A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Hispidalin, a bioactive peptide purified from the seeds of the medicinal plant B. hispida, has broad and potent inhibition against a variety of human bacterial and fungal pathogens. Synonyms: H-Ser-Asp-Tyr-Leu-Asn-Asn-Asn-Pro-Leu-Phe-Pro-Arg-Tyr-Asp-Ile-Gly-Asn-Val-Glu-Leu-Ser-Thr-Ala-Tyr-Arg-Ser-Phe-Ala-Asn-Gln-Lys-Ala-Pro-Gly-Arg-Leu-Asn-Gln-Asn-Trp-Ala-Leu-Thr-Ala-Asp-Tyr-Thr-Tyr-Arg-OH. Grades: ≥95%. CAS No. 2243219-67-0. Molecular formula: C255H378N72O78. Mole weight: 5700.25.
Hispidin
Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus , has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 555-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100618.
Hispidin
Hispidin is a polyphenol isolated from Pteris ensiformis. It exhibits antioxidant, anti-inflammatory, and cytoprotective properties. Hispidin is also a precursor of fungal luciferin, emits bioluminenscence in the luminous fungal fruiting body. Synonyms: 6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone; 6-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-4-hydroxy-2H-pyran-2-one. Grades: ≥95%. CAS No. 555-55-5. Molecular formula: C13H10O5. Mole weight: 246.2.
Hispidol
Hispidol ((Z)-Hispidol) inhibits TNF-α induced adhesion of monocytes to colon epithelial cells (IC50= 0.50 μM) and is a potential therapeutic for inflammatory bowel disease. Synonyms: (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one; Hispidol; (Z)-4',6-Dihydroxyaurone; AC1NQYA9; 6,4' -dihydroxy aurone. CAS No. 5786-54-9. Molecular formula: C15H10O4. Mole weight: 254.24.
Hispidospermidin
Hispidospermidin is a phospholipase C inhibitor produced by Chaetosphaeronema hispidulum. Synonyms: (-)-hispidospermidin. Molecular formula: C25H47N3O. Mole weight: 405.66.
Hispidulin
Hispidulin. Group: Biochemicals. Grades: Purified. CAS No. 1447-88-7. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Hispidulin
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC 50 of 2.71 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Dinatin. CAS No. 1447-88-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1950.
Hispolon
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 173933-40-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150521.
Histamine is an organic nitrogenous compound produced by basophils and by mast cells found in nearby connective tissues. Uses: An organic nitrogenous compound. Synonyms: 1h-imidazole-4-ethanamine;2-(4-IMIDAZOLYL)ETHYLAMINE;2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE;4-(2-Aminoethyl)-1H-imidazole;HISTAMINE BASE;HISTAMIN. Grades: ≥97%. CAS No. 51-45-6. Molecular formula: C5H9N3. Mole weight: 111.15.
Histamine
Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Uses: Scientific research. Group: Natural products. Alternative Names: Ergamine. CAS No. 51-45-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1204.
Present in mo. Group: Biochemicals. Alternative Names: 1-H-Imidazole-4-ethanamine-d4; 5-Imidazole-ethylamine-d4;b-Aminoethylimidazole-d4; Maxamine-d4. Grades: Highly Purified. CAS No. 344299-48-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Histamine-α,α,β,β-d4 dihydrochloride
Histamine-α, α, β, β-d 4 (dihydrochloride) is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Ergamine-α,α,β,β-d4 (dihydrochloride). CAS No. 344299-48-5. Pack Sizes: 5 mg. Product ID: HY-B1204S.
