A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
L-a-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol, a lipid-based molecule utilized in the biomedicine sector, presents as an intriguing compound due to its neuroprotective characteristics. Its efficacy in improving cognitive function and reducing brain inflammation positions it potentially as a therapeutic agent in Alzheimer's and other neurodegenerative diseases. CAS No. 62742-56-7. Molecular formula: C41H79O13P. Mole weight: 811.03.
L-A-PHOSPHATIDYLCHOLINE, B-*DOCOSAHEXAENOYL-GAMMA-ST. CAS No. 117179-07-4. Molecular formula: C48H84NO8P. Catalog: ACM117179074.
L-a-Phosphatidylinositol from Soy bean
L-a-Phosphatidylinositol from Soybean, a naturally occurring phospholipid, boasts a plethora of biomedical applications as it serves as a potent therapeutic agent for an array of ailments including but not limited to cardiovascular diseases, metabolic disorders, and cancer. This compound, with its anti-inflammatory properties, facilitates insulin signaling pathways and preserves cell membranes, hence promoting optimal brain function. The manifold benefits of this compound are a testimony to its profound therapeutic potential. Synonyms: 1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol); Phosphatidylinositols,soya; L-alpha-Phosphatidylinositol from Glycine max (soybean). CAS No. 97281-52-2. Molecular formula: C45H87O13P. Mole weight: 867.1.
L-Apiose
L-Apiose is an organic chemical constituent derived from botanical sources, exhibiting auspicious prospects within the realm of biomedical research and medicinal development. Its multifaceted properties render it a sought-after resource for the design and formulation of pharmacoresearchs targeting an array of afflictions such as neoplastic ailments, metabolic dysfunction and cardiovascular anomalies. CAS No. 6477-44-7. Molecular formula: C5H10O5. Mole weight: 150.13.
Lapis-GlcUA-Ac
Lapis-GlcUA-Ac, a paramount compound extensively employed in the biomedical sphere, assumes a pivotal function in the advancement of therapeutics for a myriad of ailments, encompassing distinct cancer forms and inflammatory disorders. Distinctive attributes inherent in this product endow it with the potential for a propitious prospect in drug exploration and precise intervention. Molecular formula: C23H24BrNO11. Mole weight: 570.34.
Lappaconitine
Lappaconitine. Group: Biochemicals. Grades: Plant Grade. CAS No. 32854-75-4. Pack Sizes: 20mg. Molecular Formula: C32H45N2O8, Molecular Weight: 585.71. US Biological Life Sciences.
Worldwide
Lappaconitine
Lappaconitine, extracted form the roots of Aconitum carmichaeli Debx, has neurotoxic, cardiotoxic and strong analgesic activities that does not involve the opioid receptor, and further suggest that the central nervous system may be involved in the action. Synonyms: (+)-Lappacontine; Acetyl-10-deoxysepaconitine; Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-. Grades: >98%. CAS No. 32854-75-4. Molecular formula: C32H44N2O8. Mole weight: 584.70.
Lappaconitine Hydrobromide
Lappaconitine Hydrobromide. Group: Biochemicals. Grades: Highly Purified. CAS No. 97792-45-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Laquinimod
Laquinimod, also known as, is an experimental immunomodulator developed by Active Biotech and Teva. It is being investigated as an oral treatment for multiple sclerosis (MS). Laquinimod is the successor of Active Biotech's failed experimental immunomodulator linomide. Laquinimod seems to be able to reduce the MS disease activity on MRI. In 2011, Teva announced its clinical trials involving laquinimod had failed, being unable to significantly reduce relapses into MS among patients beyond a placebo. However, the final results of above-mentioned phase III trial proved oral laquinimod administered once daily slowed the progression of disability and reduced the rate of relapse in patients with relapsing-remitting multiple sclerosis. Synonyms: Laquinimod; ABR 215062; ABR215062; ABR-215062. ABR-215062; SAIK-MS; TV-5600; TV5600; TV 5600. CAS No. 248281-84-7. Molecular formula: C19H17ClN2O3. Mole weight: 356.8.
