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| Product | Description | |
|---|---|---|
| Tyrosine kinase-IN-7 | Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC 50 s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC 50 s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 345615-74-9. Pack Sizes: 10 mg. Product ID: HY-156912. |  |
| Tyrosine kinase inhibitor | Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1021950-26-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-10421. | |
| Tyrosine Kinase Inhibitor Library | A unique collection of 746 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2200. Categories: Tyrosine Kinase Inhibitor Libraries. |  |
| Tyrosine Kinase Peptide 1 | Tyrosine Kinase Peptide 1 is a substrate for tyrosine kinase proteins (TPKs) that is derived from the amino acid residues CDC (26-20). Synonyms: H-Lys-Val-Glu-Lys-Ile-Gly-Glu-Gly-Thr-Tyr-Gly-Val-Val-Tyr-Lys-OH; L-lysyl-L-valyl-L-alpha-glutamyl-L-lysyl-L-isoleucyl-glycyl-L-alpha-glutamyl-glycyl-L-threonyl-L-tyrosyl-glycyl-L-valyl-L-valyl-L-tyrosyl-L-lysine. CAS No. 173691-86-6. Molecular formula: C77H124N18O23. Mole weight: 1669.9. |  |
| Tyrosine Kinase Peptide 3 | RR-src is a peptide tyrosine kinase substrate derived from the phosphorylation site of pp60(Src). It is used to monitor purification of insulin receptor and to determine tyrosine kinase activity. Synonyms: Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly. CAS No. 81156-93-6. Molecular formula: C64H106N22O21. Mole weight: 1519.7. | |
| BMP Inhibitor III, LDN-212854 (Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) | A cell-permeable pyrazolopyrimidinyl quinoline that is superior to Dorsomorphin and DMH1 as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30nM, respectively; [ATP] = 6uM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276uM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6nM) with reduced potency against ABL1/c-abl, PDGFR-beta, ALK3, and PDGFR-alpha (IC50 = 40, 68, 85.8, and 650nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6mg/kg/12h via i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?. US Biological Life Sciences. |  Worldwide |
| cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 | The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Emodin, p56lck Tyrosine Kinase Inhibitor | Occurs mostly as the rhamnoside (see Frangulin) in rhubarb root. Cathartic. Cell-permeable. A naturally occurring anthraquinone that displays a range of biological activities including anti- inflammatory, anti-tumor and neuroprotective effects. Acts as a potent p56lck tyrosine kinase inhibitor (IC50 = 18.5uM). Group: Biochemicals. Alternative Names: 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,6,8-Trihydroxy-3-methylanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; Archin; Emodin; Emodol; Frangula Emodin; Frangulic Acid; NSC 408120; NSC 622947; Rheum Emodin; Schuttgelb. Grades: Highly Purified. CAS No. 518-82-1. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C??H??O?, Molecular Weight: 270.24. US Biological Life Sciences. | Worldwide |
| Eph-like receptor tyrosine kinase hEphB1b (422-432) | Eph-like receptor tyrosine kinase hEphB1b (422-432). | |
| FAK, Negative Control (non-phospho) Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Synthetic non-phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FAK [pS910], Positive Control Peptide (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Synthetic phosphopeptide (~10aa) derived from the region of FAK that contains serine 910. See corresponding antibody F0019-58N1. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FAK [pY397], Negative Control Peptide, non-phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FAK [pY397], Positive Control Peptide, phospho, for F0019-58A (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) | Peptide (linear) Content: 80 ± 4%. Group: Molecular Biology. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 | The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 | The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 | The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution cFMS Receptor Tyrosine Kinase Inhibitor | The cFMS Receptor Tyrosine Kinase Inhibitor controls the biological activity of cFMS Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Met/Flt-3/VEGFR2 Tyrosine Kinase Inhibitor - CAS 888719-03-7 | The Met/Flt-3/VEGFR2 Tyrosine Kinase Inhibitor controls the biological activity of Met/Flt-3/VEGFR2 Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-MAP Kinase, Monophosphorylated Tyrosine antibody produced in mouse | ~2 mg/mL, clone ERK-PY193, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| non-specific protein-tyrosine kinase | Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families. Group: Enzymes. Synonyms: ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambi. Enzyme Commission Number: EC 2.7.10.2. FAK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3127; non-specific