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| Product | Description | |
|---|---|---|
| GW1929 - CAS 196808-24-9 | A potent, tyrosine-based peroxisome proliferator-activated receptor ? (PPAR?) agonist (EC?? = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Group: Fluorescence/luminescence spectroscopy. |  |
| GW1929 hydrate | >98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW 1929 hydrochloride | GW 1929 hydrochloride is a selective and orally bioactive agonist of peroxisome proliferator-activated receptor (PPAR)γ (pEC50 = 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors, respectively). GW 1929 causes a decrease of glucose, fatty acid and triglyceride levels following oral administration in vivo. Synonyms: GW 1929 hydrochloride; GW1929 hydrochloride; GW-1929 hydrochloride; N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride; (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid hydrochloride. Grade: ≥98% by HPLC. CAS No. 1217466-21-1. Molecular formula: C30H29N3O4.HCl. Mole weight: 532.03. |  |
| GW2580 | GW2580 is an orally bioavailable inhibitor of cFMS kinase. GW2580 was found to completely inhibit human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases. GW2580 at 1 microM completely inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibited bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. In contrast, GW2580 did not affect the growth of mouse NS0 lymphoblastoid cells, human endothelial cells, human fibroblasts, or five human tumor cell lines. GW2580 also did not affect lipopolysaccharide (LPS)-induced TNF, IL-6, and prostaglandin E2 production in freshly isolated human monocytes and mouse macrophages. After oral administration, GW2580 blocked the ability of exogenous CSF-1 to increase LPS-induced IL-6 production in mice, inhibited the growth of CSF-1-dependent M-NFS-60 tumor cells in the peritoneal cavity, and diminished the accumulation of macrophages in the peritoneal cavity after thioglycolate injection. Unexpectedly, GW2580 inhibited LPS-induced TNF production in mice, in contrast to effects on monocytes and macrophages in vitro. In conclusion, GW2580's selective inhibition of monocyte growth and bone degradation is consistent with cFMS kinase inhibition. The ability of GW2580 to chronically inhibit CSF-1 signaling through cFMS kinase in normal and tumor cells in vivo makes GW2580 a useful tool in assessing | |
| GW2580 | GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 ?M. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870483-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10917. |  |
| GW2580 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 2580 | GW 2580. Group: Biochemicals. Alternative Names: 5-[[3-Methoxy-4-[ (4-methoxyphenyl) methoxy]phenyl]methyl]-2, 4-pyrimidinediamine. Grades: Highly Purified. CAS No. 870483-87-7. Pack Sizes: 10mg. Molecular Formula: C20H22N4O3, Molecular Weight: 366.41. US Biological Life Sciences. |  Worldwide |
| GW274150 | GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 210354-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119. | |
| GW 274150 | GW 274150 is a potent, long-acting and highly selective inhibitor of iNOS which have a very high degree of selectivity for iNOS versus both eNOS (>100-fold) and nNOS (>80-fold). GW 274150 shows analgesic effects in rat models of inflammatory and neuropath. Synonyms: (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acidGW-274150; GW 274150; GW274150. CAS No. 210354-22-6. Molecular formula: C8H17N3O2S. Mole weight: 219.30. | |
| GW274150 phosphate | GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM). Grade: 98%. CAS No. 438542-15-5. Molecular formula: C8H20N3O6PS. Mole weight: 317.30. | |
| GW274150 phosphate | GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 438542-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119A. | |
| GW280264X | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 866924-39-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115670. | |
| GW280264X | GW280264X is a potent inhibitor of ADAM17 and ADAM10 inhibitor with IC50 of 8 nM and 11.5 nM, respectively. It prevents in vivo germ cell apoptosis induced by BPA or NP. Grade: >98%. CAS No. 866924-39-2. Molecular formula: C28H41N5O6S. Mole weight: 575.7. | |
| GW284543 | GW284543 (UNC10225170) is a selective MEK5 inhibitor. It can reduce pERK5 and reduce endogenous MYC protein. Synonyms: CHEMBL531447; BCP31359; MFCD32067894; HY-114189. Grade: 98%. CAS No. 790186-68-4. Molecular formula: C23H20N2O3. Mole weight: 372.4. | |
| GW 284543 hydrochloride | GW 284543 hydrochloride is a selective MEK5 inhibitor. Synonyms: UNC 10225170 hydrochloride; 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride. Grade: 99%. CAS No. 179246-08-3. Molecular formula: C23H20N2O3.HCl. Mole weight: 408.88. | |
| GW2974 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grade: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grade: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| GW-3333 | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grade: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
| GW3965 | GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay; Potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively; In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor In Vivo: At a dose of 10 mg/kg upregulates ABCA1 expression 8-fold and raises circulating levels of HDL by 30% with Cmax of 12.7 μg/mL and t1/2 of 2 hours. Uses: A liver x receptor agonist; represses the production of pro-inflammatory cytokines by murine mast cells; in vitro: reduces tissue factor production and inflammatory responses in human islets. Synonyms: GW3965; GW 3965; GW-3965; 2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride. Grade: ≥ 98.0%. CAS No. 405911-09-3. Molecular formula: C33H31ClF3NO3. Mole weight: 582.05. | |
