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| Product | Description | |
|---|---|---|
| GUN35901 | GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. GUN35901 is a demethyl analogue of DUN99845 (CAT#556012). GUN35901 was first reported in patent CN 112057443. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GUN35901; GUN-35901; GUN 35901; SN-011; SN011; SN 011. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2249435-90-1. Molecular formula: C25H19FN2O4S. Mole weight: 462.5. Purity: >98%. IUPACName: N-(3-((4-fluorophenyl)sulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide. Product ID: ACM2249435901. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Gunacin | It is produced by the strain of Ustilago sp. It is a quinone antibiotic. It has strong activity against gram-positive bacteria, negative bacteria and mycoplasma. Synonyms: 2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4-dihydro-4-(acetyloxy)-3,6-dihydroxy-8-methoxy-2-methyl-. Grade: 95%. CAS No. 73341-70-5. Molecular formula: C17H16O8. Mole weight: 348.33. |  |
| Gunagratinib | Gunagratinib is a tyrosine kinase inhibitor, with antineoplastic activity. Synonyms: 3-[(3,5-dimethoxyphenyl)ethynyl]-5-(methylamino)-1-[(3S)-1-(prop-2-enoyl)pyrrolidin-3-yl]-1H-pyrazole-4-carboxamide; (S)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide. CAS No. 2211082-53-8. Molecular formula: C22H25N5O4. Mole weight: 423.47. | |
| Guretolimod | Guretolimod is an agonist of Toll-like receptor 7 (TLR7) with potential immunostimulatory and antineoplastic activities. Synonyms: Glycine, N-[[4-[[2-amino-4-[[(1S)-1-(2-hydroxyethyl)butyl]amino]-6-methyl-5-pyrimidinyl]methyl]-3-methoxyphenyl]methyl]-N-(2,2,2-trifluoroethyl)-; (S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)(2,2,2-trifluoroethyl)amino)acetic acid. Grade: ≥90%. CAS No. 1488364-57-3. Molecular formula: C24H34F3N5O4. Mole weight: 513.55. | |
| Gurjum balsam | Gurjum balsam. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Gurjum balsam;Gurjum balsam rectified. Product Category: Heterocyclic Organic Compound. CAS No. 8030-55-5. Product ID: ACM8030555. Alfa Chemistry ISO 9001:2015 Certified. Categories: Gurjun balsam. | |
| Gurjun Dark - Copaene | The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-001. Olfactive Profile: Balsamic, woody, sweet, greasy, pepper. EC No: 232-444-8. Origin: Indonesia. |  New Jersey |
| Gurjun Dark - Gurjunene | "The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%)". Uses: Fragrance. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-003. Olfactive Profile: Balsamic, woody, sweet. EC No: 232-444-8. Origin: Malaysia. | New Jersey |
| Gurjunene 85%+ | "The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents". Uses: Fragrances, Cosmetics. Group: Plant Extracts. INCI Names: Gurjunene. Grades: INDUSTRIAL GRADE. CAS No. 489-40-7. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-005. Olfactive Profile: Balsamic, woody, sweet. EC No: 207-695-1. Origin: Malaysia. | New Jersey |
| Gurjun Light - Copaene | The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance Products. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-002. Olfactive Profile: Balsamic, woody, sweet, greasy, pepper. EC No: 232-444-8. Origin: Indonesia. | New Jersey |
| Gurjun Light - Gurjunene | The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance Products. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-004. Olfactive Profile: Balsamic, woody, earthy and warm. EC No: 232-444-8. Origin: Malaysia. | New Jersey |
| Gusacitinib | Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN-002. CAS No. 1425381-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103018. |  |
| Gusacitinib hydrochloride | Gusacitinib hydrochloride is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with an IC50 value of 5-46 nM. It has anticancer activity. Synonyms: ASN002 hydrochloride; ASN 002 hydrochloride; ASN-002 hydrochloride. Grade: 98% by HPLC. CAS No. 2228989-14-6. Molecular formula: C24H29ClN8O2. Mole weight: 497.0. | |
