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| Product | Description | |
|---|---|---|
| thymidine kinase | Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP-thymidine kinase), EC 2.7.1.118 (ADP-thymidine kinase) and EC 2.7.4.9 (dTMP-kinase). Group: Enzymes. Synonyms: thymidine kinase (phosphorylating); 2'-deoxythymidine kinase; deoxythymidine kinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.21. CAS No. 9002-6-6. HSV-1 TK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3045; thymidine kinase; EC 2.7.1.21; 9002-06-6; thymidine kinase (phosphorylating); 2'-deoxythymidine kinase; deoxythymidine kinase (phosphorylating). Cat No: EXWM-3045. |  |
| ADP-thymidine kinase | The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.114 (AMP-thymidine kinase) and EC 2.7.4.9 (dTMP kinase). Group: Enzymes. Synonyms: ADP:dThd phosphotransferase; adenosine diphosphate-thymidine phosphotransferase. Enzyme Commission Number: EC 2.7.1.118. CAS No. 82114-39-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2958; ADP-thymidine kinase; EC 2.7.1.118; 82114-39-4; ADP:dThd phosphotransferase; adenosine diphosphate-thymidine phosphotransferase. Cat No: EXWM-2958. | |
| AMP-thymidine kinase | The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.118 (ADP-thymidine kinase) and EC 2.7.4.9 (dTMP kinase). Group: Enzymes. Synonyms: adenylate-nucleoside phosphotransferase. Enzyme Commission Number: EC 2.7.1.114. CAS No. 60440-28-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2957; AMP-thymidine kinase; EC 2.7.1.114; 60440-28-0; adenylate-nucleoside phosphotransferase. Cat No: EXWM-2957. | |
| Recombinant Herpes simplex virus (HSV-1) thymidine kinase | Thymidine kinase HSV-1 is the key enzyme in the herpes simplex virus (HSV-1 and HSV-2) life cycle. It is a potential target for new anti-herpes drugs. Group: Enzymes. Synonyms: Thymidine kinase HSV-1; Herpes simplex virus thymidine kinase; HSV-1 thymidine kinase; HSV-1 TK; EC 2.7.1.21. Enzyme Commission Number: EC 2.7.1.21. CAS No. 9002-6-6. Purity: > 95 %. HSV-1 TK. Mole weight: 42.2 kDa. Activity: 0.4 micromole/min/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Homo sapiens. Thymidine kinase HSV-1; Herpes simplex virus thymidine kinase; HSV-1 thymidine kinase; HSV-1 TK; EC 2.7.1.21. Cat No: NATE-1014. | |
| 1-(a-D-Mannopyranosyl)thymine | 1-(a-D-Mannopyranosyl)thymine, a compound widely employed in the biomedical sector, holds immense significance. In the field of therapeutics, it serves as a valuable agent against specific viral infections, chiefly those instigated by thymidine kinase-deficient viruses. Its distinctive composition not only enables precise transportation but also exhibits potential as an antiviral entity, rendering it an auspicious contender for pharmaceutical advancements and ailment management. Synonyms: 5-Methyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]pyrimidine-2,4-dione. Grades: ≥ 98% (HPLC). CAS No. 3180-78-7. Molecular formula: C11H16N2O7. Mole weight: 288.75. |  |
| 2,3'-Anhydrothymidine | 2,3'-Anhydrothymidine, a biomedical compound, emerges as a promising therapeutic agent against viral infections caused by thymidine kinase-dependent DNA viruses, including herpes simplex viruses and varicella-zoster virus. Its distinctive ability lies in its interference with viral DNA synthesis, thus showcasing potent antiviral activity. Uses: An intermediate in the preparation of thymidine derivatives. Synonyms: 2'-Deoxy-3',2-anhydro-5-methyluridine; Anhydrothymidine; O2,3'-Cyclothymidine; 2,3'-O-Cyclothymidine; NSC 144601; (2R,3R,5R)-2,3-Dihydro-3-(hydroxymethyl)-8-methyl-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one; 2,3'-Anhydro-1-(2'-deoxy-β-D-threo-pentofuranosyl)thymine. Grades: ≥95%. CAS No. 15981-92-7. Molecular formula: C10H12N2O4. Mole weight: 224.21. | |
| 2'-?Deoxy-?5-?iodouridine 3',5'-bis(4-Methylbenzoate) | 2'-Deoxy-5-iodouridine 3',5'-Dibenzoate is a protected intermediate of Idoxuridine, antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Synonyms: 2'-Deoxy-5-iodouridine 3',5'-di-p-toluate. CAS No. 31356-86-2. Molecular formula: C23H19IN2O7. Mole weight: 562.31. | |