| GW3965 hydrochloride | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW3965 hydrochloride | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A. | |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Synonyms: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grade: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. | |
| GW-405833 | GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 also behaves as a noncompetitive CB 1 antagonist. GW-405833 suppresses inflammatory and neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242. CAS No. 180002-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110036. | |
| GW405833 hydrochloride | GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB 1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242 hydrochloride. CAS No. 1202865-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110036A. | |
| GW406108X | GW406108X is a Kif15 (Kinesin-12) inhibito. GW406108X inhibits ULK1 and autophagy flux in cells. Synonyms: GW108X. CAS No. 1644443-92-4. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. | |
| GW406108X(Z/E) | GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1. CAS No. 265098-01-9. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. | |
| GW 406381 | GW 406381 is a selective cyclooxygenase-2 (COX-2) inhibitor that is effective in the treatment of inflammatory pain, neurodynia, Trauma and others. Uses: The treatment of inflammatory pain. Synonyms: GW-406381; GW 406381; GW406381. 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine. Grade: 99%. CAS No. 221148-46-5. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
| GW4064 | GW4064 is a selective non-steroidal agonist of farnesoid X receptor (FXR) with EC50 value of 15 nM. Synonyms: GW4064; GW-4064; GW 4064. Grade: >98%. CAS No. 278779-30-9. Molecular formula: C28H22Cl3NO4. Mole weight: 542.84. | |
| GW4064 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 4064 | GW 4064. Group: Biochemicals. Alternative Names: 3- [2- [2-Chloro-4- [ [3- (2, 6-dichlorophenyl) -5- (1-methylethyl) -4-isoxazolyl] methoxy] phenyl] ethenyl] -benzoic acid. Grades: Highly Purified. CAS No. 278779-30-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C28H22Cl3NO4. US Biological Life Sciences. | Worldwide |
| GW 4064 | GW 4064 is a potent FXR agonist with an EC50 of 65 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 278779-30-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50108. | |
| GW438014A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 441756 | GW 441756 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor (IC50 = 2 nM), reducing cell proliferation and potentiates the effects of chemotherapeutic agents. Uses: A specific tropomyosin-related kinase a (trka) inhibitor. Synonyms: GW-441756; GW 441756; GW441756. 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one; (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one. Grade: ≥98%. CAS No. 504433-23-2. Molecular formula: C17H13N3O. Mole weight: 275.30. | |
| GW 441756 | GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 504433-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18314. | |
| GW4869 | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC 50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19363. | |
| GW4869 | GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Synonyms: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide; dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5. | |
| GW4869 | ?90% (NMR). Group: Fluorescence/luminescence spectroscopy. | |
| GW4869 | GW4869 Inhibitor. Uses: Scientific use. Product Category: T3640. CAS No. 6823-69-4. |  |
| GW-4869 HCl | GW-4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM). GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GW4869; GW-4869; GW 4869; GW554869A; GW-554869A; GW 554869A; GW69A; GW-69A; GW 69A; GW-4869 HCl. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.51. Purity: >98%. IUPACName: (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride. Canonical SMILES: O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.[H]Cl.[H]Cl. Product ID: ACM6823694-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GW4869 trifluoroacetate | GW4869 is a non-competitive inhibitor of neutral sphingomyelinase (N-SMase) with IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release. Synonyms: GW554869 TFA; 3-[4-[3-[4-(4,5-Dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide trifluoroacetate. Grade: 97%. Molecular formula: C30H28N6O2.2C2HF3O2. Mole weight: 732.63. | |
| GW-493838 | GW-493838 is an A1 AR agonist that was evaluated in Phase II clinical trials for the treatment of pain and migraine, and was found to inhibit electrically induced nociceptionspecific blink reflex responses 113. Grade: >98.0%. CAS No. 253124-46-8. Molecular formula: C21H21ClFN7O4. Mole weight: 489.89. | |
| GW 501516 | GW 501516 (GW 1516) is a PPARδ agonist with an EC 50 of 1.1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 1516; GSK-516. CAS No. 317318-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10838. | |
| GW 501516 | An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences. | Worldwide |
| GW 501516-13C4 | GW 501516-13C4 is a labelled GW 501516. GW501516 is a potent and highly selective PPARβ/δ agonist. Synonyms: {2-Methyl-4-[4-13C-methyl-2-(4-trifluoromethylphenyl)-4,5-13C-thiazol-5-yl-13C2-methylsulfanyl]-phenoxy}-acetic acid. Grade: 95% by HPLC; 98% atom 13C. Molecular formula: C17[13C]4H18F3NO3S2. Mole weight: 457.5. | |
| GW 501516 Methyl Ester | Precursor to GW 501516. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid. Grades: Highly Purified. CAS No. 317318-69-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GW5074 | GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have therapeutic value against neurodegenerative pathologies in humans. Synonyms: GW5074; GW 5074; GW-5074. CAS No. 220904-83-6. Molecular formula: C15H8Br2INO2. Mole weight: 520.94. | |
