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| Product | Description | |
|---|---|---|
| Acetylene-linker-Val-Cit-PABC-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate. Synonyms: LCB14-0602. Grade: >98.0%. CAS No. 1411977-95-1. Molecular formula: C67H106N10O16. Mole weight: 1307.62. |  |
| Azido-PEG3-Val-Cit-PAB-PNP | Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055047-18-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140150. |  |
| Boc-Val-Cit-PAB-PNP | Boc-Val-Cit-PAB-PNP. Synonyms: EX-A4143. Grade: 95%. CAS No. 870487-10-8. Molecular formula: C30H40N6O10. Mole weight: 644.7. | |
| DBCO-PEG4-Val-Cit-PAB-MMAF | DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244602-23-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130990. | |
| DBCO-Val-Cit-PAB-MMAE | DBCO-Val-Cit-PAB-MMAE is a drug-linker conjugate, which can be used for the synthesis of ADC molecules. MMAE (HY-15162) is a tubulin inhibitor, which can be used as an ADC toxin. DBCO-Val-Cit-PAB is the linker with the electrophilic group [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768446-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W591408. | |
| Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP | Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-136154. | |
| Fmoc-Val-Cit-PAB | Fmoc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Fmoc-Val-Cit-PAB-OH; L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-. CAS No. 159858-22-7. Molecular formula: C33H39N5O6. Mole weight: 601.70. | |
| Fmoc-Val-Cit-PAB-PNP | Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 863971-53-3. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-41189. | |
| Fmoc-Val-Cit-PAB-PNP | Fmoc-Val-Cit-PAB-PNP. Synonyms: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide. Grade: ≥98%. CAS No. 863971-53-3. Molecular formula: C40H42N6O10. Mole weight: 766.79. | |
| Mal-PEG2-Val-Cit-PABA-PNP | Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345681-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131156. | |
| Mal-PEG2-Val-Cit-PAB-OH | Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055041-38-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130222. | |
| Mal-PEG8-Val-Cit-PAB-MMAE | Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353409-69-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141156. | |
| MC-Val-Cit-PAB | MC-Val-Cit-PAB is a cleavable ADC Linker that forms part of VcMMAE (HY-15575). VcMMAE is Drug-Linker Conjugates for ADCs. The ADC Cytotoxin in VcMMAE is MMAE, a tubulin polymerization inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 159857-80-4. Pack Sizes: 5 mg; 10 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-78738. | |
| MC-Val-Cit-PAB | MC-Val-Cit-PAB is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen. Alternative Names: N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide;N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;ML-Val-Cit-PAB;MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-;MC-Val-Cit-PAB. CAS No. 159857-80-4. Product ID: INT159857804. Molecular formula: C28H40N6O7. Mole weight: 572.65. SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCCCCN2C(=O)C=CC2=O. Appearance: powder to Crystal. Category: Intermediates. |  |
| Mc-Val-Cit-PAB-Cl | Mc-Val-Cit-PAB-Cl. Synonyms: N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(chloromethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide. CAS No. 1639351-92-0. Molecular formula: C28H39ClN6O6. Mole weight: 591.1. | |
| Mc-Val-Cit-PABC-PNP | Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate. CAS No. 159857-81-5. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-20336. | |
| Mc-Val-Cit-PABC-PNP | Mc-Val-Cit-PABC-PNP. Uses: Adcs linker. Synonyms: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonateMc-Val-Cit-PABC-PNP159857-81-5MC-Val-Cit-PAB-PNPSCHEMBL3205376HYSPJPGXSALJRR-DHIFEGFHSA-NC3. Grade: >98%. CAS No. 159857-81-5. Molecular formula: C35H43N7O11. Mole weight: 737.76. | |
| MC-Val-Cit-PAB-Exatecan | MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-Val-Cit-PAB-DX8951. CAS No. 2504068-28-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145929. | |
| MC-Val-Cit-PAB-MMAE | MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate. Synonyms: VcMMAE; Maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl-monomethyl auristatin E; Vedotin. Grade: 95%. CAS No. 646502-53-6. Molecular formula: C68H105N11O15. Mole weight: 1316.63. | |
