Topotecan Suppliers USA
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Product | Description | |
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Topotecan Quick inquiry Where to buy Suppliers range | Topotecan. CAS No. 123948-87-8. | |
Topotecan Bis N-Oxide Quick inquiry Where to buy Suppliers range | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-1-(4-Ethyl-4,9-dihydroxy-6-oxido-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4',6,7]indolizino[1,2-b]quinolin-10-yl)-N,N-dimethylmethanamine Oxide. Molecular formula: C23H23N3O7. Mole weight: 453.46. | |
Topotecan carboxylic acid sodium salt Quick inquiry Where to buy Suppliers range | Topotecan carboxylic acid sodium salt. Group: Biochemicals. Alternative Names: 1-[ (Dimethylamino)methyl]-a-ethyl-9, 11-dihydro-a, 2-dihydroxy-8- (hydroxymethyl)-9-oxo-indolizino[1, 2-b]quinoline-7-acetic acid. Grades: Highly Purified. CAS No. 123949-08-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C23H24N3NaO6. US Biological Life Sciences. | Worldwide |
Topotecan Carboxylic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | Topotecan Carboxylic Acid Sodium Salt. Uses: For analytical and research use. Group: Chiral Molecules. CAS No. 123949-08-6. Pack Sizes: 2.5MG. IUPAC Name: sodium;(2S)-2-[1-[(dimethylamino)methyl]-2-hydroxy-8-methyl-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2,4-dihydroxybutanoate. Molecular formula: C23H24N3O6.Na. Mole weight: 461.44. Catalog: APS123949086. SMILES: [Na+]. CN (C)Cc1c (O)ccc2nc3C4=CC (=C (C)C (=O)N4Cc3cc12)[C@@] (O) (CCO)C (=O)[O-]. Format: Neat. Shipping: Room Temperature. | |
Topotecan-d5 Quick inquiry Where to buy Suppliers range | Labeled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4- (ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione; NSC-609669-d5; SKF-104864A-d5; Hycamtin-d5. Grades: Highly Purified. CAS No. 1133355-98-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Topotecan-d6 Quick inquiry Where to buy Suppliers range | Labelled Topotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1044904-10-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Topotecan-d6 Quick inquiry Where to buy Suppliers range | Topotecan-d6. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: Topotecan-d6, Topotecan D6 (N,N-dimethyl D6),1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[[di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-, (4S)-. CAS No. 1044904-10-0. Molecular formula: C232H6H17N3O5. Mole weight: 427.48. Catalog: APS1044904100. SMILES: [2H]C ([2H]) ([2H])N (Cc1c (O)ccc2nc3C4=CC5=C (COC (=O)[C@]5 (O)CC)C (=O)N4Cc3cc12)C ([2H]) ([2H])[2H]. Format: Neat. Product Type: Stable Isotope Labelled. | |
Topotecan-d6 Carboxylic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | Topotecan-d6 Carboxylic Acid Sodium Salt. Uses: For analytical and research use. Group: Chiral Molecules. CAS No. 1263470-27-4. Molecular formula: C23H18D6N3NaO6. Mole weight: 467.48. Catalog: APS1263470274. Format: Neat. Product Type: Stable Isotope Labelled. | |
Topotecan HCl Quick inquiry Where to buy Suppliers range | Topotecan HCl. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4', 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione hydrochloride; NSC-609669; SKF-104864A. Grades: Highly Purified. CAS No. 119413-54-6. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C23H24ClN3O5. US Biological Life Sciences. | Worldwide |
Topotecan hydrochloride Quick inquiry Where to buy Suppliers range | Topotecan hydrochloride. Group: Heterocyclic Organic Compound. Alternative Names: Topotecan hydrochloride. Grades: 96%. CAS No. 119413-54-4. Product ID: ACM119413544. Molecular formula: C23H24ClN3O5. Mole weight: 457.90700. IUPAC Name: Topotecan HCl. Appearance: White Crystalline Solid. Boiling Point: 782.9ºC at 760mmHg. Melting Point: 213-218ºC. Flash Point: 427.3ºC. | |
Topotecan hydrochloride Quick inquiry Where to buy Suppliers range | Topotecan hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 119413-54-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Topotecan Hydrochloride Quick inquiry Where to buy Suppliers range | Topotecan Hydrochloride is the water-soluble hydrochloride salt preparation of Topotecan, a potent inhibitor of topoisomerase 1, and an apoptosis inducer, producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid camptothecin. It is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells. Uses: API. CAS No. 119413-54-6. Product ID: 10-101-124. | |
TOPOTECAN, HYDROCHLORIDE Quick inquiry Where to buy Suppliers range | TOPOTECAN, HYDROCHLORIDE. CAS No. 119413-54-6. | |
Topotecan, Hydrochloride ( (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione, Hydrochloride, SKF-104864A,) Quick inquiry Where to buy Suppliers range | A DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione, Hydrochloride, SKF-104864A. Grades: Highly Purified. CAS No. 119413-54-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Topotecan hydrochloride hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC and enzymatic). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 123948-87-8 (free base). Pack Sizes: 10MG, 50MG. Mole weight: 421.45 (anhydrous free base basis). Catalog: ALP123948878. Assay: ≥98% (HPLC and enzymatic). | |
Topotecan N-Oxide Quick inquiry Where to buy Suppliers range | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. CAS No. 1398723-05-1. Molecular formula: C23H23N3O6. Mole weight: 437.46. | |
5-Hydroxy Topotecan-d6 Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan-d6. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione-d6; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin-d6. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H17D6N3O6, Molecular Weight: 443.48. US Biological Life Sciences. | Worldwide |
