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| Product | Description | |
|---|---|---|
| GW583340 dihydrochloride | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| GW 590735 | GW 590735 is a potent and selective PPARα agonist. GW 590735 can be used for the research of dyslipidemia. Synonyms: GW-590735; GW590735. CAS No. 343321-96-0. Molecular formula: C23H21F3N2O4S. Mole weight: 478.48. |  |
| GW-590735 | GW-590735 is a potent and selective agonist of PPARα. Its EC50 value is 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity than PPARγ and PPARδ. It significantly increased HDL cholesterol and decreased LDL and VLDL cholesterol. It also significantly reduced triglycerides. Uses: Gw-590735 significantly increased hdl cholesterol and decreased ldl and vldl cholesterol. it also significantly reduced triglycerides. Synonyms: GW590735; GW-590735; GW 590735. 2-Methyl-2-(4-((4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid; 2-Methyl-2-[4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid. Grade: 98%. CAS No. 622402-22-6. Molecular formula: C23H21F3N2O4S. Mole weight: 478.49. | |
| GW 610 | GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. Group: Biochemicals. Alternative Names: 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole. Grades: Highly Purified. CAS No. 872726-44-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| GW627368 | GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963. |  |
| GW 627368X | GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Synonyms: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grade: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62. | |
| GW6471 | GW6471 is a potent PPAR? antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372. | |
| GW6471 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW6471 | GW6471 is a PPARα antagonist (IC50 = 0.24 μM). GW6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Synonyms: GW-6471; GW 6471; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; N-[(2S)-2-[[(1Z)-1-Methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]propanamide; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide. Grade: ≥95%. CAS No. 880635-03-0. Molecular formula: C35H36F3N3O4. Mole weight: 619.67. | |
| GW 6471 | GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Group: Biochemicals. Alternative Names: N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propen-1-yl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide; N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propenyl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide. Grades: Highly Purified. CAS No. 880635-03-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW-6604 | GW6604 is a potent and selective ALK-5 inhibitor with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. Uses: Alk-5 inhibitor. Synonyms: GW6604; GW-6604; GW 6604; 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine. Grade: ≥98%. CAS No. 452342-37-9. Molecular formula: C19H14N4. Mole weight: 298.34. | |
| GW7647 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW7647 | GW7647 is a potent PPAR? agonist, with EC50s of 6 nM, 1.1 ?M, and 6.2 ?M for human PPAR?, PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861. | |
| GW 7647 | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPARδ. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPARα. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grade: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
| GW7647 - CAS 265129-71-3 | A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPAR?. Group: Fluorescence/luminescence spectroscopy. | |
| GW779439X | GW779439X is a novel cyclin dependent kinase inhibitor. Synonyms: TCMDC-138687. Grade: >98%. CAS No. 551919-98-3. Molecular formula: C22H21F3N8. Mole weight: 454.5. | |
| GW779439X | GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of ?-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus. Uses: Scientific research. Group: Signaling pathways. CAS No. 551919-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103645. | |
