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| Product | Description | |
|---|---|---|
| GW406108X(Z/E) | GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1. CAS No. 265098-01-9. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. |  |
| GW 406381 | GW 406381 is a selective cyclooxygenase-2 (COX-2) inhibitor that is effective in the treatment of inflammatory pain, neurodynia, Trauma and others. Uses: The treatment of inflammatory pain. Synonyms: GW-406381; GW 406381; GW406381. 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine. Grade: 99%. CAS No. 221148-46-5. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
| GW4064 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| GW4064 | GW4064 is a selective non-steroidal agonist of farnesoid X receptor (FXR) with EC50 value of 15 nM. Synonyms: GW4064; GW-4064; GW 4064. Grade: >98%. CAS No. 278779-30-9. Molecular formula: C28H22Cl3NO4. Mole weight: 542.84. | |
| GW 4064 | GW 4064. Group: Biochemicals. Alternative Names: 3- [2- [2-Chloro-4- [ [3- (2, 6-dichlorophenyl) -5- (1-methylethyl) -4-isoxazolyl] methoxy] phenyl] ethenyl] -benzoic acid. Grades: Highly Purified. CAS No. 278779-30-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C28H22Cl3NO4. US Biological Life Sciences. |  Worldwide |
| GW 4064 | GW 4064 is a potent FXR agonist with an EC50 of 65 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 278779-30-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50108. |  |
| GW438014A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 441756 | GW 441756 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor (IC50 = 2 nM), reducing cell proliferation and potentiates the effects of chemotherapeutic agents. Uses: A specific tropomyosin-related kinase a (trka) inhibitor. Synonyms: GW-441756; GW 441756; GW441756. 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one; (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one. Grade: ≥98%. CAS No. 504433-23-2. Molecular formula: C17H13N3O. Mole weight: 275.30. | |
| GW 441756 | GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 504433-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18314. | |
| GW4869 | ?90% (NMR). Group: Fluorescence/luminescence spectroscopy. | |
| GW4869 | GW4869 Inhibitor. Uses: Scientific use. Product Category: T3640. CAS No. 6823-69-4. |  |
| GW4869 | GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Synonyms: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide; dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5. | |
| GW4869 | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC 50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19363. | |
| GW-4869 HCl | GW-4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM). GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GW4869; GW-4869; GW 4869; GW554869A; GW-554869A; GW 554869A; GW69A; GW-69A; GW 69A; GW-4869 HCl. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.51. Purity: >98%. IUPACName: (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride. Canonical SMILES: O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.[H]Cl.[H]Cl. Product ID: ACM6823694-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GW4869 trifluoroacetate | GW4869 is a non-competitive inhibitor of neutral sphingomyelinase (N-SMase) with IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release. Synonyms: GW554869 TFA; 3-[4-[3-[4-(4,5-Dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide trifluoroacetate. Grade: 97%. Molecular formula: C30H28N6O2.2C2HF3O2. Mole weight: 732.63. | |
| GW-493838 | GW-493838 is an A1 AR agonist that was evaluated in Phase II clinical trials for the treatment of pain and migraine, and was found to inhibit electrically induced nociceptionspecific blink reflex responses 113. Grade: >98.0%. CAS No. 253124-46-8. Molecular formula: C21H21ClFN7O4. Mole weight: 489.89. | |
| GW 501516 | An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences. | Worldwide |
| GW 501516 | GW 501516 (GW 1516) is a PPARδ agonist with an EC 50 of 1.1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 1516; GSK-516. CAS No. 317318-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10838. | |
| GW 501516-13C4 | GW 501516-13C4 is a labelled GW 501516. GW501516 is a potent and highly selective PPARβ/δ agonist. Synonyms: {2-Methyl-4-[4-13C-methyl-2-(4-trifluoromethylphenyl)-4,5-13C-thiazol-5-yl-13C2-methylsulfanyl]-phenoxy}-acetic acid. Grade: 95% by HPLC; 98% atom 13C. Molecular formula: C17[13C]4H18F3NO3S2. Mole weight: 457.5. | |
| GW 501516 Methyl Ester | Precursor to GW 501516. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid. Grades: Highly Purified. CAS No. 317318-69-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GW5074 | powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW5074 | GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have therapeutic value against neurodegenerative pathologies in humans. Synonyms: GW5074; GW 5074; GW-5074. CAS No. 220904-83-6. Molecular formula: C15H8Br2INO2. Mole weight: 520.94. | |
| GW 5074 | GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220904-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10542. | |
| GW542573X | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 542573X | GW 542573X. Group: Biochemicals. Alternative Names: 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] -1-piperidinecarboxylic Acid; tert-Butyl 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] piperidine-1-carboxylate. Grades: Highly Purified. CAS No. 660846-41-3. Pack Sizes: 25mg. Molecular Formula: C19H28N2O5, Molecular Weight: 364.44. US Biological Life Sciences. | Worldwide |
