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| Product | Description | |
|---|---|---|
| Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 | The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 | The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase II Inhibitor VIII | The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase II Inhibitor VIII (4- (2- (4-Methoxybenzamido) thiazol-5-yl) benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII) | A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50=32 and 46nM against CK2a and CK2a', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50=2.6, 1.6, and 2.4uM, in A549, HCT116, and MCF-7 cultures, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 | The Casein Kinase II Inhibitor VI, TMCB, also referenced under CAS 905105-89-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase II Inhibitor XII, TBBz (4, 5, 6, 7-Tetra bromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) | A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at 25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. CAS No:577779-57-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 577779-57-8. Pack Sizes: 20mg. Molecular Formula: C?H?Br?N?, Primary Target: CK2. US Biological Life Sciences. | Worldwide |
| Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 | The Casein Kinase I Inhibitor, D4476, also referenced under CAS 301836-43-1, controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase I Inhibitor III, PF-4800567 | The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase I Inhibitor III, PF-4800567 (CKI Inhibitor III, PF-4800567)(3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl) | A cell-permeable pyrazolopyrimidinyl amino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKle with ~22-fold greater potency over CKld (IC50=32 and 711nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1uM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKle cells over CKld-transfected cells (IC50=0.13 and 2.65uM, respectively), and PER2 degradation in COS7-GFP-PER2-CKle cells. Unlike Casein Kinase I Inhibitor II, PF-670462, PF-4800567 exerts only marginal effect on circadian clock under similar conditions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 | The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Casein Kinase Substrates 3 | Casein Kinase Substrates 3 is a substrate of casein kinase. Synonyms: Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala; L-arginyl-L-arginyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-methionyl-L-seryl-L-isoleucyl-L-threonyl-L-alanine; Casein Kinase I substrate. Grades: ≥95% by HPLC. CAS No. 154444-97-0. Molecular formula: C85H139N27O35S. Mole weight: 2131.24. |  |
| Casein, N,N-dimethylated from bovine milk | essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Casein peptide | Casein peptide is a product made by enzymatic hydrolysis from cow milk casein. Product ID: CDF4-0245. Category: Protein peptide. Product Keywords: Protein Peptides; Casein peptide; CDF4-0245; Protein peptide;. Applications: It is widely used in common food, health food and biomedicine. Product Description: Casein peptides have small molecular weight, good stability, uniform color and easy to dissolve. |  |
| Casein phosphopeptide | Casein phosphopeptide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 691364-49-5. Pack Sizes: 25 g. Product ID: HY-W250117. |  |
| Casein, Powder, Laboratory Grade, 100 g | Casein, Powder, Laboratory Grade, 100 g. Characteristic: Off-white powder, odorless. Notes: Mixture of phosphoproteins from milk; hygroscopic. Storage Code: Green; general chemical storage. Grades: chem-grade laboratory. CAS No. 9000-71-9. Product ID: 853428. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Casein sodium salt from bovine milk | 100g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. CAS No. 9005-46-3. Prepack ID 90005635-100g. See USA prepack pricing. |  |
| Casein solution from bovine milk | 5% in water. Group: Fluorescence/luminescence spectroscopy. | |
| Cashmeran | A synthetic musk fragrance compound (polycyclic musk) used in personal care products, and can be found in the environment and the human body. Group: Biochemicals. Alternative Names: 1,2,3,5,6,7-Hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one; 6,7-Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone; (±)-Cashmeran; DPMI. Grades: Highly Purified. CAS No. 33704-61-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Cashmeran | Cashmeran. CAS No. 33704-61-9. VIGON Item # 505040. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, musk indanone, indomuscone. |  America & Internationally |
| CASIN | CASIN Inhibitor. Uses: Scientific use. Product Category: T3971. CAS No. 425399-05-9. |  |
| CASIN | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Synonyms: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol. Grades: >98%. CAS No. 425399-05-9. Molecular formula: C20H22N2O. Mole weight: 306.41. | |
