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| Product | Description | |
|---|---|---|
| AZD-5904 | AZD-5904 is a potent orally bioavailable MPO inhibitor. It inhibited the isolated MPO enzyme with an IC50 value of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity. It was used for multiple sclerosis and COPD and has been evaluated in single and multiple dose studies in healthy volunteers. Uses: Azd-5904 was used for multiple sclerosis and copd. Synonyms: AZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904. (S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one. Grade: 98%. CAS No. 618913-30-7. Molecular formula: C10H12N4O2S. Mole weight: 252.29. |  |
| AZD5991 | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grade: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
| AZD-5991 | AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2143061-81-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101533. |  |
| AZD-5991 (S-enantiomer) | AZD-5991 (S-enantiomer), the less active enantiomer of AZD-5991, is an McL-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay. Uses: Antineoplastic agents. Synonyms: 22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-, (3aS)-. Grade: ≥95%. CAS No. 2143061-82-7. Molecular formula: C35H36ClN5O3S3. Mole weight: 672.26. | |
| AZD-6126 | AZD6126 is a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. Synonyms: AZD6126; AZD 6126; N-Acetylcochinol-O-phosphate; (5S)-5-acetamido-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-3-yl dihydrogen phosphate; N-[9,10,11-Trimethoxy-3-(phosphonooxy)-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl]ethanimidic acid. CAS No. 219923-05-4. Molecular formula: C20H24NO8P. Mole weight: 437.38. | |
| AZD-6280 | AZD-6280 is a selective GABAA(α2/3) receptor modulator for the treatment of generalized anxiety disorder. Synonyms: AZD6280; UNII-B9Z1OEH19D; AZD 6280; B9Z1OEH19D; CHEMBL1783256. Grade: 98%. CAS No. 942436-93-3. Molecular formula: C20H22N4O3. Mole weight: 366.4. | |
| AZD6482 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. Phase 1. Synonyms: KIN193; AZD6482; KIN 193; AZD 6482; KIN-193; AZD-6482. Grade: >98%. CAS No. 1173900-33-8. Molecular formula: C22H24N4O4. Mole weight: 408.45. | |
| AZD6482 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| AZD 6482 | AZD 6482 (KIN-193) is a potent and selective p110? inhibitor with an IC50 of 0.69 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KIN-193. CAS No. 1173900-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10344. | |
| AZD6482 (S-isomer) | This active molecular is the S-configuration isomer of AZD6482. AZD6482 is a selective, ATP competitive PI3Kβ inhibitor and IC50 value is 0.01 μm. Meanwhile, AZD6482 also inhibited insulin-induced human adipocyte glucose uptake in vitro and IC50 value is 4.4 μm. In May 2008, AstraZeneca completed a phase I trial in Thrombosis in Sweden. In Jul 2010, Phase-I for Thrombosis in Sweden was discontinued. Uses: Thrombosis. Synonyms: AZD6482 (S-isomer); AZD 6482 (S-isomer); AZD-6482 (S-isomer); (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid,1173900-33-8 (AZD6482). Grade: 98%. CAS No. 1173900-37-2. Molecular formula: C22H24N4O4. Mole weight: 408.46. | |
| AZD6738 | AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2. Synonyms: AZD-6738; AZD 6738. Grade: 98%. CAS No. 1352226-88-0. Molecular formula: C20H24N6O2S. Mole weight: 412.51. | |
| AZD6765 dihydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZD7325 | AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor ( K i =0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes [1] [4]. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro [2]. AZD7325 has the potential for the investigation of anxiety and dravet syndrome [3]. PAM: positive allosteric modulator. Uses: Scientific research. Group: Signaling pathways. CAS No. 942437-37-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111052. | |
| AZD7507 | AZD7507 is a CSF-1R inhibitor with anti-tumor activity. Synonyms: AZD-7507; AZD 7507. Grade: >98%. CAS No. 1041852-85-0. Molecular formula: C23H27FN6O3. Mole weight: 454.5. | |
| AZD7545 | AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. Synonyms: AZD7545; AZD-7545; AZD 7545. Grade: >98%. CAS No. 252017-04-2. Molecular formula: C19H18ClF3N2O5S. Mole weight: 478.87. | |
| AZD7545 | AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 252017-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16082. | |