Histamine Dehydrogenase from E. coli, Recombinant
Histamine dehydrogenase is a homodimeric enzyme and catalyzes oxidative deamination of histamine. The gene encoding this enzyme has been sequenced and cloned by polymerase chain reactions and overexpressed in Escherichia coli. Group: Enzymes. Synonyms: Histamine : (acceptor) oxidoreductase (deaminating); EC 1.4.99; Histamine Dehydrogenase. Enzyme Commission Number: EC 1.4.99. Histamine Dehydrogenase. Activity: ~10 U/mg, ~20 mg/mL. Appearance: Yellow liquid in 10mM tris buffer pH 9.0 and 90mg BSA. Storage: at -20°C. Source: E. coli. Species: E. coli. Histamine : (acceptor) oxidoreductase (deaminating); EC 1.4.99; Histamine Dehydrogenase. Cat No: DIA-412.
Histamine dihydrochloride is a reactive oxygen species ( ROS ) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 56-92-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B0722.
Histamine dihydrochloride
25g Pack Size. Group: Bioactive Small Molecules, Building Blocks, Diagnostic Raw Materials, Research Organics & Inorganics. Formula: C5H9N3 · 2HCl. CAS No. 56-92-8. Prepack ID 19012772-25g. Molecular Weight 184.07. See USA prepack pricing.
Histamine dihydrochloride
Histamine dihydrochloride is a histamine salt used to prevent relapse in patients with acute myeloid leukemia (AML). It is also used as an active ingredient in topical analgesia for temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains and strains. Uses: Present in most mammalian tissues; primarily stored in mast cells and basophils. exhibits multiple biological effects through at least 3 specific receptors. induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. histamine has been identified as a bedbug pheromone. Synonyms: 1H-Imidazole-4-ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)imidazole Dihydrochloride; Ceplene; Peremin; 2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride. Grades: >98%. CAS No. 56-92-8. Molecular formula: C5H9N3.2HCl. Mole weight: 184.07.
Histamine Dihydrochloride
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Group: Biochemicals. Alternative Names: 1H-Imidazole-4-ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)imidazole Dihydrochloride; Ceplene; Histamine Chloride; Histamine Dichloride; Histamine Hydrochloride; Histaminediium Dichloride; Peremin. Grades: Highly Purified. CAS No. 56-92-8. Pack Sizes: 100g, 250g. Molecular Formula: C5H9N3·2HCl, Molecular Weight: 184.07. US Biological Life Sciences.
Worldwide
Histamine dihydrochloride salt 98+% (TLC)
Histamine dihydrochloride salt 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100g, 250g, 25g, 1Kg. US Biological Life Sciences.
Worldwide
Histamine diphosphate
25g Pack Size. Group: Biochemicals, Research Organics & Inorganics. Formula: C5H9N3 ¢2H3PO4. CAS No. 51-74-1. Prepack ID 13488706-25g. Molecular Weight 307.14. See USA prepack pricing.
Histamine diphosphate monohydrate
Histamine diphosphate monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 51-74-1. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C5H9N3·2H3PO4·H2O. US Biological Life Sciences.
Worldwide
Histamine free base
1g Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C5H9N3. CAS No. 51-45-6. Prepack ID 33208282-1g. Molecular Weight 111.15. See USA prepack pricing.
Histamine H4 receptor antagonist-1
Histamine H4 receptor antagonist-1 is an antagonist of histamine H4 receptor extracted from patent WO2010108059A1 compound 60 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1246207-84-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145106.
Histamine & Melatonin Receptor-Targeted Library
A unique collection of 155 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3300. Categories: Histamine & Melatonin Receptor-Targeted Libraries.
histamine N-methyltransferase
Histamine N-methyltransferase (HMT, HNMT) is an enzyme that in humans is encoded by the HNMT gene. Histamine N-methyltransferase is one of two enzymes involved in the metabolism of histamine, the other being diamine oxidase. Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N-methylhistamine. Group: Enzymes. Synonyms: histamine 1-methyltransferase; histamine methyltransferase; histamine-methylating enzyme; imidazolemethyltransferase; S-adenosylmethionine-histamine N-methyltransferase. Enzyme Commission Number: EC 2.1.1.8. CAS No. 9029-80-5. HNMT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1981; histamine N-methyltransferase; EC 2.1.1.8; 9029-80-5; histamine 1-methyltransferase; histamine methyltransferase; histamine-methylating enzyme; imidazolemethyltransferase; S-adenosylmethionine-histamine N-methyltransferase. Cat No: EXWM-1981.