| 2'-?Deoxy-?5-?iodouridine 3,5-Dibenzoate | 2'-?Deoxy-?5-?iodouridine 3,5-Dibenzoate is a protected intermediate of Idoxuridine (I205750), antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 4833-7-2. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| 2'-O-Acetyl-3'-azido-5'-O-benzoyl-3'-deoxyuridine | 2'-O-Acetyl-3'-azido-5'-O-benzoyl-3'-deoxyuridine is a highly efficacious antiviral compound extensively employed in the field of compound, manifesting its effectiveness by impeding the replication of viral DNA. The active component specifically targets viral thymidine kinase and DNA polymerase, exquisitely obstructing viral propagation. Synonyms: 1-(3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-uracil; ((2S,3R,4R,5R)-4-acetoxy-3-azido-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate. Grades: ≥95%. CAS No. 917239-19-1. Molecular formula: C18H17N5O7. Mole weight: 415.36. | |
| 3'-Deoxy-3'-fluoro-5'-O-toluoylthymidine | 3'-Deoxy-3'-fluoro-5'-O-toluoylthymidine, a remarkable antiviral compound, showcases its effectiveness in countering diverse viral infections, such as herpes simplex and varicella-zoster viruses. By selectively impeding the viral thymidine kinase enzyme, this potent agent masterfully halts viral DNA synthesis. Synonyms: 2',3'-Dideoxy-3'-fluoro-5'-O-toluoyl-D-thymidine. Molecular formula: C18H19FN2O5. Mole weight: 348.43. | |
| 3'-Deoxy-3'-fluorothymidine-5'-monophosphate-d3 Disodium Salt | A thymidine-5'-O-monophosphate analogue, for Mycobacterium tuberculosis thymidylate kinase inhibition. Synonyms: 3'-Deoxy-3'-fluoro-5'-thymidylic Acid-d3 Disodium; 2',3'-Dideoxy-3'-fluoro-5-methyluridine-d3 5'-(Dihydrogen Phosphate) Disodium; 3'-Deoxy-3'-fluoro-thymidine-d3 Monophosphate Disodium; 3'-Fluoro-3'-deoxythymidine-d3 Monophosphate Disodium. Molecular formula: C10H9D33FN2Na2O7P. Mole weight: 371.18. | |
| 3-Deoxy-3-fluorothymidine-5-monophosphate-d3 Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Group: Biochemicals. Alternative Names: 3'-Deoxy-3'-fluoro-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3'-Deoxy-3'-fluorothymidine-5'-monophosphate Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Synonyms: 3'-Deoxy-3'-fluoro-5'-thymidylic Acid Disodium; 2',3'-Dideoxy-3'-fluoro-5-methyluridine 5'-(Dihydrogen Phosphate) Disodium; 3'-Deoxy-3'-fluorothymidine Monophosphate Disodium; 3'-Fluoro-3'-deoxythymidine Monophosphate Disodium. Grades: 95%. CAS No. 1316845-74-5. Molecular formula: C10H12FN2Na2O7P. Mole weight: 368.16. | |
| 3-Deoxy-3-fluorothymidine-5-monophosphate Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Group: Biochemicals. Alternative Names: 3'-Deoxy-3'-fluoro-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3'-epi-Idoxuridine | The 3'-enantiomer of Idoxuridine. Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Synonyms: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-iodouracil. CAS No. 93780-25-7. Molecular formula: C9H11IN2O5. Mole weight: 354.1. | |
| 3-epi-Idoxuridine | The 3-enantiomer of Idoxuridine. Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Group: Biochemicals. Alternative Names: 1-(2-Deoxy- β-D-threo-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy- β-D-threo-pentofuranosyl)-5-iodouracil. Grades: Highly Purified. CAS No. 93780-25-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Thiothymidine | 4-Thiothymidine, a nucleoside analogue, exhibits potent antiviral activity by inhibiting DNA replication. This sulfur-containing compound specifically targets thymidine kinase, an enzyme essential for DNA synthesis, which offers promising applications in antiviral therapies. Notably, its efficacy has been observed against HIV and hepatitis B, making it a valuable research tool in biomedical studies. The intricate biochemistry of 4-Thiothymidine highlights its potential for further investigations and development of novel therapeutic agents. Synonyms: 4-Thio-D-thymidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one; 4-Thiodeoxythymidine; 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one; 3,4-Dihydro-5-methyl-1-(2-deoxy-β-D-ribofuranosyl)-4-thioxopyrimidin-2(1H)-one. Grades: ≥98% by HPLC. CAS No. 7236-57-9. Molecular formula: C10H14N2O4S. Mole weight: 258.29. | |
