A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
L-Arginine beta-naphthylamide hydrochloride. Group: Biochemicals. Alternative Names: Arginine-bNA·HCl. Grades: Highly Purified. CAS No. 18905-73-2. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
L-Arginine b-naphthylamide hydrochloride 99+%
L-Arginine b-naphthylamide hydrochloride 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 18905-73-2. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
L-Arginine butanoate
L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-(+)-Arginine butanoate. CAS No. 80407-72-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0455D.
L-Arginine-[d7,15N4] hydrochloride
L-Arginine-[d7,15N4] hydrochloride is the labelled analogue of L-Arginine hydrochloride. L-Arginine hydrochloride is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. Protein supplement in health care products. Synonyms: L-Arginine-d7,15N4 hydrochloride; L-Arginine-d7,15N4 HCl. Grade: 98% by CP; 98% atom D; 98% atom 15N. Molecular formula: C6H8D7Cl[15N]4O2. Mole weight: 221.68.
L-Arginine-[d7] Hydrochloride
L-Arginine-[d7] Hydrochloride is a labelled L-Arginine HCl. Arginine is an essential amino acid that can prevent heart and circulatory diseases, fatigue, as well as stimulate the immune system. Synonyms: L-Arginine D7 Hydrochloride; L-Arginine-2,3,3,4,4,5,5-d7 hydrochloride. Grade: 95% by HPLC; 98% atom D. CAS No. 204244-77-9. Molecular formula: C6H7D7N4O2.HCl. Mole weight: 217.71.
L-Arginine ethyl ester dihydrochloride
L-Arginine Ethyl Ester Dihydrochloride is a derivative of L-Arginine, an essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function). Synonyms: L-Arg-OEt 2HCl; (S)-Ethyl 2-amino-5-guanidinopentanoate dihydrochloride; H-Arg-Oet 2HCl; ethyl(2S)-2-amino-5-(diaminomethylideneamino)pentanoate,dihydrochloride; Arg-Oet 2HCl; L-Arginine Ethyl Ester Dihydrochloride. Grade: ≥ 98% (NMR). CAS No. 36589-29-4. Molecular formula: C8H18N4O2·2HCl. Mole weight: 275.20.
Arginine (abbreviated as Arg or R) encoded by the codons CGU, CGC, CGA, CGG, AGA, and AGG is an ?-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated -+NH3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated -COO- form under biological conditions), and a side chain of a 3-carbon aliphatic straight chain capped by a complex guanidinium, classifying it as a charged (at physiological pH), aliphatic amino acid. Arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Group: Biochemicals. Alternative Names: 2-Amino-5-guanidinopentanoic acid; L-(+)-Arginine; L-Arg; H-Arg-OH. Grades: Cell Culture Grade. CAS No. 74-79-3. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H14N4O2, Molecular Weight: 174.2. US Biological Life Sciences.
Worldwide
L-Argininefrom non-animal source
L-Argininefrom non-animal source. Uses: L-arginine has been used: as a roswell park memorial institute medium (rpmi) media component in the isolation and culture of peripheral blood mononuclear cells (pbmcs) as a rpmi media component for tissue culture in dmem medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (silac) and lcms/ms. Additional or Alternative Names: (S)-2-Amino-5-guanidinopentanoic acid. Product Category: Amino Acids. CAS No. 74-79-3. Molecular formula: H2NC(=NH)NH(CH2)3CH(NH2)CO2H. Mole weight: 174.2. Canonical SMILES: N[C@@H](CCCNC(N)=N)C(O)=O. ECNumber: 200-811-1. Product ID: ACM74793-4. Alfa Chemistry ISO 9001:2015 Certified.
L-Arginine, ≥99.5% (NT)
L-Arginine, ≥99.5% (NT). Uses: Peptide synthesis. Additional or Alternative Names: (S)-2-Amino-5-guanidinopentanoic acid. Product Category: Amino Acids. CAS No. 74-79-3. Molecular formula: H2NC(=NH)NH(CH2)3CH(NH2)CO2H. Mole weight: 174.2. Canonical SMILES: N[C@@H](CCCNC(N)=N)C(O)=O. ECNumber: 200-811-1. Product ID: ACM74793-2. Alfa Chemistry ISO 9001:2015 Certified.
L-Arginine-(guanidineimino-15N2) hydrochloride
98 atom % 15N, 98% (CP). Group: Fluorescence/luminescence spectroscopy.
L-Arginine-[guanido-13C] hydrochloride
L-Arginine-[guanido-13C] hydrochloride is the labelled analogue of L-Arginine hydrochloride. L-Arginine hydrochloride is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. Protein supplement in health care products. Synonyms: L-Arginine (guanido-13C) HCl. Grade: 98% by CP; 99% atom 13C. CAS No. 94740-43-9. Molecular formula: C5[13C]H15ClN4O2. Mole weight: 211.65.