| GW5074 | powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW 5074 | GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220904-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10542. | |
| GW542573X | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 542573X | GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2) with selectivity for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1). Synonyms: GW542573X; GW 542573X; GW-542573X. 4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester; tert-butyl 4-[(2-methoxyphenyl)carbamoyloxymethyl]piperidine-1-carboxylate. Grade: ≥99% by HPLC. CAS No. 660846-41-3. Molecular formula: C19H28N2O5. Mole weight: 364.44. | |
| GW 542573X | GW 542573X. Group: Biochemicals. Alternative Names: 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] -1-piperidinecarboxylic Acid; tert-Butyl 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] piperidine-1-carboxylate. Grades: Highly Purified. CAS No. 660846-41-3. Pack Sizes: 25mg. Molecular Formula: C19H28N2O5, Molecular Weight: 364.44. US Biological Life Sciences. | Worldwide |
| GW 583340 dihydrochloride | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 = 0.01 and 0.014 μM, respectively). GW 583340 selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 = 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). it is used in the treatment of breast cancer. Synonyms: GW 583340 dihydrochloride; GW-583340 dihydrochloride; GW583340 dihydrochloride; N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride. Grade: ≥97% by HPLC. CAS No. 1173023-85-2. Molecular formula: C28H25ClFN5O3S2.2HCl. Mole weight: 671.03. | |
| GW583340 dihydrochloride | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW 590735 | GW 590735 is a potent and selective PPARα agonist. GW 590735 can be used for the research of dyslipidemia. Synonyms: GW-590735; GW590735. CAS No. 343321-96-0. Molecular formula: C23H21F3N2O4S. Mole weight: 478.48. | |
| GW-590735 | GW-590735 is a potent and selective agonist of PPARα. Its EC50 value is 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity than PPARγ and PPARδ. It significantly increased HDL cholesterol and decreased LDL and VLDL cholesterol. It also significantly reduced triglycerides. Uses: Gw-590735 significantly increased hdl cholesterol and decreased ldl and vldl cholesterol. it also significantly reduced triglycerides. Synonyms: GW590735; GW-590735; GW 590735. 2-Methyl-2-(4-((4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid; 2-Methyl-2-[4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid. Grade: 98%. CAS No. 622402-22-6. Molecular formula: C23H21F3N2O4S. Mole weight: 478.49. | |
| GW 610 | GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. Group: Biochemicals. Alternative Names: 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole. Grades: Highly Purified. CAS No. 872726-44-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW627368 | GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963. | |
| GW 627368X | GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Synonyms: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grade: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62. | |
| GW6471 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW6471 | GW6471 is a PPARα antagonist (IC50 = 0.24 μM). GW6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Synonyms: GW-6471; GW 6471; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; N-[(2S)-2-[[(1Z)-1-Methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]propanamide; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide. Grade: ≥95%. CAS No. 880635-03-0. Molecular formula: C35H36F3N3O4. Mole weight: 619.67. | |
| GW6471 | GW6471 is a potent PPAR? antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372. | |
| GW 6471 | GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Group: Biochemicals. Alternative Names: N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propen-1-yl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide; N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propenyl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide. Grades: Highly Purified. CAS No. 880635-03-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW-6604 | GW6604 is a potent and selective ALK-5 inhibitor with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. Uses: Alk-5 inhibitor. Synonyms: GW6604; GW-6604; GW 6604; 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine. Grade: ≥98%. CAS No. 452342-37-9. Molecular formula: C19H14N4. Mole weight: 298.34. | |
| GW7647 | GW7647 is a potent PPAR? agonist, with EC50s of 6 nM, 1.1 ?M, and 6.2 ?M for human PPAR?, PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861. | |
| GW7647 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 7647 | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPARδ. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPARα. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grade: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
| GW7647 - CAS 265129-71-3 | A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPAR?. Group: Fluorescence/luminescence spectroscopy. | |
| GW779439X | GW779439X is a novel cyclin dependent kinase inhibitor. Synonyms: TCMDC-138687. Grade: >98%. CAS No. 551919-98-3. Molecular formula: C22H21F3N8. Mole weight: 454.5. | |
| GW779439X | GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of ?-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus. Uses: Scientific research. Group: Signaling pathways. CAS No. 551919-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103645. | |
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