Laquinimod
Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABR-215062. CAS No. 248281-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13010.
Laquinimod
A potent immunomodulator. Also displays anti-inflammatory properties. Group: Biochemicals. Alternative Names: 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide. Grades: Highly Purified. CAS No. 248282-07-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
L-Arabinaric acid dipotassium salt
L-Arabinaric acid dipotassium salt is an indispensable compound used for studying drug-resistant microbial invasions and pernicious proliferation of malignant cells. Synonyms: Dipotassium L-arabinarate; Dipotassium L-lyxarate. CAS No. 608-54-8. Molecular formula: C5H6K2O7. Mole weight: 256.29.
L-Arabinitol
L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency. Uses: Scientific research. Group: Natural products. CAS No. 7643-75-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-W040141.
L-(-)-Arabinitol
25g Pack Size. Group: Aroma Chemicals, Biochemicals, Building Blocks, Carbohydrates. Formula: C5H12O5. CAS No. 7643-75-6. Prepack ID 25675490-25g. Molecular Weight 152.15. See USA prepack pricing.
L-arabinitol 2-dehydrogenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arabinitol:NAD+ 2-oxidoreductase (L-ribulose-forming). Other names in common use include L-arabinitol dehydrogenase (ribulose-forming), and L-arabinitol (ribulose-forming) dehydrogenase. This enzyme participates in pentose and glucuronate interconversions. Group: Enzymes. Synonyms: L-arabinitol dehydrogenase (ribulose-forming); L-arabinitol (ribulose-forming) dehydrogenase. Enzyme Commission Number: EC 1.1.1.13. CAS No. 9028-20-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0033; L-arabinitol 2-dehydrogenase; EC 1.1.1.13; 9028-20-0; L-arabinitol dehydrogenase (ribulose-forming); L-arabinitol (ribulose-forming) dehydrogenase. Cat No: EXWM-0033.
L-arabinitol 4-dehydrogenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming). Other names in common use include pentitol-DPN dehydrogenase, and L-arabitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions. Group: Enzymes. Synonyms: pentitol-DPN dehydrogenase (ambiguous); L-arabitol dehydrogenase. Enzyme Commission Number: EC 1.1.1.12. CAS No. 9028-19-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0023; L-arabinitol 4-dehydrogenase; EC 1.1.1.12; 9028-19-7; pentitol-DPN dehydrogenase (ambiguous); L-arabitol dehydrogenase. Cat No: EXWM-0023.
L-Arabinitol (Standard)
L-Arabinitol (Standard) is the analytical standard of L-Arabinitol. This product is intended for research and analytical applications. L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency. Uses: Scientific research. Group: Natural products. CAS No. 7643-75-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W040141R.
L-arabinokinase
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-arabinose 1-phosphotransferase. This enzyme is also called L-arabinokinase (phosphorylating). This enzyme participates in nucleotide sugars metabolism. Group: Enzymes. Synonyms: L-arabinokinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.46. CAS No. 37277-99-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3076; L-arabinokinase; EC 2.7.1.46; 37277-99-9; L-arabinokinase (phosphorylating). Cat No: EXWM-3076.
L-arabinonate dehydratase
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in ascorbate and aldarate metabolism. Group: Enzymes. Synonyms: L-arabonate dehydrase; L-arabonate dehydratase; L-arabinonate hydro-lyase. Enzyme Commission Number: EC 4.2.1.25. CAS No. 9024-30-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5017; L-arabinonate dehydratase; EC 4.2.1.25; 9024-30-0; L-arabonate dehydrase; L-arabonate dehydratase; L-arabinonate hydro-lyase. Cat No: EXWM-5017.
L-arabinonolactonase
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is L-arabinono-1,4-lactone lactonohydrolase. This enzyme participates in ascorbate and aldarate metabolism. Group: Enzymes. Enzyme Commission Number: EC 3.1.1.15. CAS No. 9025-95-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3442; L-arabinonolactonase; EC 3.1.1.15; 9025-95-0. Cat No: EXWM-3442.