| AZD-7594 | AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator. Synonyms: AZD-7594; AZD 7594; AZD7594; AZ13189620; AZ-13189620; AZ 13189620; 3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-[(3R)-oxolan-3-yl]benzamide. CAS No. 1196509-60-0. Molecular formula: C32H32F2N4O6. Mole weight: 606.627. | |
| AZD7648 | AZD7648 is a potent and selective DNA-PK inhibitor with anti-tumor activity. Synonyms: AZD-7648; AZD 7648. Grade: 98%. CAS No. 2230820-11-6. Molecular formula: C18H20N8O2. Mole weight: 380.4. | |
| AZD-7648 | AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230820-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-111783. | |
| AZD7687 | AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). Synonyms: AZD7687; AZD 7687; AZD-7687. Grade: >98%. CAS No. 1166827-44-6. Molecular formula: C21H25N3O3. Mole weight: 367.44. | |
| AZD-7762 | AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. Synonyms: AZD 7762; AZD7762. Grade: 0.98. CAS No. 860352-01-8. Molecular formula: C17H19FN4O2S. Mole weight: 362.423. | |
| AZD-7762 | AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1. Uses: Scientific research. Group: Signaling pathways. CAS No. 860352-01-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10992. | |
| AZD 7762 hydrochloride | AZD 7762 hydrochloride is the hydrochloride salt of AZD 7762, which is a selective and potent ATP-competitive inhibitor of Chk1 and Chk2 with IC50 values of 5 nM for both kinases. It shows at least >10 fold selectivity over a panel of 164 kinases. It is used as a potentiation cytotoxicity DNA-damaging agent. It is active in vivo. Synonyms: AZD 7762 hydrochloride; AZD7762 hydrochloride; AZD-7762 hydrochloride; 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride; 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1246094-78-9. Molecular formula: C17H20FN4O2SCl. Mole weight: 398.88. | |
| AZD-7762 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZD 7986 | AZD 7986 is a potent and selective inhibitor of Dipeptidyl Peptidase 1 (DPP1) with pIC50 of 8.4. It is in phase I clinical trials by AstraZeneca for the treatment of chronic obstructive pulmonary disease (COPD). Synonyms: brensocatib; INS1007; (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide. Grade: 98%. CAS No. 1802148-05-5. Molecular formula: C23H24N4O4. Mole weight: 420.46. | |
| AZD8055 | AZD8055 Inhibitor. Uses: Scientific use. Product Category: T1859. CAS No. 1009298-09-2. |  |
| AZD8055 | A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Group: Biochemicals. Alternative Names: 5- [2, 4-Bis [ (3S) -3-methyl-4-morpholinyl] pyrido [2, 3-d] pyrimidin-7-yl] -2-methoxy Benzene methanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]- 2-methoxyphenyl] methanol; AZD 8055; [5- [2, 4-Bis ( (3S) -3-methylmorpholin-4-yl) pyrido [5, 6-e] pyrimidin-7-yl] -2-methoxyphenyl] methanol. Grades: Purified. CAS No. 1009298-09-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| AZD-8055 | AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC 50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1009298-09-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10422. | |
| AZD-8055 | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. Synonyms: AZD8055; AZD-8055; AZD 8055. Grade: 0.98. CAS No. 1009298-09-2. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| AZD8154 | AZD8154 is a novel inhaled selective inhibitor of PI3Kγδ targeting airway inflammatory disease. Synonyms: AZD-8154. CAS No. 2215022-45-8. Molecular formula: C27H29N5O4S2. Mole weight: 551.68. | |
| AZD8186 | AZD 8186 is a selective PI3Kβ/δ inhibitor (IC50= 0.003 μM for PI3Kβ, and 0.017 μM for PI3Kδ) with potential antineoplastic activity. It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 μM and exhibits high oral efficacy in mouse cancer models. Synonyms: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide; AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. | |
| AZD8186 | AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZD8186; AZD 8186; AZD-8186. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. Purity: >98%. IUPACName: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide. Canonical SMILES: O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1. Product ID: ACM1627494136. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AZD8186 | AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC 50 =4 nM) and PI3Kδ (IC50 50 =12 nM) with selectivity over PI3Kα (IC 50 =35 nM) and PI3Kγ (IC 50 =675 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1627494-13-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12330. | |