| CASIN | CASIN. Group: Biochemicals. Grades: Purified. CAS No. 425399-05-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor with an IC 50 of 2 uM. CASIN can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 425399-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12874. | |
| Casirivimab | Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN10933. CAS No. 2415933-42-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99341. | |
| CASK, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CaSO4-2H2O | CaSO4-2H2O. Uses: Designed for use in research and industrial production. Product Category: Graphene-like Materials Series. CAS No. 10101-41-4. Purity: 0.99995. Product ID: ACM10101414. Alfa Chemistry ISO 9001:2015 Certified. Categories: Calcium sulfate dihydrate, CaSO4·2H2O. |  |
| Casocidin-1 | Casocidin-1 is isolated from Bos taurus. Casocidin-1 inhibits the growth of E.coli and S.carnosus. It plays an important role in the capacity of milk to transport calcium phosphate. Synonyms: Alpha-S2-casein; Casocidin-I. | |
| Casopitant | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. Uses: Antiemetics. Synonyms: GW679769; GW 679769; GW-679769; Zunrisa; Rezonic; 4-(4-Acetylpiperazin-1-yl)-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide. CAS No. 414910-27-3. Molecular formula: C30H35F7N4O2. Mole weight: 616.62. | |
| Casopitant mesylate | Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW679769B. CAS No. 414910-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14405A. | |
| Casopitant mesylate | Casopitant mesylate. Group: Biochemicals. Alternative Names: (2R, 4S) -4- (4-Acetyl-1-piperazinyl) -N-[ (1R) -1-[3, 5-bis (trifluoromethyl) phenyl]ethyl]-2- (4-fluoro-2-methylphenyl) -N-methyl-1-piperidinecarboxamide Methanesulfonate. Grades: Highly Purified. CAS No. 414910-30-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C31H39F7N4O5S. US Biological Life Sciences. | Worldwide |
| Casopitant Mesylate | Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;methanesulfonic acid. Grades: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72. | |
| CASP8-IN-1 | CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 ( CASP8 ), with an IC 50 of 0.7 μM. CASP8-IN-1 inhibits FasL-induced apoptosis in cell Jurkat [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956368-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153161. | |
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. |  |
| caspase-10 | Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-κB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation). Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp? ...u-Thr-Asp? to yield a p13 fragment that is not N-myristoylated. Belongs in peptidase family C14. Group: Enzymes. Synonyms: FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Enzyme Commission Number: EC 3.4.22.63. CAS No. 189088-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4239; caspase-10; EC 3.4.22.63; 189088-85-5; FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Cat No: EXWM-4239. | |
| caspase-11 | This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-11. Enzyme Commission Number: EC 3.4.22.64. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4240; caspase-11; EC 3.4.22.64; CASP-11. Cat No: EXWM-4240. | |
| Caspase-1 from Human, Recombinant | Caspase 1/Interleukin-1 converting enzyme is an enzyme that proteolytically cleaves other proteins, such as the precursor forms of the inflammatory cytokines interleukin 1β and interleukin 18, into active mature peptides. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of Huntington's disease. Alternative splicing of the gene results in five transcript variants encoding distinct isoforms. Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS. Recombinant, human caspase-1 fused at the n-terminus to a hisotag sequence and expressed in e. coli useful for the study of enzyme regulation, cleavage of target substrates, and inhibitor screening. Group: Enzymes. Synonyms: CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Purity: >90% by SDS-PAGE. Caspase-1. Mole weight: 10 kDa and 20 kDa. Activity: >25,000 units/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: E. coli. Species: Human. CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Cat No: NATE-0813. | |
| Caspase-1/ICE Inhibitor Z-WEHD-FMK | Z-WEHD-FMK is an inhibitor of caspase-1, caspase-5 and cathepsin B, which can inhibit cell apoptosis in a variety of biological systems. Synonyms: CASPASE-1 INHIBITOR TFA SALT; Z-WEHD-FMK-TFA; Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA. Grades: >99%. CAS No. 210345-00-9. Molecular formula: C37H42FN7O11. Mole weight: 763.78. | |
| Caspase-1 Inhibitor I - CAS 143313-51-3 | The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor I, Cell-Permeable | The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor II - CAS 178603-78-6 | The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor IV - CAS 154674-81-4 | The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor VI | Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Group: Fluorescence/luminescence spectroscopy. | |
