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| Product | Description | |
|---|---|---|
| tRNA-guanosine34 transglycosylase | Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine. The eubacterial enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. Group: Enzymes. Synonyms: guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguou. Enzyme Commission Number: EC 2.4.2.29. CAS No. 72162-89-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2656; tRNA-guanosine34 transglycosylase; EC 2.4.2.29; 72162-89-1; guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); queuine34 transfer ribonucleate ribosyltransferase; transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase; queuine tRNA-ribosyltransferase (ambiguous); TGT; [tRNA]-guanine34:queuine tRNA-D-ribosyltransferase; transfer ribonucleic acid guanine34 transglycosylase. Cat No: EXWM-2656. |  |
| tRNAHis guanylyltransferase | In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21, histidyl-tRNA ligase.The enzyme requires a divalent cation for activity. ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis). Group: Enzymes. Synonyms: histidine tRNA guanylyltransferase; Thg1p (ambiguous); Thg1 (ambiguous). Enzyme Commission Number: EC 2.7.7.79. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3291; tRNAHis guanylyltransferase; EC 2.7.7.79; histidine tRNA guanylyltransferase; Thg1p (ambiguous); Thg1 (ambiguous). Cat No: EXWM-3291. | |
| tRNAIle2-agmatinylcytidine synthase | The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34. Group: Enzymes. Synonyms: TiaS; AF2259; tRNAIle-2-agmatinylcytidine synthetase; tRNAIle-agm2C synthetase; tRNAIle-agmatidine synthetase. Enzyme Commission Number: EC 6.3.4.22. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5792; tRNAIle2-agmatinylcytidine synthase; EC 6.3.4.22; TiaS; AF2259; tRNAIle-2-agmatinylcytidine synthetase; tRNAIle-agm2C synthetase; tRNAIle-agmatidine synthetase. Cat No: EXWM-5792. | |
| tRNAIle-lysidine synthase | The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle. Group: Enzymes. Synonyms: TilS; mesJ (gene name); yacA (gene name); isoleucine-specific transfer ribonucleate lysidine synthetase; tRNAIle-lysidine synthetase. Enzyme Commission Number: EC 6.3.4.19. CAS No. 635304-92-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5788; tRNAIle-lysidine synthase; EC 6.3.4.19; 635304-92-6; TilS; mesJ (gene name); yacA (gene name); isoleucine-specific transfer ribonucleate lysidine synthetase; tRNAIle-lysidine synthetase. Cat No: EXWM-5788. | |
| tRNA-intron lyase | The enzyme catalyses the final stage in the maturation of tRNA molecules. Group: Enzymes. Synonyms: transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Enzyme Commission Number: EC 4.6.1.16. CAS No. 117444-13-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5353; tRNA-intron lyase; EC 4.6.1.16; 117444-13-0; transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Cat No: EXWM-5353. | |
| tRNA:m4X modification enzyme | The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis. Group: Enzymes. Synonyms: TRM13; Trm13p; tRNA:Xm4 modification enzyme. Enzyme Commission Number: EC 2.1.1.225. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1828; tRNA:m4X modification enzyme; EC 2.1.1.225; TRM13; Trm13p; tRNA:Xm4 modification enzyme. Cat No: EXWM-1828. | |
| tRNAMet cytidine acetyltransferase | The enzyme acetylates the wobble base cytidine34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine. Group: Enzymes. Synonyms: YpfI; TmcA. Enzyme Commission Number: EC 2.3.1.193. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2136; tRNAMet cytidine acetyltransferase; EC 2.3.1.193; YpfI; TmcA. Cat No: EXWM-2136. | |
| tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase | The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known. Group: Enzymes. Synonyms: MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name). Enzyme Commission Number: EC 2.8.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3431; tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase; EC 2.8.4.5; MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name). Cat No: EXWM-3431. | |
| tRNA nucleotidyltransferase | Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase. Group: Enzymes. Synonyms: phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Enzyme Commission Number: EC 2.7.7.56. CAS No. 116412-36-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3267; tRNA nucleotidyltransferase; EC 2.7.7.56; 116412-36-3; phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Cat No: EXWM-3267. | |
| tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase | The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe. Group: Enzymes. Synonyms: TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Enzyme Commission Number: EC 2.5.1.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2730; tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase; EC 2.5.1.114; TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Cat No: EXWM-2730. | |
| tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase | The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine. Group: Enzymes. Synonyms: TYW3 (gene name); tRNA-yW synthesizing enzyme-3. Enzyme Commission Number: EC 2.1.1.282. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1889; tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase; EC 2.1.1.282; TYW3 (gene name); tRNA-yW synthesizing enzyme-3. Cat No: EXWM-1889. | |
| tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase | Requires Fe2+. The enzyme is not active with wybutosine. Group: Enzymes. Synonyms: TYW5; tRNA yW-synthesizing enzyme 5. Enzyme Commission Number: EC 1.14.11.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0661; tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase; EC 1.14.11.42; TYW5; tRNA yW-synthesizing enzyme 5. Cat No: EXWM-0661. | |
| tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase | The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.1.1.290. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1897; tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase; EC 2.1.1.290; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-1897. | |
| tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase | The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.3.1.231. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2179; tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase; EC 2.3.1.231; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-2179. | |
| tRNA pseudouridine13 synthase | Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA. The Pus7 protein from Saccharomyces cerevisiae is a multisite-multisubstrate pseudouridine synthase that is able to modify uridine13 in several yeast tRNAs, uridine35 in the pre-tRNATyr, uridine35 in U2 small nuclear RNA, and uridine50 in 5S rRNA. Group: Enzymes. Synonyms: TruD; YgbO; tRNA PSI13 synthase; RNA:PSI-synthase Pus7p; Pus7p; RNA:pseudouridine-synthase Pus7p; Pus7 protein. Enzyme Commission Number: EC 5.4.99.27. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5567; tRNA pseudouridine13 synthase; EC 5.4.99.27; 430429-15-5; TruD; YgbO; tRNA PSI13 synthase; RNA:PSI-synthase Pus7p; Pus7p; RNA:pseudouridine-synthase Pus7p; Pus7 protein. Cat No: EXWM-5567. | |
| tRNA pseudouridine31 synthase | The enzyme specifically acts on uridine31 in tRNA. Group: Enzymes. Synonyms: Pus6p. Enzyme Commission Number: EC 5.4.99.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5584; tRNA pseudouridine31 synthase; EC 5.4.99.42; Pus6p. Cat No: EXWM-5584. | |
| tRNA pseudouridine32 synthase | The dual-specificity enzyme from Escherichia coli also catalyses the formation of pseudouridine746 in 23S rRNA. cf. EC 5.4.99.29 (23S rRNA pseudouridine746 synthase). Group: Enzymes. Synonyms: RluA (ambiguous); pseudouridine synthase RluA (ambiguous); Pus9p; Rib2/Pus8p. Enzyme Commission Number: EC 5.4.99.28. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5568; tRNA pseudouridine32 synthase; EC 5.4.99.28; 430429-15-5; RluA (ambiguous); pseudouridine synthase RluA (ambiguous); Pus9p; Rib2/Pus8p. Cat No: EXWM-5568. | |
| tRNA pseudouridine38/39 synthase | The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase). In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu). Group: Enzymes. Synonyms: Deg1; Pus3p; pseudouridine synthase 3. Enzyme Commission Number: EC 5.4.99.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5587; tRNA pseudouridine38/39 synthase; EC 5.4.99.45; Deg1; Pus3p; pseudouridine synthase 3. Cat No: EXWM-5587. | |
| tRNA pseudouridine38-40 synthase | The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures. Group: Enzymes. Synonyms: TruA; tRNA pseudouridine synthase I; PSUI; hisT (gene name). Enzyme Commission Number: EC 5.4.99.12. CAS No. 61506-89-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5551; tRNA pseudouridine38-40 synthase; EC 5.4.99.12; 61506-89-6; TruA; tRNA pseudouridine synthase I; PSUI; hisT (gene name). Cat No: EXWM-5551. | |
| tRNA (pseudouridine54-N1)-methyltransferase | While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54. Group: Enzymes. Synonyms: TrmY; m1ψ methyltransferase. Enzyme Commission Number: EC 2.1.1.257. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1861; tRNA (pseudouridine54-N1)-methyltransferase; EC 2.1.1.257; TrmY; m1ψ methyltransferase. Cat No: EXWM-1861. | |