| AZD8329 | AZD8329 is a potent, selective 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor) with reduced acyl glucuronide liability. AZD8329 demonstrates to have improved technical profile in terms of both solubility and pharmacokinetics. The extent of acyl glucuronidation was reduced through structural optimization of both the carboxylic acid and amide substituents, coupled with a reduction in lipophilicity leading to an overall increase in metabolic stability. Synonyms: AZD-8329; AZD 8329; 4-(4-((1r,3r,5r,7r)-adamantan-2-ylcarbamoyl)-5-(tert-butyl)-1H-pyrazol-1-yl)benzoic acid. Grade: 98%. CAS No. 1048668-70-7. Molecular formula: C25H31N3O3. Mole weight: 421.54. | |
| AZD8330 | AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-424704; ARRY-704. CAS No. 869357-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12058. | |
| AZD-8330 | AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Synonyms: AZD8330; AZD-8330; AZD 8330; ARRY424704; ARRY 424704; ARRY-424704; ARRY704; ARRY-704; ARRY 704. Grade: 0.98. CAS No. 869357-68-6. Molecular formula: C16H17FIN3O4. Mole weight: 461.232. | |
| AZD8421 | AZD8421 is a selective CDK2 inhibitor (IC50 = 9 nM) as well as achieving CDK family selectivity in cells versus key off-targets (CDK1, CDK4/6, CDK9), AZD8421 had no significant kinase inhibition outside the CDK family. AZD8421 inhibits cancer cell proliferation by inhibiting pRB phosphorylation, inducing cell cycle arrest in G1/S phase and senescence. AZD8421 can be studied in research for breast cancer and ovarian cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3047321-53-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-158106. | |
| AZD-8529 | AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 , with an EC 50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092453-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107457. | |
| AZD-8529 mesylate | AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 , with an EC 50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314217-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107457A. | |
| AZD-8529 mesylate | AZD-8529 is a positive allosteric modulator at the mGluR2 receptor, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. Synonyms: 7-Methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one methanesulfonate. CAS No. 1314217-69-0. Molecular formula: C25H28F3N5O6S. Mole weight: 583.58. | |
| AZD8797 | AZD8797 is a selective allosteric non-competitive modulator of the human CX3CR1 receptor (Ki = 3.9 nM), binding CX3CR1 and effecting G-protein signalling and β-arrestin recruitment in a biased way. AZD8797 has a 720 fold selectivity for CX3CR1 receptor over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors. Synonyms: AZD8797; AZD-8797; AZD 8797; (2R)-2-[[2-amino-5-[(1S)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol. CAS No. 911715-90-7. Molecular formula: C19H25N5OS2. Mole weight: 403.56. | |
| AZD-8835 | AZD-8835 was selected as a clinical candidate for the treatment of PIK3CA-dependent cancers and is currently in phase I clinical trials. It is an orally bioavailable inhibitor of the class I (PI3K) catalytic subunit alpha (PIK3CA). IC50: PI3Kδ= 5.7 nM, PI. Synonyms: 1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one AZD-8835 1620576-64-8 GTPL8915 SCHEMBL15877923 AZD8835 ZGRDYKFVDCFJCZ-UHFFFAOYSA-N BDBM185362 AZD 8835 AKOS027338670 compo. CAS No. 1620576-64-8. Molecular formula: C22H31N9O3. Mole weight: 469.54. | |
| AZD-8931 | Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. Synonyms: AZD8931; AZD 8931; Momelotinib; Sapitinib. Grade: 0.98. CAS No. 848942-61-0. Molecular formula: C23H25ClFN5O3. Mole weight: 473.933. | |
| AZD9056 hydrochloride | AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. Uses: Scientific research. Group: Signaling pathways. CAS No. 345303-91-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19427A. | |
| AZD9272 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| AZD 9272 | AZD 9272 is a potent, long-acting and selective nervous system penetrant mGlu5 antagonist with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respectively. It shows >3900-fold selectivity for mGlu5 over other mGlu receptors and shows discriminative effects in rats. It is orally bioavailable and brain penetrant. It has psychoactive and psychomimetic effects. Synonyms: AZD-9272; AZD 9272; AZD9272; 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile; 3-(5-Fluoropyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazole. Grade: ≥98% by HPLC. CAS No. 327056-26-8. Molecular formula: C14H6F2N4O. Mole weight: 284.22. | |
