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| Product | Description | |
|---|---|---|
| Tubulysin | The Tubulysin family of secondary metabolites was originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizers and anti-microtubule toxins ( anti-microtubule toxins ), with effective IC 50 concentrations against multidrug-resistant cancer cell lines. In the picomole range. Tubulysins are ideal candidates for incorporation into small active molecule conjugate (SMDC) delivery systems and are commonly used in ADC synthesis as ADC cytotoxins ( ADC Cytotoxin ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1943604-24-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128914. |  |
| Tubulysin B | Tubulysin B is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. It also has anti-fungal properties. Synonyms: (2S,4R)-2-Methyl-4-[2-[(1R,3R)-1-acetoxy-3-[[N-[[(2R)-1-methyl-2beta-piperidinyl]carbonyl]-L-isoleucyl](butanoyloxymethyl)amino]-4-methylpentyl]thiazole-4-ylcarbonylamino]-5-(4-hydroxyphenyl)pentanoic acid. Grades: ≥95%. CAS No. 205304-87-6. Molecular formula: C42H63N5O10S. Mole weight: 830.04. |  |
| Tubulysin C | Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Synonyms: Tubulysin C; 205304-88-7; 072P54KU0L; UNII-072P54KU0L; (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-(propanoyloxymethyl)amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid; Benzenepentanoic acid, gamma-(((2-((1R,3R)-1-(acetyloxy)-4-methyl-3-(((2S,3S)-3-methyl-2-((((2R)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((1-oxopropoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-4-hydroxy-alpha-methyl-, (alphaS. ga; SCHEMBL24218753; EX-A5466C; HY-N2347; AKOS040740942; CS-0021784; BENZENEPENTANOIC ACID. GAMMA.-(((2-((1R,3R)-1-(ACETYLOXY)-4-METHYL-3-(((2S,3S)-3-METHYL-2-((((2R)-1-METHYL-2-PIPERIDINYL)CARBONYL)AMINO)-1-OXOPENTYL)((1-OXOPROPOXY)METHYL)AMINO)PENTYL)-4-THIAZOLYL)CARBONYL)AMINO)-4-HYDROXY-.ALPHA.-METHYL-, (.ALPHA.S. GAMMA.R)-. Grades: 98%. CAS No. 205304-88-7. Molecular formula: C41H61N5O10S. Mole weight: 816.02. | |
| Tubulysin D | Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. It displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Synonyms: (+)-Tubulysin D. Grades: ≥98%. CAS No. 309935-57-7. Molecular formula: C43H65N5O9S. Mole weight: 828.07. | |
| 2-[(1R,3R)-3-[[(2S,3S)-2-Azido-3-methyl-1-oxopentyl]amino]-1-hydroxy-4-methylpentyl]-4-thiazolecarboxylic Acid Methyl Ester | 2-[(1R,3R)-3-[[(2S,3S)-2-Azido-3-methyl-1-oxopentyl]amino]-1-hydroxy-4-methylpentyl]-4-thiazolecarboxylic Acid Methyl Ester is an intermediate used to prepare Tubulysin and its impurities. Group: Biochemicals. Grades: Highly Purified. CAS No. 921927-93-7. Pack Sizes: 1mg. Molecular Formula: C17H27N5O4S, Molecular Weight: 397.49. US Biological Life Sciences. |  Worldwide |
| 2, 2-Diethoxyethane thioamide | 2, 2-Diethoxyethane thioamide is an intermediate in the synthesis of Tubulysin M, an antimitotic peptide from myxobacteria. Group: Biochemicals. Grades: Highly Purified. CAS No. 73956-15-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
| Mal-PEG2-acid | Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule [1]. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374666-32-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-130442. | |
| Pyruvaldehyde (35% Aqueous) | Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 78-98-8. Pack Sizes: 1g, 10g, 100g, 250g, 500g. Molecular Formula: C?H?O?, Molecular Weight: 72.06. US Biological Life Sciences. | Worldwide |
| Pyruvic aldehyde, Technical Grade, 35-45% Aqueous Solution | Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists. Group: Biochemicals. Grades: Purified. CAS No. 78-98-8. Pack Sizes: 100g, 250g, 500g, 1Kg, 2Kg. Molecular Formula: C?H?O?, Molecular Weight: 72.06. US Biological Life Sciences. | Worldwide |
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