A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group. Group: Enzymes. Synonyms: L-histidine decarboxylase; L-histidine carboxy-lyase. Enzyme Commission Number: EC 4.1.1.22. CAS No. 9024-61-7. HDC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4767; histidine decarboxylase; EC 4.1.1.22; 9024-61-7; L-histidine decarboxylase; L-histidine carboxy-lyase. Cat No: EXWM-4767.
histidine kinase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor. Group: Enzymes. Synonyms: EnvZ;histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK1; HP165; Sln1p. Enzyme Commission Number: EC 2.7.13.3. CAS No. 420839-67-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3165; histidine kinase; EC 2.7.13.3; 420839-67-4; EnvZ;histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK1; HP165; Sln1p. Cat No: EXWM-3165.
Histidine,l-,[carboxyl-14c]
Heterocyclic Organic Compound. Alternative Names: HISTIDINE, L-, [CARBOXYL-14C]. CAS No. 10413-69-1. Molecular formula: C6H9N3O2. Mole weight: 157.17. Catalog: ACM10413691.
histidine N-acetyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. Group: Enzymes. Synonyms: acetylhistidine synthetase; histidine acetyltransferase. Enzyme Commission Number: EC 2.3.1.33. CAS No. 9027-59-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2211; histidine N-acetyltransferase; EC 2.3.1.33; 9027-59-2; acetylhistidine synthetase; histidine acetyltransferase. Cat No: EXWM-2211.
histidine transaminase
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidine:2-oxoglutarate aminotransferase. Other names in common use include histidine aminotransferase, and histidine-2-oxoglutarate aminotransferase. This enzyme participates in histidine metabolism. Group: Enzymes. Synonyms: histidine aminotransferase; histidine-2-oxoglutarate aminotransferase. Enzyme Commission Number: EC 2.6.1.38. CAS No. 37277-92-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2878; histidine transaminase; EC 2.6.1.38; 37277-92-2; histidine aminotransferase; histidine-2-oxoglutarate aminotransferase. Cat No: EXWM-2878.
histidine-tRNA ligase
This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis. Group: Enzymes. Synonyms: histidyl-tRNA synthetase; histidyl-transfer ribonucleate synthetase; histidine translase. Enzyme Commission Number: EC 6.1.1.21. CAS No. 9068-78-4. HRS. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5653; histidine-tRNA ligase; EC 6.1.1.21; 9068-78-4; histidyl-tRNA synthetase; histidyl-transfer ribonucleate synthetase; histidine translase. Cat No: EXWM-5653.
histidinol dehydrogenase
Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). Group: Enzymes. Synonyms: L-histidinol dehydrogenase. Enzyme Commission Number: EC 1.1.1.23. CAS No. 9028-27-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0136; histidinol dehydrogenase; EC 1.1.1.23; 9028-27-7; L-histidinol dehydrogenase. Cat No: EXWM-0136.
histidinol-phosphatase
This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase. This enzyme participates in histidine metabolism. Group: Enzymes. Synonyms: histidinol phosphate phosphatase; L-histidinol phosphate phosphatase; histidinolphosphate phosphatase; HPpase; histidinolphosphatase. Enzyme Commission Number: EC 3.1.3.15. CAS No. 9025-79-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3617; histidinol-phosphatase; EC 3.1.3.15; 9025-79-0; histidinol phosphate phosphatase; L-histidinol phosphate phosphatase; histidinolphosphate phosphatase; HPpase; histidinolphosphatase. Cat No: EXWM-3617.
histidinol-phosphate transaminase
A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: imidazolylacetolphosphate transaminase; glutamic-imidazoleacetol phosphate transaminase; histidinol phosphate aminotransferase; imidazoleacetol phosphate transaminase; L-histidinol phosphate aminotransferase; histidine:imidazoleacetol phosphate transaminase; IAP transaminase; imidazolylacetolphosphate aminotransferase. Enzyme Commission Number: EC 2.6.1.9. CAS No. 9032-98-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2931; histidinol-phosphate transaminase; EC 2.6.1.9; 9032-98-8; imidazolylacetolphosphate transaminase; glutamic-imidazoleacetol phosphate transaminase; histidinol phosphate aminotransferase; imidazoleacetol phosphate transaminase; L-histidinol phosphate aminotransferase; histidine:imidazoleacetol phosphate transaminase; IAP transaminase; imidazolylacetolphosphate aminotransferase. Cat No: EXWM-2931.