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; AZD9291; AZD 9291; Osimertinib. Grade: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. | |
| AZD9291DA | AZD9291-DA is a des acryl analogue of AZD9291, which is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. Uses: For research used only. Synonyms: AZD9291-Des acryl analogue; AZD9291 Des acryl precursor; Mutated EGFR-IN-1; N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine; N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine; SCHEMBL14660679. Grade: 0.98. CAS No. 1421372-66-8. Molecular formula: C25H31N7O. Mole weight: 445.571. | |
| AZD-9291 mesylate | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Synonyms: Mereletinib mesylate; EGFR inhibitor; AZD9291 mesylate; AZD 9291 mesylate. Grade: >98%. CAS No. 1421373-66-1. Molecular formula: C29H37N7O5S. Mole weight: 595.71. | |
| AZD9496 | AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. Synonyms: (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid; AZD9496; AZD-9496; AZD 9496. Grade: 98%. CAS No. 1639042-08-2. Molecular formula: C25H25F3N2O2. Mole weight: 442.48. | |
| AZD9496 | AZD9496 is an effective, selective estrogen receptor ( ERα ) antagonist with an IC 50 of 0.28 nM. AZD9496 is an orally active, selective estrogen receptor degrader (SERD). Uses: Scientific research. Group: Signaling pathways. CAS No. 1639042-08-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12870. | |
| AZD9496 maleate | AZD9496 maleate is potent downregulator of estrogen receptor in breast carcinoma cells and also antagonise ERα with good oral pharmacokinetic properties. It is in collaboration with parexel initiates enrolment in a phase I trial in health volunteers in US. Synonyms: (Z)-but-2-enedioic acid; (E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acidAZD9496 (maleate); AZD 9496 (maleate); AZD-9496 (maleate). CAS No. 1639042-28-6. Molecular formula: C29H29F3N2O6. Mole weight: 558.55. | |
| AZD9496 maleate | AZD9496 maleate is a potent and selective estrogen receptor ( ERα ) antagonist with IC 50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). Uses: Scientific research. Group: Signaling pathways. CAS No. 1639042-28-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12870A. | |
| AZD-9574 | AZD-9574 is a blood-brain barrier (BBB) penetrant selective inhibitor of PARP1 for the treatment of primary and secondary brain tumors. Synonyms: AZD 9574; AZD9574. Grade: 98% by HPLC. CAS No. 2756333-39-6. Molecular formula: C21H22F2N6O2. Mole weight: 428.4. | |
| Az-ddCTP-10 mM aqueous solution | Az-ddCTP-10 mM aqueous solution is an aqueous solution constituted by Azido-deoxy Cytidine Triphosphate (Az-ddCTP), which is a remarkable nucleotide analog. This solution empowers researchers in virology and antiviral drug development by effectively hindering viral replication. By seamlessly incorporating itself into the viral DNA chain during replication is az-ddCTP orchestrates premature termination, thereby rendering it an indispensable tool in this scientific domain. Synonyms: 3'-Azido-ddCTP.Li; 3'-Azido-2',3'-dideoxycytidine-5'-triphosphate lithium salt; AZddCTP. Grade: 90%. Molecular formula: C9H15O12N6P3·xLi. Mole weight: 492.17 (free acid). | |
| AzddMeC | Az-Dcme is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. Synonyms: Az-Dcme; 3'-Azido-2',3'-dideoxy-5-methylcytidine; AZ-5MeC; 3'-N3-5-Me-ddC; CS-92. Grade: >98%. CAS No. 87190-79-2. Molecular formula: C10H14N6O3. Mole weight: 266.26. | |
| AzddMeC | AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1 -infected human PBM cells and HIV-1 -infected human macrophages, the EC 50 values of AzddMeC are 9 nM and 6 nM, respectively [1] [2]. AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CS-92. CAS No. 87190-79-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105268. | |
| Az-ddTTP-100 mM aqueous solution | Az-ddTTP-100 mM aqueous solution is an indispensable and highly regarded recompound within the biomedical realm, emerging as a pivotal tool revolutionizing DNA sequencing methodologies. This superlative solution facilitates the meticulous investigation and research of multifaceted afflictions encompassing malignant neoplasms and hereditary maladies. Synonyms: 3'-Azido-ddTTP.Li; 3'-Azido-2',3'-dideoxythymidine-5'-triphosphate lithium salt; AzddTTP. Grade: 98%. Molecular formula: C10H16N5O13P3·xLi. Mole weight: 507.18 (free acid). | |
