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| Product | Description | |
|---|---|---|
| P11 (His-Ser-Asp-Val-His-Lys-NH2, Potent antagonist of alphavbeta3-vitronectin Interaction, Antiangiogenic) | Potent antagonist of the integrin avb3-vitronectin interaction (IC50 = 25.72nm). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic. Group: Biochemicals. Grades: Highly Purified. CAS No. 848644-86-0. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| abciximab | Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors. Group: Inhibitors. CAS No. 143653-53-6. Purity: 0.99966. Catalog: ACM143653536. |  |
| Abciximab | Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: C7E3. CAS No. 143653-53-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9934. |  |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. |  |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| Cilengitide TFA salt | Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. Synonyms: Cilengitide trifluoroacetate. Grades: >98%. CAS No. 199807-35-7. Molecular formula: C29H41F3N8O9. Mole weight: 702.68. | |
| Cyclo(-Arg-Gly-Asp-D-Phe-Val) | Cyclo(-Arg-Gly-Asp-D-Phe-Val) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. Synonyms: c-[-Arg-Gly-Asp-fV-]; Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl). CAS No. 137813-35-5. Molecular formula: C26H38N8O7. Mole weight: 574.63. | |
| Fibrinogen-Binding Peptide | Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin [1]. Uses: Scientific research. Group: Peptides. CAS No. 137235-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1741. | |
| Fibrinogen-Binding Peptide | Fibrinogen-Binding Peptide (designed by the anti-complementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. It binds to fibrinogen and inhibits platelet adhesion to fibrinogen and platelet aggregation, as well as platelet adhesion to hyalonectin. Synonyms: H-EHIPA-OH; L-alpha-glutamyl-L-histidyl-L-isoleucyl-L-prolyl-L-alanine; N-(1-(N-(N-L-alpha-glutamyl-L-histidyl)-L-isoleucyl)-L-prolyl)-L-Alanine; EHIPA. Grades: ≥95%. CAS No. 137235-80-4. Molecular formula: C25H39N7O8. Mole weight: 565.62. | |
| Fibrinogen-Binding Peptide butyl acetate | Fibrinogen-Binding Peptide (designed by the anti-complementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. It binds to fibrinogen and inhibits platelet adhesion to fibrinogen and platelet aggregation, as well as platelet adhesion to vitronectin. Synonyms: Fibrinogen-Binding Peptide (fb-acetate); H-Glu-His-Ile-Pro-Ala-OH butyl acetate; EHIPA butyl acetate; L-alpha-glutamyl-L-histidyl-L-isoleucyl-L-prolyl-L-alanine butyl acetate. Grades: ≥95%. Molecular formula: C31H51N7O10. Mole weight: 681.80. | |
| Heparin Binding Peptide I, (Biotin)-spacer- GKKQRFRHRNRKG | A heparin-binding peptide derived from vitronectin. Surfaces displaying this peptide support human embryonic stem (hES) cell adhesion and self-renewal. Group: Molecular Biology. Alternative Names: GKKQRFRHRNRKG. Grades: Purified. Pack Sizes: 5x1mg. US Biological Life Sciences. | Worldwide |
| Integrin alpha-v-beta3 Antagonist, P11 (HSDVHK, HSDVHK-NH2) | A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| P11 | P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction with IC50 value of 25.72 nM. Synonyms: H-His-Ser-Asp-Val-His-Lys-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-L-valyl-L-histidyl-L-lysinamide; HSDVHK-NH2. Grades: >98%. CAS No. 848644-86-0. Molecular formula: C30H48N12O9. Mole weight: 720.78. | |
| Tirofiban | Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ?vβ3 vitronectin receptor. Uses: Antithrombotic; in treatment of unstable angina. Synonyms: Tirofiban; MK383; MK-383; MK 383. Grades: >98%. CAS No. 144494-65-5. Molecular formula: C22H36N2O5S. Mole weight: 440.6. | |
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