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| Product | Description | |
|---|---|---|
| mRNA N1-methyladenine demethylase | Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA. Group: Enzymes. Synonyms: ALKBH3. Enzyme Commission Number: EC 1.14.11.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0673; mRNA N1-methyladenine demethylase; EC 1.14.11.54; ALKBH3. Cat No: EXWM-0673. |  |
| mRNA N6-methyladenine demethylase | Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA with low activity. Group: Enzymes. Synonyms: ALKBH5; FTO. Enzyme Commission Number: EC 1.14.11.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0672; mRNA N6-methyladenine demethylase; EC 1.14.11.53; ALKBH5; FTO. Cat No: EXWM-0672. | |
| MroN I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Adenovirus-2 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 90% of the ad-2 dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. G↑CCGGC CGGCC↓G. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Micrococcus roseus N0. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1137RE. | |
| MroX I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 50% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GAANN↑NNTTC CTTNN↓NNAAG. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer W. Storage: -20°C. Form: Liquid. Source: Micrococcus roseus X. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1138RE. | |
| Mrs 1065 | Mrs 1065. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Methoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]benzopyran-5-one;MRS 1065;4-Methoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]benzopyran-5-one. Product Category: Heterocyclic Organic Compound. CAS No. 138565-05-6. Molecular formula: C20H14O4. Mole weight: 318.327. Product ID: ACM138565056. Alfa Chemistry ISO 9001:2015 Certified. Categories: MRS1065. |  |
| MRS 1191 | solid. Group: Fluorescence/luminescence spectroscopy. |  |
| MRS1220 | MRS1220. Group: Biochemicals. Alternative Names: N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide. Grades: Highly Purified. CAS No. 183721-15-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences. |  Worldwide |
| MRS1220 | MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system[1]. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183721-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103190. |  |
| MRS 1220 | solid. Group: Fluorescence/luminescence spectroscopy. | |
| MRS 1523 | MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 212329-37-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121119. | |
| MRS 1523 | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRS 1754 | MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 264622-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14121. | |
| MRS 1754 hydrate | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| MRS 1845 | ?95% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| MRS 1845 | MRS 1845. Group: Biochemicals. Grades: Purified. CAS No. 544478-19-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2159 | >98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| MRS 2179 ammonium salt hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRS2179 tetrasodium hydrate | MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC50=1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors[1][2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation[3]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101308A. | |
| MRS 2211 | MRS 2211. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2211 (2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde Sodium Salt, P2Y13 Purinergic Receptor Antagonist, MRS2211, MRS 2211, MRS-2211) | A highly selective and competitive antagonist of P2Y13 purinergic receptor (pIC50 = 5.97). Exhibits about 20-fold greater selectivity over P2Y1 and P2Y12 receptors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MRS 2219 | MRS 2219. Group: Biochemicals. Grades: Purified. CAS No. 14141-47-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2395 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| MRS 2500 tetraammonium salt | MRS 2500 tetraammonium salt. Group: Biochemicals. Alternative Names: (1R, 2S) -4-[2-[2-Iodo-6- (methylamino) -9H-purin-9-yl]-2- (phosphonooxy) bicyclo[3. 1. 0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt. Grades: Highly Purified. CAS No. 779323-43-2,630103-23-0. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C13H18N5O8P2I·4NH3. US Biological Life Sciences. | Worldwide |
| MRS 2578 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRS 2578 | MRS 2578. Group: Biochemicals. Grades: Purified. CAS No. 711019-86-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2690 | MRS 2690. Group: Biochemicals. Grades: Purified. CAS No. 15039-58-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2693 trisodium salt | MRS 2693 trisodium salt. Group: Biochemicals. Grades: Purified. CAS No. 1448858-83-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2768 tetrasodium salt | MRS 2768 tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 1047980-83-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2957 triethylammonium salt | MRS 2957 triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 1228271-30-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 3777 hemioxalate | MRS 3777 hemioxalate. Group: Biochemicals. Grades: Purified. CAS No. 1186195-57-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MRS 4062 triethylammonium salt | MRS 4062 triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 1309871-50-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRT 10 | MRT 10. Group: Biochemicals. Grades: Purified. CAS No. 330829-30-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRT-10 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRT199665 | MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPK?1/AMPK?2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456858-57-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120877. | |
| MRT-2359 | MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2803881-11-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153356. | |
| MRT67307 | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC 50 s of 160 and 19 nM, respectively [1]. MRT67307 also inhibits ULK1 and ULK2 with IC 50 s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190378-57-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13018. | |