| guselkumab | guselkumab is a selectively blocking agent for interleukin-23 (IL-23), a cytokine involved in plaque psoriasis. guselkumab was approved by FDA as an anti-inflammatory drug for the treatment of moderate to severe plaque psoriasis. Uses: Anti-inflammatory drug. Synonyms: Tremfya. CAS No. 1350289-85-8. Molecular formula: C6402H9864N1676O1994S42. Mole weight: 143.6. | |
| Guselkumab | Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with K d values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CNTO 1959. CAS No. 1350289-85-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9931. | |
| Gusperimus | Gusperimus is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Uses: Immunosuppressive agents. Synonyms: deoxyspergualin; Deoxyspergualin Hydrochloride; Gusperimus Trihydrochloride; BMS-181173; BMS181173; BMS 181173; BMY-42215-1; BMY 42215 1; NKT-01; NKT 01; NKT01. CAS No. 104317-84-2. Molecular formula: C17H37N7O3. Mole weight: 387.52. | |
| Gusperimus trihydrochloride | Gusperimus is a derivative of the anti-tumor antibiotic spergualin, which has immunosuppressive activity. Synonyms: Spanidin; NKT-01. Grade: 98%. CAS No. 85468-01-5. Molecular formula: C17H37N7O3.3HCl. Mole weight: 496.91. | |
| Gusperimus Trihydrochloride | Gusperimus Trihydrochloride is an immunosuppressive agent, which was effective both in preventing and treating graft-vs.-host disease in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 85468-01-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C17H37N7O3; 3(HCl), Molecular Weight: 387.523364599999. US Biological Life Sciences. |  Worldwide |
| Gut Microbial Metabolite Library | A unique collection of 352 gut microbial metabolites which can be used for HTS and HCS. Uses: Scientific use. Product Category: L2540. Categories: Gut Microbial Metabolite Libraries. |  |
| Gut restricted-7 | Gut restricted-7 is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice. Synonyms: GR-7. Grade: 99%. CAS No. 2553218-46-3. Molecular formula: C25H40FNaO6S. Mole weight: 495.64. | |
| Guvacine hydrochloride | Guvacine hydrochloride is an alkaloid from the nut of Areca catechu , acts as an inhibitor of GABA transporter , and dispalys modest selectivity for cloned GABA transporters with IC 50 s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Uses: Scientific research. Group: Natural products. CAS No. 6027-91-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100809. | |
| Guvacine hydrochloride | ?97% (NMR), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Guvacine Hydrochloride | A GABA uptake inhibitor. It is used for the treatment of neurodegenerative diseases. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride; 1,2,5,6-Tetrahydro-. Grades: Highly Purified. CAS No. 6027-91-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Guvacine hydrochloride >96% \ gaba uptak | Guvacine hydrochloride >96% \ gaba uptak. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Guvacine hydrochloride, 6027-91-4, 1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride, 498-96-4, 1,2,5,6-Tetrahydronicotinic acid, Guvacine HCl, AGN-PC-00IQSI, Ambcb4141599, SureCN1057880, G007_SIGMA, MLS000859975, SPECTRUM1502126, CHEMBL1256362, CTK7I6002, MolPort-003-665-602, ANW-67778, CCG-38871, AKOS015849631, AG-A-09676, AG-G-15681. Product Category: Heterocyclic Organic Compound. CAS No. 6027-91-4. Molecular formula: C6H9NO2HCl. Mole weight: 163.6. Purity: 0.96. IUPACName: 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride. Canonical SMILES: C1CNCC(=C1)C(=O)O.Cl. Product ID: ACM6027914. Alfa Chemistry ISO 9001:2015 Certified. | |
| Guvacoline hydrobromide | Guvacoline hydrobromide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GUVACINE METHYL ESTER, HYDROBROMIDE;GUVACOLINE, HYDROBROMIDE;NORARECOLINE;Norarecoline, Guvacine Methyl Ester, Hydrobromide,;1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester;1,2,3,6-tetrahydropyridine-5-carboxylic acid methyl ester;methyl 1,2,3. Product Category: Heterocyclic Organic Compound. Appearance: Crystalline Solid. CAS No. 495-19-2. Molecular formula: C7H12BrNO2. Mole weight: 222.08. Product ID: ACM495192. Alfa Chemistry ISO 9001:2015 Certified. | |