L-Arginine-guanido-15N2HCl
L-Arginine-guanido-15N2HCl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-Arginine-guanido-15N2HCl;L-Arginine-guanido-15N2Cl. Product Category: Heterocyclic Organic Compound. CAS No. 204633-92-1. Molecular formula: H*N=CNH(*NH2)(CH2)3-CH(NH2)COOH?Cl. Product ID: ACM204633921. Alfa Chemistry ISO 9001:2015 Certified.
L-Arginine-[guanido-15N2] hydrochloride
L-Arginine-[guanido-15N2] hydrochloride is a labelled salt of L-Arginine. Arginine is an essential amino acid found at active site of proteins and enzymes. It has the potential to treat heart and circulatory diseases. Grade: 98% by HPLC; 98% atom 15N. CAS No. 204633-92-1. Molecular formula: C6H14N2[15N]2O2.HCl. Mole weight: 212.65.
L-Arginine HCI
L-Arginine HCI. CAS No: 1119-34-2
Sarchem Laboratories New Jersey NJ
L-Arginine HCl
Arginine HCl. CAS No. 1119-34-2. Categories: l-arginine hydrochloride.
1kg Pack Size. Group: Amino Acids. Formula: C6H14N4O2 ·HCl. CAS No. 1119-34-2. Prepack ID 33349826-1kg. Molecular Weight 210.66. See USA prepack pricing.
L-Arginine hydrochloride
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-(+)-Arginine hydrochloride. CAS No. 1119-34-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N0455A.
L-Arginine hydrochloride
L-Arginine hydrochloride is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. Protein supplement in health care products. Uses: Ingredient of health care products. Synonyms: Arginine Hydrochloride; L-Arginine monohydrochloride; L-Arginine HCl; H-Arg-OH.HCl; (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid hydrochloride. Grade: 98%. CAS No. 1119-34-2. Molecular formula: C6H15ClN4O2. Mole weight: 210.662.
L-Arginine Hydrochloride
An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function). Group: Biochemicals. Alternative Names: L-Arginine Monohydrochloride; Argamine; Arginine Hydrochloride; Arginine Monochloride; Arginine Monohydrochloride; Argivene; Detoxargin; L-(+)-Arginine Monohydrochloride; Levargin; Minophagen A; NSC 203450; NSC 7914; R-Gene. Grades: Cell Culture Grade. CAS No. 1119-34-2. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: C?H??ClN?O?, Molecular Weight: 210.66. US Biological Life Sciences.
Worldwide
L-Arginine hydrochloride 99+%
L-Arginine hydrochloride 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 1Kg, 2.5Kg, 10Kg. US Biological Life Sciences.
Worldwide
L-Arginine hydrochloride, Cell Culture Grade
500g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Peptide Reagents. Formula: C6H14N4O2 · HCl. CAS No. 1119-34-2. Prepack ID 90027624-500g. Molecular Weight 210.66. See USA prepack pricing.
L-Arginine hydrochloride solution
100 mM amino acid in 0.1 M HCl, analytical standard. Group: Amino acid, peptide & protein standards.
Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.11.34, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine. Group: Enzymes. Synonyms: VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Enzyme Commission Number: EC 1.14.11.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0660; L-arginine hydroxylase; EC 1.14.11.41; VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Cat No: EXWM-0660.
L-Arginine IP/BP/EP/USP
L-Arginine IP/BP/EP/USP. CAS No. 74-79-3. Molecular formula: C6H14N4O2.
L-Arginine L-aspartate
L-Arginine L-aspartate. Group: Biochemicals. Grades: Highly Purified. CAS No. 7675-83-4. Pack Sizes: 1g, 2g, 5g, 10g. Molecular Formula: C6H14N4O2·C4H7NO4. US Biological Life Sciences.
Worldwide
L Arginine L Aspartate BP/EP
L Arginine L Aspartate BP/EP. CAS No. 7675-83-4. Molecular formula: C10H21N5O6.
L-Arginine-L-glutamate
L-Arginine-L-glutamate. Group: Biochemicals. Grades: Highly Purified. CAS No. 4320-30-3. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
L-Arginine,l-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-Leucyl-L-histidyl-L-Leucyl-L-valyl-l-lysyl-l-arginyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (SER76,ARG86,87)-ACC-ALPHA (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER76,ARG86,87)-ACETYL-COA CARBOXYLASE 1 (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER77,ARG87,88)-ACC-ALPHA (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE);(SER77,ARG87,88)-ACETYL-COA CARBO. Product Category: Heterocyclic Organic Compound. CAS No. 125911-68-4. Molecular formula: C74H131N29O18S2. Mole weight: 1779.15. Purity: >95%. Product ID: ACM125911684. Alfa Chemistry ISO 9001:2015 Certified.
