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| Product | Description | |
|---|---|---|
| Thromboxane A2 | Thromboxane A2 is the predominant cyclooxygenase product formed from arachidonic acid (AA) in human platelets. Thromboxane A2 is neither stored in platelets, nor formed in the absence of activation. However, it is synthesized in response to platelet activation by a wide variety of receptor-dependent and -independent platelet agonists. Synonyms: thromboxane A2; TXA2; 57576-52-0; TXA-2; Rabbit aorta contracting substance; 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid; 4C2A5G825S; Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Benz(a)anthracene-1,7,12(2H)-trione, 3,4-dihydro-3,6,8-trihydroxy-3-methyl-, (-)-; (Z)-7-[(1S,3R,4S,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid. Grades: > 95%. CAS No. 57576-52-0. Molecular formula: C20H32O5. Mole weight: 352.48. |  |
| Pinane Thromboxane A2 | Pinane Thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TXA2R antagonist and a TXA synthase inhibitor. It inhibits coronary artery constriction and platelet aggregation. Synonyms: 15(S)-Pinane Thromboxane A2; Pinane TXA2; PTA2; 7-[3-(3-hydroxyoct-1-enyl)-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 71111-01-8. Molecular formula: C24H40O3. Mole weight: 376.6. | |
| Pta2(pinane thromboxane a2) | Pta2(pinane thromboxane a2). Uses: Designed for use in research and industrial production. Additional or Alternative Names: PTA2;PINANE THROMBOXANE A2;9ALPHA,11ALPHA-(DIMETHYL)METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID;pinane thromboxane A2 ethanol solution;Pinane-thromboxanea2synthetic;(5Z)-7-[(1S,1β,5β)-3β-[(3S,1E)-3-Hydroxy-1-octene-1-yl]-. Product Category: Heterocyclic Organic Compound. Appearance: A solution in ethanol. CAS No. 71111-01-8. Molecular formula: C24H40O3. Mole weight: 376.57. Product ID: ACM71111018. Alfa Chemistry ISO 9001:2015 Certified. Categories: 15(R)-PTA2. |  |
| 13-APA | 13-APA is a specific thromboxane A2 receptor (TP) antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 71629-07-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H37NO2, Molecular Weight: 311.5. US Biological Life Sciences. |  Worldwide |
| 1,3-bis(4-((E)-2-carboxyvinyl)benzyl)-1H-imidazol-3-ium bromide | 1,3-bis(4-((E)-2-carboxyvinyl)benzyl)-1H-imidazol-3-ium bromide is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: (E)-3-(4-((1-(4-((E)-2-Carboxyvinyl)benzyl)-1H-imidazol-3-ium-3-yl)methyl)phenyl)acrylate; 883942-98-1. CAS No. 883942-98-1. Molecular formula: C23H21BrN2O4. Mole weight: 469.34. | |
| 2-Hydroxymethyl-2,3-dihydrobenzofuran | 2-Hydroxymethyl-2,3-dihydrobenzofuran is a reactant used in the preparation of thromboxane A2 agonist indane derivatives. Group: Biochemicals. Alternative Names: 2-Hydroxymethyl-2,3-dihydrobenzofuran; 2,3-Dihydro-2-benzofuranmethanol. Grades: Highly Purified. CAS No. 66158-96-1. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 2-(Tosyloxy)methyl-2,3-dihydrobenzofuran | Protected 2-Hydroxymethyl-2,3-dihydrobenzofuran , a reactant in the preparation of thromboxane A2 agonist indane derivatives. Group: Biochemicals. Alternative Names: 2,3-Dihydro-2-benzofuranmethanol 4-Methyl Benzene sulfonate; 2,3-Dihydro-2-benzofuranmethanol p-Toluenesulfonate. Grades: Highly Purified. CAS No. 94709-25-8. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| ACA - CAS 110683-10-8 | A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Group: Fluorescence/luminescence spectroscopy. |  |
| ACA - CAS 110683-10-8 | A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 110683-10-8. Pack Sizes: 25MG. Mole weight: 337.41. Catalog: AP110683108. Assay: ?99% (HPLC). | |
| BM 567 | Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid. It has been reported as a causal factor in the onset of stroke and myocardial infarction. BM 567 is a dual acting antithrombogenic agent, which is acting as an inhibitor of thromboxane A2 (TXA2) synthase and an antagonist of the TP receptor. It also antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. Synonyms: BM567; BM-567. Grades: ≥98%. CAS No. 284464-77-3. Molecular formula: C18H28N4O5S. Mole weight: 412.5. | |
| CAY10535 | TPα and TPβ are two isoforms of the human TP receptor, which is the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ with IC50 of 99 nM than TPα with IC50 of 1970 nM in the inhibition of U46619-mediated Ca2+ mobilization. Synonyms: CAY 10535; CAY-10535. Grades: ≥98%. CAS No. 945716-28-9. Molecular formula: C18H21N3O7S. Mole weight: 423.4. | |