protein-tyrosine kinase; EC 2.7.10.2; ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); BLK; Bmk; BMX; BRK; Bruton's tyrosine kinase; Bsk; BTK; BTKL; CAKb; Cdgip; CHK; CSK; CTK; CYL; cytoplasmic protein tyrosine kinase; EMT; ETK; Fadk; FAK; FAK2; FER; Fert1/2; FES; FGR; focal adhesion kinase; FPS; FRK; FYN; HCK; HCTK; HYL; IMD1; ITK; IYK; JAK1; JAK2; JAK3; Janus kinase 1; Janus kinase 2; Janus kinase 3; JTK1; JTK9; L-JAK; LCK; LSK; LYN; MATK; Ntk; p60c-src protein tyrosine kinase; PKB; protein-tyrosine kinase (ambiguous); PSCTK; PSCTK1; PSCTK2; PSCTK4; PSCTK5; PTK2; PTK2B; PTK6; PYK2; RAFTK; RAK; Rlk; Sik; SLK; SRC; SRC2; SRK; SRM; SRMS; STD; SYK; SYN; Tck; TEC; TNK1; Tsk; TXK; TYK2; TYK3; YES1; YK2; ZAP70. Cat No: EXWM-3127. |  |
| PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor) | PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor). Group: Biochemicals. Alternative Names: 1-tert-butyl-3-[2-[4- (diethylamino) butylamino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 25mg. Molecular Formula: C28 H41 N7O3 , Molecular Weight: 523.7. US Biological Life Sciences. | Worldwide |
| PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 | The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 | The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 | The PDGFR Tyrosine Kinase Inhibitor VII, also referenced under CAS 251356-45-3, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 | The PDGFR Tyrosine Kinase Inhibitor VI, SU6668, also referenced under CAS 210644-62-5, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| receptor protein-tyrosine kinase | The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. Group: Enzymes. Synonyms: AATK; AATYK; AATYK2; AATYK3; ACH; ALK; anaplastic lymphoma kinase; ARK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); AXL; Bek; Bfgfr; BRT; Bsk; C-FMS; CAK; CCK4; CD115; CD135; CDw135; Cek1; Cek10; Cek11; Cek2; Cek3; Cek5; Cek6; Cek7; CFD1; CKIT; CSF1R; DAlk; DDR1; DDR2; Dek; DKFZp434C1418; Drosophila Eph kinase; DRT; DTK; Ebk; ECK; EDDR1; Eek; EGFR; Ehk2; Ehk3; Elk; EPH; EPHA1; EPHA2; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EphB5; ephrin-B3 receptor tyrosine kinase; EPHT; EPHT2; EPHT3; EPHX; ERBB; ERBB1; ERBB2; ERBB3; ERBB4; ERK; Eyk; FGFR1; FGFR2; FGFR3; FGFR4; FLG; FLK1; FLK2; FLT1; FLT2; FLT3; FLT4; FMS; Fv2; HBGFR; HEK11; HEK2; HEK3; HEK5; HEK6; HEP; HER2; HER3; HER4; HGFR; HSCR1; HTK; IGF1R; INSR; INSRR; insulin receptor protein-tyrosine kinase; IR; IRR; JTK12; JTK13; JTK14; JWS; K-SAM; KDR; KGFR; KIA0641; KIAA1079; KIAA1459; Kil; Kin15; Kin16; KIT; KLG; LTK; MCF3; Mdk1; Mdk2; Mdk5; MEhk1; MEN2A/B; Mep; MER;. Enzyme Commission Number: EC 2.7.10.1. Storage: Store it at +4 ?C for short term. For long term storage, | |
| Receptor-type tyrosine-protein kinase FLT3 (591-600) | Receptor-type tyrosine-protein kinase FLT3 (591-600) is a truncated fragment of Receptor-type tyrosine-protein kinase FLT3. Tyrosine-protein kinase acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Synonyms: FL cytokine receptor (591-600); Fetal liver kinase-2 (591-600); Fms-like tyrosine kinase 3 (591-600). | |
| Receptor tyrosine-protein kinase erbB-2 (1023-1032) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (1023-1032). | |
| Receptor tyrosine-protein kinase erbB-2 (369-377) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (369-377). | |
| Receptor tyrosine-protein kinase erbB-2 (391-399) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (391-399). | |
| Receptor tyrosine-protein kinase erbB-2 (402-410) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (402-410). | |
| Receptor tyrosine-protein kinase erbB-2 (435-443) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (435-443). | |
| Receptor tyrosine-protein kinase erbB-2 (466-474) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (466-474). | |
| Receptor tyrosine-protein kinase erbB-2 (48-56) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (48-56). | |
| Receptor tyrosine-protein kinase erbB-2 (5-13) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (5-13). | |
| Receptor tyrosine-protein kinase erbB-2 (63-71) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (63-71). | |
| Receptor tyrosine-protein kinase erbB-2 (650-658) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (650-658). | |
| Receptor tyrosine-protein kinase erbB-2 (654-662) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (654-662). | |
| Receptor tyrosine-protein kinase erbB-2 (665-673) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (665-673). | |
| Receptor tyrosine-protein kinase erbB-2 (689-697) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (689-697). | |
| Receptor tyrosine-protein kinase erbB-2 (754-762) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (754-762). | |
| Receptor tyrosine-protein kinase erbB-2 (952-961) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (952-961). | |