| 5-(2-Furanyl)-2-deoxyuridine | Several novel 5-substituted 2'-deoxyuridine (dUrd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase. Group: Biochemicals. Alternative Names: 2'-Deoxy-5-(2-furanyl)uridine. Grades: Highly Purified. CAS No. 92233-50-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5-Azido-5-deoxy Thymidine | It is a potential inhibitor of mycobacterium tuberculosis monophosphate kinase (TMPKmt). Synonyms: 5'-AZT; 5'-Azido-5'-deoxythymidine; NSC 254064; 5'-N3-5-Me-ddU; 5'-Azido-5-methyl-2',5'-dideoxyuridine; 1-((2R,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione. Grades: ≥95%. CAS No. 19316-85-9. Molecular formula: C10H13N5O4. Mole weight: 267.24. | |
| 5'-O-(2-Amino-2-deoxy-D-glucopyranosyl)-thymidine | 5'-O-(2-Amino-2-deoxy-D-glucopyranosyl)-thymidine is a significant compound employed in the biomedical sector to counter viral infections triggered by thymidine kinase-dependent viruses. Its profound impact lies in its function as a substrate for viral thymidine kinase, thereby leading to phosphorylation and subsequent disruption of viral DNA research and development. Molecular formula: C16H25N3O9. Mole weight: 403.38. | |
| 5'-Tosyl Thymidine | A nucleoside analogue as inhibitors of thymidylate kinases. Synonyms: 5'-(4-Methylbenzenesulfonate)thymidine; 5'-O-(p-Toluenesulfonyl)thymidine; 5'-O-Tosylthymidine; NSC 69443. Grades: 98%. CAS No. 7253-19-2. Molecular formula: C17H20N2O7S. Mole weight: 396.41. | |
| 5'-Trifluoroacetamido-5'-deoxythymidine | 5'-Trifluoroacetamido-5'-deoxythymidine is an exceedingly efficacious antiviral entity, demonstrating immense potential for the research of DNA virus-mediated detrimental infections, primarily those affiliated with herpesviruses. The discerning mode of action revolves around the selective suppression of viral DNA replication through specific antagonism of viral thymidine kinase, a critical and indispensible enzyme driving viral DNA enhancement. Synonyms: 2,2,2-Trifluoro-N-(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl)acetamide; 5'-Deoxy-5'-(2,2,2-trifluoroacetamido)thymidine. Grades: 95%. CAS No. 55812-00-5. Molecular formula: C12H14F3N3O5. Mole weight: 337.26. | |
| 5-Trifluorothymidine | Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency. Group: Biochemicals. Alternative Names: Trifluridine; Trifluorothymine Deoxyriboside; α, α, α-Trifluorothymidine; 2-Deoxy-5- (trifluoromethyl) uridine; 5-(Trifluoromethyl)-2-deoxyuridine; Viroptic. Grades: Highly Purified. CAS No. 70-00-8. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C??H??F?N?O?, Molecular Weight: 296.2. US Biological Life Sciences. | Worldwide |
| 5-(Trimethylstannyl)-2'-deoxyuridine | Several novel 5-substituted 2'-deoxyuridine analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK), which derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase. Uses: Several novel 5-substituted 2'-deoxyuridine (durd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (hsv-1)-encoded thymidine kinase (tk) derived from hsv-1 tk gene-transfected murine mammary carcinoma fm3a cells, and h. Synonyms: 2'-Deoxy-5-(trimethylstannyl)uridine. Grades: 97%. CAS No. 146629-34-7. Molecular formula: C12H20N2O5Sn. Mole weight: 391.01. | |
| 6-Amino-3-iodo-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine | 6-Amino-3-iodo-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine boasts high potential as a potent inhibitor of thymidine kinases, with implications for the treatment of herpes simplex virus type 1 and 2. Beyond these applications, this compound plays a pivotal role in the development of antiviral agents that can provide feasible solutions for a wide range of viral diseases. Synonyms: 1-(beta-D-Ribofuranosyl)-4-methoxy-3-iodo-1H-pyrazolo[3,4-d]pyrimidine-6-amine. Grades: ≥95%. CAS No. 1997362-11-4. Molecular formula: C11H14IN5O5. Mole weight: 423.16. | |
| Acyclovir (Zovirax, Acycloguanosine) | Acyclovir (Zovirax) is classified as an antiviral used in the treatment of Herpes genitalis, herpes simplex, herpes zoster and other diseases. Acyclovir inhibits the replication of viral DNA needed to reproduce itself. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase. Acycloguanosine can be used to induce apoptosis in cells transfected with HSV-TK. Inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase. Group: Biochemicals. Alternative Names: Acycloguanosine; 9-[ (2-Hydroxyethoxy) methyl]guanine. Grades: USP. CAS No. 59277-89-3. Pack Sizes: 1g, 10g, 100g. US Biological Life Sciences. | Worldwide |