| cis-5,8,11,14,17-Eicosapentaenoic acid | reduces thromboxane A2 production and platelet aggregation, inhibits 5-lipoxygenase and prevents arteriosclerosis. CAS No. 73167-03-0. Product ID: 1-01079. Molecular formula: C20H30O2. Mole weight: 302.46. Reference: Lancet., 15, 117, 1978; New Engl. J. Med., 314, 937, 1986. |  |
| Dimethyl (3-phenoxy-2-oxoproyl)phosphonate | Dimethyl (3-phenoxy-2-oxoproyl)phosphonate Travopropst (T715600), a selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma. Used in the synthesis ofnovel prostanoid thromboxane A2 agonists. Group: Biochemicals. Alternative Names: P- (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-oxo-3-Phenoxypropyl) phosphonic Acid Dimethyl Ester; (2-Oxo-3-phenoxypropyl) phosphonic Acid Dimethyl Ester; Dimethyl (2-oxo-3-phenoxypropyl) phosphonate; Dimethyl (3-Phenoxyacetonyl) phosphonate; Dimethyl 3-{Phenoxy-2-oxopropylphosphonate. Grades: Highly Purified. CAS No. 40665-68-7. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one | (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)-1-(1H-imidazol-1-yl)prop-2-en-1-one; 2452215-05-1. CAS No. 2452215-05-1. Molecular formula: C16H14N4O. Mole weight: 278.32. | |
| Epoprostenol Sodium | Epoprostenol Sodium is the sodium salt form of epoprostenol, which is a synthetic prostacyclin. It has vasodilatory and anticoagulant activity. It is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It prevents the formation of platelet plugs and is an effective vasodilator. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. It directly simulates prostaglandin receptors in arterial vascular smooth muscle, thereby causing vasodilatation. lt is also used for the treatment of pulmonary hypertension. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. It is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract. It was developed by GlaxoSmithKline and has been listed. Uses: Epoprostenol sodium has vasodilatory and anticoagulant activity. it prevents the formation of platelet plugs and is an effective vasodilator. lt is also used for the treatment of pulmonary hypertension. Synonyms: Prostacyclin Sodium Salt; (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-Dihydroxy-prosta-5,13-dien-1-oic Acid Sodium Salt; Flolan. Grades: >99 %. CAS No. 61849-14-7. Molecular formula: C20H31O5Na. Mole weight: 374.45. | |
| Furegrelate sodium | Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC 50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U-63557A. CAS No. 85666-17-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-106080A. |  |
| ICI 192,605 | ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Synonyms: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87. | |
| Ifetroban | Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291. CAS No. 143443-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218. | |
| Ifetroban | Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials for the treatment of Asthma, Hepatorenal syndrome, Portal hypertension and Systemic scleroderma is on-going. Uses: Asthma; hepatorenal syndrome; portal hypertension; systemic scleroderma. Synonyms: Ifetroban; BMS 180291-02; BMS-180291; BMS180291; CHEMBL283100; BMS-180291;SCHEMBL9589119;3-[2-[[3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]propanoic acid. Grades: 98%. CAS No. 143443-90-7. Molecular formula: C25H32N2O5. Mole weight: 440.54. | |
| Ifetroban sodium | Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291 sodium. CAS No. 156715-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218A. | |
| Imidazole | Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG 2 and PGH 2 ) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimers disease, gout, COVID-19 and thrombo-embolic disease [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene. CAS No. 288-32-4. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-D0837. | |
| I-SAP | I-SAP is a high affinity TP receptor antagonist. I-SAP binds to and induces platelet shape change, but not aggregation, with EC50 value of 9.7 nM. Synonyms: Iodophenyl sulfonyl amino pinane Thromboxane A2; Iodophenyl sulfonyl amino pinane TXA2; (Z)-7-[(1S,2S,3S,5R)-3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 133538-58-6. Molecular formula: C22H30INO4S. Mole weight: 531.4. | |