L-?Arabinopyranose
L-Arabinopyranose is a sugar molecule widely used in the biomedical industry. It serves as a building block in the synthesis of various drugs targeting metabolic disorders, such as diabetes. This product plays a crucial role in the development of therapeutic interventions aimed at regulating blood sugar levels and managing glucose metabolism associated with these diseases. Synonyms: Pectinose; L-Arabinopyranose. CAS No. 87-72-9. Molecular formula: C5H10O5. Mole weight: 150.13.
L-Arabinopyranosyl thiosemicarbazide
L-Arabinopyranosyl thiosemicarbazide is a remarkable compound with anticancer properties. It displays impressive efficacy in impeding the proliferation of select cancer cells. Synonyms: L-Arabinose (aminothioxomethyl)hydrazone; N-L-arabinopyranosyl-hydrazinecarbothioamide. CAS No. 262849-63-8. Molecular formula: C6H13N3O4S. Mole weight: 223.25.
L-Arabinose
L-Arabinose. Categories: ara; arabinopyranose.
CA, FL & NJ
L-Arabinose
L-Arabinose is a natural sugar used in the biomedicine industry. It is commonly utilized in various pharmaceutical formulations to enhance drug delivery systems. It holds potential for treating metabolic disorders like diabetes, as it assists in regulating blood glucose levels. Additionally, L-Arabinose demonstrates antimicrobial properties and is being investigated for its role in combating bacterial infections. Synonyms: L-(+)-Arabinose; (2R,3S,4S)-2,3,4,5-tetrahydroxypentanal. CAS No. 5328-37-0. Molecular formula: C5H10O5. Mole weight: 150.13.
L-Arabinose
L(+)-Arabinose is a pentose monosaccharide whose transcription is regulated by Ara-C proteins and is a substrate for L-arabinose dehydrogenase, galactose dehydrogenase. It is not fermented by yeast. Used as a one-way or reversible switch for protein expression. It is also used to make arabinosyl nucleosides. L-Arabinose is used as a substrate to identify, differentiate and characterize pentose sugar isomerase(s). L-Arabinose is used in the bioproduction of L-ribose. L-Arabinose is the naturally occurring isomer and is a constituent of plant polysaccharides. Most bacteria contain an inducible arabinose operon that codes for a series of enzymes and transporters that allows L-arabinose to be used as the sole carbon source in microbial culture. Group: Biochemicals. Alternative Names: Beta-L-Arabinopyranose; Beta-L-(+)-ARABINOSE; L-(+)-Arabinose; Pectinose; Arabitol, L-(-)-(RG); L-Arabinopyranose; (2R,3R,4S,5S)-oxane-2,3,4,5-tetrol. Grades: Reagent Grade. CAS No. 87-72-9. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula:?C5H10O5 , Molecular Weight:?150.13. US Biological Life Sciences.
Worldwide
L-(+)Arabinose
1.L-arabinose can be used as a sucrose enzyme inhibitor to lower the Glycaemic Index(GI) of sucrose containing products 2.L-arabinose can be used in developing antiviral agents such as nucleoside analogues 3.L-arabinose can be used in various foods (except foods for infants or young children) 4.L-arabinose can be used as raw material for the synthesis of fine chemicals as well as pharmaceutical intermediate 5.L-arabinose can be used in preparing bacterial medium in biological industry 6.L-arabinose can be used in the synthesis of flavours. Group: Material of health food. CAS No. 87-72-9. Molecular formula: C5H10O5. Mole weight: 150.13. Appearance: White crystalline powder. Catalog: ACM87729.
L-(+)-Arabinose
L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a noncompetitive manner and suppresses the plasma glucose increase due to sucrose ingestion. Uses: Scientific research. Group: Natural products. CAS No. 5328-37-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W015611.
L-(+)-Arabinose
100g Pack Size. Group: Sugars. Formula: C5H10O5. CAS No. 87-72-9. Prepack ID 12030733-100g. Molecular Weight 150.13. See USA prepack pricing.