Histamine phosphate
Histamine (phosphate) is a strong histamine receptor activator and vasodilator neuroagent, capable of activating nitric oxide synthase. Uses: Scientific research. Group: Natural products. Alternative Names: Histamine diphosphate. CAS No. 51-74-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-A0129.
Histamine Phosphate
Histamine phosphate is a potent histamine receptor agonist and vasodilator. It acts directly on the blood vessels to dilate arteries and capillaries mediated by both H1- and H2-receptors. Synonyms: Histamine diphosphate; Histamine acid phosphate; Histamine biphosphate; 2-(1H-imidazol-4-yl)ethanamine bis(phosphate); 1H-Imidazole-4-ethanamine, phosphate (1:2); Histamine dihydrogen phosphate; 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate); 4-(2-Aminoethyl)imidazole di-acid phosphate; 2-(1H-Imidazol-4-yl)ethanamine phosphate (1:2). Grades: ≥98%. CAS No. 51-74-1. Molecular formula: C5H9N.2H3O4P. Mole weight: 307.14.
Histapyrrodine hydrochloride
Histapyrrodine hydrochloride. Group: Biochemicals. Alternative Names: N-Phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine Hydrochloride. Grades: Highly Purified. CAS No. 6113-17-3. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C19H25ClN2. US Biological Life Sciences.
Worldwide
Histargin
Histargin is an enzyme inhibitor produced by Streptomyces roseoviridis MF118-A5. It can inhibit carboxypeptidase B activity. Synonyms: (S)-N-(2-((4-((Aminoiminomethyl)amino)-1-carboxybutyl)amino)ethyl)-L-histidine; L-Histidine, N-(2-((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)ethyl)-, (S)-. Grades: >98%. CAS No. 93361-66-1. Molecular formula: C14H25N7O4. Mole weight: 355.39.
Histatin-1
Histatin-1 is an antibacterial peptide isolated from Macaca fascicularis. It shows antibacterial and antifungal activity. Synonyms: HTN1 protein, human; Histatin 1, human; H-Asp-Ser(PO3H2)-His-Glu-Lys-Arg-His-His-Gly-Tyr-Arg-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Glu-Phe-Pro-Phe-Tyr-Gly-Asp-Tyr-Gly-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn-OH. Grades: 98.3%. CAS No. 101056-53-5. Molecular formula: C217H298N69O64P. Mole weight: 4928.
Histatin-3
Histatin 3 is a protein which in humans is encoded by the HTN3 gene. Histatin-3 is an antibacterial peptide isolated from Homo sapiens. It shows antibacterial and antifungal activity. Synonyms: Histatin 3; H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-Arg-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn-OH. Grades: 95.0%. CAS No. 112844-49-2. Molecular formula: C178H258N64O48. Mole weight: 4062.
Histatin-3 TFA
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant K i of 1.98 μM [1]. Uses: Scientific research. Group: Peptides. CAS No. 112844-49-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5272.
Histatin 5
Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH; L-alpha-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidyl-glycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-alpha-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginyl-glycyl-L-tyrosine; Human histatin 5; Peptide F-A (human parotid saliva). Grades: 98%. CAS No. 104339-66-4. Molecular formula: C133H195N51O33. Mole weight: 3036.29.
Histatin 5 acetate
Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH.CH3CO2H; L-α-Aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosine acetate salt; Human histatin 5 acetate salt; Peptide F-A (human parotid saliva) acetate salt. Grades: ≥95%. Molecular formula: C135H199N51O35. Mole weight: 3096.35.
