxin reductase (TrxR), a component of the thioredoxin system, including thioredoxin (Trx) and NADPH, catalyzes the transfer of electrons from NADPH to Trx, acts as a reductant of disulfide-containing proteins and participates in the defense system against oxidative stresses. Thioredoxin reductase (nadph) yeast recombinant produced in e. coli is a single, nonglycosylated, polypeptide chain having a molecular mass of 36 kda. thioredoxin reductase is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH. CAS No. 9074-14-0. Purity: Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. TrxR. Mole weight: 36 kDa. Activity: 5 IU/mg. Stability: NTR although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. Appearance: Sterile Filtered White lyophilized (freeze-dried) powder. Source: E. coli. Species: Yeast. NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; NTR; TrxR. Cat No: NATE-0917. | |
| Thioredoxin reductase peptide acetate | Thioredoxin reductase peptide acetate, derived from residues 53-67 in thioredoxin reductase (TrxR), is widely used in research on thioredoxin reductase. Synonyms: L-Tryptophylglycyl-L-leucylglycylglycyl-L-threonyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valylglycyl-L-cysteinyl-L-isoleucyl-L-prolyl-L-lysine acetate salt; Trp-Gly-Leu-Gly-Gly-Thr-Cys-Val-Asn-Val-Gly-Cys-Ile-Pro-Lys acetate salt. Grades: ≥95%. Molecular formula: C68H110N18O20S2. Mole weight: 1563.84. |  |
| adenylyl-sulfate reductase (thioredoxin) | Uses adenylyl sulfate, not phosphoadenylyl sulfate, distinguishing this enzyme from EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin). Uses thioredoxin as electron donor, not glutathione or other donors, distinguishing it from EC 1.8.4.9 [adenylyl-sulfate reductase (glutathione)] and EC 1.8.99.2 (adenylyl-sulfate reductase). Group: Enzymes. Synonyms: thioredoxin-dependent 5'-adenylylsulfate reductase. Enzyme Commission Number: EC 1.8.4.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1665; adenylyl-sulfate reductase (thioredoxin); EC 1.8.4.10; thioredoxin-dependent 5'-adenylylsulfate reductase. Cat No: EXWM-1665. | |
| arsenate reductase (thioredoxin) | The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase. Group: Enzymes. Synonyms: ArsC (ambiguous). Enzyme Commission Number: EC 1.20.4.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1243; arsenate reductase (thioredoxin); EC 1.20.4.4; ArsC (ambiguous). Cat No: EXWM-1243. | |
| ferredoxin:thioredoxin reductase | The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37(sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction. Group: Enzymes. Enzyme Commission Number: EC 1.8.7.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1681; ferredoxin:thioredoxin reductase; EC 1.8.7.2. Cat No: EXWM-1681. | |
| Native Escherichia coli Thioredoxin Reductase | Thioredoxin reductase (TrxR) is an NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidised thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides and hydrogen peroxide. Applications: Thioredoxin reductase from escherichia coli can be used in peroxidase-coupled thioredoxin system assay for assessing the peroxidase activitiy of cys-based thiol peroxidases. the product was used for determining the enzymatic activity of his6-ahp1p. Group: Enzymes. Synonyms: NADP-thioredoxi. Enzyme Commission Number: EC 1.8.1.9. CAS No. 9074-14-0. TrxR. Activity: >25 units/mg protein (Bradford). Storage: 2-8°C. Form: ammonium sulfate suspension; Suspension in 3.6 M (NH4)2SO4 containing 30 mM potassium phosphate buffer, pH 7.5, and 2 mM EDTA. Source: Escherichia coli. NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR. Cat No: NATE-0718. | |
| Native Rat Thioredoxin Reductase | Thioredoxin reductase (TrxR) is an NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidised thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides and hydrogen peroxide. Applications: Thioredoxin reductase from rat liver can be used for studying the uptake and reduction of a-lipoic acid... NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR; 9074-14-0. Enzyme Commission Number: EC 1.8.1.9. CAS No. 9074-14-0. TrxR. Activity: > 100 units/mg protein (Bradford). Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM EDTA, and 10% glycerol. Source: Rat liver. Species: Rat. NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR; 9074-14-0. Cat No: NATE-0713. | |
| phosphoadenylyl-sulfate reductase (thioredoxin) | Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species. Group: Enzymes. Synonyms: PAPS reductase, thioredoxin-dependent; PAPS reductase; thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase; 3'-phosphoadenylylsulfate reductase; thioredoxin:3'-phospho-adenylylsulfate reductase; phosphoadenosine-phosphosulfate reductase; adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). Enzyme Commission Number: EC 1.8.4.8. CAS No. 9068-63-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1674; phosphoadenylyl-sulfate reductase (thioredoxin); EC 1.8.4.8; 9068-63-7; PAPS reductase, thioredoxin-dependent; PAPS reductase; thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase; 3'-phosphoadenylylsulfate reductase; thioredoxin:3'-phospho-adenylylsulfate reductase; phosphoadenosine-phosphosulfate reductase; adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). Cat No: EXWM-1674. | |