| MC-Val-Cit-PAB-MMAF | MC-Val-Cit-PAB-MMAF is a potent tubulin inhibitor (MMAF), Val-Cit-PAB-MMAF is an antibody drug conjugate. Synonyms: MC-VC-PAB-MMAF. Grade: ≥98%. CAS No. 863971-17-9. Molecular formula: C68H103N11O16. Mole weight: 1330.6. | |
| MC-Val-Cit-PAB-MMAF | MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Vc-MMAF. CAS No. 863971-17-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112786. | |
| mDPR-Val-Cit-PAB-MMAE | mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate. Synonyms: N-[(2S)-3-Amino-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]-L-valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-12-(2-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2 ; -methyl-3-oxopropyl]-1-pyrrolidinyl}-2-oxoethyl)-5,8-diisopropyl-4,10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N5-carbamoyl-L-ornithinamide; L-Ornithinamide, N-[(2S)-3-amino-2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[(5S,8S,11S,12R)-12-[2-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl ethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-oxoethyl]-4,10-dimethyl-5,8-bis(1-methylethyl)-11-[(1S)-1-methylpropyl]-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl]-. Grade: ≥95%. CAS No. 1491152-26-1. Molecular formula: C65H100N12O15. Mole weight: 1289.561. | |
| SuO-Glu-Val-Cit-PAB-MMAE | SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NHS-Glutarate-Val-Cit-PAB-MMAE. CAS No. 1895916-24-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130989. | |
| Val-Cit-PAB-MMAE | Val-Cit-PAB-MMAE, a tubulin polymerase inhibitor, is a drug-linker conjugate for ADC. It contains an ADC linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. Synonyms: L-Valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-12-(2-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-2-oxoethyl)-5,8-diisopropyl-4,10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N5-carbamoyl-L-ornithinamide. Grade: ≥98%. CAS No. 644981-35-1. Molecular formula: C58H94N10O12. Mole weight: 1123.43. | |
| Val-Cit-PAB-MMAE | Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization. Uses: Scientific research. Group: Signaling pathways. CAS No. 644981-35-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100374. | |
| Val-cit-PAB-OH | Val-cit-PAB-OH is a degradable ADC linker. Uses: Scientific research. Group: Signaling pathways. CAS No. 159857-79-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-12362. | |
| Val-cit-PAB-OH | Val-cit-PAB-OH is a protease cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-omithinamide; Val-cit-PAB; (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide. Grade: 95%. CAS No. 159857-79-1. Molecular formula: C18H29N5O4. Mole weight: 379.46. | |
| ADC Control Human IgG1-vcMMAF | ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786)[1]. Uses: Scientific research. Group: Inhibitory antibodies. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164154. | |
| Bi-Mc-VC-PAB-MMAE | Bi-Mc-VC-PAB-MMAE consists ADCs linker (Bi-Mc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE, HY-15162). Bi-Mc-VC-PAB-MMAE is a drug-linker conjugate for ADC. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620837-70-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141833. | |
| Farletuzumab ecteribulin | Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MORAb-202. CAS No. 2407465-18-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99612. | |
| Fmoc-VC-PAB-MMAE | Fmoc-Val-Cit-PAB-MMAE is an antibody drug conjugate contained Fmoc-Val-Cit-PAB and MMAE and probably have antineoplastic activity. Uses: Fmoc-val-cit-pab-mmae is an antibody drug conjugate contained fmoc-val-cit-pab and mmae and probably have antineoplastic activity. Synonyms: Fmoc-Val-Cit-PAB-MMAE; CS-5428; CS 5428; CS5428. Grade: ≥98%. CAS No. 1350456-56-2. Molecular formula: C73H104N10O14. Mole weight: 1345.67. | |
| Telisotuzumab vedotin | Telisotuzumab vedotin (ABBV-399) is an antibody-drug conjugate ( ADCs ) targeting c-Met. Telisotuzumab vedotin consists of Monomethyl Auristatin E (MMAE), Telisotuzumab antibody and a cleavable mc-val-cit-PABC type linker. Telisotuzumab vedotin can be used to study non-small cell lung cancer expressing c-Met protein [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABBV-399. CAS No. 1714088-51-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141601. | |
| VcMMAE | VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE. CAS No. 646502-53-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15575. | |
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