A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
HJC0197 is a erythromycin propionate-N-acetylcysteinate inhibitor (EPAC). IC50 value is 5.9 μM for Epac2. HJC0197 can inhibit Epac1-mediated Rap1-GDP exchange activity at 25 μM, but it has no effect on cAMP-induced type I and II PKA activity at this concentration. HJC0197 can be used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion. Uses: Study the role of epac signaling. Synonyms: HJC0197; HJC-0197; HJC 0197. 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1383539-73-8. Molecular formula: C19H21N3OS. Mole weight: 339.45.
HJC0350
HJC0350 is a potent and Epac2-specific inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Synonyms: HJC 0350; HJC-0350; 1-(mesitylsulfonyl)-2,4-dimethyl-1H-pyrrole. Grades: >98%. CAS No. 885434-70-8. Molecular formula: C15H19NO2S. Mole weight: 277.38.
HJC 0350
HJC 0350. Group: Biochemicals. Grades: Purified. CAS No. 885434-70-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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H+/K+-exchanging ATPase
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. Group: Enzymes. Synonyms: H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Enzyme Commission Number: EC 3.6.3.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4647; H+/K+-exchanging ATPase; EC 3.6.3.10; H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Cat No: EXWM-4647.
HKI 357
HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grades: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05.
HKI 357
HKI 357. Group: Biochemicals. Grades: Purified. CAS No. 848133-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. Group: Inhibitors. Alternative Names: HKI-357; HKI357; HKI 357. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide. Canonical SMILES: O=C (NC1=C (OCC)C=C2N=CC (C#N)=C (NC3=CC=C (OCC4=CC=CC (F)=C4)C (Cl)=C3)C2=C1)/C=C/CN (C)C. Catalog: ACM848133175.
HKOH-1r
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2138472-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D1159.
HKPerox-2
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H 2 O 2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2245230-79-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1157.
HKPLP
HKPLP is an antibacterial peptide isolated from Hippocampus kuda. Synonyms: Phe-Leu-Gly-Leu-Ile-Phe-His-Gly-Leu-Val-His-Ala-Gly-Lys-Leu-Ile-His-Gly-Leu-Ile-His-Arg-Asn-Arg-Gly. Grades: 96.1%.
HL 010183
HL 010183 is a metformin derivative exhibiting potent antitumor effect. It inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells. Uses: Antitumor agent. Synonyms: HL 010183; HL010183; HL-010183. Grades: 99%. CAS No. 1429218-03-0. Molecular formula: C14H20N6.HCl. Mole weight: 308.81.
HL1
HL1 is a ligand for tridentate Schiff bases and is a potential fluorescent probe for metal ions. HL1 exhibits photoluminescence at a weak and strong excitation wavelength of 415 nm [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202828-10-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164055.
HL-60 Electroporation Kit
Electroporation buffer optimized for HL60 Plasmacytoma Cells. Optimized electroporation protocol provided for transfection of si/miRNA, DNA, mRNA, and small proteins. Feature high transfection efficacy and cell viability. Uses: Electroporation of DNA, RNA, protein and small molecules. Product ID: 1752.
HLCL61 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. It is used for treatment of acute myeloid leukemia. It resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in acute myeloid leukemia cells. Uses: Hlcl61 is used for treatment of acute myeloid leukemia. Synonyms: HLCL-61; HLCL 61; 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine. Grades: 98%. CAS No. 586395-74-6. Molecular formula: C23H24N2O. Mole weight: 344.19.
HLCL-61 hydrochloride
The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia. Uses: The hydrochloride salt form of hlcl-61 is an effective inhibitor of prmt5 and could probably useful in the treatment of acute myeloid leukemia. Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride; HLCL61; HLCL 61; HLCL-61. Grades: 98%. CAS No. 1158279-20-9. Molecular formula: C23H25ClN2O. Mole weight: 380.91.
HLCL65 hydrochloride
HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses recall T cell responses and reduces inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models; In vitro, HLCL65 effectively inhibits symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples. Synonyms: HLCL65 hydrochloride; HLCL 65 hydrochloride; HLCL-65 hydrochloride; 1-(6-bromo-9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine hydrochloride. Grades: 99%. Molecular formula: C23H23BrN2O.HCl. Mole weight: 459.81.
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Leucine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Leu-Gly-Leu-Leu-Leu-Arg-His-Leu-Arg-His-His-Ser-Asn-Leu-Leu-Ala-Asn-Ile-OH, the peptide sequence B18 derived from membrane-associated sea urchin sperm protein-binding proteins, triggers fusion between lipid vesicles. It has many similarities with viral fusion peptides. Grades: ≥95%. CAS No. 222557-92-8. Molecular formula: C94H160N32O22. Mole weight: 2090.48.
