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Avanafil Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 2-(2-(hydroxymethyl)pyrrolidin-1-yl)-4-((4-methoxybenzyl)amino)pyrimidine-5-carboxylate. Molecular Formula: C20H26N4O4. Mole Weight: 386.44. Catalog: APB02774.
Avanafil Impurity 29
Avanafil Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular Formula: C20H24Cl2N4O4. Mole Weight: 455.33. Catalog: APB02776.
Avanafil Impurity 29
Avanafil Impurity 29. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1364671-52-2. Molecular Formula: C19H19ClN6O3S. Mole Weight: 446.91. Catalog: APB1364671522.
Avanafil Impurity 3
Avanafil Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2250242-48-7. Molecular Formula: C16H17Cl2N3O3S. Mole Weight: 402.29. Catalog: APB2250242487.
Avanafil Impurity 3
Avanafil Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C8H10N2O3S. Mole Weight: 214.24. Catalog: APB02659.
Avanafil Impurity 30
Avanafil Impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid. CAS No. 330785-84-7. Molecular Formula: C18H21ClN4O4. Mole Weight: 392.84. Catalog: APB330785847.
Avanafil Impurity 31
Avanafil Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid. Molecular Formula: C18H21ClN4O4. Mole Weight: 392.84. Catalog: APB02773.
Avanafil Impurity 32
Avanafil Impurity 32. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-4-((4-methoxybenzyl)amino)pyrimidine-5-carboxylic acid. Molecular Formula: C18H22N4O4. Mole Weight: 358.39. Catalog: APB02771.
Avanafil Impurity 32
Avanafil Impurity 32. Uses: For analytical and research use. Group: Impurity standards. CAS No. 53554-29-3. Molecular Formula: C8H10N2O3S. Mole Weight: 214.24. Catalog: APB53554293.
Avanafil Impurity 33
Avanafil Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 247569-72-8. Molecular Formula: C8H10ClNO. Mole Weight: 171.62. Catalog: APB247569728.
Avanafil Impurity 33
Avanafil Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid. Molecular Formula: C18H20Cl2N4O4. Mole Weight: 427.28. Catalog: APB02770.
Avanafil Impurity 34
Avanafil Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C23H26ClN7O3. Mole Weight: 483.95. Catalog: APB02772.
Avanafil Impurity 35
Avanafil Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C23H25Cl2N7O3. Mole Weight: 518.4. Catalog: APB02768.
Avanafil Impurity 36
Avanafil Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C19H19ClN6O2S. Mole Weight: 430.91. Catalog: APB02769.
Avanafil Impurity 37
Avanafil Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-hydroxy-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. CAS No. 1452128-53-8. Molecular Formula: C18H17ClN6O3. Mole Weight: 400.82. Catalog: APB1452128538.
Avanafil Impurity 37
Avanafil Impurity 37. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2250242-49-8. Molecular Formula: C18H23N5O3. Mole Weight: 357.41. Catalog: APB2250242498.
Avanafil Impurity 38
Avanafil Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-hydroxybenzyl)amino)-2-hydroxy-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C17H15ClN6O3. Mole Weight: 386.79. Catalog: APB02767.
Avanafil Impurity 39
Avanafil Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((3-chloro-4-hydroxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C15H16ClN3O3S. Mole Weight: 353.82. Catalog: APB02765.
Avanafil Impurity 39
Avanafil Impurity 39. Uses: For analytical and research use. Group: Impurity standards. CAS No. 23356-96-9. Molecular Formula: C5H11NO. Mole Weight: 101.15. Catalog: APB23356969.
Avanafil Impurity 4
Avanafil Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 874482-97-0. Molecular Formula: C8H11Cl2NO. Mole Weight: 208.08. Catalog: APB874482970.
Avanafil Impurity 4
Avanafil Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C16H19N3O3S. Mole Weight: 333.41. Catalog: APB02657.
Avanafil Impurity 40
Avanafil Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 4-((3-chloro-4-hydroxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular Formula: C19H23ClN4O4. Mole Weight: 406.86. Catalog: APB02766.
Avanafil Impurity 40
Avanafil Impurity 40. Uses: For analytical and research use. Group: Impurity standards. CAS No. 68832-13-3. Molecular Formula: C5H11NO. Mole Weight: 101.15. Catalog: APB68832133.
Avanafil Impurity 41
Avanafil Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 56633-75-1. Molecular Formula: C6H11NO2. Mole Weight: 129.16. Catalog: APB56633751.