L(+)-Arabinose
100g Pack Size. Group: Biochemicals, Carbohydrates. Formula: C5H10O5. CAS No. 5328-37-0. Prepack ID 84794515-100g. Molecular Weight 150.13. See USA prepack pricing.
L-arabinose 1-dehydrogenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arabinose:NAD+ 1-oxidoreductase. This enzyme participates in ascorbate and aldarate metabolism. Group: Enzymes. Enzyme Commission Number: EC 1.1.1.46. CAS No. 9028-52-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0331; L-arabinose 1-dehydrogenase; EC 1.1.1.46; 9028-52-8. Cat No: EXWM-0331.
L-arabinose 1-dehydrogenase [NAD(P)+]
The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP+ over NAD+. In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose. Group: Enzymes. Synonyms: L-arabino-aldose dehydrogenase. Enzyme Commission Number: EC 1.1.1.376. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0294; L-arabinose 1-dehydrogenase [NAD(P)+]; EC 1.1.1.376; L-arabino-aldose dehydrogenase. Cat No: EXWM-0294.
L-Arabinose-2-13C
L-Arabinose-2-13C. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C413CH10O5, Molecular Weight: 151.12. US Biological Life Sciences.
Worldwide
L-Arabinose-BSA
L-Arabinose diethyldithioacetal
L-Arabinose diethyldithioacetal is a biomedical product utilized for various purposes in the industry. This compound is studied for its potential therapeutic applications in cancer treatment, particularly in combination with certain anti-tumor drugs. Its unique structure and properties make L-Arabinose diethyldithioacetal a promising candidate for targeted drug delivery systems and enhancing the efficacy of existing cancer medications. CAS No. 43179-48-2. Molecular formula: C9H20O4S2. Mole weight: 256.38.
L-Arabinose hydrazone
L-Arabinose hydrazone is a valuable compound employed in the biomedical industry. It exhibits promising potential in the treatment of certain diseases and drug development. Through its effective binding properties, L-Arabinose hydrazone assists in targeting and combating specific drug compounds or diseases, offering potential therapeutic benefits. Synonyms: L-Arabinose, hydrazone(9CI); (2S,3R,4S,5E)-5-hydrazinylidenepentane-1,2,3,4-tetrol. CAS No. 816-01-3. Molecular formula: C5H10N2O4. Mole weight: 162.14.
L-arabinose isomerase
Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism. The enzyme can also convert D-galactose to D-tagatose with lower efficiency. Group: Enzymes. Synonyms: L-arabinose ketol-isomerase; araA (gene name). Enzyme Commission Number: EC 5.3.1.4. CAS No. 9023-80-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5475; L-arabinose isomerase; EC 5.3.1.4; 9023-80-7; L-arabinose ketol-isomerase; araA (gene name). Cat No: EXWM-5475.
L-Arabinose - Syrup
L-Arabinose - Syrup is a superior biomedicalcompound, aiding in studying the relentless menace of diabetes.
L-Arabitol
L-Arabitol is a prominent pharmaceutical compound, used for studying an array of diseases, ranging from the pervasive diabetes mellitus and dental caries to the formidable nemesis of cancer. It functions as a pivotal additive in drug formulations. Synonyms: L-Arabinitol. CAS No. 7643-75-6. Molecular formula: C5H12O5. Mole weight: 152.15.
L-Arabonic acid-1,4-lactone
L-Arabonic acid-1,4-lactone, a widely-utilized biomedical compound in the pharmaceutical sector, plays a crucial role as a precursor for synthesizing diverse drugs ranging from antiviral agents to anticancer treatments. Synonyms: L-Arabino-1,4-lactone; L-arabinonic acid gamma-lactone; (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one. Grades: ≥95%. CAS No. 51532-86-6. Molecular formula: C5H8O5. Mole weight: 148.11.
L(-)-Arabonic acid calcium salt tetrahydrate
L(-)-Arabonic acid calcium salt tetrahydrate is a significant compound functioning as a pivotal intermediate in the synthesis of pharmaceutical drugs aimed at studying diabetes, cancer and cardiovascular disorders. Through its ability to regulate glucose metabolism, hinder tumor growth and enhance cardiac well-being, its efficacy has been meticulously examined and extensively recorded. Consequently, it stands as an invaluable component within the realms of biomedical research and drug advancement. Synonyms: Calcium-L(-)-arabonate.
