A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
NLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and numerous other autoinflammatory diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2769040-91-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148187.
NLRP3-IN-18
NLRP3-IN-18 (compound 13) is a potent NLRP3 inhibitor with an IC 50 value of ≤1.0 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2769040-06-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153554.
NLRP3-IN-2
NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16673-34-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W011082.
NLRP3-IN-25
NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC 50 of 21 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2660230-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155463.
NLRP3-IN-9
NLRP3-IN-9 is an inhibitor of caspase-1 and NLRP3 ATPase activities. It acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NLRP3-IN-9; NLRP3 IN 9; NLRP3IN9; INF-4E; INF 4E; INF4E. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 88039-46-7. Molecular formula: C12H13ClO3. Mole weight: 240.68. Purity: >98%. IUPACName: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate. Canonical SMILES: C=C(C(C1=CC=CC=C1Cl)O)C(OCC)=O. Product ID: ACM88039467. Alfa Chemistry ISO 9001:2015 Certified. Categories: NLRP3 inflammasome.
NLS-Cas9-D10A Nickase
NLS-Cas9-D10A Nickase. Nls-cas9-d10a nickase is a mutation form of cas9 nuclease which makes one active domain deactivated, thus it can only cut one single strand dna that is complementary to the guide-rna, producing one single strand cut. combined with two different grna, nls-cas9-d10a nickase produces two cut sites respectively and causes a double strand break. compared with the wild type cas9 nuclease, the two-grna guided cleavage can significantly reduce the off target effects. Group: Cloning Enzymes. Purity: 10μg; 50μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4 at 25 °C. Cat No: CE-3505.
NLS-Cas9-EGFP Nuclease
NLS-Cas9-EGFP Nuclease. Nls-cas9-egfp is a fusion protein contains a nuclear localization sequence (nls) on its n terminal and egfp on the c terminal. the egfp can be used as a reporter for tracking or sorting transfected cells, which enables the possibility of enriching cell populations for desired genome edits via fluorescence activated cell sorting (facs). it significantly reduces the labor and cost associated with single cell cloning and genotyping in genome editing applications. Group: Cloning Enzymes. Purity: 100μg; 500μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA,1 mM DTT, 50% Glycerol PH7.4, at 25°C. Cat No: CE-3506.
NLS-Cas9-NLS Nuclease
NLS-Cas9-NLS Nuclease. Nls-cas9-nls is produced by expression in an e. coli strain carrying a plasmid encoding the cas9 gene from streptococcus pyogenes with a double-ends nuclear localization signal (nls). it can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researcher´s requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4 at 25?. Cat No: CE-3504.
NLS (PKKKRKV) acetate
NLS (PKKKKKV) is a peptide that enhances nuclear entry into the field of gene transfer research. It is derived from the simian virus 40 large tumor antigen (SV40 large T antigen). Synonyms: NLS PKKKRKV acetate. Molecular formula: C42H82N14O10. Mole weight: 943.21.
NLS-StAx-h
NLS-StAx-h is a cell-permeable Wnt inhibitor that potently suppresses β-catenin-transcription factor interactions. CAS No. 2872559-21-0. Molecular formula: C161H275N55O29. Mole weight: 3445.26.
N-(L-Valyl) Valganciclovir Hydrochloride
N-(L-Valyl) Valganciclovir Hydrochloride is a dipeptide monoester prodrugs of the antiviral drug Ganciclovir. Synonyms: L-Valyl-L-valine 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3- hydroxypropyl Ester Hydrochloride. Grades: > 95%. Molecular formula: C19H32N7O6Cl. Mole weight: 489.96.
NLY01 is a long-acting, microglia-targeted GLP-1R agonist, which is undergoing clinical trials for the treatment of Parkinson's Disease and Alzheimer's Disease. Synonyms: NLY 01; NLY-01.
NM-3
NM-3 is an orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity. NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation. This agent also induces apoptosis by a mechanism involving reactive oxygen species. Synonyms: NM 3; NM3; isocoumarin NM-3; 2-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propanoic acid. CAS No. 181427-78-1. Molecular formula: C13H12O6. Mole weight: 264.23.
NMA-Gly-Cys-Gly-Val-Leu-Leu-Lys(dnp)-Arg-Arg-NH2 trifluoroacetate salt
N-Maleimido Butyryl Oxy Succinimide ester. CAS No. 80307-12-6. Pack Sizes: Milligram Quantities: 100 mg. Order Number: CL226.
www.prochemonline.com
N-Maleimidomethanol
N-Maleimidomethanol. Group: Biochemicals. Alternative Names: N-Methylolmaleimide; N- (Hydroxymethyl) maleimide; 1-(Hydroxymethyl)-1H-pyrrole-2,5-dione. Grades: Highly Purified. CAS No. 5063-96-7. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C5H5NO3. US Biological Life Sciences.