5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers). Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-, (4S)-, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin. CAS No. 504413-73-4. Molecular formula: C23H23N3O6. Mole weight: 437.45. Catalog: APS504413734. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (C (O)c4cc5c (CN (C)C)c (O)ccc5nc34)C2=O. Format: Neat. | |
5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
N-Desmethyl topotecan Quick inquiry Where to buy Suppliers range | N-Desmethyl topotecan. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 190710-79-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C22H21N3O5. US Biological Life Sciences. | Worldwide |
N-Desmethyl Topotecan Quick inquiry Where to buy Suppliers range | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 190710-79-3. Molecular formula: C23H23N3O5. Mole weight: 407.43. | |
N-Desmethyl Topotecan Quick inquiry Where to buy Suppliers range | N-Desmethyl Topotecan. Uses: For analytical and research use. Group: Chiral Molecules. CAS No. 190710-79-3. Pack Sizes: 1MG. Molecular formula: C22H21N3O5. Mole weight: 407.42. Catalog: APS190710793. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5c (CNC)c (O)ccc5nc34)C2=O. Format: Neat. Product Type: Metabolite. Shipping: Room Temperature. | |
N-Desmethyl Topotecan-d3 (>90%) Quick inquiry Where to buy Suppliers range | N-Desmethyl Topotecan-d3 (>90%). Uses: For analytical and research use. Group: Chiral Molecules. CAS No. 1217633-79-8. Pack Sizes: 1MG. Molecular formula: C22H18D3N3O5. Mole weight: 410.44. Catalog: APS1217633798. Format: Neat. Product Type: Stable Isotope Labelled. Shipping: Room Temperature. | |
(R)-Topotecan HCl Quick inquiry Where to buy Suppliers range | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4R)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride. Molecular formula: C23H23N3O5. HCl. Mole weight: 457.92. | |
(S)-Topotecan Quick inquiry Where to buy Suppliers range | (S)-Topotecan. Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. Alternative Names: TopoCED, Topophore C, 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin, Topotecan lactone,1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-, SKF 104864, Hycamptin, Nogitecan, Hycamptamine, NSC 609699, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-, (S)-Topotecan, Topotecan, 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin, SKF-S 104864, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 123948-87-8. Molecular formula: C23H23N3O5. Mole weight: 421.45. Catalog: APS123948878. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5c (CN (C)C)c (O)ccc5nc34)C2=O. Format: Neat. | |
10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin is an impurity of Topotecan (T542500), a chemotherapy agent that is a topoisomerase 1 inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-12-ethoxy-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione. Grades: Highly Purified. CAS No. 504413-76-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: (S)-10-Hydroxycamptothecin, SKF-S-104961, Hydroxycamptothecin, (+)-10-Hydroxycamptothecin, (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-, 10-Hydroxycamptothecine, Camptothecine, 10-hydroxy- (8CI), Topotecan related, 10-Hydroxycamptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-, NSC 107124, ChEMBL 273862. CAS No. 19685-09-7. Pack Sizes: 1MG. IUPAC Name: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Molecular formula: C20H16N2O5. Mole weight: 364.35. Catalog: APS19685097A. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5cc (O)ccc5nc34)C2=O. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-,(4S)- Quick inquiry Where to buy Suppliers range | 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-,(4S)-. Group: Heterocyclic Organic Compound. Alternative Names: N-DESMETHYL TOPOTECAN;(4S)-4-Ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Grades: 96%. CAS No. 190710-79-3. Molecular formula: C22H21N3O5. Mole weight: 407.42. IUPAC Name: N-Desmethyl Topotecan. Exact Mass: 407.14800. Boiling Point: 815.495ºC at 760 mmHg. Flash Point: 446.995ºC. Density: 1.529g/cm3. SMILES: CCC1 (C2=C (COC1=O)C (=O)N3CC4=C (C3=C2)N=C5C=CC (=C (C5=C4)CNC)O)O. InChIKey: ZWUJOGCYOWLZFL-QFIPXVFZSA-N. | |
Diflomotecan Quick inquiry Where to buy Suppliers range | Diflomotecan is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. Diflomotecan is also a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced plasma stability and superior preclinical anti-tumour activity as compared to the established camptothecins, irinotecan and topotecan. Diflomotecan was the first homocamptothecin to enter clinical studies. Phase I data are summarized for both the intravenous and oral schedules. The toxicity is primarily haematological while no severe gastrointestinal toxicity has been observed in contrast to other topoisomerase I inhibitors. Diflomotecan has a high oral bioavailability (72 - 95%) and the oral day 1 - 5 every 3 weeks regimen is recommended for Phase II testing because it is relatively well tolerated, convenient and mimics protracted exposure. Synonyms: BN 80915; 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-; (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione; (R)-5-Ethyl-9, 10-difluoro-5-hydroxy-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. Grades: ≥95%. CAS No. 220997-97-7. Molecular formula: C21H16F2N2O4. Mole weight: 398.36. | |
Ko 143 Quick inquiry Where to buy Suppliers range | Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines. It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. Synonyms: Ko-143; Ko-143; Ko-143. Grades: >98%. CAS No. 461054-93-3. Molecular formula: C26H35N3O5. Mole weight: 469.57. | |
YHO-13351 free base Quick inquiry Where to buy Suppliers range | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. |