Histidine,1-methyl-,monohydrate,l-(8ci)
Histidine,1-methyl-,monohydrate,l-(8ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-NT-METHYL-D3-HISTIDINE;L-N-TAU-METHYL-D3-HISTIDINE;(S)-1-Methylimidazole-4-alanine. Product Category: Heterocyclic Organic Compound. CAS No. 15507-76-3. Molecular formula: C7H11N3O2.H2O. Mole weight: 172.2. Purity: 0.96. IUPACName: (2S)-2-amino-3-[1-(trideuteriomethyl)imidazol-4-yl]propanoicacid. Canonical SMILES: CN1C=C(N=C1)CC(C(=O)O)N. Product ID: ACM15507763. Alfa Chemistry ISO 9001:2015 Certified. Categories: 91037-48-8.
histidine ammonia-lyase
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate. Group: Enzymes. Synonyms: histidase; histidinase; histidine α-deaminase; L-histidine ammonia-lyase. Enzyme Commission Number: EC 4.3.1.3. CAS No. 9013-75-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5289; histidine ammonia-lyase; EC 4.3.1.3; 9013-75-6; histidase; histidinase; histidine α-deaminase; L-histidine ammonia-lyase. Cat No: EXWM-5289.
histidine decarboxylase
A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group. Group: Enzymes. Synonyms: L-histidine decarboxylase; L-histidine carboxy-lyase. Enzyme Commission Number: EC 4.1.1.22. CAS No. 9024-61-7. HDC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4767; histidine decarboxylase; EC 4.1.1.22; 9024-61-7; L-histidine decarboxylase; L-histidine carboxy-lyase. Cat No: EXWM-4767.
histidine kinase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor. Group: Enzymes. Synonyms: EnvZ;histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK1; HP165; Sln1p. Enzyme Commission Number: EC 2.7.13.3. CAS No. 420839-67-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3165; histidine kinase; EC 2.7.13.3; 420839-67-4; EnvZ;histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK1; HP165; Sln1p. Cat No: EXWM-3165.
Histidine,l-,[carboxyl-14c]
Histidine,l-,[carboxyl-14c]. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HISTIDINE, L-, [CARBOXYL-14C]. Product Category: Heterocyclic Organic Compound. CAS No. 10413-69-1. Molecular formula: C6H9N3O2. Mole weight: 157.17. Product ID: ACM10413691. Alfa Chemistry ISO 9001:2015 Certified. Categories: 90081-11-1.
histidine N-acetyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. Group: Enzymes. Synonyms: acetylhistidine synthetase; histidine acetyltransferase. Enzyme Commission Number: EC 2.3.1.33. CAS No. 9027-59-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2211; histidine N-acetyltransferase; EC 2.3.1.33; 9027-59-2; acetylhistidine synthetase; histidine acetyltransferase. Cat No: EXWM-2211.
histidine transaminase
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidine:2-oxoglutarate aminotransferase. Other names in common use include histidine aminotransferase, and histidine-2-oxoglutarate aminotransferase. This enzyme participates in histidine metabolism. Group: Enzymes. Synonyms: histidine aminotransferase; histidine-2-oxoglutarate aminotransferase. Enzyme Commission Number: EC 2.6.1.38. CAS No. 37277-92-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2878; histidine transaminase; EC 2.6.1.38; 37277-92-2; histidine aminotransferase; histidine-2-oxoglutarate aminotransferase. Cat No: EXWM-2878.
histidine-tRNA ligase
This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis. Group: Enzymes. Synonyms: histidyl-tRNA synthetase; histidyl-transfer ribonucleate synthetase; histidine translase. Enzyme Commission Number: EC 6.1.1.21. CAS No. 9068-78-4. HRS. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5653; histidine-tRNA ligase; EC 6.1.1.21; 9068-78-4; histidyl-tRNA synthetase; histidyl-transfer ribonucleate synthetase; histidine translase. Cat No: EXWM-5653.
histidinol dehydrogenase
Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). Group: Enzymes. Synonyms: L-histidinol dehydrogenase. Enzyme Commission Number: EC 1.1.1.23. CAS No. 9028-27-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0136; histidinol dehydrogenase; EC 1.1.1.23; 9028-27-7; L-histidinol dehydrogenase. Cat No: EXWM-0136.
