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| Product | Description | |
|---|---|---|
| Urokinase | 25mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: -. CAS No. 9039-53-6. Prepack ID 13187505-25mg. Molecular Weight -. See USA prepack pricing. |  |
| Urokinase from Human, recombinant | Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium. Group: Enzymes. Synonyms: Two chain urokinase-type plasminogen acti. Enzyme Commission Number: EC 3.4.21.73. Purity: > 90% by SDS-PAGE. uPA. Mole weight: 49.3 kDa. Activity: >1500 mU/mg. Storage: Stable at -80°C for at least 1 year as supplied. Store reconstituted aliquots at -80°C. Avoid repeated freeze and thaw cycles. Form: Lyophilized powder. Source: E. coli. Species: Human. Two chain urokinase-type plasminogen activator; tcuPA; PLAU; ATF; UPA; URK; u-PA; BDPLT5; QPD; Urokinase. Cat No: NATE-1690. |  |
| Urokinase, Human urine | Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Urokinase-type plasminogen activator; Uronase; Win 22005; Win-Kinase. CAS No. 9039-53-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108904. |  |
| Urokinase light yellow powder | 100mg Pack Size. Group: Biochemicals. Formula: N/A. CAS No. 9039-53-6. Prepack ID 90029023-100mg. See USA prepack pricing. | |
| Immobilized human urokinase | Immobilized human two-chain HMW urokinase is ideal for the controlled activation of plasminogen to plasmin. After the activation is complete, the resin is simply removed and the reaction is quenched. May be used to immunopurify monoclonal and polyclonal antibodies directed against human urokinase. May be used repeatedly. Group: Enzymes. Synonyms: Urokinase; EC 3. 4. 21. 73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator. Enzyme Commission Number: EC 3. 4. 21. 73. Purity: >95% by SDS-PAGE analysis. Mole weight: 54000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Insect cell culture. Species: Human. Urokinase; EC 3. 4. 21. 73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator; Immobilized uPA; Immobilized urokinase. Cat No: NATE-1759. | |
| Native Human Urokinase | Urokinase is a serine protease (EC 3.4.21.73). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer. Urokinase from human urine. Group: Enzymes. Synonyms: Urokinase; EC 3.4.21.73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator. Enzyme Commission Number: EC 3.4.21.73. CAS No. 9039-53-6. Purity: Purity by SDS Electrophoresis ? 95 %. uPA. Activity: > 500 units/mg protein. Form: Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol. Source: Human urine. Species: Human. Urokinase; EC 3.4.21.73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator. Cat No: PHAM-262. | |
| Pro-Urokinase from Human, recombinant | Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium. Group: Enzymes. Synonyms: Single chain Urokinase-type plasminogen activator; s. Purity: > 90% by SDS-PAGE. Pro-Urokinase. Mole weight: 49.3 kDa. Activity: >1200 mU/mg. Storage: Stable at -80°C for at least 1 year as supplied. Store reconstituted aliquots at -80°C. Avoid repeated freeze and thaw cycles. Form: Lyophilized powder. Source: E. coli. Species: Human. Single chain Urokinase-type plasminogen activator; scuPA; Urokinase-type Plasminogen Activator uPA; PLAU; Pro-Urokinase. Cat No: NATE-1689. | |
| 1,4-Dichloro-7-isoquinolinesulfonyl Chloride | Intermediate of isoquinolinyl guanidines as urokinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 223671-80-5. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| 2-?Amino-?5-? (trifluoromethyl) ?pyridine | 2-?Amino-?5-?(trifluoromethyl)? is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 74784-70-6. Pack Sizes: 250mg, 1g. Molecular Formula: C6H5F3N2. US Biological Life Sciences. | Worldwide |
| 3-Amino-5,6-dichloro-2-pyrazinecarboxylic Acid Methyl Ester | 3-Amino-5,6-dichloro-2-pyrazinecarboxylic Acid Methyl Ester, is used for the preparation of 2-Amidino analogs of glycine-Amiloride (A578700) conjugates, acting as inhibitors of the protease urokinase plasminogen activator (uPA), a promising anticancer targets. Group: Biochemicals. Grades: Highly Purified. CAS No. 1458-18-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C6H5Cl2N3O2. US Biological Life Sciences. | Worldwide |
