Vorinostat Suppliers USA
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Product | Description | |
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Vorinostat Quick inquiry Where to buy Suppliers range | Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities.Vorinostat is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after treatment with other medicines. The compound was developed by Columbia University chemist Ronald Breslow and Memorial Sloan-Kettering researcher Paul Marks. Group: Heterocyclic Organic Compound. Alternative Names: Suberoylanilidehydroxamic Acid; N-Hydroxy-N-phenyloctanediamide; Vorinostat/SAHA; Suberoylanilide Hydroxamic Acid. CAS No. 149647-78-9. Product ID: ACM149647789. Molecular formula: C14H20N2O3. Mole weight: 264.32. Appearance: White crystalline solid. Melting Point: 161-162ºC. Density: 1.174 g/cm³. | |
Vorinostat Quick inquiry Where to buy Suppliers range | Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM. Uses: Antineoplastic agents; histone deacetylase inhibitors. Synonyms: MK-0683, MK 0683, MK0683, SAHA, M344, CCRIS 8456, HSDB 7930, Vorinostat, suberoylanilide hydroxamic acid, Zolinza. Grades: >98%. CAS No. 149647-78-9. Molecular formula: C14H20N2O3. Mole weight: 264.3. | |
Vorinostat Amide Impurity Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. Molecular formula: C14H20N2O2. Mole weight: 248.33. | |
Vorinostat Amination Derivative Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. Synonyms: p-Aminomethyl Vorinostat; N1-[4-(Aminomethyl)phenyl]-N8-hydroxy-octanediamide. CAS No. 1160823-16-4. Molecular formula: C15H23N3O3. Mole weight: 293.37. | |
Vorinostat Dimer Impurity Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. Molecular formula: C28H38N4O6. Mole weight: 526.64. | |
Vorinostat Impurity Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. Synonyms: N-Hydroxy-N,N-di-(N'-Phenyl-Octanediamide)amine. Molecular formula: C28H37N3O5. Mole weight: 495.62. | |
Vorinostat Impurity 1 Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. CAS No. 866824-87-5. Molecular formula: C28H37N3O5. Mole weight: 495.62. | |
Vorinostat Impurity 2 Quick inquiry Where to buy Suppliers range | One of the impurities of Vorinostat, which is a HDAC inhibitor and has been found to exhibit anti-angiogenic activity and could induce differentiation in breast cancer cells. Molecular formula: C20H24N2O2. Mole weight: 324.43. | |
Suberoylanilide-d5 Hydroxamic Acid (SAHA-d5, N-Hydroxy-N-phenyl-d5-octanediamide, Zolinza-d5, Vorinostat-d5) Quick inquiry Where to buy Suppliers range | A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells. Group: Biochemicals. Alternative Names: SAHA-d5; N-Hydroxy-N-phenyl-d5-octanediamide;Zolinza-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Suberoylanilide Hydroxamic Acid (SAHA, Zolinza, Vorinostat) Quick inquiry Where to buy Suppliers range | A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells. Group: Biochemicals. Alternative Names: SAHA; N-Hydroxy-N-phenyloctanediamide; N-Hydroxy-N-phenyloctanediamide; Zolinza; Suberoylanilide-hydroxamic acid, Vorinostat. Grades: Highly Purified. CAS No. 149647-78-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Alvespimycin Quick inquiry Where to buy Suppliers range | Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, water-soluble Hsp90 inhibitor with IC50 of 62 nM. 17-DMAG displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM. In SKBR3 and SKOV3 cells which overexpress Hsp90 client protein Her2, 17-DMAG causes down-regulation of Her2 with EC50 of 8 nM and 46 nM, respectively, as well as induction of Hsp70 with EC50 of 4 nM and 14 nM, respectively, leading to significant cytotoxicity with GI50 of 29 nM and 32 nM, respectively, consistent with Hsp90 inhibition. In combination with vorinostat, 17-DMAG synergistically induces apoptosis of the cultured MCL cells as well as primary MCL cells, more potently than either agent alone, by markedly attenuating the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and Akt. 17-DMAG treatment at 5 mg/kg or 25 mg/kg three times per week significantly reduces tumor growth of TMK-1 xenografts, by reducing vessel area and numbers of proliferating tumor cells in sections. Consistent the inhibition of FAK signaling in vivo, 17-DMAG treatment at 25 mg/kg three times a week significantly suppresses tumor growth, and metastasis of ME180 and SiHa xenografts in mice. Administration of 17-DMAG at 10 mg/kg for 16 days significantly decreases the white blood cell count and prolongs the survival in a TCL1-SCID transplant mouse model. Uses: Hsp-90 inhibitor; potential anti-cancer drug. Synonyms: 17-DMAG; KOS 1022; KOS-1022; KOS1022; 17-DMAGhydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin. Grades: >98%. CAS No. 467214-20-6. Molecular formula: C32H48N4O8. Mole weight: 616.75. | |
AR-42 Quick inquiry Where to buy Suppliers range | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
BPR1J-340 Quick inquiry Where to buy Suppliers range | BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD(+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Synonyms: BPR1J 340; BPR1J340. Grades: 98%. CAS No. 1395051-72-5. Molecular formula: C29H34N8O3. Mole weight: 542.63. | |
CG200745 Quick inquiry Where to buy Suppliers range | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
EDO-S101 Quick inquiry Where to buy Suppliers range | EDO-S101 is a pan HDAC inhibitor (IC50 = 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3, respectively). EDO-S101 is a first-in-class fusion molecule that combines DNA damaging effect of bendamustine with the pan-HDACi vorinostat. Synonyms: 7-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-N-hydroxyheptanamide; EDO-S101; EDO-S 101; EDO-S-101; EDO-S101 HCl; EDO-S101 hydrochloride; Tinostamustine hydrochloride. CAS No. 1236199-60-2. Molecular formula: C19H28Cl2N4O2. Mole weight: 415.36. |