histidinol-phosphatase
This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase. This enzyme participates in histidine metabolism. Group: Enzymes. Synonyms: histidinol phosphate phosphatase; L-histidinol phosphate phosphatase; histidinolphosphate phosphatase; HPpase; histidinolphosphatase. Enzyme Commission Number: EC 3.1.3.15. CAS No. 9025-79-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3617; histidinol-phosphatase; EC 3.1.3.15; 9025-79-0; histidinol phosphate phosphatase; L-histidinol phosphate phosphatase; histidinolphosphate phosphatase; HPpase; histidinolphosphatase. Cat No: EXWM-3617.
histidinol-phosphate transaminase
A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: imidazolylacetolphosphate transaminase; glutamic-imidazoleacetol phosphate transaminase; histidinol phosphate aminotransferase; imidazoleacetol phosphate transaminase; L-histidinol phosphate aminotransferase; histidine:imidazoleacetol phosphate transaminase; IAP transaminase; imidazolylacetolphosphate aminotransferase. Enzyme Commission Number: EC 2.6.1.9. CAS No. 9032-98-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2931; histidinol-phosphate transaminase; EC 2.6.1.9; 9032-98-8; imidazolylacetolphosphate transaminase; glutamic-imidazoleacetol phosphate transaminase; histidinol phosphate aminotransferase; imidazoleacetol phosphate transaminase; L-histidinol phosphate aminotransferase; histidine:imidazoleacetol phosphate transaminase; IAP transaminase; imidazolylacetolphosphate aminotransferase. Cat No: EXWM-2931.
Histidyl-asparagine
Histidyl-asparagine is a dipeptide composed of histidine and asparagine. CAS No. 158691-82-8. Molecular formula: C10H15N5O4. Mole weight: 269.26.
Histidyl-glutamine
Histidyl-glutamine is a dipeptide composed of histidine and glutamine. Synonyms: L-Histidyl-L-glutamine; His-Gln. CAS No. 224638-13-5. Molecular formula: C11H17N5O4. Mole weight: 283.28.
Histidyl-isoleucine
Histidyl-isoleucine is a peptide which functions as a hormone. Synonyms: L-histidyl-L-isoleucine; His-Ile; HI dipeptide. CAS No. 129050-48-2. Molecular formula: C12H20N4O3. Mole weight: 268.31.
Histidyl-threonine is a dipeptide composed of histidine and threonine. CAS No. 142879-28-5. Molecular formula: C10H16N4O4. Mole weight: 256.26.
Histidyl-tRNA Synthetase from Human, Recombinant
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Histidyl-trna synthetase human recombinant produced in...thetase is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Enzyme Commission Number: EC 6.1.1.21. CAS No. 9068-78-4. Purity: Greater than 90.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. HRS. Stability: Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Cat No: NATE-0848.
histolysain
From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Enzyme Commission Number: EC 3.4.22.35. CAS No. 92228-52-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4210; histolysain; EC 3.4.22.35; 92228-52-9; histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Cat No: EXWM-4210.
histone acetyltransferase
A group of enzymes with differing specificities towards histone acceptors. Group: Enzymes. Synonyms: nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Enzyme Commission Number: EC 2.3.1.48. CAS No. 9054-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2227; histone acetyltransferase; EC 2.3.1.48; 9054-51-7; nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Cat No: EXWM-2227.
Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V)
A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C?H?N?S?, Primary Target: KAT5. US Biological Life Sciences.
Worldwide
histone deacetylase
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490.
Histone H1-derived Peptide
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 889112-06-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2480.
Histone H2A
Histone H2A is an antibacterial peptide isolated from Oncorhynchus mykiss. It has activity against bacteria and fungi. Synonyms: Ala-Glu-Arg-Val-Gly-Ala-Gly-Ala-Pro-Val-Tyr-Leu.
Histone H2B 1
Histone H2B 1 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Molecular formula: C85H149N25O24. Mole weight: 2034.62.