| 4-Aminobenzamidine-13C2,15N4 Dihydrochloride | A labeled synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. Group: Biochemicals. Alternative Names: 4-Amino Benzene carboximidamide-13C2, 15N4 Dihydrochloride; 4-Amidinoaniline-13C2,15N4 Dihydrochloride; 4-Aminobenzamidine-13C2,15N4 Dihydrochloride; SC 67235-13C2,15N4 ; p-Aminobenzamidine-13C2,15N4 Dihydrochloride. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 4-Aminobenzamidine dihydrochloride | A synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. Synonyms: p-Aminobenzamidine 2HCl. Grades: ≥ 99 % (Assay). CAS No. 2498-50-2. Molecular formula: C7H9N3·2HCl. Mole weight: 208.09. |  |
| 4-Aminobenzamidine Dihydrochloride | A synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. Group: Biochemicals. Alternative Names: 4-Amino Benzene carboximidamide Dihydrochloride; 4-Amidinoaniline Dihydrochloride; 4-Aminobenzamidine Dihydrochloride; SC 67235; p-Aminobenzamidine Dihydrochloride. Grades: Highly Purified. CAS No. 2498-50-2. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-3-nitrobenzoic acid | 4-Chloro-3-nitrobenzoic acid has oral activity, and oral administration can affect the synthesis activity of liver proteins and the activities of urokinase and histidine kinase [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 96-99-1. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-20559. | |
| 4-Chlorophenylguanidine hydrochloride | 4-Chlorophenylguanidine hydrochloride is the hydrochloride salt of chlorophenylguanidine, which is a specific and potent inhibitor of urokinase. It is a useful reagent in the synthesis of pyrimidine derivatives. It may be a potential target for cancer treatment. Synonyms: p-Chlorophenylguanidin?e Hydrochloride; 1-(4-Chlorophenyl)?guanidine Hydrochloride; N-4-Chlorophenylguanidine Hydrochloride; N-p-Chlorophenylguanidine Hydrochloride; BW 65-100. Grades: ≥99% by HPLC. CAS No. 14279-91-5. Molecular formula: C7H9Cl2N3. Mole weight: 206.07. | |
| 4-Iodobenzylamine | 4-Iodobenzylamine ((4-Iodophenyl)methanamine) is a probe that can detect the binding patterns of serine proteases that are like trypsin, as well as urokinase-type plasminogen activator (uPA). 4-Iodobenzylamine is stable in aqueous solution [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (4-Iodophenyl)methanamine. CAS No. 39959-59-6. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-W013964. | |
| Amiloride | Amiloride (MK-870) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870. CAS No. 2609-46-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285. | |
| Amiloride hydrochloride | Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride. CAS No. 2016-88-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0285A. | |
| Amiloride hydrochloride dihydrate | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride dihydrate. CAS No. 17440-83-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285B. | |
| Amiloride (hydrochloride) (Standard) | Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride (Standard). CAS No. 2016-88-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B0285AR. | |
| Angstrom6 | Angstrom6 is a urokinase inhibitor that can be used to treat chronic lymphocytic leukemia. Synonyms: A-6 peptide; A-6; A6; A 6. CAS No. 220334-14-5. Molecular formula: C39H62N10O15. Mole weight: 910.98. | |
| BC 11 hydrobromide | BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM) with no activity at 8 other related enzymes. BC 11 inhibits clot lysis displaying no effect on clot formation. It also decreases viability of MDA-MB231 breast cancer cells in vitro. Synonyms: BC11 hydrobromide; BC-11 hydrobromide; BC 11 hydrobromide; BC-11 HBr Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide; [4- (carbamimidoylsulfanylmethyl) phenyl]boronic acid hydrobromide. CAS No. 443776-49-6. Molecular formula: C8H11BN2O2S.HBr. Mole weight: 290.97. | |
| BC-11 hydrobromide | BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase ( uPA ) inhibitor ( IC 50 =8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 443776-49-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108447. | |
| BOC-GLU-LYS-LYS-MCA | BOC-GLU-LYS-LYS-MCA is a sensitive fluorogenic substrate for urokinase-activated plasmin. Synonyms: T-BUTYLOXYCARBONYL-L-GLUTAMYL-L-LYSYL-L-LYSINE 4-METHYLCOUMARYL-7-AMIDE; BOC-GLU-LYS-LYS-AMC ACETATE SALT; BOC-GLU-LYS-LYS-AMC ACOH; BOC-GLU-LYS-LYS-MCA; Boc-Glu-Lys-Lys-AMC; N-T-boc-glu-lys-lys 7-amido-4-*methylcoumarin; N-tert-BOC-Glu-Lys 7-amido-4-methylcou. Grades: ≥97%. CAS No. 73554-85-5. Molecular formula: C32H48N6O9. Mole weight: 660.76. | |