Worldwide
N-Maleimidomethanol (N-Methylolmaleimide)
A sulfhydryl reactive crosslinking reagent. Group: Biochemicals. Alternative Names: N-Methylolmaleimide. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
N-malonylurea hydrolase
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase). Group: Enzymes. Synonyms: ureidomalonase. Enzyme Commission Number: EC 3.5.1.95. CAS No. 368888-22-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4487; N-malonylurea hydrolase; EC 3.5.1.95; 368888-22-6; ureidomalonase. Cat No: EXWM-4487.
NMD670
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC 50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2354321-33-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158183.
NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. Uses: Excitatory amino acid agonists. Synonyms: LC488A; LC 488A; LC-488A. Grades: >98%. CAS No. 6384-92-5. Molecular formula: C5H9NO4. Mole weight: 147.13.
NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Uses: Scientific research. Group: Natural products. Alternative Names: N-Methyl-D-aspartic acid. CAS No. 6384-92-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-17551.
An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
NMDAR2C/2D Inhibitor, DQP-1105
The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications. Group: Fluorescence/luminescence spectroscopy.
A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4uM) and GluN1/GluN2D (2.2uM) over GluN1/GluN2B (206uM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
NMDA Receptor NR2BCT(1292-1304)-TAT
A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function. Group: Fluorescence/luminescence spectroscopy.
A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of nMDAR function with no effect on either the catalytic activity of DAPK1 or the nMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic nMDA receptors (at 50uM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from nMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???N??O??, Molecular Weight: 3382. US Biological Life Sciences.
Worldwide
NmDef02
NmDef02 is an antimicrobial peptide found in Nicotiana megalosiphon, and has antimicrobial activity. It belongs to the defensin family. Synonyms: Putative defensin. Grades: >98%.
N-Me-D-Tyr-OH. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2R)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid. Product Category: Promotional Products. Appearance: solid. CAS No. 178357-84-1. Molecular formula: C10H13NO3. Mole weight: 195.22. Purity: 95+%. Product ID: ACM178357841-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: 19897-63-3.
N-Me-L-norleucine hydrochloride
N-Me-L-norleucine hydrochloride. Group: Biochemicals. Alternative Names: N-Me-L-Nle-OH·HCl; N-Me-L-2-aminohexanoic acid. Grades: Highly Purified. CAS No. 17343-27-0. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
N-Methacrylglycine. Group: Biochemicals. Grades: Reagent Grade. CAS No. 23578-45-2. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
N-Methacryloyl-2-methylalanine
N-Methacryloyl-2-methylalanine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-Methacryloyl-2-methylalanine. Product Category: Heterocyclic Organic Compound. CAS No. 15926-21-3. Molecular formula: C8H13NO3. Mole weight: 171.19372. Purity: 0.96. IUPACName: 2-methyl-2-(2-methylprop-2-enoylamino)propanoic acid. Canonical SMILES: CC(=C)C(=O)NC(C)(C)C(=O)O. Product ID: ACM15926213. Alfa Chemistry ISO 9001:2015 Certified.
N-Methacryloyl-5-aminosalicylic acid
N-Methacryloyl-5-aminosalicylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-methacryloyl-5-aminosalicylic acid;2-Hydroxy-5-N-methacrylamidobenzoic acid;N-(3-Carboxy-4-hydroxyphenyl)methacrylamide;2-hydroxy-5-[(2-methyl-1-oxo-2-propen-1-yl)amino]Benzoic acid. Product Category: Polymer/Macromolecule. CAS No. 53193-87-6. Molecular formula: C11H11NO4. Density: 1.37g/cm³. Product ID: ACM53193876. Alfa Chemistry ISO 9001:2015 Certified.
N-Methacryloyl-L-proline
N-Methacryloyl-L-proline is a reactant used in the preparation of affinity ligands for the androstane receptor. Group: Biochemicals. Alternative Names: 1-Methacryloyl-L-proline; 1-(2-Methyl-1-oxo-2-propen-1-yl)-L-proline. Grades: Highly Purified. CAS No. 51161-88-7. Pack Sizes: 250mg. US Biological Life Sciences.
N-(Methanethiosulfonylethylcarboxamidoethyl)-5-naphthylamine-1-sulfonic acid sodium salt
N-(Methanethiosulfonylethylcarboxamidoethyl)-5-naphthylamine-1-sulfonic acid sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MTS-1,5-EDANS-CARBOXYETHYL;N-(METHANETHIOSULFONYLETHYLCARBOXAMIDOETHYL)-5-NAPHTHYLAMINE-1-SULFONIC ACID, SODIUM SALT. Product Category: Heterocyclic Organic Compound. Appearance: Dark Yellow Powder. CAS No. 359436-83-2. Molecular formula: C16H18NNaO6S3. Mole weight: 439.5. Product ID: ACM359436832. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID90404396.