H-Leu-Gly-OH
H-Leu-Gly-OH is a Glycine (HY-Y0966) derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 686-50-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W016075.
H-Leu-his-leu-oh
Heterocyclic Organic Compound. Alternative Names: H-LEU-HIS-LEU-OH. CAS No. 126828-33-9. Molecular formula: C18H31N5O4. Mole weight: 381.47. Catalog: ACM126828339.
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grades: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33.
HLI 373
HLI 373. Group: Biochemicals. Grades: Purified. CAS No. 502137-98-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HLI373 dihydrochloride
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. Antimalarial activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782531-99-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108640A.
HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grades: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48.
HLM 006474
HLM 006474. Group: Biochemicals. Grades: Purified. CAS No. 353519-63-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HLP6
HLP6 is an antibacterial peptide isolated from Homo sapiens. Synonyms: Phe-Gln-Trp-Gln-Arg-Asn-Pro-Arg-Lys-Val-Arg.
HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb. Synonyms: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine. Grades: ≥98%. CAS No. 854847-61-3. Molecular formula: C17H17NO2. Mole weight: 267.3.
H-Lys(Abz)-Pro-Pro-pNA
H-Lys(Abz)-Pro-Pro-pNA is an internally quenched fluorogenic (FRET) substrate. CAS No. 219138-18-8. Molecular formula: C29H37N7O6. Mole weight: 579.65.
H-Lys-Ala-4MβNA 2 HCl
It is a specific fluorogenic substrate for dipeptidyl peptidase II (DPP II). Synonyms: Lys-Ala 4-methoxy-beta-naphthylamide dihydrochloride. Grades: 95%. CAS No. 118357-26-9. Molecular formula: C20H30Cl2N4O3. Mole weight: 445.38.
H-Lys-Ala-pNA 2HCl
H-Lys-Ala-pNA 2HCl, a chromogenic substrate for dipeptidyl aminopeptidase II (DPPII), is cleaved from Aspergillus fumigatus by dipeptidyl peptidase V (DPP V). Synonyms: KA-pNA dihydrochloride; L-Lysyl-N-(4-nitrophenyl)-L-alaninamide dihydrochloride; L-Alaninamide, L-lysyl-N-(4-nitrophenyl)-, hydrochloride (1:2). Grades: ≥95%. CAS No. 390366-87-7. Molecular formula: C15H23N5O4.2HCl. Mole weight: 410.30.
Heterocyclic Organic Compound. Alternative Names: KRTLR;H-LYS-ARG-THR-LEU-ARG-OH;LYS-ARG-THR-LEU-ARG. CAS No. 121145-48-0. Molecular formula: C28H56N12O7. Mole weight: 672.82. Catalog: ACM121145480.
H-Lys(Boc)-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: Nepsilon-Boc-L-lysine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Lys(Boc)-OH
H-Lys(Boc)-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 2418-95-3. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C11H22N2O4. US Biological Life Sciences.
Nε,Nε,Nε-Trimethyllysine hydrochloride is a non-protein amino acid active in the biosynthesis of carnitine. Synonyms: Lys(Me)3-OH Chloride; (S)-5-Amino-5-carboxy-N,N,N-trimethylpentan-1-aminium chloride; Nε,Nε,Nε-Trimethyllysine hydrochloride. CAS No. 55528-53-5. Molecular formula: C9H21ClN2O2. Mole weight: 224.73.
H-Lys-Phe-Glu-Arg-Gln-OH
H-Lys-Phe-Glu-Arg-Gln-OH plays a broad role in targeting protein-enhanced degradation. Synonyms: L-Glutamine, L-lysyl-L-phenylalanyl-L-α-glutamyl-L-arginyl-; H-KFERQ-OH; L-lysyl-L-phenylalanyl-L-alpha-glutamyl-L-arginyl-L-glutamine. Grades: ≥95%. CAS No. 115084-19-0. Molecular formula: C31H50N10O9. Mole weight: 706.79.
H-Lys-phe-gly-lys-oh
Heterocyclic Organic Compound. Alternative Names: H-LYS-PHE-GLY-LYS-OH ACETATE SALT;H-LYS-PHE-GLY-LYS-OH ACOH;H-Lys-Phe-Gly-Lys-OH. CAS No. 114577-12-7. Molecular formula: C23H38N6O5. Mole weight: 538.64. Catalog: ACM114577127.
H-Lys-Pro-OH has the potential as a very promising healing agent in ulcer therapy. Synonyms: Lysylproline; Lys-pro; Lysyl-Proline; L-lysyl-L-proline; KP dipeptide; Lysine Proline dipeptide; L-Proline, L-lysyl-. CAS No. 52766-27-5. Molecular formula: C11H21N3O3. Mole weight: 243.30.