| GW788388 | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-? type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 452342-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10326. | |
| GW788388 | GW788388 is a selective inhibitor of TGF-beta type I receptor (TGF-βR1/ALK5; IC50=18 nM) with a much improved pharmacokinetic profile compared with SB431542. It inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Synonyms: GW-788388; N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide. Grade: >98%. CAS No. 452342-67-5. Molecular formula: C25H23N5O2. Mole weight: 425.492. | |
| GW 788388 | GW 788388. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide. Grades: Highly Purified. CAS No. 452342-67-5. Pack Sizes: 10mg. Molecular Formula: C25H23N5O2, Molecular Weight: 425.48. US Biological Life Sciences. | Worldwide |
| GW 788388-d5 | GW 788388-d5. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H18D5N5O2, Molecular Weight: 430.51. US Biological Life Sciences. | Worldwide |
| GW788388 Hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW791343 | GW791343, as a P2X7 receptor antagonist, was a negative allosteric modulator of the human P2X(7) receptor but at the rat P2X(7) receptor its predominant effect was positive allosteric modulation. Uses: P2x7 receptor antagonist. Synonyms: GW-791343; GW791343. Grade: ≥98%. CAS No. 309712-73-0. Molecular formula: C20H24F2N4O. Mole weight: 374.4. | |
| GW 791343 dihydrochloride | The hydrochlorie salt form of GW791343 that is a non-competitive inhibitor of human P2X7 receptors amd it seems to show species-specific activity which is probably negative allosteric modulators of the human P2X7 receptor and the agonist of the same recep. Uses: The hydrochlorie salt form of gw791343 that is a non-competitive inhibitor of human p2x7 receptors. Synonyms: GW791343 (dihydrochloride); 1019779-04-4; 2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride; GW 791343; GW-791343; 3075AH. Grade: >99 %. CAS No. 1019779-04-4. Molecular formula: C20H26Cl2F2N4O. Mole weight: 447.3. | |
| GW791343 dihydrochloride | GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC 50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1019779-04-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15469. | |
| GW 791343 hydrochloride | GW 791343 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 309712-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GW 791343 trihydrochloride | GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. Synonyms: GW791343; GW 791343; GW-791343; 1019779-04-4. Grade: >98%. CAS No. 309712-55-8. Molecular formula: C20H24F2N4O.3HCl. Mole weight: 483.81. | |
| GW 791343 Trihydrochloride | GW 791343 Trihydrochloride. Group: Biochemicals. Alternative Names: 2-[ (3, 4-Difluorophenyl) amino]-N-[2-methyl-5- (1-piperazinylmethyl) phenyl]acetamide Trihydrochloride. Grades: Highly Purified. CAS No. 1019779-04-4. Pack Sizes: 10mg. Molecular Formula: C20H27Cl3F2N4O, Molecular Weight: 447.35. US Biological Life Sciences. | Worldwide |
| GW 803430 | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grade: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
| GW805758X | GW805758X is a potent CDK-4 inhibitor. Synonyms: pyrazolo[1,5-b]pyridazine deriv. 22. Grade: >98%. Molecular formula: C19H18N6. Mole weight: 330.4. | |
| GW806742X | GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 ?M. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 579515-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112292. | |
| GW806742X | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW806742X hydrochloride | GW806742X hydrochloride is an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor. It binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 with an IC50 of 2 nM. GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis. Grade: 98%. Molecular formula: C25H23ClF3N7O4S. Mole weight: 610.01. | |
| GW833972A | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| GW 833972A | GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092502-33-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101765. | |