| MRT 67307 dihydrochloride | MRT 67307 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRT67307 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRT68921 | MRT68921 is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190379-70-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100006. | |
| MRT68921 dihydrochloride | MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2080306-21-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100006A. | |
| MRT68921 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MRT-83 | MRT-83 is a potent antagonist of Smo , with an IC 50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1263131-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287. | |
| MRT-83 hydrochloride | MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359944-60-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287A. | |
| MRTX0902 | MRTX0902 is an orally active and potent SOS1 inhibitor with an IC 50 of 46 nM (WO2021127429A1; Example 12-10) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2654743-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145926. | |
| MRTX0902 | MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRTX0902; MRTX-0902; MRTX 0902. Appearance: Solid powder. CAS No. 2654743-22-1. Molecular formula: C22H24N6O. Mole weight: 388.48. Purity: >98%. IUPACName: (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido-[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile. Canonical SMILES: N#CC1=CC=CC([C@H](NC2=NN=C(C)C3=CN=C(N4CCOCC4)C=C32)C)=C1C. Product ID: ACM2654743221. Alfa Chemistry ISO 9001:2015 Certified. | |
| MRTX1133 | MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRTX1133; MRTX-1133; MRTX 1133. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2621928-55-8. Molecular formula: C33H31F3N6O2. Mole weight: 600.65. Purity: >98%. IUPACName: 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-. Canonical SMILES: OC1=CC(C2=C(F)C3=NC(OC[C@@]45CCCN4C[C@H](F)C5)=NC(N6CC(N7)CCC7C6)=C3C=N2)=C8C(C#C)=C(F)C=CC8=C1. Product ID: ACM2621928558. Alfa Chemistry ISO 9001:2015 Certified. | |
| MRTX1133 | MRTX1133 Inhibitor. Uses: Scientific use. Product Category: T9303. CAS No. 2621928-55-8. |  |
| MRTX1133 | MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2621928-55-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-134813. | |
| MRTX849 | MRTX849 Inhibitor. Uses: Scientific use. Product Category: T8369. CAS No. 2326521-71-3. | |
| MRX-1024 | MRX-1024 is a proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particlualry in instances of L-methionine deprivation, both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis. Synonyms: Methionine; D-Methionine; (R)-Methionine; NSC 45689; S-Methyl-D-homocysteine; H-D-Met-OH; (R)-2-amino-4-(methylthio)butanoic acid; D-2-Amino-4-(methylthio)butyric acid. Grade: ≥97%. CAS No. 348-67-4. Molecular formula: C5H11NO2S. Mole weight: 149.21. |  |
| MRX-2843 | MRX-2843, also known as UNC2371, is a potent and orally active MERTK and FLT3 inhibitor. MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. MRX-2843 in combination with an irreversible EGFR TKI as a novel strategy for treatment of patients with wtEGFR NSCLC. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRX-2843; MRX 2843; MRX2843; UNC2371; UNC-2371; UNC 2371; UNC2371A; UNC-2371A; UNC 2371A. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. Purity: >95%. IUPACName: (1r,4r)-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol. Canonical SMILES: O[C@H]1CC[C@H](N2C=C(C3=CC=C(CN4CCN(C)CC4)C=C3)C5=CN=C(NCCC6CC6)N=C52)CC1. Product ID: ACM1429882074. Alfa Chemistry ISO 9001:2015 Certified. | |
| MRX-2843 | MRX-2843 (UNC2371) is an orally active, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UNC2371. CAS No. 1429882-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101549. | |
| MS0015203 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MS012 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MS023 | MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1831110-54-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1992047-64-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615B. | |
| MS023 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MS049 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MS-1020 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MS-1020 | Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression. Group: Biochemicals. Alternative Names: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphthamide. Grades: Highly Purified. CAS No. 1255516-86-9. Pack Sizes: 1mg. Molecular Formula: C21H18N2O3. US Biological Life Sciences. | Worldwide |
| MS15 | MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC 50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035638-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-151613. | |
| MS170 | MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC 50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with K d s of 1.3 nM, 77 nM, and 6.5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376136-61-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145282. | |
| MS177 | MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2-PRC2 and noncanonical EZH2-cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225938-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148333. | |
| MS1943 | MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578))[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225938-17-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-133129. | |
| MS21 | MS21, a novel degrader of AKT , selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376137-05-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141807. | |
| MS 245 oxalate | MS 245 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 275363-58-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MS-275 | HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H20N4O3. US Biological Life Sciences. | Worldwide |
| MS-275 (Entinostat, SNDX-275) | Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8uM). Has no inhibitory activity towards HDAC8 (IC50>100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MS-282a | MS-282a is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 3.8 μmol/L. It has anti-gram-positive bacteria activity. Synonyms: MS-282-A. CAS No. 152158-04-8. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
| MS-282b | MS-282b is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 5.2 μmol/L. It has anti-gram-positive bacteria activity. Synonyms: MS-282-B. CAS No. 152759-50-7. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
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