| 1- (Methylsulfonyl) benzotriazole | 1- (Methylsulfonyl) benzotriazole is an intermediate in the synthesis of bis-sulfonamides as thioredoxin reductase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 37073-15-7. Pack Sizes: 5g, 10g. Molecular Formula: C7H7N3O2S. US Biological Life Sciences. |  Worldwide |
| adenylyl-sulfate reductase (glutathione) | This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by γ-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or mercaptoethanol. The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Enteromorpha intestinalis. Group: Enzymes. Synonyms: 5'-adenylylsulfate reductase (also used for EC 1.8.99.2); AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming); plant-type 5'-adenylylsulfate reductase. Enzyme Commission Number: EC 1.8.4.9. CAS No. 355840-27-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1675; adenylyl-sulfate reductase (glutathione); EC 1.8.4.9; 355840-27-6; 5'-adenylylsulfate reductase (also used for EC 1.8.99.2); AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming); plant-type 5'-adenylylsulfate reductase. Cat No: EXWM-1675. | |
| AP39 | AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It is also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Grades: ≥95%. CAS No. 1429173-57-8. Molecular formula: C37H38O2PS3. Mole weight: 641.9. | |
| arsenate reductase (glutaredoxin) | A molybdoenzyme. The enzyme is part of a system for detoxifying arsenate. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. cf. EC 1.20.4.4, arsenate reductase (thioredoxin). Group: Enzymes. Synonyms: ArsC (ambiguous). Enzyme Commission Number: EC 1.20.4.1. CAS No. 146907-46-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1240; arsenate reductase (glutaredoxin); EC 1.20.4.1; 146907-46-2; ArsC (ambiguous). Cat No: EXWM-1240. | |
| Auranofin | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Synonyms: SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162; Ridaura; NSC 321521, Ridauragold thiol; Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-; [1-(Thio-κS)-β-D-glucopyranose 2, 3, 4, 6-tetraacetato] (triethylphosphine)gold; Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate; Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-; β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex; [ (Tetra-O-acetyl-β -D-glucopyranosyl)thio] (triethylphosphine)gold; Aktil; Crisinor; Crisofin Gold Salt; Ridauran; SKF 39162D. Grades: ≥98%. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.49. | |
| Auranofin | Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2?μM for monkey kidney Vero E6 cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.48. Purity: >98%. Canonical SMILES: CC(O[C@@H]1[C@@H](OC(C)=O)[C@H]([SH-][Au+]P(CC)(CC)CC)O[C@H](COC(C)=O)[C@H]1OC(C)=O)=O. Product ID: ACM34031328. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Auranofin | Auranofin (SKF-39162) is a thioredoxin reductase ( TrxR ) inhibitor with an IC 50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21 , with a CC 50 of 4.2?μM for monkey kidney Vero E6 cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF-39162. CAS No. 34031-32-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1123. | |
| Aurothioglucose | Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC 50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Gold thioglucose. CAS No. 12192-57-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-A0068. | |
| Aurothiomalate sodium | Aurothiomalate sodium is a potent and selective oncogenic PKC Ι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 12244-57-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106381. | |
| BE-40644 | BE-40644 is an inhibitor of human Thioredoxin system produced by Actinoplanes sp. A40644. It can inhibit the growth of several tumor cells. Synonyms: 4,4,6aalpha,12bbeta-Tetramethyl-9-(hydroxymethyl)-1,3,4,4aalpha,5,6,6a,12,12aalpha,12b-decahydro-2H-benzo[a]xanthene-8,11-dione. CAS No. 172923-88-5. Molecular formula: C22H30O4. Mole weight: 358.47. | |
| betaine reductase | The reaction is observed only in the direction of betaine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for betaine binding and trimethylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.3 (sarcosine reductase). Group: Enzymes. Synonyms: acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming). Enzyme Commission Number: EC 1.21.4.4. CAS No. 125752-87-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1259; betaine reductase; EC 1.21.4.4; 125752-87-6; acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming). Cat No: EXWM-1259. | |
| Busulfan | Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 55-98-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B0245. | |
| Busulfan-d8 | Busulfan-d 8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 116653-28-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0245S. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grades: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| Chaetocin | Chaetocin is a specific inhibitor of the histone methyltransferase ( HMT ) SU(VAR)3-9 with an IC 50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase ( TrxR ) with an IC 50 of 4 μM. Uses: Scientific research. Group: Natural products. CAS No. 28097-03-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2019. | |
