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| Product | Description | |
|---|---|---|
| Validamycin A | An inhibitor of trehalase. Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9nM; IC50 = 0.7uM).1 It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi.2 This compound has also been used to study trehalase activity and trehalose biosynthesis.3. Group: Biochemicals. Alternative Names: 1,5,6-Trideoxy-4-O- β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol; Cepex 10SL; Jinganmycin A; Jinggang; Jinggangmycin; Jinggangmycin A; Validacin; Validamycin; Validamycin A; [1S-(1α,4α,5 β,6α)]-1,5,6-Trideoxy-4-O- β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol. Grades: Highly Purified. CAS No. 37248-47-8. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C20H35NO13, Molecular Weight: 497.49. US Biological Life Sciences. |  Worldwide |
| Validamycin A | The major analogue of a family of cyclitol disaccharides isolated from streptomyces hygroscopicus var. Limoneus. It is a potent antifungal agent used to control fungi in crop production and acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi. Synonyms: jinggangmycin; Antibiotic T 7545A. Grades: >95% by HPLC. CAS No. 37248-47-8. Molecular formula: C20H35NO13. Mole weight: 497.49. |  |
| Validamycin A | Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus , with a MIC of 1?μg/mL [1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani , with an IC 50 of 72 μM [2]. Validamycin A is a reversible tyrosinase inhibitor, with a K i of 5.893 mM [3]. Uses: Scientific research. Group: Natural products. CAS No. 37248-47-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0856. |  |
| validamycin A dioxygenase | The enzyme was characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus. Requires Fe2+. Group: Enzymes. Synonyms: vldW (gene name). Enzyme Commission Number: EC 1.14.11.52. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0671; validamycin A dioxygenase; EC 1.14.11.52; vldW (gene name). Cat No: EXWM-0671. |  |
| Validamycin B | Validamycin B is an impurity of Validamycin that is resistant to rice sheath blight disease and Pellicularia sasakii. Synonyms: Antibiotic T-7545-B; Val-B; (1R,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl beta-D-glucopyranoside; 1,5-Dideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol. CAS No. 102583-47-1. Molecular formula: C20H35NO14. Mole weight: 513.49. | |
| Validamycin C | An impurity of Validamycin. Validamycin is an antibiotic and fungicide. Synonyms: BRN 4835203; (3-{[4-(hexopyranosyloxy)-2,3-dihydroxy-5-(hydroxymethyl)cyclohexyl]amino}-4,5,6-trihydroxycyclohex-1-en-1-yl)methyl hexopyranoside; 2-(hydroxymethyl)-6-[[3-[[5-(hydroxymethyl)-4-[6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,3-bis(oxidanyl)cyclohexyl]amino]-4,5,6-tris(oxidanyl)cyclohexen-1-yl]methoxy]oxane-3,4,5-triol. CAS No. 12650-70-3. Molecular formula: C26H45NO18. Mole weight: 659.63. | |
| Validamycin D | An impurity of Validamycin. Validamycin is an antibiotic and fungicide. Synonyms: BRN 4830813; 1,5,6-Trideoxy-5-[(beta-D-glucopyranosyloxy)methyl]-1-[[(1S)-4beta,5alpha,6beta-trihydroxy-3-hydroxymethyl-2-cyclohexen-1beta-yl]amino]-D-chiro-inositol. CAS No. 12650-67-8. Molecular formula: C20H35NO13. Mole weight: 497.5. | |
| Validamycin E | An impurity of Validamycin. Validamycin is an antibiotic and fungicide. Synonyms: BRN 4631911; D-chiro-Inositol, O-alpha-D-glucopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-3)-1,5,6-trideoxy-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-, (1S-(1-alpha,4-alpha,5-beta,6-alpha))-; AC1L48S1; SCHEMBL5160665. CAS No. 12650-71-4. Molecular formula: C26H45NO18. Mole weight: 659.64. | |