| Azidothymidine (3'-Azido-3'-deoxythymidine, AZT, Zidovudine) | Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC?? = 3nM) with low cytotoxicity (CC?? >5uM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency. Group: Biochemicals. Alternative Names: AZT; Zidovudine; Azidothymidine; 3'-Azido-3'-deoxythymidine; Retrovis; Timazid; Retrovir; NSC 602670. Grades: Highly Purified. CAS No. 30516-87-1. Pack Sizes: 100mg, 250mg, 500mg, 1g, 5g. Molecular Formula: C10H13N5O4, Molecular Weight: 267.24. US Biological Life Sciences. | Worldwide |
| β-L-2'-Deoxythymidine | β-L-2'-Deoxythymidine is an essential nucleoside analog, holding immense potential in the biomedical sector for its application in the development of groundbreaking antiviral drugs, primarily targeting a wide range of viral infections. By exhibiting an exceptional affinity towards thymidine kinase enzymes, it embodies a pivotal role in substantially impeding viral replication. Synonyms: Telbivudine. Grades: ≥ 98% by HPLC. Molecular formula: C10H14N2O5. Mole weight: 242.23. | |
| CCT-137690 | CCT137690, an aurora kinase inhibitor CCT137690, is a highly selective, orally bioavailable imidazo[4,5-b]pyridine derivative that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays and exhibits anti-proliferative activity against a wide range of human solid tumour cell lines. CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates, respectively) in HCT116 and HeLa cells. Continuous exposure of tumour cells to the inhibitor causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis. This is accompanied by p53/p21/BAX induction, thymidine kinase 1 (TK1) downregulation and PARP cleavage. Furthermore, CCT137690 treatment of MYCN-amplified neuroblastoma cell lines inhibits cell proliferation and decreases MYCN protein expression. Importantly, in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation, this compound significantly inhibits tumour growth. The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN amplified neuroblastoma. Synonyms: CCT-137690. CCT 137690. CCT137690. CAS No. 1095382-05-0. Molecular formula: C26H31BrN8O. Mole weight: 551.48. | |
| Clevudine | Clevudine is an inhibitor of hepatitis B virus (HBV). It is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate, which are biologically active. Uses: Antiviral agents. Synonyms: 1-(2'-Deoxy-2'-fluoro-β-L-arabinofuranosyl)-5-methyluracil; L-FMAU; 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; L FMAU; LFMAU; Levovir; 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil. Grades: ≥98% by HPLC. CAS No. 163252-36-6. Molecular formula: C10H13FN2O5. Mole weight: 260.22. | |
| Cyclopentenyl cytosine | Cyclopentenyl cytosine is a compelling antiviral compound adeptly impeding DNA enhancement, thereby exhibiting inhibitory efficacy in studying viral infections alongside select carcinoma types. This pharmacological gem orchestrates its modus operandi by selectively targeting viral thymidine kinase and incorporating seamlessly into viral DNA, consequently orchestrating chain termination and exerting viral inhibition. Synonyms: 4-Amino-1-[(1R,4R,5S)-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2(1H)-pyrimidinone. CAS No. 90597-22-1. Molecular formula: C10H13N3O4. Mole weight: 239.23. | |
| Dinaciclib | Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the pan-CDK inhibitor flavopiridol, dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4nM. At 5mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro (IC50s = 7-17nM). Group: Biochemicals. Alternative Names: Sch 727965; (2S) -1- [3-Ethyl-7- [ [ (1-oxido-3-pyridinyl) methyl]amino]pyrazolo [1, 5-a]pyrimidin-5-yl]-2-piperidineethanol. Grades: Highly Purified. CAS No. 779353-01-4. Pack Sizes: 5mg. Molecular Formula: C21H28N6O2. US Biological Life Sciences. | Worldwide |
| dTMP kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism. Group: Enzymes. Synonyms: thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Enzyme Commission Number: EC 2.7.4.9. CAS No. 9014-43-1. TMPK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3219; dTMP kinase; EC 2.7.4.9; 9014-43-1; thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Cat No: EXWM-3219. | |