| Az-ddUTP-100 mM aqueous solution | Az-ddUTP-100 mM aqueous solution is a valuable tool in biomedical research acting as a substrate for reverse transcriptase to facilitate the introduction of azide-modified deoxyuridine triphosphate (ddUTP) into cDNA. This compound enables efficient labeling of RNA transcripts during in vitro transcription reactions. It finding applications in drug discovery, gene expression analysis is and understanding diseases at the molecular level. Synonyms: 3'-Azido-ddUTP.Li; 3'-Azido-2',3'-dideoxyuridine-5'-triphosphate lithium salt; AzddUTP. Molecular formula: C9H14N5O13P3·xLi. Mole weight: 493.15 (free acid). | |
| AZ Dyrk1B 33 | AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor with IC50 value of 7 nM. It shows better selectivity than AZ 191 and shows no off-target effects against a panel of 124 kinases tested. It displays distinct cellular effects when compared to DYRK1B knockdown through siRNA and has been demonstrated cellular in vitro activity. Synonyms: AZ-Dyrk1B-33; 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine. Grade: ≥98% by HPLC. CAS No. 1679330-37-0. Molecular formula: C19H16N4. Mole weight: 300.36. | |
| a-Zearalenol | a-Zearalenol. Group: Biochemicals. Alternative Names: (3S,7R,11E)-3,4,5,6,7,8,9,10-Octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one. Grades: Highly Purified. CAS No. 36455-72-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C18H24O5. US Biological Life Sciences. | Worldwide |
| Azelaic acid | Azelaic acid. CAS No. 123-99-9. Product ID: 1-00973. Molecular formula: HO2C(CH2)7CO2H. Mole weight: 188.22. Purity: >99.5%. Properties: mp 109-111°C. Reference: Merck 12, 938. |  |
| Azelaic acid | Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Nonanedioic acid. CAS No. 123-99-9. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-B0704. | |
| Azelaic acid | 100g Pack Size. Group: Bioactive Small Molecules, Building Blocks, Research Organics & Inorganics. Formula: HOOC(CH2)7COOH. CAS No. 123-99-9. Prepack ID 31437119-100g. Molecular Weight 188.22. See USA prepack pricing. |  |
| Azelaic acid | Azelaic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 123-99-9. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C9H16O4. US Biological Life Sciences. | Worldwide |
| Azelaic Acid | Azelaic Acid. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner. |  California |
| Azelaic Acid | Azelaic acid is a synthetic dicarboxylic acid that is commonly used in the treatment of acne and rosacea. It is also sometimes prescribed for other skin conditions, such as hyperpigmentation and melasma. Azelaic acid works by inhibiting the growth of acne-causing bacteria on the skin, reducing inflammation, and helping to unclog pores. It is also a mild exfoliant, which helps to remove dead skin cells and improve skin texture. Uses: 1. treatment of acne: azelaic acid is commonly used as a topical treatment for mild to moderate acne. it works by reducing the growth of bacteria that causes acne, and it also helps to unclog pores and reduce inflammation. 2. treatment of rosacea: azelaic acid also has anti-inflammatory properties that make it an effective treatment for rosacea, a chronic skin condition that causes facial redness. Group: Resin additives. Alternative Names: Anchoec acid. CAS No. 123-99-9. Product ID: Nonanedioic acid. Molecular formula: 188.22. Mole weight: C9H16O4. C(CCCC(=O)O)CCCC(=O)O. InChI=1S/C9H16O4/c10-8 (11)6-4-2-1-3-5-7-9 (12)13/h1-7H2, (H, 10, 11) (H, 12, 13). BDJRBEYXGGNYIS-UHFFFAOYSA-N. 98%. |  |
| Azelaic Acid | analytical standard. Uses: For analytical and research use. Group: Flavor and fragrance standards; api standards; pharmaceutical toxicology. Grades: analytical standard. CAS No. 123-99-9. Pack Sizes: 100MG. IUPAC Name: nonanedioic acid. Molecular formula: C9H16O4. Mole weight: 188.22. EC Number: 204-669-1. Catalog: APS123999A. Assay: ?98.5% (GC). SMILES: OC(=O)CCCCCCCC(=O)O. Format: Neat. Shipping: Room Temperature. | |
| Azelaic Acid | analytical standard. Group: Flavor and fragrance standardsapi standardspharmaceutical toxicology. | |
| Azelaic Acid 2-Ethylhexyl Ester | Azelaic Acid 2-Ethylhexyl Ester is an ester of Azelaic acid (A808140), an antiacne agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 13050-58-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C17H32O4, Molecular Weight: 300.43. US Biological Life Sciences. | Worldwide |
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