| caspase-2 | Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments. Proteolysis occurs at Asp residues and the ...s a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Enzyme Commission Number: EC 3.4.22.55. CAS No. 182372-14-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4230; caspase-2; EC 3.4.22.55; 182372-14-1; ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Cat No: EXWM-4230. | |
| Caspase 2 human | ?95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-2 Inhibitor I | The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 2 Substrate (ICH-1), chromogenic | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| caspase-3 | Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B. Caspase-3 can activate procaspase-2 (EC 3.4.22.55). Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp? is a better substrate than Asp-Val-Ala-Asp?. This is not the case for caspase-7. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CPP32; apopain; yama protein. Enzyme Commission Number: EC 3.4.22.56. CAS No. 169592-56-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4231; caspase-3; EC 3.4.22.56; 169592-56-7; CPP32; apopain; yama protein. Cat No: EXWM-4231. | |
| Caspase-3/7 Inhibitor I | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grades: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
| Caspase-3/7 Inhibitor I - CAS 220509-74-0 | The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3/7 Inhibitor II - CAS 775289-20-8 | The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 3 human | ?90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous glycerol solution, ?1.0 units/mg protein. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 3 Human, Recombinant | Caspase 3 is a member of the CED-3 subfamily of caspases and is responsible for the cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP), the inhibitor of caspase-activated deoxyribonuclease (ICAD), and gelsolin, a protein involved in apoptosis regulation. Caspase 3 is considered to be an effector caspase, activating pro-caspase 6 and pro-caspase 9 in vitro. Caspase 3 can be activated by caspase 8, caspase 6, and granzyme B. Human recombinant c-terminal histidine tagged caspase 3 is a fully active protein consisting of 17 kda and 13.5 kda subunits; the 13.5 kda subunit contains the histidine tag. Applications: Caspase-3 is a caspase prote...ve enzyme. this protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. it is the predominant caspase involved in the cleavage of amyloid-beta 4a precursor protein, which is associated with neuronal death in alzheimer's disease. alternative splicing of this gene results in two transcript variants that encode the same protein. caspase-3 shares many of the typical characteristics common to all currently-known caspases. for example, its active site contains a cysteine residue (cys-163) and histidine residue (his-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an | |
| Caspase-3 Inhibitor I - CAS 169332-60-9 | The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor I, Cell-Permeable | The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor II - CAS 210344-95-9 | The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor III - CAS 285570-60-7 | The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor VII - CAS 745046-84-8 | The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate I, Colorimetric - CAS 1177131-27-9 | Colorimetric substrate for caspase-3 (Km = 9.7 μM) and related cysteine proteases. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate IX, Fluorogenic | A non-fluorescent peptidyl (DEVD)-Rhodamine 110-bisamide that acts as a highly sensitive, photostable caspase-3 fluorogenic substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate VII, Fluorogenic | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| caspase-4 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Enzyme Commission Number: EC 3.4.22.57. CAS No. 182762-08-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4232; caspase-4; EC 3.4.22.57; 182762-08-9; ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Cat No: EXWM-4232. | |
| Caspase-4 Inhibitor I - CAS 402832-01-3 | The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-4 Inhibitor I, Cell-Permeable | The Caspase-4 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 4 Inhibitor (ICH-2) | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| caspase-5 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). Unlike caspase-4, this enzyme can be induced by lipopolysaccharide. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Enzyme Commission Number: EC 3.4.22.58. CAS No. 192465-11-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4233; caspase-5; EC 3.4.22.58; 192465-11-5; ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Cat No: EXWM-4233. | |
| Caspase-5 Inhibitor I | Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8. Group: Fluorescence/luminescence spectroscopy. | |
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