| tRNA pseudouridine55 synthase | Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules. The bifunctional archaeal enzyme also catalyses the pseudouridylation of uridine54. It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in Escherichia coli tRNAs by thymine. Group: Enzymes. Synonyms: TruB; aCbf5; Pus4; YNL292w (gene name); ψ55 tRNA pseudouridine synthase; tRNA:ψ55-synthase; tRNA pseudouridine 55 synthase; tRNA:pseudouridine-55 synthase; ψ55 synthase; tRNA ψ55 synthase; tRNA:ψ55 synthase; tRNA-uridine55 uracil mutase; Pus10; tRNA-uridine54/55 uracil mutase. Enzyme Commission Number: EC 5.4.99.25. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5565; tRNA pseudouridine55 synthase; EC 5.4.99.25; 430429-15-5; TruB; aCbf5; Pus4; YNL292w (gene name); ψ55 tRNA pseudouridine synthase; tRNA:ψ55-synthase; tRNA pseudouridine 55 synthase; tRNA:pseudouridine-55 synthase; ψ55 synthase; tRNA ψ55 synthase; tRNA:ψ55 synthase; tRNA-uridine55 uracil mutase; Pus10; tRNA-uridine54/55 uracil mutase. Cat No: EXWM-5565. | |
| tRNA pseudouridine65 synthase | TruC specifically modifies uridines at positions 65 in tRNA. Group: Enzymes. Synonyms: TruC; YqcB. Enzyme Commission Number: EC 5.4.99.26. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5566; tRNA pseudouridine65 synthase; EC 5.4.99.26; 430429-15-5; TruC; YqcB. Cat No: EXWM-5566. | |
| tRNA-queuosine β-mannosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Enzyme Commission Number: EC 2.4.1.110. CAS No. 9055-6-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2337; tRNA-queuosine β-mannosyltransferase; EC 2.4.1.110; 9055-06-5. Cat No: EXWM-2337. | |
| tRNASer (uridine44-2'-O)-methyltransferase | The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA). Group: Enzymes. Synonyms: TRM44. Enzyme Commission Number: EC 2.1.1.211. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1813; tRNASer (uridine44-2'-O)-methyltransferase; EC 2.1.1.211; TRM44. Cat No: EXWM-1813. | |
| tRNase Z | No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii. Group: Enzymes. Synonyms: 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Enzyme Commission Number: EC 3.1.26.11. CAS No. 98148-84-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3587; tRNase Z; EC 3.1.26.11; 98148-84-6; 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Cat No: EXWM-3587. | |
| tRNA sulfurtransferase | A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor. Group: Enzymes. Synonyms: transfer ribonucleate sulfurtransferase; RNA sulfurtransferase; ribonucleate sulfurtransferase; transfer RNA sulfurtransferase; transfer RNA thiolase. Enzyme Commission Number: EC 2.8.1.4. CAS No. 9055-57-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3362; tRNA sulfurtransferase; EC 2.8.1.4; 9055-57-6; transfer ribonucleate sulfurtransferase; RNA sulfurtransferase; ribonucleate sulfurtransferase; transfer RNA sulfurtransferase; transfer RNA thiolase. Cat No: EXWM-3362. | |
| tRNAThr (cytosine32-N3)-methyltransferase | The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer. Group: Enzymes. Synonyms: ABP140; Trm140p. Enzyme Commission Number: EC 2.1.1.268. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1873; tRNAThr (cytosine32-N3)-methyltransferase; EC 2.1.1.268; ABP140; Trm140p. Cat No: EXWM-1873. | |
| tRNA (uracil54-C5)-methyltransferase | Unlike this enzyme, EC 2.1.1.74 (methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)), uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54. Group: Enzymes. Synonyms: transfer RNA uracil54 5-methyltransferase; transfer RNA uracil54 methylase; tRNA uracil54 5-methyltransferase; m5U54-methyltransferase; tRNA:m5U54-methyltransferase; RUMT; TrmA; 5-methyluridine54 tRNA methyltransferase; tRNA(uracil-54,C5)-methyltransferase; Trm2; tRNA(m5U54)methyltransferase. Enzyme Commission Number: EC 2.1.1.35. CAS No. 37257-02-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1939; tRNA (uracil54-C5)-methyltransferase; EC 2.1.1.35; 37257-02-6; transfer RNA uracil54 5-methyltransferase; transfer RNA uracil54 methylase; tRNA uracil54 5-methyltransferase; m5U54-methyltransferase; tRNA:m5U54-methyltransferase; RUMT; TrmA; 5-methyluridine54 tRNA methyltransferase; tRNA(uracil-54,C5)-methyltransferase; Trm2; tRNA(m5U54)methyltransferase. Cat No: EXWM-1939. | |
| tRNA-uridine 2-sulfurtransferase | The enzyme, found in bacteria, catalyses formation of the 2-thiouridine modification in the wobble position of tRNAGln, tRNALys and tRNAGlu. Group: Enzymes. Synonyms: mnmA (gene name). Enzyme Commission Number: EC 2.8.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3358; tRNA-uridine 2-sulfurtransferase; EC 2.8.1.13; mnmA (gene name). Cat No: EXWM-3358. | |