| GW841819X | GW841819X, a benzodiazepin derivative, has been found to be a BET bromodomains inhibitor that could be probably significant in the study of myeloma and leukemia at some extent. Synonyms: KB-75882; KB 75882; KB75882; benzyl (1-methyl-6-phenyl-4hbenzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate. Grade: 98%. CAS No. 146135-18-4. Molecular formula: C25H21N5O2. Mole weight: 423.48. | |
| GW843682X | GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ?30 other kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW843682. CAS No. 660868-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-11003. | |
| GW843682X | GW843682X is a cell-permeable thiophene-benzimidazole compound that acts a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM(PLK1) and 9.1 nM(PLK3). Uses: A polo-like kinase-1 (plk1) and polo-like kinase-3 (plk3) inhibitor. Synonyms: GW843682X; GW 843682X; GW-843682X. 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide; Polo-like Kinase Inhibitor III. Grade: ≥98%. CAS No. 660868-91-7. Molecular formula: C22H18F3N3O4S. Mole weight: 477.46. | |
| GW843682X | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| GW 848687X | GW 848687X is a potent and selective antagonist of EP1 receptor (IC50 = 2.5 nM). GW 848687X displays >400-fold selectivity for EP1 relative to the other EP receptor subtypes, the PGD2 receptor, DP1, and the prostacyclin receptor, IP. Synonyms: 6-[2-[5-chloro-2-[(2,4-digluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid. Grade: ≥98%. CAS No. 612831-24-0. Molecular formula: C24H18ClF2NO3. Mole weight: 441.9. | |
| GW-870086 | GW-870086 is a glucocorticoid receptor agonist with a pIC50 of 10.1 in A549 cells expressing NF-κB. It can be used as an anti-inflammatory agent. Synonyms: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X. CAS No. 827319-43-7. Molecular formula: C31H39F2NO6. Mole weight: 559.651. | |
| GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 885101-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15589. | |
| GW9508 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, and stimulates insulin secretion in a glucose-sensitive manner. GW9508 is commonly used in the treatment of type 2 diabetes. Synonyms: GW9508; GW-9508; GW 9508; 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid. Grade: > 98%. CAS No. 885101-89-3. Molecular formula: C22H21NO3. Mole weight: 347.414. | |
| GW9508 | GW9508. Group: Biochemicals. Alternative Names: 4- [ [ (3-Phenoxyphenyl) methyl] amino] benzenepropanoic Acid. Grades: Highly Purified. CAS No. 885101-89-3. Pack Sizes: 5mg. Molecular Formula: C22H21NO3, Molecular Weight: 347.41. US Biological Life Sciences. | Worldwide |
| GW9508 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 9578 | GW 9578 is a potent agonist of PPARα, which is highly selective for PPARα compared to PPARγ and PPARδ. Synonyms: 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl-propanoic acid. Grade: ≥98%. CAS No. 247923-29-1. Molecular formula: C26H34F2N2O3S. Mole weight: 492.6. | |
| GW9662 | GW9662 is a potent and selective PPAR? antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 22978-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16578. | |
| GW9662 | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GW 9662 | GW 9662. Group: Biochemicals. Grades: Purified. CAS No. 22978-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GW 9662 (2-Chloro-5-nitrobenzanilide) | A potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by > 90% at a dose of 0.1uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 22978-25-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GW-9820 | GW-9820 is a PPAR-gamma agonist with potential antidiabetic effect. Synonyms: 2-[4-[2-[(4-fluorophenyl)carbamoyl-heptylamino]ethyl]phenoxy]-2-methylpropanoic acid; GW-9820; GW 9820; GW9820. Grade: >98%. CAS No. 195131-60-3. Molecular formula: C26H35FN2O4. Mole weight: 458.57. | |