Larazotide
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection. Group: Inhibitors. Alternative Names: larazotide;Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine;Unii-zn3R5560zv. CAS No. 258818-34-7. Molecular formula: C32H55N9O10. Mole weight: 725.83. Density: 1.254. Catalog: ACM258818347.
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 258818-34-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-106268.
Larazotide acetate
Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection. Uses: Scientific research. Group: Peptides. CAS No. 881851-50-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106268A.
Larazotide acetate
Larazotide acetate is a tight junction regulator and reverses leaky junctions to their normally closed state. Synonyms: H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH.CH3CO2H. Grades: 98%. CAS No. 881851-50-9. Molecular formula: C34H59N9O12. Mole weight: 785.9.
Larch arabinogalactan
Larch arabinogalactan is extracted from the heartwood of the western larch Larix occidentalis. These arabinogalactans have a backbone of (1-3)-linked β-D-galactopyranosyl units each of which contain a side chain at position C-6. Most of these side chains are galactobiosyl units containing a (1-6)-β-D-linkage. Another side chain type that occurs is a single L-arabinofuranose unit or 3-O-(β-L-arabinopyranosyl)-α-L-arabinofuranosyl units. Arabinogalactans are used as emulsifiers, stabilizers and adhesives in the food, pharmaceutical and cosmetic industries. Synonyms: Galactoarabinan; 9036-66-2; ARABINOGALACTAN; (+)-Arabinogalactan; (+)-Arabinogalactan from Larch Wood,; 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol; D-Galacto-L-arabinan; Larch arabinogalactan; DTXSID90864173; SATHPVQTSSUFFW-UHFFFAOYSA-N; YL29121; FT-0604415; E80438; B1999-382163; 3-O-Methylpentopyranosyl-(1->6)-3-O-methylhexopyranosyl-(1->4)-2,6-anhydro-1-deoxyheptitol. Molecular formula: C20H36O14. Mole weight: 500.5.
Larch resinol. Uses: For analytical and research use. Group: Impurity standards. CAS No. 27003-73-2. Molecular Formula: C20H24O6. Mole Weight: 360.41. Catalog: APB27003732.
Larch Tree Berry Arabinogalactans
Larch Tree Berry Arabinogalactans.
CA, FL & NJ
L-Arg(1)-Icatibant
L-Arg(1)-Icatibant is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Synonyms: L-arginyl-L-arginyl-L-prolyl-L-hydroxyprolyl-glycyl-L-thienylalanyl-L-seryl-D-1,2,3,4-tetrahydroisoquinolyl-L-octahydroindole-L-arginine; Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH; L-Arginine, L-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-. CAS No. 193618-59-6. Molecular formula: C59H89N19O13S. Mole weight: 1304.54.
Largazole
Largazole is a novel histone deacetylase (HDAC) inhibitor. Screening against the National Cancer Institute's 60 cell lines revealed that largazole is particularly active against several colon cancer cell types. Largazole inhibits HDACs in tumor tissue in vivo. Largazole strongly stimulated histone hyperacetylation in the tumor, showed efficacy in inhibiting tumor growth, and induced apoptosis in the tumor. This effect probably is mediated by the modulation of levels of cell cycle regulators, antagonism of the AKT pathway through insulin receptor substrate 1 down-regulation, and reduction of epidermal growth factor receptor levels. Synonyms: (+)-Largazole; S-((E)-4-((12Z,22Z,24R,5S,8S)-5-isopropyl-24-methyl-3,6,10-trioxo-24,25-dihydro-7-oxa-4,11-diaza-1(4,2),2(2,4)-dithiazolacyclododecaphane-8-yl)but-3-en-1-yl) octanethioate. CAS No. 1009815-87-5. Molecular formula: C29H42N4O5S3. Mole weight: 622.86.