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| Product | Description | |
|---|---|---|
| Tofacitinib | Tofacitinib is an orally available JAK3/2/1 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib; CP-690550. CAS No. 477600-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354. |  |
| Tofacitinib | Tofacitinib is an orally available JAK3 inhibitor (IC50 = 1 nM), exhibiting 20- and 100-fold less potency against JAK2 and JAK1. Tofacitinib induces G1 cell cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. It is approved for the treatment of rheumatoid arthritis (RA). Synonyms: Tasocitinib; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550. Grades: >98%. CAS No. 477600-75-2. Molecular formula: C16H20N6O. Mole weight: 312.37. |  |
| Tofacitinib | Tofacitinib is a novel Janus kinase 3 (JAK3) inhibitor. JAK3 is a critical cytoplasmic tyrosine kinase in the signaling pathways of multiple cytokines (interleukin (IL)-2, -7, -15 and -21) that are associated with various T cell functions. Group: Biochemicals. Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)- β -oxo-1-piperidinepropane nitrile; 1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine; CP 690550; Tofacitinib. Grades: Highly Purified. CAS No. 936487-63-7. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. |  Worldwide |
| Tofacitinib citrate | Tofacitinib citrate. Group: Biochemicals. Alternative Names: 3-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 200mg. Molecular Formula: C16H20N6O·C6H8O7. US Biological Life Sciences. | Worldwide |
| Tofacitinib citrate | Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile; 2-Hydroxy-1,2,3-propanetricarboxylate. Product Category: Inhibitors. CAS No. 540737-29-9. Molecular formula: C22H28N6O8. Mole weight: 504.4986. Purity: 0.96. Product ID: ACM540737299. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Tofacitinib citrate | Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib citrate; CP-690550 citrate. CAS No. 540737-29-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354A. | |
| Tofacitinib Citrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardspharmaceutical toxicology. Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-?-oxo-1-piperidinepropanenitrile 2-Hydroxy-1,2,3-propanetricarboxylate (1:1), CP 690500-10, Tasocitinib citrate, Xeljanz, 3-Piperidinamine, 1-(cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI), CP 690550-10, Tofacitinib citrate. |  |
| Tofacitinib Citrate Liposome | Tofacitinib Citrate (TOF) is a JAK3 inhibitor that achieves efficacy in treating rheumatoid arthritis by inhibiting the intracellular target Janus kinases (JAKs). This product is a pre-formulated liposome encapsulating Tofacitinib Citrate. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. |  |
| Tofacitinib Impurity 5 | Tofacitinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride. CAS No. 1062580-52-2. Molecular formula: C14H22N2·2HCl. Mole weight: 291.26. Catalog: APB1062580522. | |
| Tofacitinib Impurity C (Racimic Mixture) | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Molecular formula: C16H20N6O. Mole weight: 312.38. | |
| Tofacitinib Impurity E | Synonyms: (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE; 477600-70-7; cis-1-Benzyl-N,4-dimethylpiperidin-3-amine; (3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine; MFCD09475548; 477600-69-4; 3-PIPERIDINAMINE, N,4-DIMETHYL-1-(PHENYLMETHYL)-, (3R,4R)-; (3R,4R)-(1-BENZYL-4-METHYL-PIPERIDIN-3-YL)-METHYL-AMINE; Tofacitinib Impurity E; Tofacitinib Impurity F; MFCD11978163; TJY7EV26LJ; CIS-(1-BENZYL-4-METHYL-PIPERIDIN-3-YL)-METHYL-AMINE; SCHEMBL352022; AMY4163; DTXSID70659968; NVKDDQBZODSEIN-OCCSQVGLSA-N; CS-B0451; CUA60069; AKOS007930642; AKOS015919918; DS-0688; FS-2942; AC-24272; A25786; EN300-188822; (3R,4R)-1-benzyl-N,4-dimethyl-3-piperidinamine; (3R,4R)-1-Benzyl-N,4-dimethyl piperidin-3-amine; A1-00088; J-504320; (3R,4R)-(1-Benzyl-4-methylpiperidin-3-yl)-methylamine; 3-Piperidinamine,N,4-dimethyl-1-(phenylmethyl)-,(3R,4R)-rel-. CAS No. 477600-70-7. Molecular formula: C14H22N2. Mole weight: 218.34. | |
| Tofacitinib Impurity F | Cas No. 384338-23-2. | |
| Tofacitinib Impurity I | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H22N2. 2HCl. Mole weight: 291.26. | |
| Tofacitinib Impurity J | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H22N2. 2HCl. Mole weight: 291.26. | |
| Tofacitinib Impurity K | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N5O3. Mole weight: 332.39. | |
| Tofacitinib Impurity L | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide; 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanamide; Tofacitinib Impurity 25; Tofacitinib impurity L; SCHEMBL17718764; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl) amino)piperidin-1-yl)-3-oxopropanamide; CS-M2251; AKOS037650370; CS-14706; C12680. Molecular formula: C16H22N6O2. Mole weight: 330.39. | |
| Tofacitinib Impurity N | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-methyl-N-((3s,4s)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 1260614-73-0. Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Impurity (N-Des-(2-Cyanide-acetyl)-(3R,4S)) | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-Des-(2-Cyanide-acetyl)-(3R,4S). Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Impurity (N-Des-(2-Cyanide-acetyl)-(3S,4R)) | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-Des-(2-Cyanide-acetyl)-(3S,4R). Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Impurity O | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine. Molecular formula: C20H25N5. Mole weight: 335.46. | |