| Receptor tyrosine-protein kinase erbB-2 precursor (369-386) | Receptor tyrosine-protein kinase erbB-2, is a protein that in humans is encoded by the ERBB2 gene. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Synonyms: CD340 precursor (369-386). | |
| Syk Inhibitor V ( (S) -2- (2- ( (3, 5-dimethylphenyl) amino) pyrimidin-4-yl) -N- (1-hydroxypropan-2-yl) -4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor) | A cell-permeable, 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible, and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki=9nM). Exhibits excellent selectivity over Cdk2 (Ki=3.33uM), ROCK (Ki=2.3uM), Src (Ki=3.33uM), and ZAP70 (Ki=240nM). Shown to inhibit mast cell degranulation (IC50=70nM) that is commonly observed in asthma and other allergic diseases. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 397.5. US Biological Life Sciences. | Worldwide |
| [tyrosine 3-monooxygenase] kinase | The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation. Group: Enzymes. Synonyms: pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating). Enzyme Commission Number: EC 2.7.11.6. CAS No. 103537-12-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3157; [tyrosine 3-monooxygenase] kinase; EC 2.7.11.6; 103537-12-8; pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating). Cat No: EXWM-3157. | |
| Tyrosine Protein Kinase JAK 2 Phospho-Tyr8, 9 | Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2. CAS No. 247171-44-4. Molecular formula: C88H138N20O34P2. Mole weight: 2082.1. | |
| VEGFR2 Kinase Inhibitor VII, SKLB1002 (VEGFR Tyrosine Kinase Inhibitor XXXV, 6,7-Dimethoxy-4-(5-methyl-1,3,4-thiadiazol-2-ylthio)quinazoline, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VII) | A cell-permeable quinazoline that acts as a potent, ATP-binding site-targeting, VEGFR2-selective inhibitor (IC50=32nM), while exhibiting much reduced or little activity against 16 other kinases. An effective antiangiogenesis agent (98% inhibition of HUVEC tube formation at 10uM; 80% inhibition of zebrafish embryos intersegmental vessel growth at 2.5uM) that significantly suppresses SW620- and HepG2-derived tumor growth in mice (by 72% and 63%, respectively, in 18 days; 100mg/kg/day; i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor | The VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor controls the biological activity of VEGFR/Tie-2/PDGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 | The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| VEGFR Tyrosine Kinase Inhibitor V | The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 - CAS 269390-77-4 | The VEGFR Tyrosine Kinse Inhibitor VI, ALL-993, also referenced under CAS 269390-77-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| ZAP-70 Tyrosine Kinase human | ?90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ?150 U/mg. Group: Fluorescence/luminescence spectroscopy. | |
| ZAP-70 Tyrosine Kinase human, Recombinant | ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues. ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration. > 90% (sds-page), recombinant, expressed in baculovirus infected insect cells (histidine tagged), buffered aqueous glycerol solution, > 150 u/mg. Applications: Human zap-70 tyrosine kinase was used for mapping the phosphorylation sites on lat (linker for activation of t cells) for investigating the mechanism of activation of signalling proteins in t cells. Group: Enzymes. Synonyms: ZAP-70 Tyrosine Kinase; Zeta-chain-associated protein kinase 70; ZAP-70; SRK; STCD; STD; TZK; ZAP70. Purity: > 90% (SDS-PAGE). ZAP70. Mole weight: mol wt 70 kDa. Activity: > 150 U/mg. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells (Histidine tagged). Species: Human. ZAP-70 Tyrosine Kinase; Zeta-chain-associated protein kinase 70; ZAP-70; SRK; STCD; STD; TZK; ZAP70. Cat No: NATE-0738. | |
| 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene | 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene is an intermediate used to prepare heterocyclic tyrosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 91562-20-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H17IO2, Molecular Weight: 320.17. US Biological Life Sciences. | Worldwide |
| 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene-d6 | 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene-d6 is labelled 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene which is an intermediate used to prepare heterocyclic tyrosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H11D6IO2, Molecular Weight: 326.2. US Biological Life Sciences. | Worldwide |
| 1,2,3,4,5,6-Hexabromocyclohexane | 1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It inhibits JAK2 activation, and reduces growth hormone-mediated JAK2 autophosphorylation. Synonyms: Benzene Hexabromide; JAK2 Inhibitor II. Grade: >98%. CAS No. 1837-91-8. Molecular formula: C6H6Br6. Mole weight: 557.54. | |
| 1,2,3,4,5,6-Hexabromocyclohexane | Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1uM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50uM elimates nearly all JAK2 activity. Non-cytotoxic at 100uM. Group: Biochemicals. Grades: Purified. CAS No. 1837-91-8. Pack Sizes: 50mg. Molecular Formula: C6H6Br6. US Biological Life Sciences. | Worldwide |