| ent-Idoxuridine | The enantiomer of Idoxuridine. Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Group: Biochemicals. Alternative Names: 1-(2-Deoxy- β-L-erythro-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 2-Deoxy-L-5-iodouridine; 5-Iodo-2'-deoxy-L-uridine. Grades: Highly Purified. CAS No. 162239-35-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ent-Idoxuridine | The enantiomer of Idoxuridine. Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Synonyms: 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-L-5-iodouridine; 5-Iodo-2'-deoxy-L-uridine. CAS No. 162239-35-2. Molecular formula: C9H11IN2O5. Mole weight: 354.1. | |
| Fazarabine | Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Synonyms: CCRIS 93; CCRIS-93; CCRIS93; NSC 281272; NSC-281272; NSC281272; Ara-AC; 5-Azacytosine arabinoside; 1-beta-D-Arabinofuranosyl-5-azacytosine. CAS No. 65886-71-7. Molecular formula: C8H12N4O5. Mole weight: 244.20. | |
| Ganciclovir | Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]-6H-purin-6-one; 2-NDG; 2-Nor-2-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert. Grades: Highly Purified. CAS No. 82410-32-0. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C?H??N?O?, Molecular Weight: 255.23. US Biological Life Sciences. | Worldwide |
| Indole-3-carbinol | Indole-3-carbinol is an inhibitor of cell growth via suppressing incorporation of [3H]thymidine, triggering G1 cell cycle arrest and downregulation of cyclin-dependent kinase 6 (CDK6) expression. It exhibits anticancer activity by inhibition of NF-κB and Akt signaling pathways. Nutritional supplement in health care products. Synonyms: 3-Indolemethanol; (1H-Indol-3-yl)methanol; Indole-3-methanol; Indol-3-yl-methanol; 3-Hydroxymethylindole; I3C; Indinol. Grades: 98%. CAS No. 700-06-1. Molecular formula: C9H9NO. Mole weight: 147.17. | |
| Mitoguazone | Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. Synonyms: MeGAG; methyl-G; methyl-GAG; MGBG; MGGH; DRG-0223; DRG 0223; DRG0223; NSC32946; NSC 32946; NSC-32946. Grades: 99.38%. CAS No. 459-86-9. Molecular formula: C5H12N8. Mole weight: 184.21. | |
| Omaciclovir | This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral thymidine kinase to its monophosphate form and it is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase. Preclinical trials for Herpes simplex virus infections, HIV infections and Varicella zoster virus infections were discontinued. Uses: Herpes simplex virus infections, hiv infections and varicella zoster virus infections. Synonyms: ABT-091; ABT091; ABT 091; H2G; H 2G; (-)-2HM-HBG; A-182091; 2HMHBG; Omaciclovir; 2-HMHBG; UNII-C9H909GLI3; Omaciclovir [USAN:INN]; C9H909GLI3; H 2G;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one. Grades: 98%. CAS No. 124265-89-0. Molecular formula: C10H15N5O3. Mole weight: 253.26. | |
| Phenyl Chlorothionoformate. | Phenyl Chlorothionoformate is used in the preparation of an bicyclic thymidine analogs as selective inhibitors of Thymidine monophosphate kinase Mycobacterium tuberculosis (TMPKmt). Group: Biochemicals. Alternative Names: Carbonochloridothioic Acid O-Phenyl Ester; Chlorothioformic Acid O-Phenyl Ester; NSC 99103; O-Phenyl Carbonochloridothioate ; O-Phenyl Chlorothiocarbonate; O-Phenyl Chlorothioformate; O-Phenyl Chlorothionoformate; Phenoxythiocarbonyl Chloride; Phenyl Chlorothiocarbonate; Phenyl Chlorothionoformate; Phenyl Thiochloroformate; Phenyl Thionochloroformate; Phenyl Thioxochloroformate. Grades: Highly Purified. CAS No. 1005-56-7. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| PRX 08066 | PRX 08066, a selective 5-hydroxytryptamine receptor 2B(5-HT2BR) antagonist, causes selective vasodilation of pulmonary arteries. Its IC50 value is 3.4 nM. It can potentially inhibit the pathologic 5-HT-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (PAH). It reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. It shows effects on the vascular muscularization induced by 5-HT in the in vitro studies. It inhibits 5-HT-induced mitogen-activated protein kinase activation and markedly reduces thymidine incorporation in Chinese hamster ovary cells expressing the human 5-HT2BR in vitro. It decrea...ts and mice without affecting the systemic mean arterial pressure in the animals. It is also found to have anti-proliferative and anti-fibrotic effects. It was developed by Allergan company and is in clinical phase 2 with no progression. Uses: Prx 08066 can potentially inhibit the pathologic 5-ht-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (pah). it is also found to have anti-proliferative and anti-fibrotic effects. Synonyms: PRX-08066; PRX 08066; PRX08066. 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methyl]-2-fluorobenzonitrile. Grades: >98%. CAS No. 866206-54-4. Molecular formula: C19H17ClFN5S. Mole weight: 401.89. | |