Histidyl-asparagine
Histidyl-asparagine is a dipeptide composed of histidine and asparagine. CAS No. 158691-82-8. Molecular formula: C10H15N5O4. Mole weight: 269.26.
Histidyl-aspartyl-glutamyl-leucine
Heterocyclic Organic Compound. CAS No. 129623-52-5. Catalog: ACM129623525.
Histidyl-glutamine
Histidyl-glutamine is a dipeptide composed of histidine and glutamine. Synonyms: L-Histidyl-L-glutamine; His-Gln. CAS No. 224638-13-5. Molecular formula: C11H17N5O4. Mole weight: 283.28.
Histidyl-isoleucine
Histidyl-isoleucine is a peptide which functions as a hormone. Synonyms: L-histidyl-L-isoleucine; His-Ile; HI dipeptide. CAS No. 129050-48-2. Molecular formula: C12H20N4O3. Mole weight: 268.31.
Histidyl-threonine is a dipeptide composed of histidine and threonine. CAS No. 142879-28-5. Molecular formula: C10H16N4O4. Mole weight: 256.26.
Histidyl-tRNA Synthetase from Human, Recombinant
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Histidyl-trna synthetase human recombinant produced in...thetase is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Enzyme Commission Number: EC 6.1.1.21. CAS No. 9068-78-4. Purity: Greater than 90.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. HRS. Stability: Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Cat No: NATE-0848.
histolysain
From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Enzyme Commission Number: EC 3.4.22.35. CAS No. 92228-52-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4210; histolysain; EC 3.4.22.35; 92228-52-9; histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Cat No: EXWM-4210.
histone acetyltransferase
A group of enzymes with differing specificities towards histone acceptors. Group: Enzymes. Synonyms: nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Enzyme Commission Number: EC 2.3.1.48. CAS No. 9054-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2227; histone acetyltransferase; EC 2.3.1.48; 9054-51-7; nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Cat No: EXWM-2227.
Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V)
A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C?H?N?S?, Primary Target: KAT5. US Biological Life Sciences.
Worldwide
histone deacetylase
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490.
Histone H1-derived Peptide
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 889112-06-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2480.
Histone H2A
Histone H2A is an antibacterial peptide isolated from Oncorhynchus mykiss. It has activity against bacteria and fungi. Synonyms: Ala-Glu-Arg-Val-Gly-Ala-Gly-Ala-Pro-Val-Tyr-Leu.
Histone H2B 1
Histone H2B 1 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Molecular formula: C85H149N25O24. Mole weight: 2034.62.
Histone H2B 3
Histone H2B 3 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Synonyms: Pro-Asp-Pro-Ala-Lys-Thr-Ala-Pro-Lys-Lys-Lys-Ser-Lys-Lys-Ala-Val-Thr. Molecular formula: C80H143N23O23. Mole weight: 1795.16.
Histone H3 (1-20)
Synonyms: H3 (1-20); H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-OH; L-alanyl-L-arginyl-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonyl-glycyl-glycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 380598-30-1. Molecular formula: C91H167N35O27. Mole weight: 2183.52.
Histone H3 (1-34) is a histone peptide that acts as a substrate for methyltransferase/demethylase enzymes. Synonyms: Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly. Molecular formula: C144H260N54O44. Mole weight: 3451.98.