| Bovine Plasminogen | Purified from freshly collected bovine plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. No Plasmin activity is detected using chromogenic substrate S-2251. Plasminogen is activated to the serine protease plasmin via urokinase, streptokinase or tissue plasminogen activator. Group: Zymogens. Purity: >94% by SDS-PAGE. Plasminogen. Mole weight: 90,000-94,000. Stability: 30 months. Storage: 2-8°C. Source: Bovine. Bovine Plasminogen; Plasminogen. Pack: 1mg. Cat No: CZY-030. | |
| CJ463 | CJ463 is a potent ans selective Urokinase (uPA) inhibitor, which plays a crucial role in carcinogenesis by facilitating tumor cell invasion and metastasis. It may be a novel agent for treatment of lung cancer. Uses: Cj463 may be a novel agent for treatment of lung cancer. Synonyms: CJ-463; CJ 463; CJ463. (S) -N- (4-carbamimidoylbenzyl) -3-hydroxy-2- ( (R) -3-hydroxy-2- ( (phenylmethyl) sulfonamido) propanamido) propanamide. Grades: 98%. CAS No. 600142-19-6. Molecular formula: C21H27N5O6S. Mole weight: 477.54. | |
| Gabexate mesylate | Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K i s of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K i s of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FOY. CAS No. 56974-61-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0385. | |
| GGACK | GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor [1]. Uses: Scientific research. Group: Peptides. CAS No. 65113-67-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137495. | |
| GGACK Dihydrochloride (H-Glu-Gly-Arg-CMK, Glu-Gly-Arg-chloromethylketone, Dihydrochloride) | A potent and irreversible inhibitor of Urokinase (uPA (IC50<1uM), Factor VIIa, Factor IXa, Factor Xa, and trypsin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| matriptase | This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active α- and β-HGF, but It does not activate plasminogen, which shares high homology with HGF.The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. Belongs in peptidase family S1A. Group: Enzymes. Synonyms: serine protease 14; membrane-type serine protease 1; MT-SP1; prostamin; serine protease TADG-15; tumor-associated differentially-expressed gene 15 protein; ST14; breast cancer 80 kDa protease; epithin; serine endopeptidase SNC19. Enzyme Commission Number: EC 3.4.21.109. CAS No. 241475-96-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4104; matriptase; EC 3.4.21.109; 241475-96-7; serine protease 14; membrane-type serine protease 1; MT-SP1; prostamin; serine protease TADG-15; tumor-associated differentially-expressed gene 15 protein; ST14; breast cancer 80 kDa protease; epithin; serine endopeptidase SNC19. Cat No: EXWM-4104. | |
| Nα-Benzoyl-L-arginine amide hydrochloride | A substrate for cathepsin and competitive inhibitor of human urokinase. Synonyms: Bz-L-Arg-NH2 HCl; (S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride; N-ALPHA-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; N-α-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate. Grades: ≥ 99% (TLC). CAS No. 4299-03-0. Molecular formula: C13H19N5O2·HCl. Mole weight: 313.80. | |
| Native Human Plasmin | Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products. Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes. Applications: A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. it has also been used in a study to investigate activation of human epithelial sodium channel (enac) by plasmin and chymotrypsin. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Enzyme Commission Number: EC 3.4.21.7. CAS No. 9001-90-5. PLG. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing sodium phosphate, mannitol, and NaCl. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3.4.21.7; 9001-90-5; PLG. Cat No: NATE-0598. | |
| Plasminogen, Human plasma | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-91-6. Pack Sizes: 1 mg. Product ID: HY-P2821. | |
| Sarcosine t-butyl ester hydrochloride | Sarcosine t-butyl ester hydrochloride is a reactant used in various syntheses. It was used in the preparation of sulfonamidoisoquinolinyl guanidines which are selective urokinase-type plasminogen activator inhibitors. Also used in the development of pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3). Synonyms: H-Sar-OtBu HCl; H-MeGly-OtBu HCl; N-α-Methylglycine t-butyl ester hydrochloride. CAS No. 136088-69-2. Molecular formula: C7H16ClNO2. Mole weight: 181.66. | |