Avanafil Impurity 41
Avanafil Impurity 41. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3-chloro-4-hydroxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid. Molecular Formula: C17H19ClN4O4. Mole Weight: 378.81. Catalog: APB02764.
Avanafil Impurity 42
Avanafil Impurity 42. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-(1-(4-((3-chloro-4-methoxybenzyl)amino)-5-((pyrimidin-2-ylmethyl)carbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl acetate. Molecular Formula: C25H28ClN7O4. Mole Weight: 525.99. Catalog: APB02762.
Avanafil Impurity 42
Avanafil Impurity 42. Uses: For analytical and research use. Group: Impurity standards. CAS No. 61350-65-0. Molecular Formula: C6H11NO2. Mole Weight: 129.16. Catalog: APB61350650.
Avanafil Impurity 43
Avanafil Impurity 43. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 4-((3-chlorobenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular Formula: C19H23ClN4O3. Mole Weight: 390.86. Catalog: APB02763.
Avanafil Impurity 44
Avanafil Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chlorobenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid. Molecular Formula: C13H12ClN3O2S. Mole Weight: 309.77. Catalog: APB02761.
Avanafil Impurity 45
Avanafil Impurity 45. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((3-chlorobenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C15H16ClN3O2S. Mole Weight: 337.82. Catalog: APB02760.
Avanafil Impurity 46
Avanafil Impurity 46. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3-chlorobenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C22H24ClN7O2. Mole Weight: 453.92. Catalog: APB02759.
Avanafil Impurity 5
Avanafil Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C16H17Cl2N3O3S. Mole Weight: 402.3. Catalog: APB02654.
Avanafil Impurity 50
Avanafil Impurity 50. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2310299-29-5. Molecular Formula: C14H14ClN3O5S. Mole Weight: 371.79. Catalog: APB2310299295.
Avanafil Impurity 51
Avanafil Impurity 51. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1624833-89-1. Molecular Formula: C19H19ClN6O4S. Mole Weight: 462.91. Catalog: APB1624833891.
Avanafil Impurity 52
Avanafil Impurity 52. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1711677-06-3. Molecular Formula: C20H23ClN4O5. Mole Weight: 434.88. Catalog: APB1711677063.
Avanafil Impurity 56
Avanafil Impurity 56. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1830294-64-8. Molecular Formula: C23H24ClN7O4. Mole Weight: 497.94. Catalog: APB1830294648.
Avanafil Impurity 6
Avanafil Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-((2-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Molecular Formula: C16H18ClN3O3S. Mole Weight: 367.85. Catalog: APB02655.
Avanafil Impurity 6
Avanafil Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2520113-98-6. Molecular Formula: C24H24ClN7O4. Mole Weight: 509.95. Catalog: APB2520113986.
Avanafil Impurity 63
Avanafil Impurity 63. Uses: For analytical and research use. Group: Impurity standards. CAS No. 59566-45-9. Molecular Formula: C6H5N3. Mole Weight: 119.13. Catalog: APB59566459.
Avanafil Impurity 68
Avanafil Impurity 68. Uses: For analytical and research use. Group: Impurity standards. CAS No. 41965-95-1. Molecular Formula: C8H11Cl2NO. Mole Weight: 208.08. Catalog: APB41965951.
Avanafil Impurity 69
Avanafil Impurity 69. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5909-24-0. Molecular Formula: C8H9ClN2O2S. Mole Weight: 232.68. Catalog: APB5909240.
Avanafil Impurity 7
Avanafil Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid. Molecular Formula: C14H14ClN3O3S. Mole Weight: 339.8. Catalog: APB02656.
Avanafil Impurity 7
Avanafil Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1638497-26-3. Molecular Formula: C23H26ClN7O3. Mole Weight: 483.96. Catalog: APB1638497263.
Avanafil Impurity 75
Avanafil Impurity 75. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C26H38ClN7O4. Mole Weight: 548.09. Catalog: APB06513.
Avanafil Impurity 76
Avanafil Impurity 76. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C23H26ClN7O4. Mole Weight: 499.96. Catalog: APB06514.
Avanafil Impurity 77
Avanafil Impurity 77. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C23H26ClN7O4. Mole Weight: 499.96. Catalog: APB06515.
Avanafil Impurity 78
Avanafil Impurity 78. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C41H45Cl2N11O6. Mole Weight: 858.78. Catalog: APB06517.