| 2-C-Methyl-L-ribono-1,4-lactone | 2-C-Methyl-L-ribono-1,4-lactone, an organic compound, serves as a critical building block in the intricate biosynthetic pathway of validamycin A, an antibiotic with robust fungicidal and insecticidal effectiveness. The antibiotic has been conventionally employed to combat intractable fungal infections triggered by pathogenic agents like Aspergillus fumigatus and Candida albicans, highlighting its ability to combat a wide variety of fungal immune defense systems. Synonyms: (3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one; 2-Methyl-L-ribonic acid 1,4-lactone. Grades: 95%. Molecular formula: C6H10O5. Mole weight: 162.14. | |
| 2-epi-5-epi-valiolone synthase | The enzyme is highly specific for α-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase. Group: Enzymes. Synonyms: AcbC; ValA; CetA; SalQ; C7-cyclitol synthase. Enzyme Commission Number: EC 4.2.3.152. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5167; 2-epi-5-epi-valiolone synthase; EC 4.2.3.152; AcbC; ValA; CetA; SalQ; C7-cyclitol synthase. Cat No: EXWM-5167. | |
| (2R, 3S, 4S, 5R)-5-Hydroxy-2, 3, 4-tris (phenylmethoxy)-5-[ (phenylmethoxy)methyl]-cyclohexanone | (2R, 3S, 4S, 5R)-5-Hydroxy-2, 3, 4-tris (phenylmethoxy)-5-[ (phenylmethoxy)methyl]-cyclohexanone is used to explore the steric course of 5-epi-valiolone dehydratase in validamycin A biosynthesis. It can also be used to synthesize 1-Silyl-2,6-diketones as versatile intermediates for divergent synthesis of five and six-membered carbocycle cyclitols under radical and anionic conditions. Group: Biochemicals. Grades: Highly Purified. CAS No. 911439-19-5. Pack Sizes: 5mg, 50mg. Molecular Formula: C35H36O6, Molecular Weight: 552.66. US Biological Life Sciences. | Worldwide |
| 3-ketovalidoxylamine C-N-lyase | Requires Ca2+. Eliminates 4-nitroaniline from 4-nitrophenyl-3-ketovalidamine, or 4-nitrophenol from 4-nitrophenyl-α-D-3-dehydroglucoside. Involved in the degradation of the fungicide validamycin A by Flavobacterium saccharophilum. Group: Enzymes. Synonyms: 3-ketovalidoxylamine A C-N-lyase; p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase; 4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase. Enzyme Commission Number: EC 4.3.3.1. CAS No. 99889-98-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5302; 3-ketovalidoxylamine C-N-lyase; EC 4.3.3.1; 99889-98-2; 3-ketovalidoxylamine A C-N-lyase; p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase; 4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase. Cat No: EXWM-5302. | |
| C7-cyclitol 7-kinase | The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A. Group: Enzymes. Synonyms: valC (gene name); vldC (gene name). Enzyme Commission Number: EC 2.7.1.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3050; C7-cyclitol 7-kinase; EC 2.7.1.214; valC (gene name); vldC (gene name). Cat No: EXWM-3050. | |
| Notonesomycin A | Notonesomycin A is originally isolated from Str. aminophilus subsp. notonesogenes 647-AV1. It has the effect of resisting plant pathogenic bacteria and fungi, and its effect is similar to that of Validamycin. Synonyms: NSC608604. CAS No. 102525-63-3. Molecular formula: C68H111NO30S. Mole weight: 1454.66. | |
| validoxylamine A 7'-phosphate phosphatase | The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A. Group: Enzymes. Synonyms: vldH (gene name). Enzyme Commission Number: EC 3.1.3.101. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3610; validoxylamine A 7'-phosphate phosphatase; EC 3.1.3.101; vldH (gene name). Cat No: EXWM-3610. | |
| validoxylamine A glucosyltransferase | The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A. Group: Enzymes. Synonyms: vldK (gene name); valG (gene name). Enzyme Commission Number: EC 2.4.1.338. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2576; validoxylamine A glucosyltransferase; EC 2.4.1.338; vldK (gene name); valG (gene name). Cat No: EXWM-2576. | |
| valienol-1-phosphate guanylyltransferase | The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A. Group: Enzymes. Synonyms: vldB (gene name). Enzyme Commission Number: EC 2.7.7.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3305; valienol-1-phosphate guanylyltransferase; EC 2.7.7.91; vldB (gene name). Cat No: EXWM-3305. | |
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