Histone H3 (21-44)
Histone H3 (21-44) is a histone fragment that is used as a substrate for the protein arginine methyltransferase PRMT4. Synonyms: H3 (21-44); H-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-OH; L-Alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycine. Grades: ≥95%. CAS No. 1373516-71-2. Molecular formula: C109H185N39O29. Mole weight: 2505.91.
A cell-permeable iron chelating benzisothiazolone compound with microbicide and fungicide properties that acts as a potent, selective, and reversible inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases (IC50 = 3uM for JARID1B). Also blocks the activity of other related demethylases at higher concentration (IC50 = 6, 4.9, and 28uM for JARID1A, JARID1C, and JMJD2E, respectively). However, it does affect the activity of unrelated UTX and JMJD3 H3K27me3 demethylases. HeLa cells overexpressing full length JARID1B show a significant reduction in H3K4Me3 activity following PBIT treatment (~10uM). Blocks the proliferation of UACC-812 tumor cells expressing higher levels of JARDID1B, but does not significantly affect MCF7 or MCF10A cells expressing lower levels of JARDID1B. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NOS, Primary Target: JARID1 Histone Demethylases. US Biological Life Sciences.
A pyridinyl -pyrimidinyl aminopropanoic acid that effectively inhibits KDM6 family H3K27m3 demethylases JMJD3 and UTX (IC50 = 18 and 56uM, respectively, by MALDI Mass detection) in an alpha-ketoglutarate-competitive, peptide substrate-non-competitive manner, displaying much reduced potency against JARID1C, JMJD1a, JMJD2a, JMJD2c, JMJD2d, JMJD2e, as well as112 kinases and 60 non-kinase enzymes. Recommended for cell-free assays only. For culture treatment, use the cell-permeable pro-drug GSK-J4. Group: Biochemicals. Grades: Highly Purified. CAS No. 1373422-53-7. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable GSK-J1 prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50uM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-alpha production in primary human macrophage cultures (IC50 = 9uM by ELISA). Group: Biochemicals. Grades: Highly Purified. CAS No. 1373423-53-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: H3K27me3 demethylases JMJD3 & UTX. US Biological Life Sciences.
Worldwide
histone-lysine N-methyltransferase
One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase. Group: Enzymes. Synonyms: protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.43. CAS No. 9055-8-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1947; histone-lysine N-methyltransferase; EC 2.1.1.43; 9055-08-7; protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Cat No: EXWM-1947.
A cell-permeable compound that is shown (at 1uM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. At concentrations between 200nM and 2000nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. At concentrations up to ≥ 1000nM, DZNep dose-dependently increases the percentage of apoptotic cells up to > ~ 38%, with greater potency against OCI-AML3 than HL-60 cultures and inhibits colony growth up to > ~ 85% for both cell lines. In OCI-AML3 cultures, 1000nM of treatment demonstrates a significant increase in the accumulation of cells in the G0/G1 phase (58.5%) with a concomitant decrease in the number of c Group: Biochemicals. Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?; HCl; H?O. US Biological Life Sciences.
Worldwide
Histone Modification Compound Library
A unique collection of 362 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3500. Categories: Histone Modification Compounds Libraries.
Histrelin
Histrelin is a nonapeptide analog of GnRH (gonadotropin-releasing hormone) with added potency. When present in the bloodstream, it can act on gonadotropes. Histrelin can stimulate these cells to release luteinizing hormone and follicle-stimulating hormone. Histrelin is considered a GnRH agonist. It can be used for the treatment of menstruation disorders. Uses: Menstruation disorders. Synonyms: Histrelinum; ORF 17070. Grades: 98%. CAS No. 76712-82-8. Molecular formula: C66H86N18O12. Mole weight: 1323.5.
Histrelin
Histrelin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 76712-82-8. Molecular Formula: C66H86N18O12. Mole Weight: 1323.53. Catalog: APB76712828.
Histrelin acetate
Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis [1] [2] [5]. Uses: Scientific research. Group: Peptides. CAS No. 220810-26-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0056A.