| Tranexamic acid | Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: cyclocapron. CAS No. 1197-18-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0149. | |
| UK122 | UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC 50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC 50 >100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 940290-58-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111056. | |
| UK-356202 | UK-356202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM) that has been investigated for the topical treatment of chronic ulcerous wounds by topical administration. Synonyms: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202; 3-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]benzoic acid; UK-356202; 223671-94-1. Grades: >98%. CAS No. 223671-94-1. Molecular formula: C17H13ClN4O2. Mole weight: 340.767. | |
| UK-371804 | UK-371804 is a novel and selective inhibitors of urokinase plasminogen activator (uPA). UK-371804 exhibits excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Synonyms: 2- ( (4-chloro-1- ( (diaminomethylene) amino) isoquinoline) -7-sulfonamido) -2-methylpropanoic acid; UK-371804; UK371804; UK 371804; UK-371,804; UK 371,804; UK371,804. Grades: >98%. CAS No. 256477-09-5. Molecular formula: C14H16ClN5O4S. Mole weight: 385.82. | |
| UK-371804 HCl | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor. Study in vitro showed that it inhibited exogenous uPA in human chronic wound fluid (IC50=0.89 mM); In a porcine acute excisional wound model, it penetrated into pig wounds and suppressed exogenous uPA activity. UK-371804 is promisingly to be used for the treatment of chronic dermal ulcers. Synonyms: UK-371804 HCl; UK 371804 HCl; UK371804 HCl; SCHEMBL6437767; 2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid hydrochloride. Grades: 99.56 %. CAS No. 256476-36-5. Molecular formula: C14H16ClN5O4S.HCl. Mole weight: 422.29. | |
| Upamostat | This active molecular is 3-amidinophenylalanine-derived prodrug targeting the human urokinase plasminogen activator (uPA) system. It is a second generation serine protease inhibitor with potential antineoplastic and antimetastatic activities. Though inhibition of uPA may lead to inhibit growth and metastasis of tumor. In Jan 2016, Link Health planed a phase I trial for Solid tumours in China and two phase II trials in Cancer. Synonyms: 1-Piperazinecarboxylic acid, 4-[ (2S) -3-[3-[ (E) -amino (hydroxyimino) methyl]phenyl]-1-oxo-2-[[[2, 4, 6-tris (1-methylethyl) phenyl]sulfonyl]amino]propyl]-, ethyl ester; Ethyl 4-[ (2S) -3-[3-[ (E) -amino (hydroxyimino) methyl]phenyl]-1-oxo-2-[[[2, 4, 6-tris (1-methylethyl) phenyl]sulfonyl]amino]propyl]-1-piperazinecarboxylate; RHB 107; RHB-107; RHB107. Grades: 98%. CAS No. 1191101-18-4. Molecular formula: C32H47N5O6S. Mole weight: 629.82. | |
| Upamostat | Upamostat (WX-671) is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WX-671. CAS No. 590368-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16511. | |
| u-plasminogen activator | Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26. Group: Enzymes. Synonyms: urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A. Enzyme Commission Number: EC 3.4.21.73. CAS No. 9039-53-6. uPA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4165; u-plasminogen activator; EC 3.4.21.73; 9039-53-6; urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A. Cat No: EXWM-4165. | |
| Z-Val-Gly-Arg-pNA acetate salt | Z-Val-Gly-Arg-pNA is a colorimetric substrate for urokinase. Synonyms: L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-valylglycyl-N-(4-nitrophenyl)-, monoacetate; Carbobenzoxy-valyl-glycyl-arginine-p-nitroanilide acetate; Chromozym TRY acetate; Z-Val-Gly-Arg p-nitroanilide acetate salt; N-[(Phenylmethoxy)carbonyl]-L-valylglycyl-N-(4-nitrophenyl)-L-argininamide acetate salt; Cbz-Val-Gly-Arg-pNA acetate salt; Benzyl ((S)-1-((2-(((S)-5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate acetate salt. Grades: 95%. CAS No. 86170-43-6. Molecular formula: C29H40N8O9. Mole weight: 644.68. | |
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