| L-670,596 | L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist with IC50 value of 5.5 nM. It displays ALDH1A1 specific inhibitory activity. It inhibits human platelet aggregation and U-44069-induced contractions of guinea pig trachea in vitro. It also inhibits thromboxane-mediated endothelial cell death. It is orally active in vivo. Synonyms: L-670596; L 670596; L670596; (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid; 2-[6,8-Difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid. Grades: ≥98% by HPLC. CAS No. 121083-05-4. Molecular formula: C22H21F2NO4S. Mole weight: 433.47. | |
| methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate | methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: methyl (E)-3-(4-(methoxymethyl)phenyl)acrylate; AKOS020185360; 121379-29-1. CAS No. 121379-29-1. Molecular formula: C12H14O3. Mole weight: 206.24. | |
| ONO3708 | ONO3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo. It could play an important role in the pathogenesis of thrombosis and may be of therapeutic use in preventing cerebral vasospasm. It has therapeutic advantages in preventing thrombosis. Uses: Ono3708 may be of therapeutic use in preventing cerebral vasospasm. it has therapeutic advantages in preventing thrombosis. Synonyms: Ono3708; Ono-3708; Ono 3708;5-Heptenoic acid, 7-((1S,2S,3S,5R)-3-(((2R)-cyclopentylhydroxyacetyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-, (5Z)-;(Z)-7-[(1R,3S,4S,5S)-3-[[(2R)-2-cyclopentyl-2-hydroxyacetyl]amino]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: >98 %. CAS No. 102191-05-9. Molecular formula: C23H37NO4. Mole weight: 391.55. | |
| Ozagrel | Ozagrel is an antiplatelet agent working as a thromboxane A2 (TXA2) synthesis inhibitor. It has been a clinical objective for many years. lt is a 1-alkyl imidazole derivative that acts as a selective inhibitor of TXA2 with an IC50 of 11 nM. lt was selected as the best compound of highly selective inhibitors of TXA2 synthase. lt increased 6-keto-PGF1 alpha in various isolated cells and tissues. It blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values. Uses: Ozagrel was selected as the best compound of highly selective inhibitors of txa2 synthase. lt increased 6-keto-pgf1 alpha in various isolated cells and tissues. Synonyms: OKY046; OKY 046; OKY-046; 2-Propenoic acid,3-[4-(1H-imidazol-1- ylmethyl)phenyl]-,(2E)-;(E)-p-(Imidazol-1-ylmethyl)cinnamic acid;(E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid;(E)-3-[P-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid. Grades: >98%. CAS No. 82571-53-7. Molecular formula: C13H12N2O2. Mole weight: 228.25. | |
| Ozagrel Methyl Ester | Ozagrel Methyl Ester is an impurity of Ozagrel, an antiplatelet drug that acts as a thromboxane A2 synthesis inhibitor. Synonyms: methyl (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylate; (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-methyl Ester 2-Propenoic Acid. CAS No. 956932-46-0. Molecular formula: C14H14N2O2. Mole weight: 242.27. | |
| Ozagrel sodium | Ozagrel is a thromboxane A2 synthase inhibitor used as an antiplatelet agent. It reduces the risk of neurological impairment and the volume of brain damage. Synonyms: KCT-0809; Cataclot; Xanbo; (E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoate sodium. CAS No. 189224-26-8. Molecular formula: C13H11N2O2·Na. Mole weight: 250.23. | |
| Picotamide | Picotamide is a combined inhibitor of thromboxane A2 (TxA2) synthase and receptor. Picotamide has antiplatelet activity. Picotamide promotes the reduction of microalbuminuria and the inhibition of growth of carotid plaques in diabetes. Picotamide can be used for researching acute or chronic cardiovascular diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 32828-81-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B1735. | |
| Picotamide | Picotamide is a dual inhibitor of thromboxane A2 (TXA2) receptors and TXA2 synthase. It is used as an antiplatelet drug. Picotamide has been demonstrated that reduces overall mortality in type 2 diabetic patients with associated peripheral arterial disease (PAD). Synonyms: 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide. Grades: ≥98%. CAS No. 32828-81-2. Molecular formula: C21H20N4O3. Mole weight: 376.4. | |