| Guvacoline hydrobromide | Guvacoline hydrobromide. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide. Grades: Highly Purified. CAS No. 17210-51-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C7H12BrNO2. US Biological Life Sciences. | Worldwide |
| Guvacoline, Hydrobromide (Norarecoline, Guvacine Methyl Ester, Hydrobromide) | A useful tool in the identification of muscarinic receptors. Group: Biochemicals. Alternative Names: Norarecoline, Guvacine Methyl Ester, Hydrobromide. Grades: Highly Purified. CAS No. 17210-51-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Guvacoline hydrochloride | Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra , can act as a weak full agonist of atrial and ileal muscarinic receptors [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 6197-39-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5016. | |
| GV-196771 | GV-196771, an indole derivative, has been found to be a non-opioid analgesic agent which is also a NMDA antagonist binds to glycine-binding site and was once studied in pain therapy. Synonyms: GV-196771; GW-196771; GV 196771; GW 196771; GV196771; GW196771; AC1OC7O7; SCHEMBL499308; 4,6-dichloro-3-[(E)-(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylic acid; GV196771A; GV 196771A; GV-196771A. Grade: 98%. CAS No. 166974-22-7. Molecular formula: C20H14Cl2N2O3. Mole weight: 401.24. | |
| GV-196771A | GV-196771A, the sodium salt form of GV196771, is an antagonist of NMDA receptor. Synonyms: Monosodium 4,6-dichloro-3-((E)-(2-oxo-1-phenyl-3-pyrrolidinylidene)methyl)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-((E)-(2-oxo-1-phenyl-3-pyrrolidinylidene)methyl)-, monosodium salt. Grade: ≥95%. CAS No. 166974-23-8. Molecular formula: C20H13Cl2N2NaO3. Mole weight: 423.22. | |
| GV-58 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GV-58 | GV-58, a pupin derivative, has been found to be a P/Q-type Ca²?-channel agonist that could be used to against neuromuscular weakness. IC50: 7.21/8.81 uM (N-type/P-Q-type Ca2+ channel). Uses: Gv-58 has been found to be a p/q-type ca²?-channel agonist that could be used to against neuromuscular weakness. Synonyms: GV-58; CS-3617; GV 58; CS 3617; GV58; CS3617; CHEMBL2206242; SCHEMBL17628602; BDBM50400564. Grade: 98%. CAS No. 1402821-41-3. Molecular formula: C18H26N6OS. Mole weight: 374.50. | |
| GVK-904 | GVK-904 is an inhibitor of Trk-A with high selectivity for wild-type cancers. GVK-904 is a non-ATP-competitive inhibitor. It can be used to treat cancers induced by Trk-A. Uses: Antitumor drug. Synonyms: GVK 904; GVK904. | |
| GW0742 | GW0742 is a potent PPARβ and PPARδ agonist, with an IC 50 of 1 nM for human PPARδ in binding assay, and EC 50 s of 1 nM, 1.1 μM and 2 μM for human PPARδ , PPARα, and PPARγ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW610742. CAS No. 317318-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13928. | |
| GW0742 | GW0742. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] acetic acid. Grades: Highly Purified. CAS No. 317318-84-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H17F4NO3S2. US Biological Life Sciences. | Worldwide |
| GW0742 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. | |
| GW0742 | GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Synonyms: GW0742; GW-0742; GW 0742; GW0742X; GW-0742X; GW 0742X; GW610742; GW-610742; GW 610742. Grade: >98%. CAS No. 317318-84-6. Molecular formula: C21H17F4NO3S2. Mole weight: 471.49. | |
| GW0742 (4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] Acetic Acid) | A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] Acetic Acid. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GW 1100 | GW 1100 is a selective G protein-coupled receptor GPR40 antagonist. GW 1100 has been shown to reverse the effects GPR40 agonists which induce glucose-stimulated insulin secretion. Group: Biochemicals. Alternative Names: 4-[5-[ (2-Ethoxy-5-pyrimidinyl) methyl]-2-[[ (4-fluorophenyl) methyl]thio]-4-oxo-1 (4H) -pyrimidinyl]benzoic Acid Ethyl Ester; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| GW-1100 | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Synonyms: GW 1100; GW-1100; GW1100. Grade: >98%. CAS No. 306974-70-9. Molecular formula: C27H25FN4O4S. Mole weight: 520.58. | |