| GX15-070, BCl-2 Inhibitor ((Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole Methanesulfonate) | Cell-permeable. A small molecule pan-Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2-, Bcl-xl-, Bcl-w-, and Mcl-1-mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 803712-79-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GX-674 | GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly expressed in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. GX-674 has the potential to alleviate extreme pains. Synonyms: GX-674; GX674; GX 674; 4-(2-(2-Amino-1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide. CAS No. 1432913-36-4. Molecular formula: C21H13ClF2N6O3S2. Mole weight: 534.94. | |
| GXpep-3 | GXpep-3 is a novel polypeptide inhibitor of phospholipid hydroperoxidase glutathione peroxidase (GPX4). Currently GPX4 is found to be a target which selectively induces iron-dependent cell death (ferroptosis) in cancer cells that express mutant Ras. GXpep-3 is promisingly developed to be a antitumor drug. Uses: Antitumor. Synonyms: GXpep 3; GXpep3. | |
| Gyki 13324 | GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. It can produce long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, seems to be a candidate in the clinical management of colorectal tumors. Uses: Colorectal tumor. Synonyms: GYKI-13324; GYKI 13324; GYKI13324. N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea. Grade: 98%. CAS No. 76123-41-6. Molecular formula: C10H18Cl2N6O6. Mole weight: 389.19. | |
| GYKI-13380 | GYKI-13380is a bio-active compound. But no detailed information has been published ye. Synonyms: GYKI-13380; GYKI 13380; GYKI13380; LS-79445; LS 79445; LS79445. 4-((3-(Cyclopentyloxy)-4-methoxyphenyl)methyl)-2-imidazolidinone. Grade: 98%. CAS No. 75614-09-4. Molecular formula: C16H22N2O3. Mole weight: 290.36. | |
| GYKI 14166 | Efegatran is a thrombin inhibitor under the development of Eli Lilly. It can be used for the treatment of thromboembolic disorders. No development reported was reported for the treatment of Thrombosis. Uses: Thrombosis. Synonyms: Efegatran; RGH 2958; LY 294468; GYKI 14166; RGH2958; LY294468; GYKI14166; RGH-2958; LY-294468; GYKI-14166; (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide sulfate. Grade: 98%. CAS No. 83997-16-4. Molecular formula: C20H30N6O3.H2O4S. Mole weight: 500.57. | |
| GYKI14451 | GYKI14451 is a synthetic tripeptide inhibitor of thrombin. It has anti-atherosclerotic activity. Uses: Gyki14451 has anti-atherosclerotic activity. Synonyms: GYKI-14451; GYKI14451; LY-178207; GYKI 14451; LY 178207; LY178207; Boc-D-Phe-Pro-Arg-H; Tert-butyl ((R)-1-((S)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate. Grade: 98%. CAS No. 69201-89-4. Molecular formula: C25H38N6O5. Mole weight: 502.61. | |
| GYKI-14451 sulfate | GYKI-14451 is a synthetic tripeptide inhibitor of thrombin.It has anti-atherosclerotic activity. Uses: Thrombosis. Synonyms: GYKI-14451 sulfate; GYKI 14451 sulfate; GYKI14451 sulfate; tert-butyl ((R)-1-((S)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate hemisulfate; LY 178207; LY178207; LY-178207; Boc-D-Phe-Pro-Arg-H; 69201-89-4 (free base). Grade: 98%. CAS No. 83861-29-4. Molecular formula: C50H76N12O10.H2O4S. Mole weight: 1103.30. | |
| GYKI-16084 | GYKI-16084 is a postsynaptic alpha2-blocker with the potential to treat benign prostatic hyperplasia. Synonyms: 2-[3-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methylamino]propyl]pyridazin-3-one; GYKI16084; GYKI 16084; GYKI-16084R-2-(3-N-(2-benzo(1,4)dioxanylmethyl)-amino-1-propyl)-3(2H)-pyridazinone hydrochloride. Grade: >98%. CAS No. 185739-21-3. Molecular formula: C16H19N3O3. Mole weight: 301.346. | |
| GYKI-16638 | GYKI-16638 is Potassium channel and Sodium channel antagonist originated by Nonindustrial source. It is a novel antiarrhythmic agent. Uses: Arrhythmias. Synonyms: GYKI-16638; GYKI 16638; GYKI16638; N-(4-(2-((1-(2,6-dimethoxyphenoxy)propan-2-yl)(methyl)amino)ethyl)phenyl)methanesulfonamide. Grade: 98%. CAS No. 778564-77-5. Molecular formula: C21H30N2O5S. Mole weight: 422.54. | |