| Pimprinine (3-(2-Methyl-5-oxazolyl)-1H-indole, Antibiotic WS-30581C, NSC80793, 5-(3-Indoyl)-2-methyloxazole) | Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances. Group: Biochemicals. Grades: Highly Purified. CAS No. 13640-26-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C12H10N2O, Molecular Weight: 198.2. US Biological Life Sciences. | Worldwide |
| Piperlongumine (Piplartine, 5,6-Dihydro-1-(1-oxo-3-trans-2-propenyl)-2-pyridinone) | Cytotoxic against tumor cell lines. Induces necrosis and apoptosis in cancer cells. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation. Shows significant anxiolytic and antidepressant activities. Promotes adipogenesis of 3T3-L1 cells. Induces in vivo and in vitro mutagenicity in eukaryotic models. Selectively kills cancer cells by targeting the stress response to ROS. Shows in vitro schistosomicidal activity. Group: Biochemicals. Alternative Names: Piplartine, 5,6-Dihydro-1-(1-oxo-3--trans-2-propenyl)-2-pyridinone. Grades: Highly Purified. CAS No. 20069-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ridogrel | Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 68070. CAS No. 110140-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0221. | |
| Seratrodast | Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AA 2414. CAS No. 112665-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0774. | |
| Seratrodast | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: (+/-)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic Acid; AA-2414; Benzeneheptanoic acid, ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-; Benzeneheptanoic acid, ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-, (±)-; ζ-(2,4,5-Trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)benzeneheptanoic acid; (±)-2,4,5-Trimethyl-3,6-dioxo-ζ-phenyl-1,4-cyclohexadiene-1-heptanoic acid; 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid; A 73001; AA 2414; AA2414; Abbott 73001; ABT 001; Bronica; Seratodrast. Grades: >98%. CAS No. 112665-43-7. Molecular formula: C22H26O4. Mole weight: 354.44. | |
| Seratrodast ((±)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic Acid, AA-2414,. Abbott 73001, Bronica) | Thromboxane A2-receptor antagonist. Antiasthmatic. Group: Biochemicals. Alternative Names: (±)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic Acid; AA-2414; Abbott 73001; Bronica. Grades: Highly Purified. CAS No. 112665-43-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Terutroban | Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 induced increase pressure in the bronchi. Synonyms: Terutroban; S 18886; S-18886; S18886; 3-[(6R)-6-[(4-chlorophenyl)sulfonylamino]-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid3-((6R)-6-(((4-chlorophenyl)sulfonyl)amino)-2-methyl-5,6,7,8 te. CAS No. 165538-40-9. Molecular formula: C20H22ClNO4S. Mole weight: 407.91. | |
| thromboxane-A synthase | A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2. Group: Enzymes. Synonyms: thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Enzyme Commission Number: EC 5.3.99.5. CAS No. 61276-89-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5513; thromboxane-A synthase; EC 5.3.99.5; 61276-89-9; thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase. Cat No: EXWM-5513. |  |
| Thromboxane B2 | Thromboxane B2 is a stable metabolite of Thromboxane A2 and is important in the platelet-release reaction. Synonyms: 9α,11,15S-trihydroxythromba-5Z,13E-dien-1-oic acid; TXB2. Grades: > 95%. CAS No. 54397-85-2. Molecular formula: C20H34O6. Mole weight: 370.49. | |
| U 46619 | U 46619 is a PGH2 (TXA2) analog that is reported to be a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U 46619 has been shown to stimulate TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. U 46619 also activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors. Synonyms: U46619, U-46619, U 46619; (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid. Grades: ≥98% by HPLC. CAS No. 56985-40-1. Molecular formula: C21H34O4. Mole weight: 350.5. | |
| U-46619 | U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation [1] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 9,11-Methanoepoxy PGH2. CAS No. 56985-40-1. Pack Sizes: 1 mg (28.5 mM * 100 μL in Methyl acetate); 5 mg (28.5 mM * 500 μL in Methyl acetate). Product ID: HY-108566. | |
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