| tRNA-uridine aminocarboxypropyltransferase | The enzyme was studied in the bacterium Escherichia coli. The modification is found in the variable loop of the tRNA. Group: Enzymes. Synonyms: S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase. Enzyme Commission Number: EC 2.5.1.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2762; tRNA-uridine aminocarboxypropyltransferase; EC 2.5.1.25; S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase. Cat No: EXWM-2762. | |
| TRO 19622 | Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modulators. It is a molecule that has a cholesterol-like structure and displays neuroprotective properties. TRO19622 is as effective as a cocktail of three neurotrophic factors in keeping motor neurons alive in culture. Preclinical studies have demonstrated that the compound promotes the function and survival of neurons and other cell types under disease-relevant stress conditions through interactions with the mitochondrial permeability transition pore (mPTP). A 2009-2011 phase 3 clinical trial of olesoxime in amyotrophic lateral sclerosis did not demonstrate a significant increase in survival versus placebo. The results of a 2011-2013 combined phase 2/3 trial of olesoxime in spinal muscular atrophy (SMA) indicated that the compound prevents deterioration of muscle function, suggesting that olesoxime might become the first drug approved to treat SMA. Synonyms: TRO-19622; TRO19622; TRO19622; RG6083; RG 6083; RG-6083; NSC 21311; NSC-21311; NSC21311; Olesoxime. Grades: >98%. CAS No. 22033-87-0. Molecular formula: C27H45NO. Mole weight: 399.65. |  |
| TRO 19622 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| TRO 19622 | TRO 19622. Group: Biochemicals. Grades: Purified. CAS No. 22033-87-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Trodat | Trodat. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ethanethiol, 2-[[2-[[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]-, trifluoroacetate salt (1:3);Ethanethiol, 2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]-, [1R-(exo,exo)]-, trifluoroacetate salt (1:3);TRODAT;tropantiol;2-[[2-[[[(1R,2R,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol;Unii-7844H41L5z. Product Category: Heterocyclic Organic Compound. CAS No. 189950-11-6. Molecular formula: C21H34ClN3S2C6H3F9O6. Mole weight: 428.1. Density: 1.143. Product ID: ACM189950116. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Trodusquemine | Trodusquemine, also called as MSI-1436 or Aminosterol-1436, with the potential to treat type 2 diabetes and obesity, it is a non-competitive cholestane inihbitor that specifically targets the enzyme protein tyrosine phosphatase 1B (PTB-1B) with 200-fold s. Synonyms: [ (3R, 6R) -6-[ (3S, 5R, 7R, 8R, 9S, 10S, 13R, 14S, 17R) -3-[3-[4- (3-aminopropylamino) butylamino]propylamino]-7-hydroxy-10, 13-dimethyl-2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate 3-N-1(sperm. CAS No. 186139-09-3. Molecular formula: C37H72N4O5S. Mole weight: 685.06. | |
| Troethylene Tetramine 112-24-3 | Troethylene Tetramine - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY. |  North America & APAC |
| Trofinetide | Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury. Uses: Scientific research. Group: Peptides. Alternative Names: NNZ-2566. CAS No. 853400-76-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16757. |  |
| Trofinetide | Trofinetide is a NMDA antagonist under the development of Neuren Pharmaceuticals. It is an analogue of the neuropeptide (1-3) IGF-1, which is a simple tripeptide with sequence Gly-Pro-Glu formed by enzymatic cleavage of the growth factor IGF-1 within the brain. Phase II clinical trials against Fragile X syndrome and Rett syndrome are on-going. Uses: Brain injuries; fragile x syndrome; rett syndrome. Synonyms: NNZ-2566; NNZ 2566; NNZ2566; Trofinetide; ((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid. Grades: 98%. CAS No. 853400-76-7. Molecular formula: C13H21N3O6. Mole weight: 315.32. | |
| Trofinetide Impurity 3 | Trofinetide Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1138-80-3. Molecular formula: C10H11NO4. Mole weight: 209.2. Catalog: APB1138803. | |
| Trofosfamide | Antineoplastic; one derivative. Group: Biochemicals. Alternative Names: N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide. Grades: Highly Purified. CAS No. 22089-22-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Trofosfamide | Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: Trofosfamide; Ixoten; Genoxal Trofosfamida; A-4828; A 4828; A4828. Grades: 98%. CAS No. 22089-22-1. Molecular formula: C9H18Cl3N2O2P. Mole weight: 323.58. | |