| GW-1100 | GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. Uses: Scientific research. Group: Signaling pathways. CAS No. 306974-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-50691. | |
| GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone) | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW1929 | Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone. Group: Biochemicals. Alternative Names: N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S) - ( (2-Benzoylphenyl) amino-3- [4- [2- (methylpyridin-2-ylamino) ethoxy] phenyl] propionic acid. Grades: Highly Purified. CAS No. 196808-24-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C30H29N3O4. US Biological Life Sciences. | Worldwide |
| GW1929 | A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Synonyms: GW 1929; GW-1929. Grade: >98%. CAS No. 196808-24-9. Molecular formula: C30H29N3O4. Mole weight: 495.57. | |
| GW1929 | GW 1929 is an orally active peroxisome proliferator-activated receptor-? (PPAR?) agonist with a pKi of 8.84 for human PPAR-?, and pEC50s of 8.56 and 8.27 for human PPAR-? and murine PPAR-?, respectively. GW 1929 (hydrochloride) has antidiabetic efficacy and neuroprotective potential[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 196808-24-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15655. | |
| GW1929 - CAS 196808-24-9 | A potent, tyrosine-based peroxisome proliferator-activated receptor ? (PPAR?) agonist (EC?? = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Group: Fluorescence/luminescence spectroscopy. | |
| GW1929 hydrate | >98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW 1929 hydrochloride | GW 1929 hydrochloride is a selective and orally bioactive agonist of peroxisome proliferator-activated receptor (PPAR)γ (pEC50 = 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors, respectively). GW 1929 causes a decrease of glucose, fatty acid and triglyceride levels following oral administration in vivo. Synonyms: GW 1929 hydrochloride; GW1929 hydrochloride; GW-1929 hydrochloride; N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride; (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid hydrochloride. Grade: ≥98% by HPLC. CAS No. 1217466-21-1. Molecular formula: C30H29N3O4.HCl. Mole weight: 532.03. | |
| GW2580 | GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 ?M. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870483-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10917. | |
| GW2580 | GW2580 is an orally bioavailable inhibitor of cFMS kinase. GW2580 was found to completely inhibit human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases. GW2580 at 1 microM completely inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibited bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. In contrast, GW2580 did not affect the growth of mouse NS0 lymphoblastoid cells, human endothelial cells, human fibroblasts, or five human tumor cell lines. GW2580 also did not affect lipopolysaccharide (LPS)-induced TNF, IL-6, and prostaglandin E2 production in freshly isolated human monocytes and mouse macrophages. After oral administration, GW2580 blocked the ability of exogenous CSF-1 to increase LPS-induced IL-6 production in mice, inhibited the growth of CSF-1-dependent M-NFS-60 tumor cells in the peritoneal cavity, and diminished the accumulation of macrophages in the peritoneal cavity after thioglycolate injection. Unexpectedly, GW2580 inhibited LPS-induced TNF production in mice, in contrast to effects on monocytes and macrophages in vitro. In conclusion, GW2580's selective inhibition of monocyte growth and bone degradation is consistent with cFMS kinase inhibition. The ability of GW2580 to chronically inhibit CSF-1 signaling through cFMS kinase in normal and tumor cells in vivo makes GW2580 a useful tool in assessing | |
| GW2580 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 2580 | GW 2580. Group: Biochemicals. Alternative Names: 5-[[3-Methoxy-4-[ (4-methoxyphenyl) methoxy]phenyl]methyl]-2, 4-pyrimidinediamine. Grades: Highly Purified. CAS No. 870483-87-7. Pack Sizes: 10mg. Molecular Formula: C20H22N4O3, Molecular Weight: 366.41. US Biological Life Sciences. | Worldwide |