L-Arginine methyl ester is a protected form of L-Arginine. L-Arginine is a conditionally essential amino acid for humans and adult mammals as its requirements exceed production during certain developmental stages in life (such as pregnancy). L-Arginine also prevents blood toxicity from intravenous amino acid administration in humans. Synonyms: L-Arginine, methyl ester, hydrochloride (1:2); L-Arginine, methyl ester, dihydrochloride; Arginine, methyl ester, dihydrochloride, L-; Arginine methyl ester dihydrochloride; Methyl (2S)-2-amino-5-guanidinopentanoate dihydrochloride; Methyl L-arginine dihydrochloride; N-α-L-Arginine methyl ester dihydrochloride. Grade: ≥95%. CAS No. 26340-89-6. Molecular formula: C7H16N4O2.2HCl. Mole weight: 261.15.
L-Arginine, reagent grade, ≥98%. Uses: L-arginine has been used to study non-enzymatic gluconeogenesis.it has also been used to study the effects of l-arginine supplementation on kidney and liver injury in rats with myocardial infarction. Additional or Alternative Names: (S)-2-Amino-5-guanidinopentanoic acid. Product Category: Amino Acids. CAS No. 74-79-3. Molecular formula: H2NC(=NH)NH(CH2)3CH(NH2)CO2H. Mole weight: 174.2. Canonical SMILES: N[C@@H](CCCNC(N)=N)C(O)=O. ECNumber: 200-811-1. Product ID: ACM74793-3. Alfa Chemistry ISO 9001:2015 Certified.
L-arginine-specific L-amino acid ligase
The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline. Group: Enzymes. Synonyms: RizA; L-amino acid ligase RizA. Enzyme Commission Number: EC 6.3.2.48. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5766; L-arginine-specific L-amino acid ligase; EC 6.3.2.48; RizA; L-amino acid ligase RizA. Cat No: EXWM-5766.
L-Arginine (Standard)
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 74-79-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0455R.
L-Arginine-tert-butyl ester dihydrochloride
L-Arginine tert-butyl ester is a protected form of L-Arginine. L-Arginine is a conditionally essential amino acid for humans and adult mammals as its requirements exceed production during certain developmental stages in life (such as pregnancy). L-Arginine also prevents blood toxicity from intravenous amino acid administration in humans. Synonyms: L-Arg-OtBu 2HCl; H-Arg-OtBu 2HCl; L-Arginine t-butyl ester dihydrochloride. Grade: ≥ 98% (TLC). CAS No. 87459-72-1. Molecular formula: C10H22N4O2·2HCl. Mole weight: 303.30.
L-Arginine-tert-butyl ester dihydrochloride
L-Arginine-tert-butyl ester dihydrochloride. Group: Biochemicals. Alternative Names: L-Arg-OtBu·2HCl. Grades: Highly Purified. CAS No. 87459-72-1. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
L-argininosuccinic acid-[arginine-13C6,15N4] barium salt dihydrate
L-argininosuccinic acid-[arginine-13C6,15N4] barium salt dihydrate is a labelled analogue of L-Argininosuccinic acid. Argininosuccinic acid is formed from citrulline, aspartate and ATP in the urea cycle. Synonyms: L-argininosuccinic acid barium salt dihydrate (arginine-13C6,15N4). Grade: 90% by CP; 99% atom 13C; 99% atom 15N. Molecular formula: C4[13C]6H16Ba[15N]4O6.2H2O. Mole weight: 471.54.
L-Arg-Pro-pNA
Substrate for Dipeptidyl peptidase IV. Synonyms: L-Arginyl-L-proline 4-nitroanilide. Grade: ≥ 98% (TLC). CAS No. 112898-06-3. Molecular formula: C17H25N7O4. Mole weight: 391.43.
L-Arg-Pro-pNA
L-Arg-Pro-pNA. Group: Biochemicals. Alternative Names: L-Arginyl-L-proline 4-nitroanilide. Grades: Highly Purified. CAS No. 112898-06-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg. US Biological Life Sciences.
Worldwide
L-Arg-Pro-pNA 98+% (TLC)
L-Arg-Pro-pNA 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 50mg. US Biological Life Sciences.
Worldwide
Lariatin A
Peptide with lasso structure. Antimycobacterial. Group: Biochemicals. Grades: Highly Purified. CAS No. 732286-09-8. Pack Sizes: 250ug, 1mg. Molecular Formula: C94H143N27O25. US Biological Life Sciences.