| Trofosfamide | Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22089-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-119824. | |
| Troglitazone | Troglitazone, PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity, which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, but was withdrawn from the market due to hepatotoxicity. It binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. It also induces cell cycle arrest and apoptosis in several cancer cell lines. It displays no activity at PPARα or PPARδ receptors and displays anti-invasive effect on human breast cancer cells. It also inhibits cell growth of hematopoietic cell lines and inhibits lamellipodia formation and actin polymerization. Uses: Hypoglycemic agents. Synonyms: CI-991; CI991; CI 991; CS-045; CS 045; CS045; GR 92132X; GR92132X; Prelay; Troglitazone; Rezulin, Resulin, Romozin, Noscal. Grades: >98%. CAS No. 97322-87-7. Molecular formula: C24H27NO5S. Mole weight: 441.54. | |
| Troglitazone | Troglitazone. Group: Biochemicals. Grades: Purified. CAS No. 97322-87-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Troglitazone | Troglitazone is an orally active PPARγ agonist, with EC 50 s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CS-045. CAS No. 97322-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50935. | |
| Troglitazone (5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal,) | An oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Group: Biochemicals. Alternative Names: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Troglitazone ((±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione) | An antidiabetic thiazolidinedione (TDZ) drug with anti-inflammatory and anti-tumor activities. A potent and selective PPARγ agonist. The EC50 values for transactivation of human and murine PPARγ in a cell-based assay are 0.55 and 0.78uM, respectively. Group: Biochemicals. Alternative Names: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Troglitazone (5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X) | Potent and selective PPARgamma agonist with no activation of PPARalpha and PPARdelta. Anti-diabetic agent with potent glucose-lowering effects and decreasing insulin resistance in adipose tissues. Stimulates adipogenesis. Apoptosis and cell cycle arrest inducer in several cancer cell lines. Anti-inflammatory. Inhibits vascular smooth muscle cell (VSMC) migration. Group: Biochemicals. Alternative Names: 5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Trolamine salicylate | analytical standard. Group: Uv blockers. | |
| Trolamine Salicylate | Trolamine Salicylate. Categories: triethanolamine salicylate; trolamine salicylate. |  CA, FL & NJ |
| Trolox | Trolox. Group: Biochemicals. Alternative Names: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic Acid; (±)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-Benzopyran-2-carboxylic Acid; (R,S)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic Acid; (±)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (±)-Trolox; 6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic Acid; 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid; Trolox C. Grades: Highly Purified. CAS No. 53188-07-1. Pack Sizes: 1g. Molecular Formula: C14H18O4, Molecular Weight: 250.29. US Biological Life Sciences. | Worldwide |
| Trolox | Trolox is a cell-permeable and water soluble derivative of vitamin E as an antioxidant. Trolox exhibits an inhibitory effect on osteoclast formation and IL-1-induced osteoclast bone loss. Trolox may be the therapy for certain cancers. Uses: Antioxidants. Synonyms: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid; 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-; 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (±)-; (R,S)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid; (±)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (±)-Trolox; 6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid; Trolox C. Grades: 95%. CAS No. 53188-07-1. Molecular formula: C14H18O4. Mole weight: 250.29. | |
| Trolox | Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53188-07-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-101445. | |
| Trolox | Trolox. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TIMTEC-BB SBB005933;TROLOX;TROLOX(R);TROLOXTM C;6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID;6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC;6-HYDROXYTETRAMETHYLCHROMAN-2-CARBOXYLI. Product Category: Heterocyclic Organic Compound. CAS No. 56305-04-5. Molecular formula: C14H18O4. Mole weight: 250.29. Product ID: ACM56305045. Alfa Chemistry ISO 9001:2015 Certified. | |
| Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-Carboxylic Acid) | Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays. Trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging. It has been shown that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. Group: Biochemicals. Grades: Highly Purified. CAS No. 53188-07-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| Tromantadine | Tromantadine is a topical antiherpetic drug that has two independent actions on herpes simplex virus type 1 (HSV-1) replication: early, during virus binding or penetration and late, after the initiation of DNA synthesis. Synonyms: N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide; D 41; N-(1-adamantyl)-2-(2-dimethylaminoethoxy)acetamide; tromantadin; tromantadine; tromantadine monohydrochloride; tromantadine monohydrochloride, monohydrate; tromantidine; Viru-Merz; Viru-Merz serol; Viru-Serol. Grades: ≥99.0%. CAS No. 53783-83-8. Molecular formula: C16H28N2O2. Mole weight: 280.41. | |
| Tromantadine | Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 53783-83-8. Molecular formula: C16H28N2O2. Mole weight: 280.409. Product ID: ACM53783838. Alfa Chemistry ISO 9001:2015 Certified. | |
| Tromantadine hydrochloride | Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 41544-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-U00124B. | |
| Tromethamine | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Tromethamine USP | Tris(hydroxymethylaminomethane). Grades: USP. CAS No. 77-86-1. Product ID: 8-01645. Molecular formula: C4H11NO3. Mole weight: 121.14. Properties: mp 114 - 118°C[a]. |  |
| Trontinemab | Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 ( TFR1 ). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RG6102; RO-7126209. CAS No. 2568868-35-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9999. | |
| Tropaeolin O | 100g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials, Stains & Indicators. Formula: C12H10N2O5S.Na. CAS No. 547-57-9. Prepack ID 61804883-100g. Molecular Weight 316.27. See USA prepack pricing. |  |
| Tropaeolin O | Tropaeolin O. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g. US Biological Life Sciences. | Worldwide |
| Tropaeolin OO | 25g Pack Size. Group: Stains & Indicators. Formula: C18H14N3O3SNa. CAS No. 554-73-4. Prepack ID 23894342-25g. Molecular Weight 375.38. See USA prepack pricing. | |
| Tropaeolin O sodium salt | Tropaeolin O sodium salt. Group: Biochemicals. Alternative Names: 4- ([2, 4-Dihydroxyphenyl]azo) benzenesulfonic acid sodium salt; Resorcinol Yellow; Acid Orange 6; Chrysoin. Grades: Highly Purified. CAS No. 547-57-9. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C12H9N2O5SNa. US Biological Life Sciences. | Worldwide |
| Tropanyl-3,5-dimethylbenzoate | Tropanyl-3,5-dimethylbenzoate. Group: Biochemicals. Grades: Purified. CAS No. 85181-40-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Tropanyl-3,5-dimethylbenzoate | Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist. Synonyms: Tropanserin; MDL-72422; MDL 72422; MDL72422; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3,5-dimethylbenzoate. Grades: ≥99%. CAS No. 85181-40-4. Molecular formula: C17H23NO2. Mole weight: 273.37. | |
| Trophoblast glycoprotein (17-25) | Trophoblast glycoprotein (17-25) is a 9-aa peptide. Trophoblast glycoprotein is a heavily N-glycosylated transmembrane protein belonging to the leucine-rich repeat family of proteins. It is typically expressed during fetal development and cancer. Synonyms: 5T4 oncofetal antigen (17-25); 5T4 oncofetal trophoblast glycoprotein (17-25); Wnt-activated inhibitory factor 1 (17-25). | |
| Tropicacid | Tropicacid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[4-(Acetyloxy)phenyl]-N-ethylacetamide; N-Ethyl-p-aminophenol-diacetyl-deriv.; N-Ethyl-p-aminophenol,N,O-diacetyl derivative. Product Category: Heterocyclic Organic Compound. CAS No. 529-94-6. Molecular formula: C12H15NO3. Mole weight: 221.252. Purity: 0.96. IUPACName: [4-[acetyl(ethyl)amino]phenyl] acetate. Product ID: ACM529946. Alfa Chemistry ISO 9001:2015 Certified. Categories: Tropic acid. | |
| Tropic acid | Tropic acid (DL-Tropic acid) is a laboratory reagent used in the chemical synthesis of Atropine and Hyoscyamine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Tropic acid. CAS No. 552-63-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-W041194. | |
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