N-Methane thiosulfonylethylene -N6- (6-biotinamidocaproyl) lysineamido-N-a- Ammonium Trifluoroacetic Acid Salt
N-Methoxy-2-(4-methoxy-cyclohexyl)-N-methyl-acetamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-methoxy-2-(2-naphthyl)acetamide; 2-Naphthaleneacetamide,N-methoxy; N-methoxy-2-(cis/trans-4-methoxycyclohexyl)-N-methylacetamide. Product Category: Heterocyclic Organic Compound. CAS No. 848170-25-2. Molecular formula: C11H21NO3. Mole weight: 215.289. Purity: 0.96. IUPACName: N-Methoxy-2-(4-methoxycyclohexyl)-N-methylacetamide. Product ID: ACM848170252. Alfa Chemistry ISO 9001:2015 Certified.
N-Methoxy-2,N-dimethylacrylamide
N-Methoxy-2,N-dimethylacrylamide. Group: Biochemicals. Alternative Names: N-Methoxy-N,2-dimethyl-2-propenamide. Grades: Highly Purified. CAS No. 132960-14-6. Pack Sizes: 2.5g. US Biological Life Sciences.
Worldwide
N-Methoxycarbonyl Dabigatran Ethyl Ester
An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, showing that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Synonyms: N-[[2-[[[4-[Imino[ (methoxycarbonyl) amino]methyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β -alanine Ethyl Ester; Ethyl 3- (2- ( ( (4- (N- (methoxycarbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate. Grades: ≥95%. CAS No. 211914-96-4. Molecular formula: C29H31N7O5. Mole weight: 557.61.
N-(Methoxycarbonyl)-L-serine Methyl Ester
N-(Methoxycarbonyl)-L-serine Methyl Ester. Group: Biochemicals. Alternative Names: (S) -N- (Methoxycarbonyl) serine Methyl Ester. Grades: Highly Purified. CAS No. 96854-24-9. Pack Sizes: 1g. Molecular Formula: C6H11NO5, Molecular Weight: 177.16. US Biological Life Sciences.
Worldwide
N-(Methoxycarbonyl)-L-tert-leucine
N-(Methoxycarbonyl)-L-tert-leucine. Group: Biochemicals. Alternative Names: N-(Methoxycarbonyl)-3-methyl-L-valine. Grades: Highly Purified. CAS No. 162537-11-3. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
N-(Methoxycarbonyl) L-tryptophan methyl ester
N-(Methoxycarbonyl) L-tryptophan methyl ester. Group: Biochemicals. Alternative Names: N.alpha.-Methoxycarbonyl-L-tryptophan methyl ester. Grades: Highly Purified. CAS No. 58635-46-4. Pack Sizes: 2g, 5g, 10g, 25g, 50g. Molecular Formula: C14H16N2O4. US Biological Life Sciences.
N-(Methoxycarbonyl) Maleimide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
N-Methoxycarbonyl Vigabatrin-13C,d2 Ethyl Ester
Used in the preparation of Vigabatrin. Group: Biochemicals. Alternative Names: 4-[ (Methoxycarbonyl) amino]-5-hexenoic Acid Ethyl Ester-13C,d2. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
N-Methoxycarbonyl Vigabatrin Ethyl Ester
Used in the preparation of Vigabatrin. Group: Biochemicals. Alternative Names: 4-[ (Methoxycarbonyl) amino]-5-hexenoic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
N-(Methoxymethyl)acrylamide (stabilized with MEHQ)
N-(Methoxymethyl)acrylamide (stabilized with MEHQ). Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-(Methoxymethyl)-2-propenamide (stabilized with MEHQ). Product Category: Acrylamide Monomers. Appearance: Colorless to Light Yellow Clear Liquid. CAS No. 3644-11-9. Molecular formula: C5H9NO2. Mole weight: 115.13 g/mol. Purity: 95.0%(GC)(T). Product ID: ACM-MO-3644119. Alfa Chemistry ISO 9001:2015 Certified.
N-(Methoxymethyl)methacrylamide, ≥85%,stabilized with MEHQ
N-Methoxy-N-methyl-2,?3,?4,?6-tetrakis-O-(phenylmethyl)?-β-D-glucopyranosylamine is an intermediate of 6-α-D-Glucopyranosyl Maltotriose, a sugar composition of sake. Synonyms: N, O-Dimethyl-N- ( (2R, 3R, 4S, 5R, 6R)-3, 4, 5-tris (benzyloxy)-6- ( (benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)hydroxylamine. CAS No. 1269490-02-9. Molecular formula: C36H41NO6. Mole weight: 583.71.
N-Methoxy-N-methyl-2-furamide
N-Methoxy-N-methyl-2-furamide. Group: Biochemicals. Grades: Reagent Grade. CAS No. 95091-92-2. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences.