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| Product | Description | |
|---|---|---|
| Topotecan | Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 104864A; NSC 609669. CAS No. 123948-87-8. Pack Sizes: 1 mg. Product ID: HY-13768. |  |
| Topotecan Bis N-Oxide | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-1-(4-Ethyl-4,9-dihydroxy-6-oxido-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4',6,7]indolizino[1,2-b]quinolin-10-yl)-N,N-dimethylmethanamine Oxide. Molecular formula: C23H23N3O7. Mole weight: 453.46. |  |
| Topotecan carboxylic acid sodium salt | Topotecan carboxylic acid sodium salt. Group: Biochemicals. Alternative Names: 1-[ (Dimethylamino)methyl]-a-ethyl-9, 11-dihydro-a, 2-dihydroxy-8- (hydroxymethyl)-9-oxo-indolizino[1, 2-b]quinoline-7-acetic acid. Grades: Highly Purified. CAS No. 123949-08-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C23H24N3NaO6. US Biological Life Sciences. |  Worldwide |
| Topotecan-d5 | Labeled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4- (ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione; NSC-609669-d5; SKF-104864A-d5; Hycamtin-d5. Grades: Highly Purified. CAS No. 1133355-98-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Topotecan-d6 | Labelled Topotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1044904-10-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Topotecan-d6 | Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4',6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC-609669-d6; SKF-104864A-d6; Hycamtin-d6. Product Category: Inhibitors. Appearance: Yellow Solid. CAS No. 1044904-10-0. Molecular formula: C23H17D6N3O5. Mole weight: 427.48. Purity: 0.96. IUPACName: Topotecan-d6. Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O. Product ID: ACM1044904100. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Topotecan HCl | Topotecan HCl. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4', 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione hydrochloride; NSC-609669; SKF-104864A. Grades: Highly Purified. CAS No. 119413-54-6. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C23H24ClN3O5. US Biological Life Sciences. | Worldwide |
| Topotecan hydrochloride | Topotecan hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 119413-54-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Topotecan hydrochloride | Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,4-Di[4-(3-phenoxypropoxy)-2-butynyl]piperazine. Product Category: Inhibitors. Appearance: Light-yellow powder. CAS No. 119413-54-6. Molecular formula: C23H24ClN3O5. Mole weight: 457.91. Purity: 0.98. IUPACName: (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride. Canonical SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl. Product ID: ACM119413546. Alfa Chemistry ISO 9001:2015 Certified. | |
| Topotecan hydrochloride | Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. Uses: Scientific research. Group: Natural products. Alternative Names: SKF 104864A hydrochloride; NSC 609669 hydrochloride. CAS No. 119413-54-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13768A. | |
| Topotecan Hydrochloride | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardschiral moleculesenzyme activators, inhibitors & substrates. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-, Hycamtin, SKF-S-104864-A, (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)- (9CI), Nogitecan hydrochloride, Topotecan hydrochloride, SKFS 104864A, Xinze, SKF-S-104864,(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydrochloride (1:1), SKF 104864A, Topotecan chlorohydrate, SKF-S-106567, NSC 609669. |  |
| Topotecan, Hydrochloride ( (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione, Hydrochloride, SKF-104864A,) | A DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione, Hydrochloride, SKF-104864A. Grades: Highly Purified. CAS No. 119413-54-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Topotecan hydrochloride hydrate | ?98% (HPLC and enzymatic). Group: Fluorescence/luminescence spectroscopy. | |
| Topotecan Hydrochloride Liposome (PEGylated) | Topotecan Hydrochloride (TPT) is a semi-synthetic derivative of the plant alkaloid camptothecin (CPT) with cytotoxic properties. Like other drugs in the CPT family, TPT is a specific inhibitor of topoisomerase I, causing lethal DNA damage in the S phase of mitosis. Liposome preparation and anti-tumor activity research. This product is a pre-formulated liposome encapsulating Topotecan Hydrochloride. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. |  |
| Topotecan N-Oxide | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. CAS No. 1398723-05-1. Molecular formula: C23H23N3O6. Mole weight: 437.46. | |
| Topotecan Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Topotecan Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 5-Hydroxy Topotecan-d6 | 5-Hydroxy Topotecan-d6. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione-d6; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin-d6. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H17D6N3O6, Molecular Weight: 443.48. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl topotecan | N-Desmethyl topotecan. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 190710-79-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C22H21N3O5. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Topotecan | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 190710-79-3. Molecular formula: C23H23N3O5. Mole weight: 407.43. | |
| (R)-Topotecan HCl | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4R)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride. Molecular formula: C23H23N3O5. HCl. Mole weight: 457.92. | |
| 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin | 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin is an impurity of Topotecan (T542500), a chemotherapy agent that is a topoisomerase 1 inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-12-ethoxy-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione. Grades: Highly Purified. CAS No. 504413-76-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Diflomotecan | Diflomotecan is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. Diflomotecan is also a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced plasma stability and superior preclinical anti-tumour activity as compared to the established camptothecins, irinotecan and topotecan. Diflomotecan was the first homocamptothecin to enter clinical studies. Phase I data are summarized for both the intravenous and oral schedules. The toxicity is primarily haematological while no severe gastrointestinal toxicity has been observed in contrast to other topoisomerase I inhibitors. Diflomotecan has a high oral bioavailability (72 - 95%) and the oral day 1 - 5 every 3 weeks regimen is recommended for Phase II testing because it is relatively well tolerated, convenient and mimics protracted exposure. Synonyms: BN 80915; 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-; (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione; (R)-5-Ethyl-9, 10-difluoro-5-hydroxy-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. Grades: ≥95%. CAS No. 220997-97-7. Molecular formula: C21H16F2N2O4. Mole weight: 398.36. | |
| DNA relaxation-IN-1 | DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 ( DNA Lig1 ) inhibitor, which inhibits DNA ligation and disrupts Lig Is DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2190506-29-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161152. | |
| Ko 143 | Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines. It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. Synonyms: Ko-143; Ko-143; Ko-143. Grades: >98%. CAS No. 461054-93-3. Molecular formula: C26H35N3O5. Mole weight: 469.57. | |
| YHO-13351 free base | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. | |
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