Avanafil Impurity 79
Avanafil Impurity 79. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C26H38ClN7O4. Mole Weight: 548.09. Catalog: APB06516.
Avanafil Impurity 8
Avanafil Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((3-chloro-4-hydroxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. CAS No. 330785-05-2. Molecular Formula: C22H24ClN7O3. Mole Weight: 469.92. Catalog: APB330785052.
Avanafil Impurity 8
Avanafil Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2221018-00-2. Molecular Formula: C30H30Cl2N6O7. Mole Weight: 657.51. Catalog: APB2221018002.
Avanafil Impurity 80
Avanafil Impurity 80. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2259648-80-9. Molecular Formula: C32H30FN5O4. Mole Weight: 567.62. Catalog: APB2259648809.
Avanafil Impurity 81
Avanafil Impurity 81. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C23H27N7O4. Mole Weight: 465.51. Catalog: APB06518.
Avanafil Impurity 82
Avanafil Impurity 82. Uses: For analytical and research use. Group: Impurity standards. CAS No. 372115-53-2. Molecular Formula: C24H29N7O4. Mole Weight: 479.54. Catalog: APB372115532.
Avanafil Impurity 83
Avanafil Impurity 83. Uses: For analytical and research use. Group: Impurity standards. CAS No. 372117-76-5. Molecular Formula: C16H18ClN3O5S. Mole Weight: 399.85. Catalog: APB372117765.
Avanafil Impurity 9
Avanafil Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2520114-34-3. Molecular Formula: C23H26ClN7O3. Mole Weight: 483.96. Catalog: APB2520114343.
Avanafil Impurity 9
Avanafil Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((S)-1-(4-((3-chloro-4-methoxybenzyl)amino)-5-((pyrimidin-2-ylmethyl)carbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl 4-((3-chloro-4-methoxybenzyl)amino)-2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular Formula: C41H45Cl2N11O6. Mole Weight: 858.77. Catalog: APB02653.
Avanafil Impurity O
Avanafil Impurity O. Uses: For analytical and research use. Group: Impurity standards. CAS No. 330785-83-6. Molecular Formula: C20H25ClN4O4. Mole Weight: 420.89. Catalog: APB330785836.
Avanafil Impurity P
Avanafil Impurity P. Uses: For analytical and research use. Group: Impurity standards. CAS No. 330785-81-4. Molecular Formula: C16H18ClN3O3S. Mole Weight: 367.85. Catalog: APB330785814.
Avanafil Impurity R-1
Avanafil Impurity R-1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1638497-22-9. Molecular Formula: C20H25ClN4O4. Mole Weight: 420.89. Catalog: APB1638497229.
Avanafil Impurity R-2
Avanafil Impurity R-2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1638497-25-2. Molecular Formula: C18H21ClN4O4. Mole Weight: 392.84. Catalog: APB1638497252.
Avanafil Impurity V
Avanafil Impurity V. Uses: For analytical and research use. Group: Impurity standards. CAS No. 330785-99-4. Molecular Formula: C15H16ClN3O4. Mole Weight: 337.76. Catalog: APB330785994.
Avanafil Intermediates
Avanafil Intermediates. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246834-64-9. Molecular Formula: C7H11N3O2. Mole Weight: 169.18. Catalog: APB1246834649.
Avanafil metabolite M4
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grades: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95.
Avanafil Polymer 1
Avanafil Polymer 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C41H45Cl2N11O6. Mole Weight: 858.78. Catalog: APB06509.
Avanafil Polymer 2
Avanafil Polymer 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C36H40Cl2N8O7. Mole Weight: 767.68. Catalog: APB06511.
Avanafil Polymer 3
Avanafil Polymer 3. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C41H45Cl2N11O6. Mole Weight: 858.78. Catalog: APB06510.
Avanafil Related Compound 1
Avanafil Related Compound 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 330785-82-5. Molecular Formula: C16H18ClN3O4S. Mole Weight: 383.85. Catalog: APB330785825.
Avanafil Related Compound 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1364671-62-4. Molecular Formula: C19H19ClN6O2S. Mole Weight: 430.91. Catalog: APB1364671624.
Avapritinib
BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Synonyms: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; BLU-285; BLU 285; BLU285; UNII-513P80B4YJ; SCHEMBL16652297. CAS No. 1703793-34-3. Molecular formula: C26H27FN10. Mole weight: 498.56.