| CoA-glutathione reductase | A flavoprotein. The substrate is a mixed disulfide. May be identical to EC 1.8.1.9, thioredoxin-disulfide reductase. Group: Enzymes. Synonyms: coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH2:CoA-glutathione oxidoreductase. Enzyme Commission Number: EC 1.8.1.10. CAS No. 37256-33-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1636; CoA-glutathione reductase; EC 1.8.1.10; 37256-33-0; coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH2:CoA-glutathione oxidoreductase. Cat No: EXWM-1636. | |
| cobalt-factor III methyltransferase | Isolated from Bacillus megaterium. The enzyme catalyses both methylation at C-17 and ring contraction. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. Group: Enzymes. Synonyms: CbiH60 (gene name). Enzyme Commission Number: EC 2.1.1.272. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1878; cobalt-factor III methyltransferase; EC 2.1.1.272; CbiH60 (gene name). Cat No: EXWM-1878. | |
| D9 | D9 is a thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). It exhibits an inhibitory effect on tumor proliferation in vitro and in vivo by inducing cell death. Uses: Antitumor agent. Synonyms: TrxR-IN-D9; D9; (Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold. Grades: ≥98% by HPLC. CAS No. 1527513-89-8. Molecular formula: C25H20AuOPS. Mole weight: 596.43. | |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| Disulfide Oxidoreductase, Recombinant | DsbA appears to be necessary for correct formulation of disulfide bonds in exported proteins in vivo. DsbA is useful as a standard in immunoblotting. This protein catalyses the reduction and exchange of disulfide bonds and the oxidation of free sulfhydryl groups in vitro. It is the strongest oxidant of the thioredoxin superfamily. This thio/disulfide oxidoreductase is required for efficient disulfide bond formation in the periplasm of E. coli. Disulfide oxidoreductase produced in e. coli is a periplasmic protein isolated from e. coli, containing 208 amino acids having a molecular mass of 23,149 dalton. the dsba is purified by proprietary chromatographic techniques. Applications: Western blot. Group: Enzymes. Syno. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. DsbA. Mole weight: 23,149 Da. Stability: Lyophilized DsbA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution DsbA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. Appearance: Sterile Filtered White lyophilized (freeze-dried) powder. Source: E. coli. DsbA; Thiol:disulfide interchange protein dsbA; Disulfide Oxidoreductase. Cat No: NATE-0828. | |
| Eprenetapopt | Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53 -mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 ( TrxR1 ), a key regulator of cellular redox balance [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APR-246; PRIMA-1Met. CAS No. 5291-32-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19980. | |
| ERO1 Inhibitor I, Erodoxin (Endoplasmic Reticulum Oxidase 1 Inhibitor, 1-Bromo-5-methoxy-2,4-dinitrobenzene) | A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1a (IC50=400uM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C?H?BrN?O?, Molecular Weight: 277. US Biological Life Sciences. | Worldwide |
| Ethaselen | Ethaselen, also known as BBSKE, is a novel organoselenium thioredoxin reductase inhibitor, is currently being investigated in a phase I clinical trial in China. Ethaselen enhanced the efficacy of radiation therapy both in vivo and in vitro without observable toxicity. BBSKE was found to suppress irradiation-induced activation dramatically when using A549 cells stably transfected with luciferase reporter. Ethaselen is a potentially promising agent for the treatment of patients with NSCLC clinically. Synonyms: 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane; BBSKE. CAS No. 217798-39-5. Molecular formula: C16H12N2O2Se2. Mole weight: 422.199. | |
| glycine reductase | The reaction is observed only in the direction of glycine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.3 (sarcosine reductase) and EC 1.21.4.4 (betaine reductase). Group: Enzymes. Enzyme Commission Number: EC 1.21.4.2. CAS No. 39307-24-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1257; glycine reductase; EC 1.21.4.2; 39307-24-9. Cat No: EXWM-1257. | |
| LCS3 | LCS3 is a reversible and uncompetitive glutathione disulfide reductase ( GSR ) and thioredoxin reductase 1 ( TXNRD1 ) inhibitor ( IC 50 =3.3 μM and 3.8 μM, respectively). LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 109844-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147328. | |
| LCS3 | LCS3 is a reversible inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 μM and 3.8 μM, respectively. CAS No. 109844-92-0. Molecular formula: C11H7ClN2O4. Mole weight: 266.64. | |