| GW 542573X | GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2) with selectivity for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1). Synonyms: GW542573X; GW 542573X; GW-542573X. 4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester; tert-butyl 4-[(2-methoxyphenyl)carbamoyloxymethyl]piperidine-1-carboxylate. Grade: ≥99% by HPLC. CAS No. 660846-41-3. Molecular formula: C19H28N2O5. Mole weight: 364.44. | |
| GW 583340 dihydrochloride | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 = 0.01 and 0.014 μM, respectively). GW 583340 selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 = 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). it is used in the treatment of breast cancer. Synonyms: GW 583340 dihydrochloride; GW-583340 dihydrochloride; GW583340 dihydrochloride; N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride. Grade: ≥97% by HPLC. CAS No. 1173023-85-2. Molecular formula: C28H25ClFN5O3S2.2HCl. Mole weight: 671.03. | |
| GW583340 dihydrochloride | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW 590735 | GW 590735 is a potent and selective PPARα agonist. GW 590735 can be used for the research of dyslipidemia. Synonyms: GW-590735; GW590735. CAS No. 343321-96-0. Molecular formula: C23H21F3N2O4S. Mole weight: 478.48. | |
| GW-590735 | GW-590735 is a potent and selective agonist of PPARα. Its EC50 value is 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity than PPARγ and PPARδ. It significantly increased HDL cholesterol and decreased LDL and VLDL cholesterol. It also significantly reduced triglycerides. Uses: Gw-590735 significantly increased hdl cholesterol and decreased ldl and vldl cholesterol. it also significantly reduced triglycerides. Synonyms: GW590735; GW-590735; GW 590735. 2-Methyl-2-(4-((4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid; 2-Methyl-2-[4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid. Grade: 98%. CAS No. 622402-22-6. Molecular formula: C23H21F3N2O4S. Mole weight: 478.49. | |
| GW 610 | GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. Group: Biochemicals. Alternative Names: 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole. Grades: Highly Purified. CAS No. 872726-44-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW627368 | GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963. | |
| GW 627368X | GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Synonyms: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grade: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62. | |
| GW6471 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW6471 | GW6471 is a potent PPAR? antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372. | |
| GW6471 | GW6471 is a PPARα antagonist (IC50 = 0.24 μM). GW6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Synonyms: GW-6471; GW 6471; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; N-[(2S)-2-[[(1Z)-1-Methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]propanamide; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide. Grade: ≥95%. CAS No. 880635-03-0. Molecular formula: C35H36F3N3O4. Mole weight: 619.67. | |
| GW 6471 | GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Group: Biochemicals. Alternative Names: N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propen-1-yl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide; N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propenyl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide. Grades: Highly Purified. CAS No. 880635-03-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW-6604 | GW6604 is a potent and selective ALK-5 inhibitor with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. Uses: Alk-5 inhibitor. Synonyms: GW6604; GW-6604; GW 6604; 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine. Grade: ≥98%. CAS No. 452342-37-9. Molecular formula: C19H14N4. Mole weight: 298.34. | |
| GW7647 | GW7647 is a potent PPAR? agonist, with EC50s of 6 nM, 1.1 ?M, and 6.2 ?M for human PPAR?, PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861. | |
| GW7647 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 7647 | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPARδ. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPARα. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grade: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
| GW7647 - CAS 265129-71-3 | A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPAR?. Group: Fluorescence/luminescence spectroscopy. | |
| GW779439X | GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of ?-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus. Uses: Scientific research. Group: Signaling pathways. CAS No. 551919-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103645. | |
| GW779439X | GW779439X is a novel cyclin dependent kinase inhibitor. Synonyms: TCMDC-138687. Grade: >98%. CAS No. 551919-98-3. Molecular formula: C22H21F3N8. Mole weight: 454.5. | |
| GW788388 | GW788388 is a selective inhibitor of TGF-beta type I receptor (TGF-βR1/ALK5; IC50=18 nM) with a much improved pharmacokinetic profile compared with SB431542. It inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Synonyms: GW-788388; N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide. Grade: >98%. CAS No. 452342-67-5. Molecular formula: C25H23N5O2. Mole weight: 425.492. | |
| GW788388 | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-? type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 452342-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10326. | |
| GW 788388 | GW 788388. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide. Grades: Highly Purified. CAS No. 452342-67-5. Pack Sizes: 10mg. Molecular Formula: C25H23N5O2, Molecular Weight: 425.48. US Biological Life Sciences. | Worldwide |
