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| Product | Description | |
|---|---|---|
| Z-VAD-FMK | Z-VAD-FMK Inhibitor. Uses: Scientific use. Product Category: T7020. CAS No. 161401-82-7. |  |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Synonyms: Z-VAD (OMe)-FMK; Caspase Inhibitor I. Grades: >98.0%. CAS No. 187389-52-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. |  |
| Z-VAD-FMK (Cell permeable) | Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3-induced cells. Used in apoptosis and inflammasome studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 187389-52-2, 634911-81-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H30FN3O7. US Biological Life Sciences. |  Worldwide |
| Z-VAD(OH)-FMK | Z-VAD(OH)-FMK, also known as Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone, is an irreversible tripeptide inhibitor of all caspases. Group: Inhibitors. Alternative Names: Z-VAD(OH)-FMK; Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.47. Appearance: Solid powder. Purity: >98%. IUPACName: (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid. Canonical SMILES: O=C (O)C[C@@H] (C (CF)=O)NC ([C@H] (C)NC ([C@H] (C (C)C)NC (OCC1=CC=CC=C1)=O)=O)=O. Catalog: ACM161401827. |  |
| Z-VAD(OH)-FMK | Z-VAD(OH)-FMK is an irreversible pan-caspase inhibitor. Synonyms: Z VAD(OH) FMK. Grades: 98%. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.46. | |
| Z-VAD(OMe)-FMK | Z-VAD(OMe)-FMK Inhibitor. Uses: Scientific use. Product Category: T6013. CAS No. 187389-52-2. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. Grades: ≥95%. CAS No. 210344-92-6. Molecular formula: C32H46FN5O11. Mole weight: 695.74. | |
| Bardoxolone | Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor ( NRf-2 ) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDDO; RTA 401. CAS No. 218600-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14909. |  |
| Ivachtin | Ivachtin is a potent and non-competitive caspase-3 inhibitor. It exhibits 10-100 fold selectivity over other caspases and more potent anti-apoptotic activity than Z-VAD-FMK. Synonyms: Caspase-3 Inhibitor VII; 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate. Grades: 99%. CAS No. 745046-84-8. Molecular formula: C20H21N3O7S. Mole weight: 447.46. | |
| N-[ (Phenylmethoxy) carbonyl]-L-valyl-N-[3-fluoro-1- (2-methoxy-2-oxoethyl) -2-oxopropyl]-L-alaninamide | N-[ (Phenylmethoxy) carbonyl]-L-valyl-N-[3-fluoro-1- (2-methoxy-2-oxoethyl) -2-oxopropyl]-L-alaninamide. Group: Biochemicals. Alternative Names: Z-VAD-FMK; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone. Grades: Highly Purified. CAS No. 634911-81-2. Pack Sizes: 1 mg. Molecular Formula: C22H30FN3O7, Molecular Weight: 467.49. US Biological Life Sciences. | Worldwide |
| Q-VD-OPh (Anhydrous) | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6- difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. CAS Number:1135695-98-5 (anhydrous). Group: Biochemicals. Alternative Names: Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone, (3S) -5- (2, 6-Difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-pentanoic Acid. Grades: Highly Purified. CAS No. 1135695-98-5. Pack Sizes: 1mg, 3x1mg, 5mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
| Z-VA-DL-D(OMe)-FMK trifluoroacetate salt | Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor. Synonyms: Caspase-1 Inhibitor V; Z-VAD-FMK; Z-VAD(OMe)-FMK; Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone. Grades: ≥95%. Molecular formula: C22H30FN3O7·xCF3COOH. Mole weight: 467.49. | |
| Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Z-VAD-FMK is an irreversible tripeptide inhibitor of all caspases, useful in studies involving enzymes. Synonyms: Z-vad-FMK; N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide; benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone. CAS No. 634911-81-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. | |
| Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone is a cell-permeable fluoromethylketone that specifically inhibits caspase-2 and, to a lesser extent, caspase-3 and caspase-7. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-VDVA-(DL-Asp)-FMK; Methyl (5S,8S,11S,14S)-17-(fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate. Grades: ≥90%. CAS No. 1926163-61-2. Molecular formula: C32H46FN5O11. Mole weight: 695.73. | |
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