Histrelin acetate
An acetate salt obtained by combining histrelin with acetic acid. The amount of acetic acid present can vary and a variable amount of water may be present. Histrelin acetate is used as a subcutaneous hydrogel implant for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. Synonyms: 1-9-Luteinizing hormone-releasing factor (swine), 6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-, acetate (1:x); 1-9-Luteinizing hormone-releasing factor (swine), 6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-, acetate (salt); Supprelin; H-Pyr-His-Trp-Ser-Tyr-D-His(1-Bn)-Leu-Arg-Pro-NHEt.xCH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline ethylamide acetic acid. Grades: >98%. CAS No. 220810-26-4. Molecular formula: C66H86N18O12.xC2H4O2. Mole weight: 1323.50 (free base).
Histrelin Acetate
Histrelin Acetate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 220810-26-4. Molecular Formula: C68H90N18O14. Mole Weight: 1383.58. Catalog: APB220810264.
His-Val-OH
His-Val-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 76019-15-3. Pack Sizes: 100mg, 250mg. US Biological Life Sciences.
Worldwide
His-Val-OH 98+% (TLC)
His-Val-OH 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Hitachimycin
Hitachimycin is a macrolide antibiotic produced by Streptomyces No. KG-2245. It can inhibit tumor cell growth and antiprotozoal effects. Synonyms: Stubomycin. Grades: 95%. CAS No. 77642-19-4. Molecular formula: C29H35NO5. Mole weight: 477.59.
HI TOPK 032 is a novel TOPK inhibitor as a T-LAK-cell-originated protein kinase (TOPK) inhibitor, blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. Uses: A novel topk inhibitor. Synonyms: HI-TOPK-032; HI-TOPK032; HI-TOPK 032. N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide. Grades: ≥98%. CAS No. 487020-03-1. Molecular formula: C20H11N5OS. Mole weight: 369.4.
HI TOPK 032
HI TOPK 032. Group: Biochemicals. Grades: Purified. CAS No. 487020-03-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Hiv-1 env protein gp120(278-292)(strains bh10,bh8,hxb2,hxb3,pv22)
Heterocyclic Organic Compound. Alternative Names: GP120 (313-327);H-ARG-ILE-GLN-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE-GLY-LYS-OH;HIV (GP120) FRAGMENT (315-329);ARG-ILE-GLN-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE-GLY-LYS;R15K;HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22). CAS No. 114991-28-5. Molecular formula: C73H126N26O18. Mole weight: 1655.94. Catalog: ACM114991285.
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC 50 s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC 50 s ranging from 0.9 to 1.5 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821309-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134851.
HIV-1 integrase inhibitor
HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 544467-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13025.
HIV-1 integrase inhibitor
HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. Synonyms: (Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid. Grades: >98%. CAS No. 544467-07-4. Molecular formula: C11H9N3O4. Mole weight: 247.21.
HIV-1 integrase inhibitor 2
HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. Synonyms: CX04328; CX-04328; CX 04328; 3-Quinolineacetic acid, 6-chloro-2-methyl-4-phenyl-a-propyl-. Grades: >98%. CAS No. 957890-42-5. Molecular formula: C21H20ClNO2. Mole weight: 353.84.
HIV-1 Protease, Recombinant
HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV. HIV protease cleaves newly synthesized viral polyproteins at the appropriate places into functional protein products as mature protein components of an infectious HIV virion. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells. Group: Enzymes. Synonyms: HIV-1 retropepsin; HIV-1 Protease (PR); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 90%. Mole weight: 38.4 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31 kDa during SEC and SDS-PAGE analyses. Activity: > 1mU/mg. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-1 retropepsin; HIV-1 Protease (PR); cd05482; HIV1 protease. Cat No: NATE-1662.
HIV-1 retropepsin
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses. Type example of peptidase family A2. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4253; HIV-1 retropepsin; EC 3.4.23.16; 144114-21-6; human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Cat No: EXWM-4253.