| GW 788388-d5 | GW 788388-d5. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H18D5N5O2, Molecular Weight: 430.51. US Biological Life Sciences. | Worldwide |
| GW788388 Hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW791343 | GW791343, as a P2X7 receptor antagonist, was a negative allosteric modulator of the human P2X(7) receptor but at the rat P2X(7) receptor its predominant effect was positive allosteric modulation. Uses: P2x7 receptor antagonist. Synonyms: GW-791343; GW791343. Grade: ≥98%. CAS No. 309712-73-0. Molecular formula: C20H24F2N4O. Mole weight: 374.4. | |
| GW 791343 dihydrochloride | The hydrochlorie salt form of GW791343 that is a non-competitive inhibitor of human P2X7 receptors amd it seems to show species-specific activity which is probably negative allosteric modulators of the human P2X7 receptor and the agonist of the same recep. Uses: The hydrochlorie salt form of gw791343 that is a non-competitive inhibitor of human p2x7 receptors. Synonyms: GW791343 (dihydrochloride); 1019779-04-4; 2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride; GW 791343; GW-791343; 3075AH. Grade: >99 %. CAS No. 1019779-04-4. Molecular formula: C20H26Cl2F2N4O. Mole weight: 447.3. | |
| GW791343 dihydrochloride | GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC 50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1019779-04-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15469. | |
| GW 791343 hydrochloride | GW 791343 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 309712-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GW 791343 trihydrochloride | GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. Synonyms: GW791343; GW 791343; GW-791343; 1019779-04-4. Grade: >98%. CAS No. 309712-55-8. Molecular formula: C20H24F2N4O.3HCl. Mole weight: 483.81. | |
| GW 791343 Trihydrochloride | GW 791343 Trihydrochloride. Group: Biochemicals. Alternative Names: 2-[ (3, 4-Difluorophenyl) amino]-N-[2-methyl-5- (1-piperazinylmethyl) phenyl]acetamide Trihydrochloride. Grades: Highly Purified. CAS No. 1019779-04-4. Pack Sizes: 10mg. Molecular Formula: C20H27Cl3F2N4O, Molecular Weight: 447.35. US Biological Life Sciences. | Worldwide |
| GW 803430 | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grade: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
| GW805758X | GW805758X is a potent CDK-4 inhibitor. Synonyms: pyrazolo[1,5-b]pyridazine deriv. 22. Grade: >98%. Molecular formula: C19H18N6. Mole weight: 330.4. | |
| GW806742X | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW806742X | GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 ?M. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 579515-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112292. | |
| GW806742X hydrochloride | GW806742X hydrochloride is an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor. It binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 with an IC50 of 2 nM. GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis. Grade: 98%. Molecular formula: C25H23ClF3N7O4S. Mole weight: 610.01. | |
| GW833972A | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW 833972A | GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092502-33-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101765. | |
| GW841819X | GW841819X, a benzodiazepin derivative, has been found to be a BET bromodomains inhibitor that could be probably significant in the study of myeloma and leukemia at some extent. Synonyms: KB-75882; KB 75882; KB75882; benzyl (1-methyl-6-phenyl-4hbenzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate. Grade: 98%. CAS No. 146135-18-4. Molecular formula: C25H21N5O2. Mole weight: 423.48. | |
| GW843682X | GW843682X is a cell-permeable thiophene-benzimidazole compound that acts a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM(PLK1) and 9.1 nM(PLK3). Uses: A polo-like kinase-1 (plk1) and polo-like kinase-3 (plk3) inhibitor. Synonyms: GW843682X; GW 843682X; GW-843682X. 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide; Polo-like Kinase Inhibitor III. Grade: ≥98%. CAS No. 660868-91-7. Molecular formula: C22H18F3N3O4S. Mole weight: 477.46. | |
| GW843682X | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW843682X | GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ?30 other kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW843682. CAS No. 660868-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-11003. | |
| GW 848687X | GW 848687X is a potent and selective antagonist of EP1 receptor (IC50 = 2.5 nM). GW 848687X displays >400-fold selectivity for EP1 relative to the other EP receptor subtypes, the PGD2 receptor, DP1, and the prostacyclin receptor, IP. Synonyms: 6-[2-[5-chloro-2-[(2,4-digluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid. Grade: ≥98%. CAS No. 612831-24-0. Molecular formula: C24H18ClF2NO3. Mole weight: 441.9. | |
| GW-870086 | GW-870086 is a glucocorticoid receptor agonist with a pIC50 of 10.1 in A549 cells expressing NF-κB. It can be used as an anti-inflammatory agent. Synonyms: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X. CAS No. 827319-43-7. Molecular formula: C31H39F2NO6. Mole weight: 559.651. | |
| GW9508 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, and stimulates insulin secretion in a glucose-sensitive manner. GW9508 is commonly used in the treatment of type 2 diabetes. Synonyms: GW9508; GW-9508; GW 9508; 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid. Grade: > 98%. CAS No. 885101-89-3. Molecular formula: C22H21NO3. Mole weight: 347.414. | |
| GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 885101-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15589. | |
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