Worldwide
Lariatin A
Lariatin A is an antimycobacterial lasso peptide isolated from Rhodococcus jostii. Lariains A has inhibitory effect on the growth of Mycobacterium smegmatis with MIC value of 3.13 mg/ml in agar dilution method. Synonyms: Peptide K01-B0171-B; N(1)Gly-Ser-Gln-Leu-Val-Tyr-Arg-Glu(1)-Trp-Val-Gly-His-Ser-Asn-Val-Ile-Lys-Pro-OH; L-Proline, glycyl-L-seryl-L-glutaminyl-L-leucyl-L-valyl-L-tyrosyl-L-arginyl-L-α-glutamyl-L-tryptophyl-L-valylglycyl-L-histidyl-L-seryl-L-asparaginyl-L-valyl-L-isoleucyl-L-lysyl-, (8→1)-lactam. Grade: ≥95%. CAS No. 732286-09-8. Molecular formula: C94H143N27O25. Mole weight: 2051.31.
Lariatin B
Lariatin B is an antibacterial peptide isolated from Rhodococcus jostii K01-B0171. It has activity against gram-positive bacteria. Synonyms: Gly-Ser-Gln-Leu-Val-Tyr-Arg-Glu-Trp-Val-Gly-His-Ser-Asn-Val-Ile-Lys-Gly-Pro-Pro. Grade: 95.2%. Molecular formula: C101H153N29O27. Mole weight: 2205.51.
Lariciresinol
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity ( IC 50 of 6.97 μM; K i of 0.046 μM). Lariciresinol dereases Bcl-2 , upregulates Bax and induces Apoptosis ?Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 27003-73-2. Pack Sizes: 1 mg. Product ID: HY-N3405.
Laricitrin
Laricitrin. Group: Biochemicals. Grades: Highly Purified. CAS No. 53472-37-0. Pack Sizes: 2mg, 5mg. US Biological Life Sciences.
Larixyl acetate is a potent and selective TRPC6 inhibitor with IC 50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP , respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 4608-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101795.
Larixyl Acetate
Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (Αs,1S,4S,4As,8Ar)-4-(Acetyloxy)-Α-Ethenyldecahydro-Α,5,5,8A-Tetramethyl-2-Methylene-1-Naphthalenepropanol. Product Category: Inhibitors. CAS No. 4608-49-5. Molecular formula: C22H36O3. Mole weight: 348.52. Purity: 0.9621. Canonical SMILES: CC(=O)OC1CC(=C)C([C@]2(C1C(CCC2)(C)C)C)CCC(C)(C=C)OC(=O)C. Product ID: ACM4608495. Alfa Chemistry ISO 9001:2015 Certified.
Laropal A 81
Laropal A 81 - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
Laropiprant
Laropiprant is a potent and selective DP receptor antagonist with K i values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0524. CAS No. 571170-77-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50175.
Laropiprant-[d4]
Laropiprant-[d4] is the labelled analogue of Laropiprant. Laropiprant is a medication for the treatment of dyslipidemia commonly used together with niacin, which can reduce LDL-C and raise HDL-C. Synonyms: Laropiprant D4. Grade: 95% by HPLC; 95% atom D. CAS No. 1132664-22-2. Molecular formula: C21H15D4ClFNO4S. Mole weight: 439.92.
Larotaxel
Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS. Group: Biochemicals. Alternative Names: (αR. Grades: Highly Purified. CAS No. 156294-36-9. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Larotaxel
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XRP9881. CAS No. 156294-36-9. Pack Sizes: 1 mg. Product ID: HY-125374.
Larotrectinib
Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-101; ARRY-470. CAS No. 1223403-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12866.
LarotrectinibLOXO-101, ARRY-470
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase, demonstrating high selectivity exclusively for the TRK family of receptors (IC50s = 2-20 nM). CAS No. 1223403-58-4. Product ID: API1223403584. Molecular formula: C21H22F2N6O2. Mole weight: 428.44. SMILES: C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F. Category: Anti-Tumor APIs.
Larotrectinib sulfate
Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-101 sulfate; ARRY-470 sulfate. CAS No. 1223405-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12866A.
Larotrectinib Sulfate (ARRY 470, LOXO 101)
A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma,...odels. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons. Group: Biochemicals. Alternative Names: (3S) -N- [5- [ (2R) -2- (2, 5-Difluorophenyl) -1-pyrrolidinyl] pyrazolo [1, 5-a] pyrimidin-3-yl] -3-hydroxy-1-pyrrolidinecarboxamide ; ARRY 470; LOXO 101; Vitrakvi.; (S) -N- (5- ( (R) -2- (2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo[1, 5-a]pyrimidin-3-yl) -3-hydroxypyrrolidine-1-carboxamide Sulfate. CAS No. 1223405-08-0. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??F?N?O? H?O?S. US Biological Life Sciences.