| GW274150 | GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 210354-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119. | |
| GW 274150 | GW 274150 is a potent, long-acting and highly selective inhibitor of iNOS which have a very high degree of selectivity for iNOS versus both eNOS (>100-fold) and nNOS (>80-fold). GW 274150 shows analgesic effects in rat models of inflammatory and neuropath. Synonyms: (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acidGW-274150; GW 274150; GW274150. CAS No. 210354-22-6. Molecular formula: C8H17N3O2S. Mole weight: 219.30. | |
| GW274150 phosphate | GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 438542-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119A. | |
| GW274150 phosphate | GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM). Grade: 98%. CAS No. 438542-15-5. Molecular formula: C8H20N3O6PS. Mole weight: 317.30. | |
| GW280264X | GW280264X is a potent inhibitor of ADAM17 and ADAM10 inhibitor with IC50 of 8 nM and 11.5 nM, respectively. It prevents in vivo germ cell apoptosis induced by BPA or NP. Grade: >98%. CAS No. 866924-39-2. Molecular formula: C28H41N5O6S. Mole weight: 575.7. | |
| GW280264X | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 866924-39-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115670. | |
| GW284543 | GW284543 (UNC10225170) is a selective MEK5 inhibitor. It can reduce pERK5 and reduce endogenous MYC protein. Synonyms: CHEMBL531447; BCP31359; MFCD32067894; HY-114189. Grade: 98%. CAS No. 790186-68-4. Molecular formula: C23H20N2O3. Mole weight: 372.4. | |
| GW 284543 hydrochloride | GW 284543 hydrochloride is a selective MEK5 inhibitor. Synonyms: UNC 10225170 hydrochloride; 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride. Grade: 99%. CAS No. 179246-08-3. Molecular formula: C23H20N2O3.HCl. Mole weight: 408.88. | |
| GW2974 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grade: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grade: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| GW-3333 | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grade: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
| GW3965 | GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay; Potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively; In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor In Vivo: At a dose of 10 mg/kg upregulates ABCA1 expression 8-fold and raises circulating levels of HDL by 30% with Cmax of 12.7 μg/mL and t1/2 of 2 hours. Uses: A liver x receptor agonist; represses the production of pro-inflammatory cytokines by murine mast cells; in vitro: reduces tissue factor production and inflammatory responses in human islets. Synonyms: GW3965; GW 3965; GW-3965; 2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride. Grade: ≥ 98.0%. CAS No. 405911-09-3. Molecular formula: C33H31ClF3NO3. Mole weight: 582.05. | |
| GW3965 hydrochloride | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW3965 hydrochloride | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A. | |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Synonyms: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grade: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. | |
| GW-405833 | GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 also behaves as a noncompetitive CB 1 antagonist. GW-405833 suppresses inflammatory and neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242. CAS No. 180002-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110036. | |
| GW405833 hydrochloride | GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB 1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242 hydrochloride. CAS No. 1202865-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110036A. | |
| GW406108X | GW406108X is a Kif15 (Kinesin-12) inhibito. GW406108X inhibits ULK1 and autophagy flux in cells. Synonyms: GW108X. CAS No. 1644443-92-4. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. | |
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