| Tofacitinib Impurity P | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-((3S,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 1252883-90-1. Molecular formula: C20H25N5. Mole weight: 335.46. | |
| Tofacitinib Impurity R | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 4-Chloro-7-tosyl-7h-pyrrolo[2,3-d]pyrimidine. CAS No. 479633-63-1. Molecular formula: C13H10ClN3O2S. Mole weight: 307.76. | |
| Tofacitinib Impurity S | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C27H31N5O2S. Mole weight: 489.64. | |
| Tofacitinib Impurity T | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H18N6O. Mole weight: 310.36. | |
| Tofacitinib Impurity U | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18ClN5. Mole weight: 297.77. | |
| Tofacitinib Impurity V | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H19ClN6O. Mole weight: 346.82. | |
| Tofacitinib Impurity W | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18ClN5. Mole weight: 279.77. | |
| Tofacitinib Impurity X | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Impurity Y | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H21N5. Mole weight: 259.36. | |
| Tofacitinib Impurity Z | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)-. CAS No. 477600-76-3. Molecular formula: C15H21N5O. Mole weight: 287.37. | |
| Tofacitinib N-hydroxy impurity | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5O. Mole weight: 261.33. | |
| Tofacitinib N-Oxide | Tofacitinib N-Oxide is an impurity of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: Tofacitib related impuritie 8; 1-Piperidinepropanenitrile, 4-methyl-3-(methyloxido-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-. Grades: ≥95%. CAS No. 2028267-73-2. Molecular formula: C16H20N6O2. Mole weight: 328.37. | |
| Tofacitinib related compound 1 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N6O2. Mole weight: 330.39. | |
| Tofacitinib Related Compound 10 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Related Compound 11 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H20N6O. Mole weight: 288.36. | |
| Tofacitinib Related Compound 12 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C20H25N5. Mole weight: 335.46. | |
| Tofacitinib Related Compound 13 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C20H25N5. Mole weight: 335.46. | |
| Tofacitinib Related Compound 14 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C14H19N5O. Mole weight: 273.34. | |
| Tofacitinib Related Compound 15 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C15H21N5O. Mole weight: 287.37. | |
| Tofacitinib Related Compound 16 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C15H23N5. Mole weight: 273.38. | |
| Tofacitinib related compound 2 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C10H17N3O. Mole weight: 195.27. | |
| Tofacitinib related compound 3 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H18N4O2. Mole weight: 262.31. | |
| Tofacitinib related compound 4 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H20N6O. Mole weight: 312.38. | |
| Tofacitinib related compound 5 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C13H19N5. Mole weight: 245.33. | |
| Tofacitinib Related Compound 6 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C19H21N7O2. Mole weight: 379.42. | |
| Tofacitinib Related Compound 7 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C16H22N6O2. Mole weight: 330.39. | |
| Tofacitinib Related Compound 8 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C29H38N10O2. Mole weight: 558.69. | |
| Tofacitinib Related Compound 9 | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Molecular formula: C34H45N7. Mole weight: 551.78. | |
| Tofacitinib Related Impurity (PF-05579970) | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: PF-05579970. Molecular formula: C15H21N5O. Mole weight: 287.37. | |
| (3R,4S)-Tofacitinib | (3R,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity A; 3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-46-5. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| (3R,4S)-Tofacitinib | (3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC 50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092578-46-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-40354D. | |
| (3S,4R)-Tofacitinib | (3S,4R)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity B; 3-((3S,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-48-7. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| (3S,4S)-Tofacitinib | (3S,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity C; 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-47-6. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| CP 690550 Citrate (Potent JAK Inhibitor, Tofacitinib citrate) ((3R,4R)-4-Methyl-3-(methyl-7H-pyrro lo[2,3-d]pyrimidin-4-ylamino)-b-oxo-1-piperidinepro panenitrile citrate) | Potent JAK inhibitor (IC50 values are 1, 20, and 112nm for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models. Group: Biochemicals. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CP-690550 Citrate (Tofacitinib Citrate) | CP-690550 is a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis. Group: Biochemicals. Alternative Names: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)- β -oxo-1-piperidinepropane nitrile; 2-Hydroxy-1,2,3-propanetricarboxylate; (3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2-Hydroxy-1,2,3-propanetricarboxylate; CP 690500-10; CP 690550-10; Tofacitinib Citrate. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Dihydro Tofacitinib Citrate | An impurity of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: Tofacitinib Impurity; 5,6-Dihydro CP-690550 citrate; 5,6-Dihydro Tofacitinib citrate. Molecular formula: C22H30N6O8. Mole weight: 506.51. | |