Histone H2B 3
Histone H2B 3 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Synonyms: Pro-Asp-Pro-Ala-Lys-Thr-Ala-Pro-Lys-Lys-Lys-Ser-Lys-Lys-Ala-Val-Thr. Molecular formula: C80H143N23O23. Mole weight: 1795.16.
Histone H3 (1-20)
Synonyms: H3 (1-20); H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-OH; L-alanyl-L-arginyl-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonyl-glycyl-glycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 380598-30-1. Molecular formula: C91H167N35O27. Mole weight: 2183.52.
Histone H3 (1-34) is a histone peptide that acts as a substrate for methyltransferase/demethylase enzymes. Synonyms: Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly. Molecular formula: C144H260N54O44. Mole weight: 3451.98.
Histone H3 (21-44)
Histone H3 (21-44) is a histone fragment that is used as a substrate for the protein arginine methyltransferase PRMT4. Synonyms: H3 (21-44); H-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-OH; L-Alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycine. Grades: ≥95%. CAS No. 1373516-71-2. Molecular formula: C109H185N39O29. Mole weight: 2505.91.
A cell-permeable iron chelating benzisothiazolone compound with microbicide and fungicide properties that acts as a potent, selective, and reversible inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases (IC50 = 3uM for JARID1B). Also blocks the activity of other related demethylases at higher concentration (IC50 = 6, 4.9, and 28uM for JARID1A, JARID1C, and JMJD2E, respectively). However, it does affect the activity of unrelated UTX and JMJD3 H3K27me3 demethylases. HeLa cells overexpressing full length JARID1B show a significant reduction in H3K4Me3 activity following PBIT treatment (~10uM). Blocks the proliferation of UACC-812 tumor cells expressing higher levels of JARDID1B, but does not significantly affect MCF7 or MCF10A cells expressing lower levels of JARDID1B. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NOS, Primary Target: JARID1 Histone Demethylases. US Biological Life Sciences.
A pyridinyl -pyrimidinyl aminopropanoic acid that effectively inhibits KDM6 family H3K27m3 demethylases JMJD3 and UTX (IC50 = 18 and 56uM, respectively, by MALDI Mass detection) in an alpha-ketoglutarate-competitive, peptide substrate-non-competitive manner, displaying much reduced potency against JARID1C, JMJD1a, JMJD2a, JMJD2c, JMJD2d, JMJD2e, as well as112 kinases and 60 non-kinase enzymes. Recommended for cell-free assays only. For culture treatment, use the cell-permeable pro-drug GSK-J4. Group: Biochemicals. Grades: Highly Purified. CAS No. 1373422-53-7. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable GSK-J1 prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50uM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-alpha production in primary human macrophage cultures (IC50 = 9uM by ELISA). Group: Biochemicals. Grades: Highly Purified. CAS No. 1373423-53-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: H3K27me3 demethylases JMJD3 & UTX. US Biological Life Sciences.
Worldwide
histone-lysine N-methyltransferase
One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase. Group: Enzymes. Synonyms: protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.43. CAS No. 9055-8-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1947; histone-lysine N-methyltransferase; EC 2.1.1.43; 9055-08-7; protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Cat No: EXWM-1947.
A cell-permeable compound that is shown (at 1uM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. At concentrations between 200nM and 2000nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. At concentrations up to ≥ 1000nM, DZNep dose-dependently increases the percentage of apoptotic cells up to > ~ 38%, with greater potency against OCI-AML3 than HL-60 cultures and inhibits colony growth up to > ~ 85% for both cell lines. In OCI-AML3 cultures, 1000nM of treatment demonstrates a significant increase in the accumulation of cells in the G0/G1 phase (58.5%) with a concomitant decrease in the number of c Group: Biochemicals. Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?; HCl; H?O. US Biological Life Sciences.
Worldwide
Histone Modification Compound Library
A unique collection of 362 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3500. Categories: Histone Modification Compounds Libraries.