| Sorivudine | Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BV-araU. CAS No. 77181-69-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123032. |  |
| Sorivudine | Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: sorivudine;1-(β-D-Arabinofuranosyl)-5-[(E)-2-bromoethenyl]uracil;1-β-D-Arabinofuranosyl-5-[(E)-2-bromovinyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;Brovavir;BvAraU;BV-araU;YN-72;Bravavir. Product Category: Inhibitors. Appearance: Solid. CAS No. 77181-69-2. Molecular formula: C11H13BrN2O6. Mole weight: 349.136. Canonical SMILES: O=C1NC(C(/C=C/Br)=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O)=O. Product ID: ACM77181692. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Stavudine sodium | Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine sodium triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes. Synonyms: Zerit sodium; d4T sodium. Grades: >98%. CAS No. 134624-73-0. Molecular formula: C10H11N2NaO4. Mole weight: 246.2. | |
| Thymidine 5-diphosphate sodium | Thymidine 5-diphosphate (dTDP) sodium is the key product of pyrimidine synthesis in organisms. Thymidine 5-diphosphate sodium is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5-thymidine monophosphate (dTMP), which requires ATP and Mg 2+. Thymidine 5-diphosphate sodium is further catalyzed by TMPK to thymidine 5-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5-diphosphate [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: dTDP sodium. CAS No. 108322-12-9. Pack Sizes: 5 mg. Product ID: HY-131576A. | |
| Thymidine 5'-Diphosphate Sodium Salt | Thymidine 5'-Diphosphate Sodium Salt is a nucleoside diphosphate derived from phosphorylation of Thymidine. Which is produced from Thymidine monophosphate by Thymidylate kinase (TMPK), that is a nucleoside monophosphate kinase and can be futher phosphorylated to its active triphosphate antiviral or antitumor moieties. A proximate precursor for DNA synthesis. Synonyms: Thymidine 5'-(Trihydrogen Diphosphate) Sodium Salt. Grades: 90%. CAS No. 108322-12-9. Molecular formula: C10H16N2O11P2 xNa. Mole weight: 402.19. | |
| Thymidine 5'-Monophosphate Disodium Salt Hydrate | A nucleoside monophosphate derived from phosphorylation of Thymidine, Which is converted to Thymidine diphosphate by Thymidylate kinase (TMPK), and it's a nucleoside monophosphate kinase. It's also a constituent of Deoxyribonucleic Acid. Synonyms: 5'-Thymidylic Acid Disodium Salt Hydrate; Disodium 5'-dTMP Hydrate; Disodium TMP Hydrate. Grades: 97%. Molecular formula: C10H13N2Na2O8P xH2O. Mole weight: 366.17. | |
| TMP-CP | TMP-CP is a non-hydrolytic analogue of thymidine-5'-diphosphate and an inhibitor of thymidine kinase. It is also used as a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Synonyms: Thymidine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 55065-40-2. Molecular formula: C11H18N2O10P2 (free acid). Mole weight: 400.2 (free acid). | |
| Valacyclovir Hydrochloride Hydrate (L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy)ethyl Ester Hydrochloride hydrate; Valaciclovir) | Valacyclovir is a prodrug of Acyclovir with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. Group: Biochemicals. Grades: Highly Purified. CAS No. 124832-27-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor yet not has inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Synonyms: ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate. Grades: 99%. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. | |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: YMU1; YMU 1; YMU-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. Purity: >98%. IUPACName: ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate. Canonical SMILES: O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC. Product ID: ACM902589962. Alfa Chemistry ISO 9001:2015 Certified. Categories: YMusic. | |
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