HIV-1 TAT (48-60)
HIV-1 TAT (48-60) is a cell-penetrating peptide generated from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way. Synonyms: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grades: ≥95%. Molecular formula: C70H131N35O16. Mole weight: 1719.04.
HIV-1 TAT 48-60
HIV-1 TAT 48-60 is a cell-penetrating peptide derived from human immunodeficiency virus (HIV)-1 TAT protein residues 48-60. It is used to deliver exogenous macromolecules into cells in a non-destructive way. Synonyms: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grades: ≥95%. Molecular formula: C70H131N35O16. Mole weight: 1719.00.
HIV-1 TAT Protein Peptide
It is a cell-permeable peptide (CPP) derived from the HIV-1 tat protein transduction domain (PTD), which has been shown to promote the entry of nucleic acids into several cell types. Synonyms: HIV-1 Tat Protein (47-57); H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; TAT (47-57); L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grades: 98%. CAS No. 191936-91-1. Molecular formula: C64H118N32O14. Mole weight: 1559.83.
HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional ce...epsin; HIV-2 Protease (PR2); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 85%. Mole weight: 38.3 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31.5 kDa during SEC and SDS-PAGE analyses. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-2 retropepsin; HIV-2 Protease (PR2); cd05482; HIV2 protease. Cat No: NATE-1661.
HIV-2 retropepsin
In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein. Group: Enzymes. Enzyme Commission Number: EC 3.4.23.47. CAS No. 144114-21-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4284; HIV-2 retropepsin; EC 3.4.23.47; 144114-21-6. Cat No: EXWM-4284.
Hivernal® Neo. CAS No. 300371-33-9. Kosher: Y. VIGON Item # 508452. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
Hiv(gp120)fragment(308-331)
Heterocyclic Organic Compound. Alternative Names: ASN-ASN-THR-ARG-LYS-SER-ILE-ARG-ILE-GLN-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE-GLY-LYS-ILE-GLY;HIV ENVELOPE PROTEIN (GP120) FRAGMENT 308-331;HIV (GP120) FRAGMENT (308-331);H-ASN-ASN-THR-ARG-LYS-SER-ILE-ARG-ILE-GLN-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE. CAS No. 115416-08-5. Molecular formula: C114H199N41O31. Mole weight: 2640.06. Catalog: ACM115416085.
HIV-IN-6 is a HIV-1 viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301357-74-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147314.
HIV p17 Gag 77-85
HIV p17 Gag 77-85 is used in the research of anti-HIV. Synonyms: HIV-1 gag Protein p17 (76-84); H-Ser-Leu-Tyr-Asn-Thr-Val-Ala-Thr-Leu-OH; L-seryl-L-leucyl-L-tyrosyl-L-asparagyl-L-threonyl-L-valyl-L-alanyl-L-threonyl-L-leucine; HIV P17 GAG (77-85). Grades: ≥95%. CAS No. 147468-65-3. Molecular formula: C44H72N10O15. Mole weight: 981.10.
HIV Protease Mutant, Recombinant
HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious. Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Mole weight: mol wt ~10.8 kDa. Storage: -70°C. Form: Supplied as a solution in 0.5M Sodium Acetate, pH 4.7with 50mM Tris-HCL, 1M NaCL, 1mM EDTA, 5mM DTT and 15% glycerol. Source: E. coli. human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Pack: 100 unit vial containing > 100ug protein. Cat No: NATE-0344.
HIV Protease Substrate VI is a sensitive chromogenic substrate for both HIV-1 and HIV-2 proteases. Synonyms: H-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2; L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide; L-Norleucinamide, L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-α-glutamyl-L-alanyl-. Grades: ≥95%. CAS No. 130877-92-8. Molecular formula: C40H66N12O11. Mole weight: 891.04.
HJC-0123
HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grades: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46.