| GYKI-16638 HCl | GYKI-16638 is a novel antiarrhythmic agent, shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation seen after chronic amiodarone treatment. Uses: A novel antiarrhythmic agent. Synonyms: GYKI-16638 HCl; GYKI 16638 HCl; GYKI16638 HCl; N-[4-[2-[1-(2,6-dimethoxyphenoxy)propan-2-yl-methylamino]ethyl]phenyl]methanesulfonamide; hydrochloride. Grade: ≥98%. CAS No. 307556-59-8. Molecular formula: C21H31ClN2O5S. Mole weight: 458.998. | |
| GYKI-20238 | GYKI-20238 is a thiazolidine compound with anti-amnesic activity. Uses: Anti-amnesic. Synonyms: GYKI-20238; GYKI20238; GYKI 20238; GYKI-20,238; GYKI20,238; GYKI 20,238. 2-Methylimino-3-(2,6-dichlorophenyl)-4-methylthiazolidine. Grade: ≥96%. CAS No. 30725-74-7. Molecular formula: C11H12Cl2N2S. Mole weight: 274.01. | |
| GYKI-23107 | GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. Uses: Antiarrhythmic agent. Synonyms: N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine; GYKI-23107; GYKI 23107; GYKI23107. Grade: 98%. CAS No. 83843-49-6. Molecular formula: C13H22N2. Mole weight: 206.33. | |
| GYKI-23107 dihydrochloride | GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. Uses: Antiarrhythmic agent. Synonyms: GYKI-23107 dihydrochloride; GYKI 23107 dihydrochloride; GYKI23107 dihydrochloride; 83843-49-6 (free base); N1-(2,6-dimethylphenyl)-N2,N2-dimethylpropane-1,2-diamine dihydrochloride. Grade: 98%. CAS No. 83843-39-4. Molecular formula: C13H24Cl2N2. Mole weight: 279.25. | |
| GYKI-46903 HCl | GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. No development was reported for the treatment of Cognition disorders, Nausea and vomiting. Uses: Cognition disorders; nausea and vomiting. Synonyms: GYKI-46903; GYKI 46903; GYKI46903; GYKI-46,903; GYKI 46,903; GYKI46,903; (4R,5R)-6-(4-fluorophenyl)-1-azabicyclo[3.3.1]non-6-en-4-yl propionate hydrochloride. Grade: 98%. CAS No. 142999-59-5. Molecular formula: C17H21ClFNO2. Mole weight: 325.81. | |
| GYKI-47261 | GYKI-47261 is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM) and a CYP2E1 inducer. GYKI-47261 shows broad spectrum anticonvulsive activity and neuroprotective effects in vivo. Synonyms: 4-(8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline; GYKI 47261; GYKI47261; GYKI-47261. Grade: >99 %. CAS No. 220445-20-5. Molecular formula: C18H15ClN4. Mole weight: 322.796. | |
| GYKI 47261 dihydrochloride | This active molecular is Non-competitiv a AMPA antagonist with IC50 value of 2.5 μM. GYKI-47261 is also a CYP2E1 inducer. GYKI-47261 showed broad spectrum of anticonvulsive and really good neuroprotective effect in vivo. AMPA and NMDA receptors have been implicated in the regulation of corticostriatal synaptic efficacy which abundantly expressed on striatal medium spiny neurons. In 2000, preclinical development for Epilepsy in Hungar was on-going, but no development was reported yet. Uses: Epilepsy; parkinson's disease; stroke. Synonyms: GYKI 47261 dihydrochloride; GYKI47261 dihydrochloride; GYKI-47261 dihydrochloride; 4-(8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline; dihydrochloride; 220445-20-5 (free base). Grade: 98%. CAS No. 1217049-32-5. Molecular formula: C18H17Cl3N4. Mole weight: 395.71. | |
| GYKI 47261 dihydrochloride | GYKI 47261 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1217049-32-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GYKI-52466 | GYKI-52466 is a non-competitive AMPA receptor antagonist. It belongs to 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist. It has anticonvulsant and neuroprotective properties. It is an orally-active anticonvulsant and skeletal muscle relaxant. It also was found to have therapeutic potential for cocaine addiction treatment. Uses: Gyki-52466 is an orally-active anticonvulsant and skeletal muscle relaxant. it also was found to have therapeutic potential for cocaine addiction treatment. Synonyms: 4-(8-Methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline; GYKI-52466; GYKI52466; GYKI 52466; GYKI-5,2466; GYKI52,466; GYKI 52,466. Grade: >99 %. CAS No. 102771-26-6. Molecular formula: C17H15N3O2. Mole weight: 293.33. | |
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