| 1-Benzyl-4-methyl-3-(methylamino)piperidine Dihydrochloride | A dihydrochloride salt form of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine;dihydrochloride; 1-benzyl-N,4-dimethylpiperidin-3-amine;dihydrochloride. Grades: 99 %. CAS No. 1228879-37-5. Molecular formula: C14H24Cl2N2. Mole weight: 291.26. | |
| 1-Benzyl-4-methyl-3-piperidinamine | 1-Benzyl-4-methyl-3-piperidinamine is an intermediate of Tofacitinib (T528000); an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1039738-27-6. Pack Sizes: 250mg, 1g. Molecular Formula: C13H20N2, Molecular Weight: 204.31. US Biological Life Sciences. | Worldwide |
| 3-((3R,4R)-4-methyl-3-(methylamino)piperidin-1-yl)-3-oxopropanenitrile hydrochloride | An impurity of Tofacitinib, a Janus kinase inhibitor that could be used against rheumatoid arthritis. CAS No. 1640971-87-4. Molecular formula: C10H18ClN3O. Mole weight: 231.72. | |
| (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride | (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is an impurity of Tofacitinib, a medication used to treat rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. Synonyms: (3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine;dihydrochloride; (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine;dihydrochloride. CAS No. 1062580-52-2. Molecular formula: C14H24Cl2N2. Mole weight: 291.26. | |
| (3R,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine | (3R,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine is an impurity of Tofacitinib, a medication used to treat rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. CAS No. 1638499-31-6. Molecular formula: C14H22N2. Mole weight: 218.34. | |
| (3S,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine | (3S,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is an impurity of Tofacitinib, a medication used to treat rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. Synonyms: (3S,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine. CAS No. 1638499-33-8. Molecular formula: C14H22N2. Mole weight: 218.34. | |
| (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is an impurity of Tofacitinib, a medication used to treat rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. Synonyms: Tofacitinib impurity G; Tofacitinib Impurity 02; cis-1-Benzyl-3-(methylamino)-4-methylpiperidine dihydrochloride. CAS No. 1354486-07-9. Molecular formula: C14H24Cl2N2. Mole weight: 291.3. | |
| 6-Chloro-7-deazapurine | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 4-Chloropyrrolo[2,3-d]pyrimidine; NSC 64952. Grades: ≥98% by HPLC. CAS No. 3680-69-1. Molecular formula: C6H4ClN3. Mole weight: 153.57. | |
| CP-690550A | This active molecular is a novel Janus Kinase 3 (JAK3) inhibitor. CP-690550A is an immunosuppressant for the treatment of rheumatoid arthritis, psoriasis, transplant rejection and other immune-mediated disorders. Uses: Immune-mediated disorders. Synonyms: CP-690550A; CP-690,550A; CP 690550A; CP690550A; Tofacitinib metabolite M2; UNII-Q7ZOK859UK; Tofacitinib metabolite M2; Q7ZOK859UK; CHEMBL1630791; 2-hydroxy-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone. Grades: 98%. CAS No. 1243290-37-0. Molecular formula: C15H21N5O2. Mole weight: 303.37. | |
| N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Synonyms: N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 477600-74-1. Molecular formula: C13H19N5. Mole weight: 245.32. | |
| PF-956980 | PF-956980, a close analogue of Tofacitinib, is a JAK3-selective inhibitor used as an anti-inflammatory agent. Besides, some studies showed that PF-956980 strikingly reversed the cytoprotective action of IL-4 on CLL cells. Synonyms: PF-956980; PF 956980; PF956980; Methanone, [(3R,?4R)?-4-methyl-3-(methyl-7H-pyrrolo[2,?3-d]?pyrimidin-4-ylamino)?-1-piperidinyl]?-1-pyrrolidinyl-. CAS No. 1262832-74-5. Molecular formula: C18H26N6O. Mole weight: 342.44. | |
| Upadacitinib | Upadacitinib is a selective JAK inhibitor under the development of AbbVie.ABT-494 is nearly 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Preliminary evidence suggests that ABT-494 may spare Jak2 and Jak3 dependent signaling compared to tofacitinib. Phase II for the treatment of Atopic dermatitis and Crohn's disease, Phase III for the treatment of Rheumatoid arthritis and Ulcerative colitis was on-going. Uses: Rheumatoid arthritis; ulcerative colitis;atopic dermatitis; crohn's disease. Synonyms: UNII-4RA0KN46E0;ABT494;(3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide. Grades: 98%. CAS No. 1310726-60-3. Molecular formula: C17H19F3N6O. Mole weight: 380.37. | |
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