| 123C4 | 123C4 is an effective, selective and competitive receptor tyrosine kinase EPHA4 agonist with a Ki value of 0.65 μM. Synonyms: 4-amino-N-((S)-1-(((S)-3-(4-chlorophenyl)-1-(((S)-1-((2-(5-methoxy-1H-indol-3-yl)ethyl)amino)-1-oxo-3-(pyridin-4-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-(5-hydroxy-1H-indol-3-yl)-1-oxopropan-2-yl)butanamide. Grade: ≥98%. CAS No. 2034159-30-1. Molecular formula: C43H47ClN8O6. Mole weight: 807.34. | |
| 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride | 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride is used in the synthesis of 6-substituted-4- (3-bromophenylamino) quinazoline derivatives which functions as irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59826-28-7. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H10ClNO, Molecular Weight: 159.61. US Biological Life Sciences. | Worldwide |
| 1,2-bis(4-methylpiperazin-1-yl)ethanone | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-(5CI); Nintedanib Impurity E. Grade: ≥95%. CAS No. 856843-88-4. Molecular formula: C12H24N4O. Mole weight: 240.35. | |
| 1,3-dimethyl-1H-indazol-6-amine | 1,3-dimethyl-1H-indazol-6-amine is an impurity in the synthesis of Pazopanib, which is a potent and selective multi-targeted receptor tyrosine kinase inhibitor for the treatment of renal cell carcinoma and soft tissue sarcoma. Synonyms: 1H-Indazol-6-amine, 1,3-dimethyl-; 1,3-Dimethyl-6-amino-1H-indazole; Pazopanib Impurity 17; 1,3-Dimethyl-1H-indazol-6-ylamine; Pazopanib Impurity 3. Grade: 97.0%. CAS No. 221681-92-1. Molecular formula: C9H11N3. Mole weight: 161.20. | |
| 1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: 2-Pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy-; Dacomitinib Impurity WYQJ. Grade: ≥95%. CAS No. 2190490-31-2. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81. | |
| 1-[4-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one | 1-[4-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one is an inhibitor for brutons tyrosine kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 936563-92-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C25H24N6O2, Molecular Weight: 440.5. US Biological Life Sciences. | Worldwide |
| 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Urea Impurity; Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2-fluoro-4-hydroxyphenyl)-. CAS No. 1333390-56-9. Molecular formula: C14H9ClF4N2O2. Mole weight: 348.68. | |
| 1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea | 1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea is an impurity of Sorafenib (S676850), a kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1129683-83-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C14H10ClF3N2O2, Molecular Weight: 330.69. US Biological Life Sciences. | Worldwide |
| 1- (4-Chloro-3- (trifluoromethyl) phenyl) urea | 1- (4-Chloro-3- (trifluoromethyl) phenyl) urea is an impurity of Sorafenib (S676850); a multiple kinase inhibitor targeting both RAF and receptor tyrosine kinases that promote angiogenesis. Also antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H6ClF3N2O, Molecular Weight: 238.59. US Biological Life Sciences. | Worldwide |
| 1-(4-Chloro-3-(trifluoromethyl)phenyl)urea | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]urea; Sorafenib Impurity 1; Sorafenib related compound 1; 1-[3-(Trifluoromethyl)-4-chlorophenyl]urea; Sorafenib Related Compound 9. Grade: > 95%. CAS No. 343247-69-8. Molecular formula: C8H6ClF3N2O. Mole weight: 238.59. | |
| 1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide | 1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide is a metabolite of Lenvatinib (L329400) which is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 417724-81-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C11H10N2O3, Molecular Weight: 218.21. US Biological Life Sciences. | Worldwide |
| 1-Boc-pyrazole-4-boronic Acid Pinacol Ester | 1-Boc-pyrazole-4-boronic Acid Pinacol Ester is used as a reagent in the synthesis of several inhibitors including thieno[3,2-c]pyridin-4-amines which are a novel series of Brutons tyrosine kinase (BTK) inhibitors which can be used in drug design. Group: Biochemicals. Grades: Highly Purified. CAS No. 552846-17-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C14H23BN2O4, Molecular Weight: 294.149999999999. US Biological Life Sciences. | Worldwide |
| 1-Chloro-3-iodo-5- (trifluoromethyl) benzene | 1-Chloro-3-iodo-5- (trifluoromethyl) benzene has been used in the research of Bruton's tyrosine kinase inhibitors through the synthesis of pyrimidinyl bipiperidine.1. Group: Biochemicals. Grades: Highly Purified. CAS No. 1189352-83-7. Pack Sizes: 250mg, 1g. Molecular Formula: C7H3ClF3I, Molecular Weight: 306.45. US Biological Life Sciences. | Worldwide |
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