| L-methionine (S)-S-oxide reductase | Requires NADPH. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase]. Group: Enzymes. Synonyms: fSMsr; methyl sulfoxide reductase I and II; acetylmethionine sulfoxide reductase; methionine sulfoxide reductase; L-methionine:oxidized-thioredoxin S-oxidoreductase; methionine-S-oxide reductase; free-methionine (S)-S-oxide reductase. Enzyme Commission Number: EC 1.8.4.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1668; L-methionine (S)-S-oxide reductase; EC 1.8.4.13; fSMsr; methyl sulfoxide reductase I and II; acetylmethionine sulfoxide reductase; methionine sulfoxide reductase; L-methionine:oxidized-thioredoxin S-oxidoreductase; methionine-S-oxide reductase; free-methionine (S)-S-oxide reductase. Cat No: EXWM-1668. | |
| peroxiredoxin | Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see mechanism). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydr...se thioredoxin as an electron donor. The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule. Group: Enzymes. Synonyms: thioredoxin peroxidase; tryparedoxin peroxidase; alkyl hydroperoxide reductase C22; AhpC; TrxPx; TXNPx; Prx; PRDX. Enzyme Commission Number: EC 1.11.1.15. CAS No. 207137-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0496; peroxiredoxin; EC 1.11.1.15; 207137-51-7; thioredoxin peroxidase; tryparedoxin peroxidase; alkyl hydroperoxide reductase C22; AhpC; TrxPx; TXNPx; Prx; PRDX. Cat No: EXWM-0496. | |
| Peroxiredoxin-5, mitochondrial (163-172) | Peroxiredoxin-5, mitochondrial (163-172) is a truncated fragment of Peroxiredoxin-5, mitochondrial. Peroxiredoxin-5 interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. Synonyms: Peroxisomal Antioxidant Enzyme (163-172); Thioredoxin Peroxidase PMP20 (163-172); Antioxidant Enzyme B166 (163-172). | |
| PMX 464 | PMX 464, a thiol-reactive quinol and putative thioredoxin inhibitor, is a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system, which shown to inhibit Trx and induce a G1/S block in HT29 cells, and inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Synonyms: PMX464; PMX-464; PMX 464; 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one. Grades: ≥98% by HPLC. CAS No. 485842-97-5. Molecular formula: C13H9NO2S. Mole weight: 243.28. | |
| PNRI-299 | PNRI-299 is a selective AP-1 transcription inhibitor without affecting NF-kappaB transcription or thioredoxin. Synonyms: PNRI-299; PNRI299; PNRI 299. Grades: >98%. CAS No. 550368-41-7. Molecular formula: C21H15N5O4. Mole weight: 401.37. | |
| prostamide/prostaglandin F2α synthase | The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2&alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2. Group: Enzymes. Synonyms: prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Enzyme Commission Number: EC 1.11.1.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0502; prostamide/prostaglandin F2α synthase; EC 1.11.1.20; prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Cat No: EXWM-0502. | |
| ribonucleoside-diphosphate reductase | This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. An iron protein. While the enzyme is activated by ATP, it is inhibited by dATP. Group: Enzymes. Synonyms: ribonucleotide reductase; CDP reductase; ribonucleoside diphosphate reductase; UDP reductase; ADP reductase; nucleoside diphosphate reductase; ribonucleoside 5'-diphosphate reductase; ribonucleotide diphosphate reductase; 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase; RR. Enzyme Commission Number: EC 1.17.4.1. CAS No. 9047-64-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1090; ribonucleoside-diphosphate reductase; EC 1.17.4.1; 9047-64-7; ribonucleotide reductase; CDP reductase; ribonucleoside diphosphate reductase; UDP reductase; ADP reductase; nucleoside diphosphate reductase; ribonucleoside 5'-diphosphate reductase; ribonucleotide diphosphate reductase; 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase; RR. Cat No: EXWM-1090. | |
| ribonucleoside-triphosphate reductase | Requires a cobamide coenzyme and ATP. Group: Enzymes. Synonyms: ribonucleotide reductase; 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase. Enzyme Commission Number: EC 1.17.4.2. CAS No. 9068-66-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1091; ribonucleoside-triphosphate reductase; EC 1.17.4.2; 9068-66-0; ribonucleotide reductase; 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase. Cat No: EXWM-1091. | |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Synonyms: RTA408; RTA408; RTA-408. Omaveloxolone; Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-. Grades: >98%. CAS No. 1474034-05-3. Molecular formula: C33H44F2N2O3. Mole weight: 554.723. | |
| sarcosine reductase | The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase). Group: Enzymes. Enzyme Commission Number: EC 1.21.4.3. CAS No. 125752-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1258; sarcosine reductase; EC 1.21.4.3; 125752-88-7. Cat No: EXWM-1258. | |
| SBI-477 | SBI-477 is a small-molecule probe that can stimulate insulin signaling by deactivating the transcription factor MondoA, causing reduction of expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). It coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes in study. Uses: Probe. Synonyms: SBI 477; SBI477. CAS No. 781628-99-7. Molecular formula: C24H25N3O6S. Mole weight: 483.54. | |
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