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3-Amino-1,1,1-trifluoropropan-2-ol. Group: Biochemicals. Grades: Highly Purified. CAS No. 431-38-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C3H6F3NO, Molecular Weight: 129.08. US Biological Life Sciences.
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3-Bromo-1,1,1-trifluoropropane
3-Bromo-1,1,1-trifluoropropane is used in the discovery of potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 460-32-2. Pack Sizes: 250mg, 1g. Molecular Formula: C3H4BrF3, Molecular Weight: 176.96. US Biological Life Sciences.
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3-Chloro-1,1,1-trifluoropropane
3-Chloro-1,1,1-trifluoropropane. Group: Biochemicals. Grades: Highly Purified. CAS No. 460-35-5. Pack Sizes: 500mg, 1g. Molecular Formula: C3H4ClF3, Molecular Weight: 132.51. US Biological Life Sciences.
Methyl 2-amino-3,3,3-trifluoropropanoate hydrochloride is an alanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 134297-36-2. Pack Sizes: 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W050444.
1,1-Dibromo-3,3,3-trifluoroacetone
Used in synthesis of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors. Group: Biochemicals. Alternative Names: 3,3-Dibromo-1,1,1-trifluoro-2-propanone; 1,1,1-Trifluoro-3,3-dibromoacetone; 3,3-Dibromo-1,1,1-trifluoropropan-2-one. Grades: Highly Purified. CAS No. 431-67-4. Pack Sizes: 1g, 10g, 25g, 50g. US Biological Life Sciences.
It is an important monomeric silane which combines the excellent properties of both organosilicon and organic fluorine. In its molecule, there are reaction groups which can bond with inorganic materials and groups which can bond with organic polymers. It is normally used as a silane coupling agent or an fluoro intermediate. Uses: It is mainly used as a fluoro silane coupling agent and an adhesion promoter. it can be introduced to improve adhesion, mechanical properties and chemical properties of various composites. Group: Biomaterials. Alternative Names: 3-(Trimethoxysilyl)-1,1,1-trifluoropropane. CAS No. 429-60-7. Molecular formula: C6H13F3O3Si. Mole weight: 218.25. Appearance: Clear liquid. Purity: >96%. IUPACName: trimethoxy(3,3,3-trifluoropropyl)silane. Canonical SMILES: CO[Si](CCC(F)(F)F)(OC)OC. Density: 1.098 g/mL. ECNumber: 207-059-3. Catalog: ACM429607.
A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. SPR data indicates potent binding to p300 (KD=15 nM). In PC-3 cells A-485 reduces H3K27ac with IC50 of 73 nM while not affecting H3K9ac levels. Inhibition of cellular proliferation is observed in several cancer cell types, most notably AR+ prostate, multiple myeloma, and NHL. A-486 is a suitable control with 1000-fold higher IC50 in the p300 TR-FRET assay. Group: Inhibitors. Alternative Names: A-485; A 485; A485. CAS No. 1889279-16-6. Molecular formula: C25H24F4N4O5. Mole weight: 536.48. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide. Canonical SMILES: O=C (N1CC (N ([C@H] (C (F) (F)F)C)CC2=CC=C (F)C=C2)=O)[C@@]3 (OC1=O)CCC4=CC (NC (NC)=O)=CC=C43. Catalog: ACM1889279166.
BAY-2402234
BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY 2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. In vivo, BAY 2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Group: Inhibitors. Alternative Names: BAY-2402234; BAY 2402234; BAY2402234; Orludodstat; Orludodstatum. CAS No. 2225819-06-5. Molecular formula: C21H18ClF5N4O4. Mole weight: 520.84. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide. Canonical SMILES: FC1=C (NC (C2=CC (F)=C (N3N=C (CO)N (CC)C3=O)C=C2O[C@@H] (C)C (F) (F)F)=O)C (Cl)=CC=C1. Catalog: ACM2225819065.
Iclepertin
Iclepertin, a glycine transporter inhibitor, is an antipsychotic drug. Synonyms: [5-(methanesulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl}methanone; (5-(methylsulfonyl)-2-(((R)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone. CAS No. 1421936-85-7. Molecular formula: C20H18F6N2O5S. Mole weight: 512.42.
PF-06442609
PF-06442609 is a potent, metabolic stable γ-secretase modulators. It displayed a favorable rodent pharmacokinetic profile, and robust reductions of brain Aβ42 and Aβ40 were observed in a guinea pig time-course experiment. F-06442609 may be used for the treatment of Alzheimer's disease in the future. Uses: Alzheimer's disease. Synonyms: PF-06442609; PF 06442609; PF06442609; PF-6442609; PF 6442609; PF6442609. 2-((S)-1-(4-fluoro-2-((R)-1,1,1-trifluoropropan-2-yl)phenoxy)propan-2-yl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione. Grades: 98%. CAS No. 1402002-76-9. Molecular formula: C24H24F4N4O3. Mole weight: 492.47.
Pirtobrutinib
Pirtobrutinib, also known as LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover. Group: Inhibitors. Alternative Names: Pirtobrutinib; LOXO-305; LOXO 305; LOXO305; LY 3527727; LY-3527727; LY3527727. CAS No. 2101700-15-4. Molecular formula: C22H21F4N5O3. Mole weight: 479.44. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide. Canonical SMILES: O=C (C1=C (N)N ([C@@H] (C)C (F) (F)F)N=C1C2=CC=C (CNC (C3=CC (F)=CC=C3OC)=O)C=C2)N. Catalog: ACM2101700154.
Pirtobrutinib
Pirtobrutinib is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Synonyms: BTK inhibitor 16; LY 3527727; LOXO-305; (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide. Grades: >98%. CAS No. 2101700-15-4. Molecular formula: C22H21F4N5O3. Mole weight: 479.4.
Trifluoropyruvic Acid Ethyl Ester is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles. Group: Biochemicals. Alternative Names: 3,3,3-Trifluoro-2-oxopropanoic Acid Ethyl Ester; Ethyl 2-Oxo-3,3,3-trifluoropropanoate; Ethyl 3,3,3-Trifluoropyruvate; Ethyl 3,3,3-Trifluoro-2-oxopropanoate; Ethyl Trifluoropyruvate. Grades: GC. CAS No. 13081-18-0. Pack Sizes: 5g, 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
Worldwide
Vorasidenib
Vorasidenib / AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations. Group: Fluorinated apis. Alternative Names: AG-881. CAS No. 1644545-52-7. Molecular formula: C14H13ClF6N6. Mole weight: 414.74. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. Catalog: OFC1644545527.
Vorasidenib
Vorasidenib is a potent and orally available pan-IDH (isocitrate dehydrogenase) mutant form inhibitor. It has the potential for the treatment of various cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma. Synonyms: AG-881; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. CAS No. 1644545-52-7. Molecular formula: C14H13ClF6N6. Mole weight: 414.74.
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